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# Anecrit's Newsletter #37
- URL: https://www.anecrit.com/anecrits-newsletter-37/
- Published: 2026-06-27T11:40:45.000Z
- Updated: 2026-07-04T11:13:28.000Z
- Author: BENHALIMA Othmane
- Tags: Newsletter

Hundreds of anesthesia & critical care papers, distilled weekly.

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Hey!

This week's highlight: three new AHA scientific statements on perioperative anemia and patient blood management in cardiac surgery, secondary prevention after CABG, and perinatal heart failure. Plus the usual roundup — 36 papers in anaesthesiology, 47 in critical care.

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---

# **Anesthesiology:**

## ***Guidelines & Consensus:***

### 1- Cardiovascular & Hemodynamics:

1. Perioperative Anemia and Patient Blood Management in Cardiac Surgery: A Scientific Statement From the American Heart Association, Circulation, 22 June 2026, [Link](https://www.ahajournals.org/doi/10.1161/CIR.0000000000001446)
2. Secondary Prevention After Coronary Artery Bypass Graft Surgery: 2026 Update: A Scientific Statement From the American Heart Association, Circulation, 13 May 2026, [Link](https://www.ahajournals.org/doi/10.1161/CIR.0000000000001434)

### 2- Obstetrics & Gynecology:

1. Heart Failure Occurring in the Perinatal Period: A Scientific Statement From the American Heart Association, Circulation, 24 June 2026, [Link](https://www.ahajournals.org/doi/10.1161/CIR.0000000000001450)

---

## ***Systematic reviews & meta-analyses:***

### 1- Neuro:

1. Remimazolam Versus Propofol for Anesthesia in Intracranial Neurosurgeries: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Journal of Neurosurgical Anesthesiology, 19 June 2026, [Link](https://journals.lww.com/jnsa/abstract/9900/remimazolam%5Fversus%5Fpropofol%5Ffor%5Fanesthesia%5Fin.247.aspx)

### 2- Cardiovascular & Hemodynamics:

1. Machine learning vs. traditional methods for predicting postoperative cardiac complications after non-cardiac surgery: a systematic review and Bayesian network meta-analysis, Anaesthesia, 22 June 2026, [Link](https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/ftr/10.1111/anae.70237)
2. Hemodynamic effects of dexmedetomidine versus propofol in cardiac surgery: a systematic review and meta-analysis, BMC Anesthesiology, 20 June 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04027-z)

### 3- Regional Anesthesia & Pain Management:

1. Effect of ultrasound-guided fascial plane block (UGPB) on pain control of rib fractures: a systematic review and meta-analysis, BMC Anesthesiology, 24 June 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04045-x)
2. Effects of single-injection vs. continuous brachial plexus blocks for shoulder surgeries on patient-reported outcomes: a systematic review and meta-analysis with trial sequential analysis of randomised controlled trials, Anaesthesia, 23 June 2026, [Link](https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/ftr/10.1111/anae.70249)

---

## ***Clinical trials:***

### 1- Airway & Mechanical Ventilation:

1. Respiration-Related Catheter Displacement and Physiological Tolerance of High-Frequency Very-Low Tidal Volume Ventilation with Peak Pressure Limitation During Atrial Fibrillation Ablation: A Prospective One-Way Crossover Pilot Study, Journal of Cardiothoracic and Vascular Anesthesia, 24 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026005100)
2. Hypotension and pulmonary atelectasis during general anaesthesia: a randomised crossover laboratory study, BJA, 24 June 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900361-2/fulltext)
3. Individualized PEEP titration guided by static lung compliance reduces postoperative atelectasis in elderly patients during laparoscopic Trendelenburg surgery: a randomized controlled trial, Perioperative Medicine, 19 June 2026, [Link](https://link.springer.com/article/10.1186/s13741-026-00708-y)
4. Stellate ganglion block for attenuating postoperative sore throat after double-lumen tube intubation in thoracic surgery: a randomized clinical study, Perioperative Medicine, 17 June 2026, [Link](https://link.springer.com/article/10.1186/s13741-026-00710-4)

