# Anecrit
> Weekly roundup of the most important anesthesia & ICU papers, curated for busy clinicians. Read by anesthesiology and intensive care medicine professionals across 30+ countries.
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Append `.md` to any post or page URL to get the content in Markdown (for example, `/example-post.md`).
## Pages
### About
URL: https://www.anecrit.com/about/
Last updated: 2026-09-27T18:36:10.000Z
Hi there! Welcome to Anecrit. If you've landed here, you've likely explored some of my content, so you might already have an idea of what I write about
### First, who am I?
My name is Benhalima Othmane, and I'm a PGY4 resident in anesthesiology and critical care medicine from Algeria, a North African country and the largest on the continent.
### What's anecrit?
When I first started Anecrit, I considered making it just another medical blog. But after a lot of reflection, I realized my vision was different. Anecrit is essentially my personal knowledge base – imagine my Obsidian or Notion notes, but in a public website format! This way, I can share what I'm learning, and critically, open myself up to feedback and learning from others. Having this public knowledge base also keeps me incredibly disciplined, motivating me to constantly read, learn, and create high-quality content.
> If you can't explain it simply, you don't understand it well enough. Albert Einstein
---
### The newsletter
The newsletter is designed to help both you and me stay updated and current in our ever-evolving and rapidly shifting domain. Primarily, it serves as my personal curated list of the most relevant papers published each week. This allows me to review them in one sitting, select what to read in the coming days, and add to my reading waitlist. I make an effort to track all relevant journals, not just the most well-known ones. Since I'm already doing this work for myself, sharing it seems natural, and it further motivates me to stay disciplined with this daily review, rather than just doing it when I feel motivated.
---
So, if what I'm doing resonates with you, please consider subscribing to my website and newsletter. Feel free to share it with others who might benefit. Ultimately, my hope is to build a growing community where we can all discuss and learn from each other.
*Benhalima Othmane, M.D*
### Disclaimer
URL: https://www.anecrit.com/disclaimer/
Last updated: 2024-12-14T17:54:32.000Z
## **Disclaimer for Anecrit.com**
The information provided on Anecrit.com is for general informational purposes related to anesthesiology and critical care medicine. It is not intended to serve as a substitute for professional medical advice, diagnosis, or treatment. Always consult qualified healthcare professionals for medical conditions or concerns.
## **No Medical Advice**
The content on this website, including articles, blog posts, and other materials, is not intended to replace or act as a substitute for professional medical advice. The information is based on general knowledge and should not be considered as specific medical guidance.
## **Accuracy and Completeness**
While we strive to provide accurate and up-to-date information, Anecrit.com makes no representations or warranties of any kind, express or implied, regarding the accuracy, reliability, suitability, or completeness of the information on this website. Any reliance you place on such information is at your own risk.
## **Medical Decisions and Treatment**
Any decisions made based on information from Anecrit.com are solely at your discretion and risk. We do not endorse or recommend any specific tests, physicians, products, procedures, opinions, or other information featured on the website.
## **Professional Medical Consultation**
Users should always consult qualified healthcare professionals for personalized medical advice, diagnosis, or treatment. Never disregard professional medical advice or delay seeking it due to something you’ve read on this site.
## **Limitation of Liability**
Under no circumstances will Anecrit.com be liable for any loss or damage, including but not limited to indirect or consequential loss or damage, arising from the use of this website.
## **External Links**
Anecrit.com may contain links to third-party websites for additional information or resources. We do not endorse or take responsibility for the content, practices, or actions of external sites.
## **Changes to Disclaimer**
Anecrit.com reserves the right to modify or update this disclaimer at any time without prior notice. By continuing to use this website, you agree to be bound by the updated disclaimer.
## **Contact Us**
If you have any questions or concerns regarding this disclaimer or the content on our website, please contact us at [anecrit@gmail.com](mailto:anecrit@gmail.com).
### Terms and Conditions
URL: https://www.anecrit.com/terms_conditions/
Last updated: 2025-01-03T13:49:47.000Z
## Terms and Conditions for Anecrit.com
These **"Terms"** and **"Conditions"** govern your use of Anecrit.com ("the Website"), operated by Dr Benhalima Othmane. By accessing or using the Website, you agree to comply with these **"Terms"** and **"Conditions"**. If you do not agree with any part of the **"Terms"** and **"Conditions"**, you must refrain from using the Website.
### 1\. **Use of the Website**
- **Content:** The content on this Website is provided for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of qualified healthcare professionals regarding any medical concerns.
- **User Accounts:** Certain features of the Website may require the creation of a user account. You are responsible for maintaining the confidentiality of your account information and for all activities under your account.
- **Prohibited Activities:** You agree not to engage in any unlawful, abusive, or unauthorized use of the Website, including but not limited to: violating applicable laws, infringing on intellectual property rights, or transmitting harmful content.
### 2\. **Intellectual Property Rights**
- **Ownership:** All content, including but not limited to articles, images, logos, and trademarks, on the Website is the property of Anecrit.com and is protected by copyright and other intellectual property laws.
- **Use of Content:** You may access and use the content on the Website for personal, non-commercial purposes only. Reproduction, distribution, or use of the content for commercial purposes requires prior written permission from Anecrit.com.
### 3\. **Limitation of Liability**
- **Disclaimer:** The information provided on the Website is offered "as is." Anecrit.com makes no representations or warranties, express or implied, about the accuracy, completeness, reliability, or suitability of the content for any purpose.
- **Limitation of Liability:** Anecrit.com shall not be liable for any direct, indirect, incidental, consequential, or punitive damages arising from your access to or use of the Website.
### 4\. **Privacy**
Your use of the Website is also governed by our Privacy Policy, which details how we collect, use, and protect your personal information. By using the Website, you consent to the practices outlined in the Privacy Policy.
### 5\. **Changes to Terms**
Anecrit.com reserves the right to modify or update these Terms at any time, without prior notice. Continued use of the Website after such changes constitutes acceptance of the revised Terms.
### 6\. **Governing Law**
These **"Terms"** and your use of the Website shall be governed by and construed in accordance with the applicable laws, without regard to its conflict of law provisions.
### 7\. **Contact Us**
If you have any questions or concerns regarding these Terms, please contact us at anecrit@gmail.com.
### Privacy Policy
URL: https://www.anecrit.com/privacy/
Last updated: 2024-12-14T19:19:10.000Z
### Privacy Policy for Anecrit.com
This Privacy Policy explains how Anecrit.com collects, uses, and safeguards the information you provide when using our website, including any personal information.
#### Information We Collect
- **Personal Information:** This may include your name, email address, billing information, and any other details you voluntarily provide when subscribing to our services or engaging with the website.
- **Non-Personal Information:** We may collect non-personal information such as your browser type, IP address, referring site, and pages visited. This information helps us improve our website, services, and user experience.
#### How We Use Your Information
- **To Provide Services:** Your personal information is used to deliver the services you’ve subscribed to, including sending newsletters, updates, and managing your subscription.
- **Improvement of Services:** We may analyze non-personal information to enhance our website, services, and overall user experience.
- **Communication:** We may use your contact information to respond to inquiries, provide customer support, and communicate important updates or changes related to our services.
#### Protection of Information
- We employ industry-standard security measures to protect your personal information from unauthorized access, misuse, alteration, or loss.
- We do not sell, trade, or transfer your personal information to third parties without your consent, except as required by law or to facilitate services (e.g., payment processors).
#### Cookies and Tracking Technologies
- Our website may use cookies and similar tracking technologies to enhance your user experience and collect non-personal information. You can manage cookie preferences through your browser settings.
#### Third-Party Links
- Our website may contain links to third-party websites or services. We are not responsible for their privacy practices and encourage you to review their privacy policies.
#### Your Choices and Rights
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- You can opt out of receiving marketing communications from us by following the unsubscribe instructions included in our emails.
#### Changes to This Privacy Policy
- We reserve the right to update or modify this Privacy Policy at any time. Any changes will be reflected on this page with an updated effective date.
#### Contact Us
If you have any questions, concerns, or requests regarding this Privacy Policy or our data practices, please contact us at anecrit@gmail.com.