### 2- Cardiovascular & Hemodynamics:

1. Effect of the orexin receptor antagonist, suvorexant, on sleep architecture in the early postoperative period following cardiac surgery: a randomized controlled trial, Critical Care, 23 June 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06151-1)
2. Perioperative intravenous fluid and chronic kidney disease: long-term follow-up of the Restrictive *versus* Liberal Fluid Therapy in Major Abdominal Surgery (RELIEF) randomised trial, BJA, 22 June 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900363-6/abstract)

### 3- Obstetrics & Gynecology:

1. Low-dose esketamine for postoperative fatigue after gynecological laparoscopic surgery: a randomized controlled trial, BMC Anesthesiology, 26 June 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04051-z)
2. Low-dose intrathecal morphine versus intrathecal fentanyl for post-caesarean analgesia in a resource-constrained setting: a pragmatic randomised trial, BMC Anesthesiology, 23 June 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04034-0)
3. Remimazolam vs. propofol for prevention of postoperative nausea and vomiting in laparoscopic gynecological surgery: a randomized non-inferiority trial, Perioperative Medicine, 16 June 2026, [Link](https://link.springer.com/article/10.1186/s13741-026-00713-1)

### 4- Regional Anesthesia & Pain Management:

1. Self-Directed vs Clinician-Delivered Cognitive Behavioral Therapy for Chronic Pain: A Randomized Clinical Trial, JAMA, 24 June 0226, [Link](https://jamanetwork.com/journals/jama/fullarticle/2850722)
2. Stellate ganglion block for attenuating postoperative sore throat after double-lumen tube intubation in thoracic surgery: a randomized clinical study, Perioperative Medicine, 17 June 2026, [Link](https://link.springer.com/article/10.1186/s13741-026-00710-4)

### 5- Other:

1. Intravenous lidocaine reduces propofol requirements during endoscopic ultrasound: a randomized, double-blinded, controlled trial, BMC Anesthesiology, 22 June 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04018-0)

---

## ***Reviews:***

### 1- Neuro:

1. Central nervous system stimulants: basic pharmacology and relevance to anaesthesia and critical care, Anaesthesia & Intensive Care Medicine, 24 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926000925)

### 2- Cardiovascular & Hemodynamics:

1. Preoperative cardiac optimization, Anaesthesia & Intensive Care Medicine, 24 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926001001)
2. Noninvasive Arterial Pressure Monitoring during Anesthesia, Anesthesiology, 18 June 2026, [Link](https://journals.lww.com/anesthesiology/citation/9900/noninvasive%5Farterial%5Fpressure%5Fmonitoring%5Fduring.1057.aspx)

### 3- Regional Anesthesia & Pain Management:

1. Eye-tracking technology applied to regional anaesthesia task performance, safety and skill acquisition: a scoping review, BJA, 25 June 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900392-2/fulltext)
2. Enhanced recovery pathways for patients with chronic pain: beyond standard protocols – a narrative review, Current Opinion in Anesthesiology, 23 June 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/enhanced%5Frecovery%5Fpathways%5Ffor%5Fpatients%5Fwith.441.aspx)
3. Novel technologies and innovations in postoperative follow-up after regional anesthesia, Current Opinion in Anesthesiology, 19 June 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/novel%5Ftechnologies%5Fand%5Finnovations%5Fin.440.aspx)

### 4- Other:

1. Prehabilitation, Anaesthesia & Intensive Care Medicine, 24 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926000937)
2. Confidentiality: a practical guide for anaesthetic and intensive care medicine practitioners, Anaesthesia & Intensive Care Medicine, 24 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926000962)
3. Conflict resolution, Anaesthesia & Intensive Care Medicine, 24 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926000998)
4. Suction devices, Anaesthesia & Intensive Care Medicine, 24 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926001013)
5. Omics and anaesthesia: pharmacogenomics, proteomics and metabolomics, Anaesthesia & Intensive Care Medicine, 24 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926001025)
6. Frailty assessment in the pre-operative setting, Anaesthesia & Intensive Care Medicine, 24 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926001062)
7. Gastric disorders: modifications of gastric content, antacids and drugs influencing gastric secretions and motility, Anaesthesia & Intensive Care Medicine, 24 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926000974)
8. Clinical aspects of hepatic disease, Anaesthesia & Intensive Care Medicine, 24 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926001037)
9. Drugs and the liver, Anaesthesia & Intensive Care Medicine, 24 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926001050)
10. European simulation-based education and training in anaesthesiology and intensive care: evidence, value and inevitable evolution, European Journal of Anaesthesiology, 22 June 2026, [Link](https://journals.lww.com/ejanaesthesiology/abstract/9900/european%5Fsimulation%5Fbased%5Feducation%5Fand%5Ftraining.436.aspx)

---

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# **Critical Care:**

## ***Guidelines & Consensus:***

### 1- Cardiovascular & Hemodynamics:

1. Heart Failure Occurring in the Perinatal Period: A Scientific Statement From the American Heart Association, Circulation, 24 June 2026, [Link](https://www.ahajournals.org/doi/10.1161/CIR.0000000000001450)
2. Perioperative Anemia and Patient Blood Management in Cardiac Surgery: A Scientific Statement From the American Heart Association, Circulation, 22 June 2026, [Link](https://www.ahajournals.org/doi/10.1161/CIR.0000000000001446)
3. Secondary Prevention After Coronary Artery Bypass Graft Surgery: 2026 Update: A Scientific Statement From the American Heart Association, Circulation, 13 May 2026, [Link](https://www.ahajournals.org/doi/10.1161/CIR.0000000000001434)

---

## ***Systematic reviews & meta-analyses:***

### 1- Cardiovascular & Hemodynamics:

1. The effectiveness of tissue-perfusion-guided resuscitation in shock: A systematic review and meta-analysis, Annals of Intensive Care, 25 June 2026, [Link](https://www.sciencedirect.com/science/article/pii/S211058202600141X)

### 2- Neuro-muscular:

1. Ventriculostomy-Related Infections by Country-Income Level: A Systematic Review and Bayesian Hierarchical Meta-analysis, Journal of Neurosurgical Anesthesiology, 15 June 2026, [Link](https://journals.lww.com/jnsa/abstract/9900/ventriculostomy%5Frelated%5Finfections%5Fby.246.aspx)
2. Association Between Intracranial Pressure Variability and Clinical Outcomes in Acute Brain Injury: A Systematic Review and Meta-Analysis, Journal of Neurosurgical Anesthesiology, 15 June 2026, [Link](https://journals.lww.com/jnsa/abstract/9900/association%5Fbetween%5Fintracranial%5Fpressure.241.aspx)

### 3- Trauma:

1. Acute intoxication and trauma severity in emergency department patients: a systematic review, BMC Emergency Medicine, 23 June 2026, [Link](https://link.springer.com/article/10.1186/s12873-026-01623-7)
2. Clinical outcomes of hemostatic interventions in patients with traumatic injury: A systematic review of randomized controlled trials, The Journal of Trauma and Acute Care Surgery, 15 June 2026, [Link](https://journals.lww.com/jtrauma/abstract/9900/clinical%5Foutcomes%5Fof%5Fhemostatic%5Finterventions%5Fin.1408.aspx)

### 4- Infectious Diseases:

1. Comparative efficacy and safety of extended versus continuous infusion of beta-lactam antibiotics for severe infection: a network meta-analysis of randomized trials, Critical Care, 20 June 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06142-2)
2. Diagnostic accuracy of presepsin for sepsis in adult patients according to the criteria of sepsis-3: systematic review and meta-analysis, BMC Anesthesiology, 19 June 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03983-w)

---

## ***Clinical trials:***

### 1- Cardiovascular & Hemodynamics:

1. Effect of the orexin receptor antagonist, suvorexant, on sleep architecture in the early postoperative period following cardiac surgery: a randomized controlled trial, Critical Care, 23 June 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06151-1)

### 2- Thorax/Lungs/Airways/Mechanical ventilation:

1. Standardized low-flow ventilation with PEEP maintenance during bronchoscopy in mechanically ventilated ICU patients: a pilot trial, Journal of Intensive Care, 21 June 2026, [Link](https://link.springer.com/article/10.1186/s40560-026-00895-2)