### Guidelines
URL: https://www.anecrit.com/guidelines/
Last updated: 2026-07-05T18:37:03.000Z
💡
This page is updated regularly to ensure the inclusion of the most relevant and up-to-date guidelines in anesthesiology and critical care medicine. However, it is not intended to be a definitive or exhaustive resource. Guidelines may evolve over time, and users are encouraged to consult original sources and professional societies for the most current recommendations.
#### Anesthesiology
- AI
- [Neuro](https://www.anecrit.com/neurological-guidelines/)
- [Airway & Mechanical Ventilation](https://www.anecrit.com/airways-mv-anesthesia/)
- [Cardiovascular & Hemodynamics](https://www.anecrit.com/cardiovascular-anesthesiology-guidelines/)
- [Thoracic](https://www.anecrit.com/thoracic-anesthesia-guidelines/)
- [Abdomen](https://www.anecrit.com/liver-surgery-anesthesiology-guidelines/)
- [General](https://www.anecrit.com/general-guidelines/)
- [Obstetrics & Gynecology](https://www.anecrit.com/obstetric-anesthesia-guidelines/)
- [Pediatric](https://www.anecrit.com/pediatric-anesthesia-guidelines/)
- Orthopedic
- [Regional Anesthesia & Pain Management](https://www.anecrit.com/regional-anesthesia-pain-management-guidelines/)
- [Other](https://www.anecrit.com/renal-anesthesia-guidelines/)
---
#### Intensive Care Medicine
- [AI in Critical Care](https://www.anecrit.com/ai-in-critical-care/)
- [Cardiovascular & Hemodynamics](https://www.anecrit.com/cardiovascular-cc-guidelines/)
- [Thorax/Lungs/Airways/Mechanical ventilation](https://www.anecrit.com/guidelines-cc-lungs/)
- [Neuro-muscular](https://www.anecrit.com/neurocriticalcare-guidelines/)
- [Renal](https://www.anecrit.com/renal-guidelines/)
- [Trauma](https://www.anecrit.com/trauma-guidelines/)
- [Liver & GI](https://www.anecrit.com/liver-gi-cc-guidelines/)
- [Blood & hemostasis](https://www.anecrit.com/blood-hemostasis-cc-guidelines/)
- [Nutrition](https://www.anecrit.com/nutrition-cc-guidelines/)
- [Infectious Diseases](https://www.anecrit.com/infectious-diseases-guidelines/)
- [Sedation & analgesia](https://www.anecrit.com/sedation-analgesia-guidelines/)
- Pediatric critical care
- [Endocrine and Metabolic](https://www.anecrit.com/endocrine-metabolic-guidelines/)
### Regional Anesthesia & Pain Management
URL: https://www.anecrit.com/regional-anesthesia-pain-management-guidelines/
Last updated: 2025-08-10T16:23:21.000Z
#### Complications:
- [Evidence-based clinical practice guidelines on postdural puncture headache: a consensus report from a multisociety international working group](https://rapm.bmj.com/content/49/7/471) 15 August 2023.
### Pediatric Anesthesia
URL: https://www.anecrit.com/pediatric-anesthesia-guidelines/
Last updated: 2026-07-05T18:21:27.000Z
#### Pediatric Anesthesia
- Perioperative hemodynamic optimisation - Paediatrics, Anaesthesia Critical Care & Pain Medicine, January 2026, [Link](https://www.sciencedirect.com/science/article/pii/S235255682500195X)
- [Airway management in neonates and infants: European Society of Anaesthesiology and Intensive Care and British **Journal of Anaesthesia* joint guidelines](https://journals.lww.com/ejanaesthesiology/pages/articleviewer.aspx?year=2024&issue=01000&article=00002&type=Fulltext), January 2024.
****SFAR:**
- Structural, material and functional organisation of centres performing paediatric anaesthesia, Anaesthesia Critical Care & Pain Medicine, May 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556825000748)
****ASA:**
- [Statement on Practice Recommendations for Pediatric Anesthesia](https://www.asahq.org/standards-and-practice-parameters/statement-on-practice-recommendations-for-pediatric-anesthesia), 13 October 2021.
#### Regional Anesthesia & pain management in Pediatrics
****ESRA:**
- [The European Society of Regional Anaesthesia and Pain Therapy/American Society of Regional Anesthesia and Pain Medicine Recommendations on Local Anesthetics and Adjuvants Dosage in Pediatric Regional Anesthesia](https://rapm.bmj.com/content/43/2/211), February 2018.
****ASA:**
- [Statement on the Practice of Pediatric Pain Medicine](https://www.asahq.org/standards-and-practice-parameters/statement-on-the-practice-of-pediatric-pain-medicine#:~:text=The%20treatment%20of%20pain%20in,diagnosis%2Dspecific%2C%20treatment%20plans.), 18 **October 2023.*
#### Airway Management in Pediatrics
****ESAIC:**
- [Airway management in neonates and infants: European Society of Anaesthesiology and Intensive Care and British **Journal of Anaesthesia* joint guidelines](https://journals.lww.com/ejanaesthesiology/pages/articleviewer.aspx?year=2024&issue=01000&article=00002&type=Fulltext), January 2024.
****SFAR:**
- [Management of the child's airway under anaesthesia: The French guidelines](https://www.sciencedirect.com/science/article/pii/S2352556819300700), December 2019.
#### Preoperative
****ASA:**
- [2023 American Society of Anesthesiologists Practice Guidelines for Preoperative Fasting: Carbohydrate-containing Clear Liquids with or without Protein, Chewing Gum, and Pediatric Fasting Duration—A Modular Update of the 2017 American Society of Anesthesiologists Practice Guidelines for Preoperative Fasting](https://journals.lww.com/anesthesiology/fulltext/2023/02000/2023%5Famerican%5Fsociety%5Fof%5Fanesthesiologists.8.aspx), February 2023.
###
###
###
###
### Obstetric & Gynecology Anesthesia
URL: https://www.anecrit.com/obstetric-anesthesia-guidelines/
Last updated: 2026-01-31T12:37:18.000Z
#### Obstetric Anesthesia
****ASA:**
- [Practice Guidelines for Obstetric Anesthesia: An Updated Report by the American Society of Anesthesiologists Task Force on Obstetric Anesthesia and the Society for Obstetric Anesthesia and Perinatology.](https://journals.lww.com/anesthesiology/fulltext/2016/02000/practice%5Fguidelines%5Ffor%5Fobstetric%5Fanesthesia%5F%5Fan.14.aspx)
- [Statement on Neuraxial Analgesia or Anesthesia in Obstetrics.](https://www.asahq.org/standards-and-practice-parameters/statement-on-neuraxial-anesthesia-in-obstetrics)
- [Statement on Optimal Goals for Anesthesia Care in Obstetrics.](https://www.asahq.org/standards-and-practice-parameters/statement-on-optimal-goals-for-anesthesia-care-in-obstetrics#:~:text=%E2%80%8BStatement%20on%20Optimal%20Goals%20for%20Anesthesia%20Care%20in%20Obstetrics,-Developed%20By%3A%20Committee&text=ABSTRACT%3A%20Good%20obstetric%20care%20requires,available%20varies%20widely%20among%20hospitals.)
#### Pain and Analgesia in Obstetrics
****ESAIC:**
- [ESAIC focused guidelines for the management of the failing epidural during labour epidural analgesia.](https://journals.lww.com/ejanaesthesiology/fulltext/2025/02000/esaic%5Ffocused%5Fguidelines%5Ffor%5Fthe%5Fmanagement%5Fof%5Fthe.2.aspx?context=featuredarticles&collectionid=3)
****ASA:**
- [Statement on Pain During Cesarean Delivery](https://www.asahq.org/standards-and-practice-parameters/statement-on-pain-during-cesarean-delivery).
- [Statement on the Use of Adjuvant Medications and Management of Intraoperative Pain During Cesarean Delivery.](https://www.asahq.org/standards-and-practice-parameters/statement-on-the-use-of-adjuvant-medications-and-management-of-intraoperative-pain-during-cesarean-delivery#:~:text=Maternal%20discomfort%20during%20cesarean%20delivery,of%20conversion%20to%20general%20anesthesia.)
- [Statement on Neuraxial Analgesia or Anesthesia in Obstetrics.](https://www.asahq.org/standards-and-practice-parameters/statement-on-neuraxial-anesthesia-in-obstetrics)
- [Statement on Neurologic Complications of Neuraxial Analgesia/Anesthesia in Obstetrics](https://www.asahq.org/standards-and-practice-parameters/statement-on-neurologic-complications-of-neuraxial-analgesia-anesthesia-in-obstetrics).
#### Obstetrical Complications
- Prevention and Treatment of Maternal Stroke in Pregnancy and Postpartum: A Scientific Statement From the American Heart Association, Stroke, 28 January 2026, [Link](https://www.ahajournals.org/doi/10.1161/STR.0000000000000514)
- [Guidelines for the management of women with severe pre-eclampsia.](https://www.sciencedirect.com/science/article/abs/pii/S2352556821001053?via%3Dihub)
- [Statement on Anesthesiologists' Role in Reducing Maternal Mortality and Severe Maternal Morbidity.](https://www.asahq.org/standards-and-practice-parameters/statement-on-anesthesiologists-role-in-reducing-maternal-mortality-and-severe-maternal-morbidity)
- [Statement on Neurologic Complications of Neuraxial Analgesia/Anesthesia in Obstetrics](https://www.asahq.org/standards-and-practice-parameters/statement-on-neurologic-complications-of-neuraxial-analgesia-anesthesia-in-obstetrics).
#### Other Aspects of Obstetric Anesthesia
****SFAR:**
- [Guidelines for the management of urgent obstetric situations in emergency medicine, 2022.](https://www.sciencedirect.com/science/article/abs/pii/S2352556822001084)
****ASA:**
- [Statement on Providing Psychological Support for Obstetric Patients.](https://www.asahq.org/standards-and-practice-parameters/statement-on-providing-psychological-support-for-obstetric-patients#:~:text=Statement%20on%20Providing%20Psychological%20Support%20for%20Obstetric%20Patients,-Developed%20by%3A%20Committee&text=This%20statement%20highlights%20the%20importance,the%20perioperative%20and%20perinatal%20periods.)
- [Statement on Oral Intake During Labor.](https://www.asahq.org/standards-and-practice-parameters/statement-on-oral-intake-during-labor)
####
####
### Abdomen
URL: https://www.anecrit.com/liver-surgery-anesthesiology-guidelines/
Last updated: 2026-07-05T18:39:09.000Z
#### Perioperative Care for Liver Surgery
- [Guidelines for Perioperative Care for Liver Surgery: Enhanced Recovery After Surgery (ERAS) Society Recommendations 2022](https://onlinelibrary.wiley.com/doi/10.1007/s00268-022-06732-5)
### Other
URL: https://www.anecrit.com/renal-anesthesia-guidelines/
Last updated: 2026-07-05T18:28:11.000Z
#### AKI in the perioperative period
- ****SFAR:**
- - [Acute kidney injury in the perioperative period and in intensive care units (excluding renal replacement therapies).](https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-016-0145-5)
#### Anesthesia & diabetes
- [Perioperative management of adult diabetic patients (free full issue).](https://www.sciencedirect.com/journal/anaesthesia-critical-care-and-pain-medicine/vol/37/suppl/S1)
### Neurological
URL: https://www.anecrit.com/neurological-guidelines/
Last updated: 2025-07-26T18:48:55.000Z
#### Anesthesia for neurosurgery
- ****SFAR:**
- - [Anaesthetic and peri-operative management for thrombectomy procedures in stroke patients.](https://www.sciencedirect.com/science/article/pii/S2352556822001692)
- [French recommendations for the management of patients with spinal cord injury or at risk of spinal cord injury.](https://www.sciencedirect.com/science/article/pii/S2352556820300308)
## Neurological complications associated with anesthesia
#### Perioperative visual loss
- ****ASA:**
- - [Practice Advisory for Perioperative Visual Loss Associated with Spine Surgery 2019: An Updated Report by the American Society of Anesthesiologists Task Force on Perioperative Visual Loss, the North American Neuro-Ophthalmology Society, and the Society for Neuroscience in Anesthesiology and Critical Care.](https://journals.lww.com/anesthesiology/fulltext/2019/01000/practice%5Fadvisory%5Ffor%5Fperioperative%5Fvisual%5Floss.12.aspx)
#### Peripheral Nerve Injury
- ****ASA :**
- - [Practice Advisory for the Prevention of Perioperative Peripheral Neuropathies 2018: An Updated Report by the American Society of Anesthesiologists Task Force on Prevention of Perioperative Peripheral Neuropathies.](https://journals.lww.com/anesthesiology/fulltext/2018/01000/practice%5Fadvisory%5Ffor%5Fthe%5Fprevention%5Fof.11.aspx)
#### Postoperative delirium
- ****ESAIC:**
- - [Update of the European Society of Anaesthesiology and Intensive Care Medicine evidence-based and consensus-based guideline on postoperative delirium in adult patients.](https://journals.lww.com/ejanaesthesiology/fulltext/2024/02000/update%5Fof%5Fthe%5Feuropean%5Fsociety%5Fof%5Fanaesthesiology.2.aspx)
#### Neurologic Complications of Neuraxial Analgesia/Anesthesia
- ****ASA:**
- - [Statement on Post-Dural Puncture Headache Management.](https://www.asahq.org/standards-and-practice-parameters/statement-on-post-dural-puncture-headache-management)
- [Statement on Neurologic Complications of Neuraxial Analgesia/Anesthesia in Obstetrics.](https://www.asahq.org/standards-and-practice-parameters/statement-on-neurologic-complications-of-neuraxial-analgesia-anesthesia-in-obstetrics)
#### Neurophysiological Monitoring
- ****ASA:**
- - [Practice Advisory for Intraoperative Awareness and Brain Function Monitoring: A Report by the American Society of Anesthesiologists Task Force on Intraoperative Awareness.](https://journals.lww.com/anesthesiology/fulltext/2006/04000/practice%5Fadvisory%5Ffor%5Fintraoperative%5Fawareness%5Fand.30.aspx)
### Thoracic Anesthesia
URL: https://www.anecrit.com/thoracic-anesthesia-guidelines/
Last updated: 2025-01-18T17:39:17.000Z
- **SFAR:**
- [Expert consensus-based clinical practice guidelines on enhanced recovery after pulmonary lobectomy.](https://www.sciencedirect.com/science/article/pii/S2352556820302770?via%3Dihub)
### Cardiovascular & Hemodynamics
URL: https://www.anecrit.com/cardiovascular-anesthesiology-guidelines/
Last updated: 2026-07-05T18:17:25.000Z
#### Preoperative cardiovascular assessment before non-cardiac surgery
AHA
- [2024 AHA/ACC/ACS/ASNC/HRS/SCA/SCCT/SCMR/SVM Guideline for Perioperative Cardiovascular Management for Noncardiac Surgery: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.](https://www.ahajournals.org/doi/10.1161/CIR.0000000000001285)
- [Periprocedural Management and Multidisciplinary Care Pathways for Patients With Cardiac Implantable Electronic Devices: A Scientific Statement From the American Heart Association.](https://www.ahajournals.org/doi/10.1161/CIR.0000000000001264)
ESC
- [2022 ESC Guidelines on cardiovascular assessment and management of patients undergoing non-cardiac surgery: Developed by the task force for cardiovascular assessment and management of patients undergoing non-cardiac surgery of the European Society of Cardiology (ESC) Endorsed by the European Society of Anaesthesiology and Intensive Care (ESAIC) .](https://academic.oup.com/eurheartj/article/43/39/3826/6675076?login=false)
ESAIC:
- [ESAIC focused guideline for the use of cardiac biomarkers in perioperative risk evaluation.](https://journals.lww.com/ejanaesthesiology/fulltext/2023/12000/esaic%5Ffocused%5Fguideline%5Ffor%5Fthe%5Fuse%5Fof%5Fcardiac.4.aspx)
ASA:
- [Practice Advisory for the Perioperative Management of Patients with Cardiac Implantable Electronic Devices: Pacemakers and Implantable Cardioverter–Defibrillators 2020.](https://journals.lww.com/anesthesiology/fulltext/2020/02000/practice%5Fadvisory%5Ffor%5Fthe%5Fperioperative%5Fmanagement.9.aspx)
- [Practice Alert for the Perioperative Management of Patients with Coronary Artery StentsA Report by the American Society of Anesthesiologists Committee on Standards and Practice Parameters.](https://journals.lww.com/anesthesiology/fulltext/2009/01000/practice%5Falert%5Ffor%5Fthe%5Fperioperative%5Fmanagement%5Fof.7.aspx)
#### Hemodynamic Optimization
- Perioperative hemodynamic optimization - Adults including obstetrics, Anaesthesia Critical Care & Pain Medicine, January 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2352556825001948)
- Perioperative Quality Initiative consensus statement on goal-directed haemodynamic therapy, BJA, September 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900347-2/fulltext)
- Perioperative Quality Initiative consensus statement on goal-directed haemodynamic therapy, British Journal of Anaesthesia, 2025, Guidelines, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900347-2/fulltext)
- 2024 EACTS/EACTAIC Guidelines on Patient Blood Management in Adult Cardiac Surgery in Collaboration With EBCP, Journal of Cardiothoracic and Vascular Anesthesia, August 2025, [Link](https://www.sciencedirect.com/science/article/pii/S1053077024007894)
#### Acute Cardiac Events
ESAIC:
- [Cardiac arrest in the perioperative period: a consensus guideline for identification, treatment, and prevention from the European Society of Anaesthesiology and Intensive Care and the European Society for Trauma and Emergency Surgery.](https://journals.lww.com/ejanaesthesiology/fulltext/2023/10000/cardiac%5Farrest%5Fin%5Fthe%5Fperioperative%5Fperiod%5F%5Fa.3.aspx)
#### Specific Diagnostic Tools
- Considerations of Intraoperative Transesophageal Echocardiography During Adult Cardiac Surgery: A Scientific Statement From the American Heart Association, Circulation, 12 June 2025, [Link](https://www.ahajournals.org/doi/10.1161/CIR.0000000000001342)
- [Practice Guidelines for Pulmonary Artery Catheterization: An Updated Report by the American Society of Anesthesiologists Task Force on Pulmonary Artery Catheterization.](https://journals.lww.com/anesthesiology/fulltext/2003/10000/practice%5Fguidelines%5Ffor%5Fpulmonary%5Fartery.35.aspx)
#### Anesthesia of patients with congenital heart disease:
- [Guidelines for anaesthesia of adults with congenital heart disease in non-cardiac surgery](https://www.sciencedirect.com/science/article/abs/pii/S2352556825000724), August 2025.