### 3- Neuro-muscular:

1. Safety and Efficacy of Nerinetide at Year 1 in Participants Enrolled in ESCAPE‐NEXT: A Multicenter, Double‐Blind, Randomized Controlled Trial, Journal of the American Heart Association, 23 June 2026, [Link](https://www.ahajournals.org/doi/10.1161/JAHA.125.044080)
2. CN-105 in Participants with Acute Supratentorial Intracerebral Hemorrhage Trial in Singapore (S-CATCH): A Phase 2b, Randomized, Double-blind, Placebo-Controlled Trial, Neurocritical Care, 23 June 2026, [Link](https://link.springer.com/article/10.1007/s12028-026-02563-7)
3. Concordance Between Bedside and Electronic Detection of Intracranial Pressure Crises: Insights From the Brain Tissue Oxygen Monitoring and Management in Severe Traumatic Brain Injury II Trial, Critical Care Medicine, 18 June 2026, [Link](https://journals.lww.com/ccmjournal/abstract/9900/concordance%5Fbetween%5Fbedside%5Fand%5Felectronic.892.aspx)

### 4- Trauma:

1. Prolonged tourniquet use in extremity trauma: What you need to know, The Journal of Trauma and Acute Care Surgery, 19 June 2026, [Link](https://journals.lww.com/jtrauma/abstract/9900/prolonged%5Ftourniquet%5Fuse%5Fin%5Fextremity%5Ftrauma%5F%5Fwhat.1416.aspx)

### 5- Infectious Diseases:

1. Benzylpenicillin versus flucloxacillin or cloxacillin for the treatment of penicillin-susceptible *Staphylococcus aureus* bacteraemia (SNAP): an international, multicentre, open-label, non-inferiority randomised controlled trial, The Lancet, 17 June 2026, [Link](https://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2826%2900761-0/fulltext)

---

## ***Reviews:***

### 1- Thorax/Lungs/Airways/Mechanical ventilation:

1. PEEP and alveolar recruitment after 60 years of acute respiratory distress syndrome, Intensive Care Medicine, 22 June 2026, [Link](https://link.springer.com/article/10.1007/s00134-026-08511-5)
2. The role of mechanical power in lung ventilation for the prevention of ventilator-induced lung injury: a narrative review, European Respiratory Review, 29 April 2026, [Link](https://publications.ersnet.org/content/errev/35/180/250283)

### 2- Neuro-muscular:

1. Central nervous system stimulants: basic pharmacology and relevance to anaesthesia and critical care, Anaesthesia & Intensive Care Medicine, 24 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926000925)
2. Beyond the Catheter: Contemporary Aspiration Pump Systems in Neurointerventional Stroke Therapy, Stroke: Vascular and Interventional Neurology, 22 June 2026, [Link](https://www.ahajournals.org/doi/10.1161/SVIN.126.002487)
3. Emerging Therapy Critique: Glibenclamide for Cerebral Edema—A Semi-CHARMed Treatment, Stroke, 22 June 2026, [Link](https://www.ahajournals.org/doi/10.1161/STROKEAHA.126.049690)
4. Early Autonomic Dysfunction Following TBI and Possible Interventions: A Narrative Review, Journal of Neurosurgical Anesthesiology, 18 June 2026, [Link](https://journals.lww.com/jnsa/abstract/9900/early%5Fautonomic%5Fdysfunction%5Ffollowing%5Ftbi%5Fand.248.aspx)
5. Immune System of the Ischemic Brain: Old Paradigms Revisited, Stroke, 27 May 2026, [Link](https://www.ahajournals.org/doi/10.1161/STROKEAHA.125.051471)
6. Taking a Glimpse Into the Brain’s Immune System: Imaging and Blood-Based Biomarkers of the Poststroke Immune Response, Stroke, 27 May 2026, [Link](https://www.ahajournals.org/doi/10.1161/STROKEAHA.125.051472)
7. Inflammation in Acute Ischemic Stroke: Translational Barriers and Implications for Treatment, Stroke, 27 May 2026, [Link](https://www.ahajournals.org/doi/10.1161/STROKEAHA.126.056147)
8. Thromboinflammation in Acute Stroke: From Pathophysiological Challenges to Emerging Therapeutic Opportunities, Stroke, 27 May 2026, [Link](https://www.ahajournals.org/doi/10.1161/STROKEAHA.125.051476)
9. Inflammation in Aneurysmal Subarachnoid Hemorrhage: Cause, Consequence, or Both? Focus on Pathogen Pattern Recognition, Stroke, 27 May 2026, [Link](https://www.ahajournals.org/doi/10.1161/STROKEAHA.125.051475)
10. Inflammation as a Key Driver for Chronic Subdural Hematomas, Stroke, 27 May 2026, [Link](https://www.ahajournals.org/doi/10.1161/STROKEAHA.126.055340)