#### Anesthesia for Vascular surgery:
- Management of anaesthesia for transfemoral transcatheter aortic valve implantation: an Italian interdisciplinary consensus statement, BJA, 2 January 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900801-3/abstract)
####
### Nutrition
URL: https://www.anecrit.com/nutrition-cc-guidelines/
Last updated: 2025-07-26T18:45:46.000Z
#### General
- [Expert consensus‑based clinical practice guidelines for nutritional support in the intensive care unit: the French Intensive Care Society (SRLF) and the French-Speaking Group of Pediatric Emergency Physicians and Intensivists (GFRUP)](https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-025-01509-0), 15 July 2025.
- [ESPEN practical and partially revised guideline: Clinical nutrition in the intensive care unit.](https://www.clinicalnutritionjournal.com/article/S0261-5614%2823%2900230-3/fulltext)
- [ESPEN guideline on clinical nutrition in the intensive care unit.](https://www.sciencedirect.com/science/article/pii/S0261561418324324)
- [Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Pediatric Critically Ill Patient: Society of Critical Care Medicine and American Society for Parenteral and Enteral Nutrition.](https://aspenjournals.onlinelibrary.wiley.com/doi/10.1177/0148607117711387)
- [Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient. Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.).](https://aspenjournals.onlinelibrary.wiley.com/doi/full/10.1177/0148607115621863)
#### Enteral nurition
- [Early enteral nutrition in critically ill patients: ESICM clinical practice guidelines.](https://link.springer.com/article/10.1007/s00134-016-4665-0)
#### Parenteral nutrition
### Blood & Hemostasis
URL: https://www.anecrit.com/blood-hemostasis-cc-guidelines/
Last updated: 2026-07-05T18:15:32.000Z
#### Transfusion
- [Transfusion strategies in non-bleeding critically ill adults: a clinical practice guideline from the European Society of Intensive Care Medicine.](https://link.springer.com/article/10.1007/s00134-019-05884-8)
- [Transfusion strategies in bleeding critically ill adults: a clinical practice guideline from the European Society of Intensive Care Medicine.](https://link.springer.com/article/10.1007/s00134-021-06531-x)
#### Anticoagulants
- [Anticoagulant management in emergency settings: 2024 guidelines from the French Society of Emergency Medicine (SFMU), the French Society of Anaesthesia and Intensive Care Medicine (SFAR), the French Society of Thrombosis and Haemostasis (SFTH) and the French Working Group on Perioperative Haemostasis (GIHP)\*.](https://www.sciencedirect.com/science/article/abs/pii/S235255682500116X)
- [Clinical guideline on reversal of direct oral anticoagulants in patients with life threatening bleeding.](https://journals.lww.com/ejanaesthesiology/fulltext/2024/05000/clinical%5Fguideline%5Fon%5Freversal%5Fof%5Fdirect%5Foral.1.aspx)
- [Guideline for Reversal of Antithrombotics in Intracranial Hemorrhage: Executive Summary. A Statement for Healthcare Professionals From the Neurocritical Care Society and the Society of Critical Care Medicine.](https://journals.lww.com/ccmjournal/fulltext/2016/12000/guideline%5Ffor%5Freversal%5Fof%5Fantithrombotics%5Fin.16.aspx)
#### Bleeding and coagulopathy in trauma
- [Tranexamic acid in trauma: A joint position statement and resource document of NAEMSP, ACEP, and ACS-COT](https://journals.lww.com/jtrauma/fulltext/2025/09000/tranexamic%5Facid%5Fin%5Ftrauma%5F%5Fa%5Fjoint%5Fposition.6.aspx), September 2025.
- [The European guideline on management of major bleeding and coagulopathy following trauma: sixth edition](https://ccforum.biomedcentral.com/articles/10.1186/s13054-023-04327-7)
- [The European guideline on management of major bleeding and coagulopathy following trauma: fifth edition.](https://ccforum.biomedcentral.com/articles/10.1186/s13054-019-2347-3)
- [The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition.](https://ccforum.biomedcentral.com/articles/10.1186/s13054-016-1265-x)
- [Management of bleeding following major trauma: a European guideline.](https://ccforum.biomedcentral.com/articles/10.1186/cc5686)
#### Sickle cell disease
- Guidelines for the management of emergencies and critical illness in pediatric and adult patients with sickle cell disease, Annals of Intensive Care, 29 May 2025, [Link](https://link.springer.com/article/10.1186/s13613-025-01479-3)
#### Drug management
- Anticoagulant management in Emergency settings: 2024 guidelines from the French Society of Emergency Medicine (SFMU), the French Society of Anaesthesia and Intensive Care Medicine (SFAR), the French Society of Thrombosis and Haemostasis (SFTH) and the French Working Group on Perioperative Haemostasis (GIHP), endorsed by the French Neurovascular Society, Anaesthesia Critical Care & Pain Medicine, September 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S235255682500116X)
### Endocrine and Metabolic
URL: https://www.anecrit.com/endocrine-metabolic-guidelines/
Last updated: 2025-02-13T17:14:28.000Z
#### Sodium
- [Clinical practice guideline on diagnosis and treatment of hyponatraemia.](https://academic.oup.com/ejendo/article/170/3/G1/6668028)
#### Glycemic control
- [Society of Critical Care Medicine Guidelines on Glycemic Control for Critically Ill Children and Adults 2024.](https://journals.lww.com/ccmjournal/fulltext/2024/04000/society%5Fof%5Fcritical%5Fcare%5Fmedicine%5Fguidelines%5Fon.22.aspx)
#### Hyperglycemic Crises in Adults With Diabetes
- [Hyperglycemic Crises in Adults With Diabetes: A Consensus Report.](https://diabetesjournals.org/care/article/47/8/1257/156808/Hyperglycemic-Crises-in-Adults-With-Diabetes-A)
#### Critical illness-related corticosteroid insufficiency (CIRCI)
- [Guidelines for the Diagnosis and Management of Critical Illness-Related Corticosteroid Insufficiency (CIRCI) in Critically Ill Patients (Part I): Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) 2017.](https://journals.lww.com/ccmjournal/Fulltext/2017/12000/Guidelines%5Ffor%5Fthe%5FDiagnosis%5Fand%5FManagement%5Fof.16.aspx)
- [Guidelines for the Diagnosis and Management of Critical Illness-Related Corticosteroid Insufficiency (CIRCI) in Critically Ill Patients (Part II): Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) 2017.](https://journals.lww.com/ccmjournal/Fulltext/2018/01000/Guidelines%5Ffor%5Fthe%5FDiagnosis%5Fand%5FManagement%5Fof.19.aspx)
### Infectious Diseases
URL: https://www.anecrit.com/infectious-diseases-guidelines/
Last updated: 2026-01-31T12:42:30.000Z
#### Sepsis & septic shock
- [The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2024.](https://onlinelibrary.wiley.com/doi/10.1002/ams2.70037)New
- [Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.](https://journals.lww.com/ccmjournal/fulltext/2021/11000/surviving%5Fsepsis%5Fcampaign%5F%5Finternational.21.aspx)
- [Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children.](https://journals.lww.com/pccmjournal/fulltext/2020/02000/surviving%5Fsepsis%5Fcampaign%5Finternational%5Fguidelines.20.aspx)
- [Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19).](https://link.springer.com/article/10.1007/s00134-020-06022-5)
- [Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016.](https://journals.lww.com/ccmjournal/fulltext/2017/03000/surviving%5Fsepsis%5Fcampaign%5F%5Finternational.15.aspx)
- [Surviving Sepsis CampaignInternational Guidelines for Management of Severe Sepsis and Septic Shock : 2012.](https://journals.lww.com/ccmjournal/fulltext/2013/02000/surviving%5Fsepsis%5Fcampaign%5F%5Finternational.24.aspx)
- [Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock : 2008.](https://link.springer.com/article/10.1007/s00134-007-0934-2)
- [Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock : 2004.](https://journals.lww.com/ccmjournal/abstract/2004/03000/surviving%5Fsepsis%5Fcampaign%5Fguidelines%5Ffor.38.aspx#errata)
#### Antimicrobials
- [European Society of Clinical Microbiology and Infectious Diseases (ESCMID) guidelines for the treatment of infections caused by multidrug-resistant Gram-negative bacilli (endorsed by European society of intensive care medicine).](https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X%2821%2900679-0/fulltext)
- [Antimicrobial de-escalation in critically ill patients: a position statement from a task force of the European Society of Intensive Care Medicine (ESICM) and European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Critically Ill Patients Study Group (ESGCIP).](https://link.springer.com/article/10.1007/s00134-019-05866-w)
- [Optimization of the treatment with beta-lactam antibiotics in critically ill patients—guidelines from the French Society of Pharmacology and Therapeutics (Société Française de Pharmacologie et Thérapeutique—SFPT) and the French Society of Anaesthesia and Intensive Care Medicine (Société Française d’Anesthésie et Réanimation—SFAR).](https://ccforum.biomedcentral.com/articles/10.1186/s13054-019-2378-9)
#### Community-acquired pneumonia (CAP)
- [ERS/ESICM/ESCMID/ALAT guidelines for the management of severe community-acquired pneumonia.](https://publications.ersnet.org/content/erj/61/4/2200735)
#### Ventilator-associated pneumonia (VAP) & hospital-acquired pneumonia (HAP)
- [International ERS/ESICM/ESCMID/ALAT guidelines for the management of hospital-acquired pneumonia and ventilator-associated pneumonia.](https://publications.ersnet.org/content/erj/50/3/1700582)
#### Invasive Candidiasis
- [Treatment of Invasive Pulmonary Aspergillosis and Preventive and Empirical Therapy for Invasive Candidiasis in Adult Pulmonary and Critical Care Patients: An Official American Thoracic Society Clinical Practice Guideline.](https://www.atsjournals.org/doi/10.1164/rccm.202410-2045ST)New
#### Meningitis and encephalitis
- [A clinical practice guideline for tuberculous meningitis](https://www.thelancet.com/journals/laninf/article/PIIS1473-3099%2825%2900364-0/abstract), 18 August 2025
- [****2017 Infectious Diseases Society of America’s Clinical Practice Guidelines for Healthcare-Associated Ventriculitis and Meningitis**.](https://academic.oup.com/cid/article/64/6/e34/2996079)
- [ESCMID guideline: diagnosis and treatment of acute bacterial meningitis.](https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X%2816%2900020-3/fulltext)
- [German guidelines on community-acquired acute bacterial meningitis in adults.](https://neurolrespract.biomedcentral.com/articles/10.1186/s42466-023-00264-6)
- [Management of acute community-acquired bacterial meningitis (excluding newborns). Long version with arguments.](https://www.sciencedirect.com/science/article/pii/S0399077X18300428?via%3Dihub)
#### Other
- A consensus of international experts on definition, sampling, treatment, and prevention of peripheral extracorporeal membrane oxygenation cannula-site infection obtained by the Delphi method: the SAVECMO study, Intensive Care Medicine, 8 Janaury 2026, [Link](https://link.springer.com/article/10.1007/s00134-025-08269-2)
- [Society of Critical Care Medicine and the Infectious Diseases Society of America Guidelines for Evaluating New Fever in Adult Patients in the ICU****.**](https://journals.lww.com/ccmjournal/fulltext/2023/11000/society%5Fof%5Fcritical%5Fcare%5Fmedicine%5Fand%5Fthe.13.aspx)
### Liver & GI
URL: https://www.anecrit.com/liver-gi-cc-guidelines/
Last updated: 2026-07-05T18:34:31.000Z
#### Mesenteric ischemia & infarcts
- [Acute mesenteric ischemia: updated guidelines of the World Society of Emergency Surgery.](https://wjes.biomedcentral.com/articles/10.1186/s13017-022-00443-x)
#### Acute pancreatitis
- [2019 WSES guidelines for the management of severe acute pancreatitis.](https://wjes.biomedcentral.com/articles/10.1186/s13017-019-0247-0)
- [Guidelines for the management of patients with severe acute pancreatitis, 2021.](https://www.sciencedirect.com/science/article/abs/pii/S2352556822000418?via%3Dihub)
#### Gastrointestinal Bleeding
- [Society of Critical Care Medicine and American Society of Health-System Pharmacists Guideline for the Prevention of Stress-Related Gastrointestinal Bleeding in Critically Ill Adults.](https://journals.lww.com/ccmjournal/fulltext/2024/08000/society%5Fof%5Fcritical%5Fcare%5Fmedicine%5Fand%5Famerican.22.aspx)
#### Liver failure
- [Guidelines for the Management of Adult Acute and Acute-on-Chronic Liver Failure in the ICU: Cardiovascular, Endocrine, Hematologic, Pulmonary and Renal Considerations: Executive Summary.](https://journals.lww.com/ccmjournal/Fulltext/2020/03000/Guidelines%5Ffor%5Fthe%5FManagement%5Fof%5FAdult%5FAcute%5Fand.17.aspx)
- [Guidelines for the Management of Adult Acute and Acute-on-Chronic Liver Failure in the ICU: Neurology, Peri-Transplant Medicine, Infectious Disease, and Gastroenterology Considerations.](https://journals.lww.com/ccmjournal/fulltext/2023/05000/guidelines%5Ffor%5Fthe%5Fmanagement%5Fof%5Fadult%5Facute%5Fand.11.aspx)
### Trauma
URL: https://www.anecrit.com/trauma-guidelines/
Last updated: 2026-01-31T12:39:42.000Z
#### Trauma (general)
- American Association for the Surgery of Trauma–World Society of Emergency Surgery guidelines on the diagnosis and management of major thoracic vascular injuries, **Journal of Trauma and Acute Care Surgery,* February 2026, [Link](https://journals.lww.com/jtrauma/pages/articleviewer.aspx?year=2026&issue=02000&article=00020&type=Fulltext)
- American Association for the Surgery of Trauma—World Society of Emergency Surgery Guidelines on the diagnosis and management of cervical vascular injuries, **Journal of Trauma and Acute Care Surgery*, 13 January 2026, [Link](https://journals.lww.com/jtrauma/fulltext/9900/american%5Fassociation%5Ffor%5Fthe%5Fsurgery%5Fof.1211.aspx)
- [Guidelines for the acute care of severe limb trauma patients.](https://www.sciencedirect.com/science/article/pii/S2352556821000667?via%3Dihub)
- [French recommendations for the management of patients with spinal cord injury or at risk of spinal cord injury.](https://www.sciencedirect.com/science/article/pii/S2352556820300308)
- [Early management of severe pelvic injury (first 24 hours).](https://www.sciencedirect.com/science/article/pii/S2352556818305678?via%3Dihub)
- [Management of severe traumatic brain injury (first 24 hours).](https://www.sciencedirect.com/science/article/pii/S2352556817303703)
- [Chest trauma: First 48 hours management.](https://www.sciencedirect.com/science/article/pii/S2352556817300061?via%3Dihub)
#### Bleeding and coagulopathy in trauma
- [Tranexamic acid in trauma: A joint position statement and resource document of NAEMSP, ACEP, and ACS-COT](https://journals.lww.com/jtrauma/fulltext/2025/09000/tranexamic%5Facid%5Fin%5Ftrauma%5F%5Fa%5Fjoint%5Fposition.6.aspx), September 2025.