### 3- Liver & GI:

1. Gastric disorders: modifications of gastric content, antacids and drugs influencing gastric secretions and motility, Anaesthesia & Intensive Care Medicine, 24 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926000974)
2. Drugs and the liver, Anaesthesia & Intensive Care Medicine, 24 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926001050)

### 4- Blood & hemostasis:

1. Mouse models to study von Willebrand factor in inflammation: a scoping review, Intensive Care Medicine Experimental, 24 June 2026, [Link](https://link.springer.com/article/10.1186/s40635-026-00935-z)

### 5- Nutrition:

1. Feeding under support in critical care illness: metabolic and nutritional management during extracorporeal membrane oxygenation and continuous renal replacement therapy, Current Opinion in Critical Care, 22 June 2026, [Link](https://journals.lww.com/co-criticalcare/abstract/9900/feeding%5Funder%5Fsupport%5Fin%5Fcritical%5Fcare%5Fillness%5F.372.aspx)

### 6- Infectious Diseases:

1. Bundibugyo Virus Disease in 2026 — Clinical and Public Health Responses, NEJM, 24 June 2026, [Link](https://www.nejm.org/doi/full/10.1056/NEJMra2607216)
2. Systemic corticosteroids for severe community-acquired pneumonia: a narrative review of mechanisms and critical appraisal of recent trials in ICU, European Respiratory Review, 24 June 2026, [Link](https://publications.ersnet.org/content/errev/35/180/250259)
3. Antimicrobial Resistance in Patients with Sepsis, Critical Care Clinics, 22 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070426000357)
4. Real-time Subgrouping of Sepsis and Systemic Inflammatory Syndromes, Critical Care Clinics, 22 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070426000370)
5. Post-Sepsis Syndrome after Critical Illness: Epidemiology and Long-term Outcomes, Critical Care Clinics, 22 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070426000400)

### 7- Pediatric critical care:

1. Hypodermoclysis for Fluid Administration in Hospitalized Pediatric Patients: A Scoping Review, Pediatric Emergency Care, 22 June 2026, [Link](https://journals.lww.com/pec-online/abstract/9900/hypodermoclysis%5Ffor%5Ffluid%5Fadministration%5Fin.856.aspx)

### 8- Other: 

1. Neurocritical Care Fellowship Training in the USA: Challenges and Potential Solutions, Neurocritical Care, 26 June 2026, [Link](https://link.springer.com/article/10.1007/s12028-026-02574-4)
2. Consent, Anaesthesia & Intensive Care Medicine, 25 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926000950)
3. Immune-Mediated Inflammatory Diseases and the Critically Ill, Critical Care Clinics, 25 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070426000308)
4. Negligence, Anaesthesia & Intensive Care Medicine, 24 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926000949)
5. Confidentiality: a practical guide for anaesthetic and intensive care medicine practitioners, Anaesthesia & Intensive Care Medicine, 24 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926000962)
6. Conflict resolution, Anaesthesia & Intensive Care Medicine, 24 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926000998)
7. European simulation-based education and training in anaesthesiology and intensive care: evidence, value and inevitable evolution, European Journal of Anaesthesiology, 22 June 2026, [Link](https://journals.lww.com/ejanaesthesiology/abstract/9900/european%5Fsimulation%5Fbased%5Feducation%5Fand%5Ftraining.436.aspx)
8. Multinational collaborations in critical care research: feasible and useful?, Current Opinion in Critical Care, 22 June 2026, [Link](https://journals.lww.com/co-criticalcare/abstract/9900/multinational%5Fcollaborations%5Fin%5Fcritical%5Fcare.371.aspx)

---

### **Feedback & Suggestions**

Don't hesitate to share your thoughts and suggestions in the comments below; they'll be a great help in improving future issues of the newsletter.

💡

****Disclaimer:**  
For educational use only; not a substitute for professional medical judgment. The papers shared in this newsletter are provided for informational purposes and do not necessarily reflect our views or clinical opinions.

See you next time :)

**Benhalima Othmane, MD.**

**Anecrit.com**