- [The European guideline on management of major bleeding and coagulopathy following trauma: sixth edition](https://ccforum.biomedcentral.com/articles/10.1186/s13054-023-04327-7)
- [The European guideline on management of major bleeding and coagulopathy following trauma: fifth edition.](https://ccforum.biomedcentral.com/articles/10.1186/s13054-019-2347-3)
- [The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition.](https://ccforum.biomedcentral.com/articles/10.1186/s13054-016-1265-x)
- [Management of bleeding following major trauma: a European guideline.](https://ccforum.biomedcentral.com/articles/10.1186/cc5686)
### Renal
URL: https://www.anecrit.com/renal-guidelines/
Last updated: 2026-01-31T12:42:03.000Z
#### Acute Kidney Injury (AKI)
- [An Official ATS/ERS/ESICM/SCCM/SRLF Statement: Prevention and Management of Acute Renal Failure in the ICU PatientAn International Consensus Conference in Intensive Care Medicine.](https://www.atsjournals.org/doi/10.1164/rccm.200711-1664ST)
- [Acute kidney injury in the perioperative period and in intensive care units (excluding renal replacement therapies).](https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-016-0145-5)
- [KDIGO Clinical Practice Guideline for Acute Kidney Injury.](https://kdigo.org/guidelines/acute-kidney-injury/)
#### Renal replacement therapy (RRT)
- Multidisciplinary guidelines on renal replacement therapy in intensive care medicine, Critical Care, 14 January 2026, [Link](https://link.springer.com/article/10.1186/s13054-025-05817-6)
- [Liberation from continuous renal replacement therapy due to renal recovery in adults and children: a literature review and Delphi consensus on clinical practice](https://ccforum.biomedcentral.com/articles/10.1186/s13054-025-05517-1), 8 July 2025.
- [Renal replacement therapy in an intensive care unit: guidelines from the SRLF-GFRUP consensus conference](https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-025-01517-0), 16 July 2025.
- [Renal replacement therapy in adult and pediatric intensive care: Recommendations by an expert panel from the French Intensive Care Society (SRLF) with the French Society of Anesthesia Intensive Care (SFAR) French Group for Pediatric Intensive Care Emergencies (GFRUP) the French Dialysis Society (SFD).](https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-015-0093-5)
## Posts
### Anecrit's Newsletter #51
URL: https://www.anecrit.com/anecrits-newsletter-51/
Last updated: 2026-10-03T10:44:20.000Z
_This post is for subscribers only._
### Anecrit's Newsletter #41-50
URL: https://www.anecrit.com/anecrits-newsletter-41-50/
Last updated: 2026-09-27T17:57:51.000Z
**Welcome back to Anecrit.**
It’s been over two months since our last issue, and I want to say a huge thank you for staying subscribed. After a completely disconnected 15-day vacation and catching up on clinical duties, I am thrilled to be back at the keyboard.
Even better: **we are returning to our regular weekly schedule starting today.**
I am currently deep into the final stretch of preparation for my specialty boards this December, which means I'll be sifting through a lot of literature over the coming months—and I’m bringing you right along for the ride. Let’s get to the updates.
---
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---
Hundreds of anesthesia & critical care papers, distilled weekly.
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# **Anesthesiology:**
## ***Guidelines & Consensus:***
### 1- Airway & Mechanical Ventilation:
1. Project for Universal Management of Airways: guidelines for providing a foundation for airway management, Anaesthesia, 27 August 2026, [Link](https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/ftr/10.1111/anae.70366)
2. Project for Universal Management of Airways: guidelines for tracheal extubation, Anaesthesia, 26 August 2026, [Link](https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/ftr/10.1111/anae.70365)
3. Risk assessment and prevention of postoperative and postprocedural respiratory failure: recommendations from an international expert panel, BJA, 31 July 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900471-X/abstract)
### 2- Cardiovascular & Hemodynamics:
1. EACTS/STS/AATS Guidelines on temporary mechanical circulatory support in adult cardiac surgery: An Expert Analysis for Cardiothoracic Anesthesia and Critical Care, Journal of Cardiothoracic and Vascular Anesthesia, 21 September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026009365)
2. 2026 Chinese expert consensus on perioperative management for left ventricular assist device implantation in adults, Anesthesiology and Perioperative Science, 28 August 2026, [Link](https://link.springer.com/article/10.1007/s44254-026-00189-8)
### 3- Obstetrics & Gynecology:
1. Pain management after major oncological breast surgery: an updated systematic review and procedure-specific postoperative pain management (PROSPECT) recommendations, Anaesthesia, 12 August 2026, [Link](https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/abs/10.1111/anae.70313)
2. OSA in Pregnancy: An American College of Chest Physicians Clinical Practice Guideline, CHEST, 21 July 2026, [Link](https://www.sciencedirect.com/science/article/pii/S0012369226061817)
### 4- Pediatric:
1. Guideline update: Neonatal and infant airway management, The American Journal of Emergency Medicine, November 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0735675726003797)
2. Important Residual Lesions and Early Unplanned Reinterventions After Pediatric Cardiac Surgery: A Scientific Statement From the American Heart Association, Circulation, 1 September 2026, [Link](https://www.ahajournals.org/doi/10.1161/CIR.0000000000001465)
3. Educational framework for harmonised minimal standards in Paediatric Anaesthesia training in Europe based on a modified Delphi approach: On behalf of The European Society of Anaesthesiology and Intensive Care and European Society for Paediatric Anaesthesiology Taskforce, European Journal of Anaesthesiology, 14 August 2026, [Link](https://www.ovid.com/jnls/ejanaesthesiology/fulltext/10.1097/eja.0000000000002450~educational-framework-for-harmonised-minimal-standards-in)
### 5- Orthopedic:
1. PROSPECT guideline for total hip arthroplasty: updated systematic review and procedure-specific postoperative pain management recommendations, Anaesthesia, 20 July 2026, [Link](https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/full/10.1111/anae.70299)
### 6- Other:
1. Peri-operative management of patients having day surgery: a consensus statement from the Association of Anaesthetists, British Association for Day Surgery and the Association of Paediatric Anaesthetists, Great Britain and Ireland, Anaesthesia, 15 September 2026, [Link](https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/full/10.1111/anae.70408)
2. Anaesthesia for patients with non-vascular Ehlers-Danlos syndromes: recommendations based on a descriptive cohort study of 69 patients and 127 orthopaedic operations, Perioperative Medicine, 9 September 2026, [Link](https://link.springer.com/article/10.1186/s13741-026-00731-z)
3. Consensus guideline from the European Malignant Hyperthermia Group on perioperative management of patients with an inherited primary disorder of skeletal muscle, BJA, 30 July 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900437-X/abstract)
---
## ***Systematic reviews & meta-analyses:***
### 1- AI:
1. Artificial Intelligence-Enabled Electrocardiograms and Pregnancy-Related Cardiomyopathy: A Systematic Review and Diagnostic Meta-Analysis, JACC: Advances, 9 September 2026, [Link](https://www.jacc.org/doi/10.1016/j.jacadv.2026.103180)
### 2- Neuro:
1. Non-opioid pharmacologic interventions for the prevention of delirium after cardiac surgery in adults: systematic review and network meta-analysis, Perioperative Medicine, 14 September 2026, [Link](https://link.springer.com/article/10.1186/s13741-026-00738-6)
2. Intravenous Methylene Blue for Prevention of Postoperative Delirium in Noncardiac Major Surgery: A Systematic Review and Meta-analysis, Anesthesia & Analgesia, 11 August 2026, [Link](https://www.ovid.com/jnls/anesthesia-analgesia/abstract/10.1213/ane.0000000000008280~intravenous-methylene-blue-for-prevention-of-postoperative)
### 3- Airway & Mechanical Ventilation:
1. Perioperative mechanical ventilation strategies in adult cardiac surgery with cardiopulmonary bypass: a meta-analysis of randomised controlled trials, BJA, 27 August 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900575-1/abstract)
2. Classification of videolaryngoscopy: a systematic review, Anaesthesia, 26 August 2026, [Link](https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/full/10.1111/anae.70358)
3. Sitting Versus Supine Modified Mallampati Test for Predicting Difficult Airway: A Systematic Review and Meta-analysis, Anesthesia & Analgesia, 24 July 2026, [Link](https://www.ovid.com/jnls/anesthesia-analgesia/abstract/10.1213/ane.0000000000008235~sitting-versus-supine-modified-mallampati-test-for)
### 4- Cardiovascular & Hemodynamics:
1. Continuous versus intermittent non-invasive blood pressure monitoring and intraoperative hypotension: a systematic review and meta-analysis, Anaesthesia Critical Care & Pain Medicine, 22 September 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2352556826001670)
2. Acute kidney injury after cardiac surgery: a systematic review of pharmacological and non-pharmacological interventions, Journal of Cardiothoracic and Vascular Anesthesia, 18 September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026009250)
3. Intraoperative blood pressure management strategies and postoperative outcomes in patients undergoing noncardiac surgery: a systematic review and meta-analysis, Anesthesiology and Perioperative Science, 14 September 2026, [Link](https://link.springer.com/article/10.1007/s44254-026-00188-9)
4. Mechanical Circulatory Support for Complex High‐Risk Indicated Percutaneous Coronary Intervention: Network Meta‐Analysis of Randomized Trials, Journal of the American Heart Association, 9 September 2026, [Link](https://www.ahajournals.org/doi/10.1161/JAHA.126.052609)
5. Diagnostic Performance of Pulse Pressure Variation for Predicting Fluid Responsiveness During Spine Surgery in the Prone Position: A Systematic Review and Meta-Analysis, Journal of Neurosurgical Anesthesiology, 7 September 2026, [Link](https://www.ovid.com/jnls/jnsa/abstract/10.1097/ana.0000000000001160~diagnostic-performance-of-pulse-pressure-variation-for)
6. Remote Ischemic Preconditioning and Survival in Noncardiac Surgery: An Updated Meta-analysis of Randomized Trials, Anesthesia & Analgesia, 3 September 2026, [Link](https://www.ovid.com/jnls/anesthesia-analgesia/abstract/10.1213/ane.0000000000008291~remote-ischemic-preconditioning-and-survival-in-noncardiac)
7. Mortality and adverse events of extracorporeal haemoadsorption therapy in cardiac surgery: a systematic review and meta-analysis of randomised controlled trials, BJA, September 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900419-8/fulltext)
8. Vasoplegia After Left Ventricular Assist Device Implantation: A Meta-analysis of Incidence, Predictors, and Clinical Outcomes, Journal of Cardiothoracic and Vascular Anesthesia, 24 August 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026008530)
9. Racial Differences in the Incidence and Outcomes of Postoperative Atrial Fibrillation After Isolated Coronary Artery Bypass Grafting: A Systematic Review, Journal of Cardiothoracic and Vascular Anesthesia, 18 August 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026006415)
10. Sivelestat Sodium versus Standard Care for Prevention of Postoperative Lung Injury and Acute Respiratory Distress Syndrome in Adult Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass: A Systematic Review and Meta-Analysis, Journal of Cardiothoracic and Vascular Anesthesia, 18 August 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026007779)
11. Intraoperative hypotension and adverse postoperative outcomes: a systematic review and meta-analysis of randomised controlled trials, BJA, 10 August 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900504-0/fulltext)
12. Propofol-Supplemented Cardioplegic Solution Effect on Myocardial Protection: A Systematic Review and Bayesian Meta-analysis of Randomized Controlled Trials, Journal of Cardiothoracic and Vascular Anesthesia, 6 August 2026, [Link](https://www.sciencedirect.com/science/article/pii/S1053077026006488)
13. Intraoperative hemoadsorption and cardiac surgery-associated acute kidney injury: an updated systematic review and meta-analysis with trial sequential analysis, Critical Care, 24 July 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06099-2)
14. Clinical Effectiveness of Acute Normovolemic Hemodilution in Cardiac Surgery: A Systematic Review and Meta-analysis, Anesthesia & Analgesia, 13 July 2026, [Link](https://www.ovid.com/jnls/anesthesia-analgesia/abstract/10.1213/ane.0000000000008221~clinical-effectiveness-of-acute-normovolemic-hemodilution-in)
### 5- Abdomen:
1. Competing Hemodynamic Goals During Hepatectomy in Patients with Fontan Circulation: A Systematic Review of Case Reports, Journal of Cardiothoracic and Vascular Anesthesia, 25 September 2026, [Link](https://www.sciencedirect.com/science/article/pii/S1053077026009535)
### 6- General:
1. Remimazolam versus sevoflurane for general anaesthesia: A meta-analysis with trial sequential analysis of haemodynamic and clinical outcomes, European Journal of Anaesthesiology, 4 September 2026, [Link](https://www.ovid.com/jnls/ejanaesthesiology/abstract/10.1097/eja.0000000000002412~remimazolam-versus-sevoflurane-for-general-anaesthesia-a)
### 7- Obstetrics & Gynecology:
1. Burden of chronic postsurgical pain after caesarean delivery on maternal quality of life: a systematic review, Anaesthesia, 24 September 2026, [Link](https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/full/10.1111/anae.70362)
2. Minimal clinically important difference and psychometric properties of the Obstetric Quality of Recovery-10 measure: a systematic review and network meta-analysis, Anaesthesia, 24 September 2026, [Link](https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/full/10.1111/anae.70363)
3. Intravenous vs Oral Iron for Treating Iron Deficiency Anemia in Pregnancy: A Systematic Review and Meta-Analysis, JAMA Open, 23 September 2026, [Link](https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2854382)
4. Bayesian Meta-Analysis of Carbetocin vs. Oxytocin to Prevent Postpartum Hemorrhage in Cesarean Section, Current Anesthesiology Reports, 12 August 2026, [Link](https://link.springer.com/article/10.1007/s40140-026-00722-2)
5. Effects of acupoint stimulation for postoperative analgesia after Cesarean delivery: a systematic review and meta-analysis of randomized controlled trials, Canadian Journal of Anesthesia, 30 June 2026, [Link](https://link.springer.com/article/10.1007/s12630-026-03147-x)
### 8- Pediatric:
1. Non-pharmacological preoperative interventions for the prevention of emergence delirium in children under general anesthesia: a systematic review and network meta-analysis, BMC Anesthesiology, 20 July 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04052-y)
### 9- Regional Anesthesia & Pain Management:
1. Peripheral Nerve Blocks for Postoperative Pain Management in Cardiothoracic Surgery: A Systematic Review and Meta-Analysis, Journal of Cardiothoracic and Vascular Anesthesia, 26 September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026009638)
2. Comparison of the efficacy of different interventions for rebound pain after brachial plexus block in upper extremity surgery: A systematic review and network meta-analysis, European Journal of Anaesthesiology, 17 September 2026, [Link](https://www.ovid.com/jnls/ejanaesthesiology/fulltext/10.1097/eja.0000000000002486~comparison-of-the-efficacy-of-different-interventions-for)
3. The Impact of Intrathecal Hydrophilic Opioids on Postoperative Pain, Opioid Consumption and Adverse Events for Abdominal Surgery: A Systematic Review and Meta-analysis, Current Anesthesiology Reports, 29 August 2026, [Link](https://link.springer.com/article/10.1007/s40140-026-00726-y)
4. Elevated electrical stimulation thresholds for sciatic nerve block in individuals with diabetic complications: a systematic review and meta-analysis, BMC Anesthesiology, 24 August 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04202-2)
5. The Effect of Behavioural Interventions that Include Goal Setting on Pain, Disability, and Physical Activity in People With Chronic Musculoskeletal Pain: A Systematic Review and Meta-analysis, The Clinical Journal of Pain, 12 August 2026, [Link](https://www.ovid.com/jnls/clinicalpain/fulltext/10.1097/ajp.0000000000001413~the-effect-of-behavioural-interventions-that-include-goal)
6. Incidence and risk factors of persistent postoperative pain after cardiac surgery: a systematic review and meta-analysis, BMC Anesthesiology, 6 August 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04089-z)
7. Dexmedetomidine Versus Dexamethasone as an Adjuvant in TAP Blocks for Cesarean Section: A Meta-Analysis of Randomized Clinical Trials, Current Anesthesiology Reports, 5 August 2026, [Link](https://link.springer.com/article/10.1007/s40140-026-00721-3)
8. Erector spinae plane block in bariatric surgery: a systematic review and meta-analysis of randomized controlled trials with trial sequence analysis, BMC Anesthesiology, 5 August 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04130-1)
9. Effectiveness of extended reality in simulation-based ultrasound-guided regional anesthesia training: a systematic review, Canadian Journal of Anesthesia, 3 August 2026, [Link](https://link.springer.com/article/10.1007/s12630-026-03159-7)
### 10- Other:
1. Systematic literature review and meta-analysis on the safety of fibrinogen concentrate versus cryoprecipitate in patients with surgical bleeding, BMC Anesthesiology, 22 September 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04238-4)
2. Global anesthesia care: a systematic review of capacity, workforce, and access, BMC Anesthesiology, 15 September 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04215-x)
3. Prevalence of burnout among practising anaesthesia providers: a systematic review, Anaesthesia, 4 September 2026, [Link](https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/ftr/10.1111/anae.70359)
4. Translational simulation in anaesthesia: a systematic review of applications, processes, outcomes, and implementation factors, BJA, 28 August 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900577-5/fulltext)
5. Association Between Intraoperative Anesthesia Handover and Patient Morbidity and Mortality: a Systematic Review and Meta-Analysis, Anesthesia & Analgesia, 24 August 2026, [Link](https://www.ovid.com/jnls/anesthesia-analgesia/abstract/10.1213/ane.0000000000008269~association-between-intraoperative-anesthesia-handover-and)
6. Impact of propofol-based vs. volatile-based anaesthesia on survival and recurrence after cancer surgery: a systematic review and meta-analysis of randomised trials, Anaesthesia, 17 August 20226, [Link](https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/full/10.1111/anae.70347)
7. Perioperative esketamine and postoperative sleep quality: a systematic review and meta-analysis of randomized trials, BMC Anesthesiology, 15 August 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04177-0)
8. Assessing impact of supervision in aerobic exercise training on fitness and clinical outcomes: a systematic review and meta-analysis, BJA, 4 August 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900478-2/fulltext)
9. Measuring patient disability in the peri-operative period using the WHODAS 2.0 questionnaire: a systematic review, Anaesthesia, 24 July 2026, [Link](https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/full/10.1111/anae.70287)
---
## ***Clinical trials:***
### 1- AI:
1. AI-assisted preoperative anesthesia evaluation workflow versus conventional bedside evaluation: a randomized controlled non-inferiority trial, BMC Anesthesiology, 23 September 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04280-2)
2. Bridging the experience gap: reasoning-oriented LLMs as cognitive scaffolds for junior anesthesiologists—a multi-arm controlled study, BMC Anesthesiology, 14 August 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04173-4)
### 2- Neuro:
1. Maintaining intraoperative mean arterial pressure at 85 mmHg or higher to reduce postoperative delirium in older patients with arterial hypertension having non-cardiac surgery: rationale and design of the multicentre randomised ASPIRE-85 trial, BJA Open, 22 September 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2772609626003631)
2. Opioid-Sparing Versus Opioid-Based Analgesia for Craniotomy: A Multicenter Randomized Controlled Trial, Journal of Neurosurgical Anesthesiology, 7 September 2026, [Link](https://www.ovid.com/jnls/jnsa/abstract/10.1097/ana.0000000000001163~opioid-sparing-versus-opioid-based-analgesia-for-craniotomy)
3. Determinants of procedural sedation requirements during endovascular treatment for acute anterior circulation ischaemic stroke: a post-hoc analysis of the INDIVIDUATE trial, European Stroke Journal, 31 August 2026, [Link](https://academic.oup.com/esj/article/11/8/aakag102/8776980)
4. Transcranial Electrical Stimulation and Delirium Among Postoperative Patients: A Randomized Clinical Trial, JAMA Open, 18 August 2026, [Link](https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2852967)
5. Comparison of dexmedetomidine and droperidol-fentanyl for asleep-awake-asleep techniques in awake craniotomy anesthesia: a randomized controlled study, BMC Anesthesiology, 23 July 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04117-y)
6. Cerebral Hemodynamic and Metabolic Responses to Anesthesia and Vasopressors in Adult Shoulder Surgery: a 2x2 Factorial Design Randomized Controlled Trial with Light-based Neuromonitoring (CHEM-FACT study), Anesthesiology, 16 July 2026, [Link](https://www.ovid.com/jnls/anesthesiology/abstract/10.1097/aln.0000000000006239~cerebral-hemodynamic-and-metabolic-responses-to-anesthesia)
### 3- Airway & Mechanical Ventilation:
1. Preoxygenation with deep breathing plus pressure support and positive end-expiratory pressure in obese patients and ultrasound assessment of gastric distension: a randomized controlled trial, BMC Anesthesiology, 22 September 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04281-1)
2. Ventilatory Mechanics, Oxygenation and Postoperative pulmonary complications according to surgical approach in patients with Individualised Ventilatory Approach. A secondary analysis of the iPROVE-OLV trial, Anaesthesia Critical Care & Pain Medicine, 22 September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556826001803)
3. Oxygen reserve index-based positive end-expiratory pressure allocation and end-of-surgery lung ultrasound findings during robot-assisted laparoscopic prostatectomy: a prospective randomized controlled trial, BMC Anesthesiology, 21 September 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04263-3)
4. Omitting face-mask ventilation before tracheal intubation in low-risk adults: a randomized non-inferiority trial, BMC Anesthesiology, 19 September 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04276-y)
5. Manual ventilation with and without a flow-limiting device during induction of general anesthesia: A randomized crossover trial, Resuscitation Plus, 14 September 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2666520426002791)
6. High-flow nasal cannula oxygenation in sedated endoscopy for high-risk obstructive sleep apnoea patients: a Simon two-stage trial, BJA, September 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900439-3/abstract)
7. Volume-controlled inverse ratio ventilation versus volume-controlled equal ratio ventilation for improving respiratory mechanics and oxygenation in morbidly obese patients undergoing laparoscopic bariatric surgery: A randomized controlled trial, Trends in Anaesthesia and Critical Care, October 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2210844026000766)
8. Effect of salbutamol during one-lung ventilation in patients with chronic obstructive pulmonary disease: a randomized controlled trial, Canadian Journal of Anesthesia, 26 August 2026, [Link](https://link.springer.com/article/10.1007/s12630-026-03180-w)
9. Negative pressure ventilation during induction of general anaesthesia in predicted difficult airways: a feasibility study, BJA, 25 August 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900579-9/abstract)
10. Sigh ventilation versus conventional protective ventilation in cardiac surgery: a proof-of-concept randomized controlled trial, Critical Care, 17 August 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06251-y)
11. Effect of SEEKflex\-guided versus conventional intubation on hemodynamic responses in elderly hypertensive patients: a randomized controlled trial, BMC Anesthesiology, 13 August 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04164-5)
12. Modified nasopharyngeal airway device facilitates nasal fiberoptic intubation for trainee anesthesiologists: a randomized clinical study, BMC Anesthesiology, 8 August 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04154-7)
13. Conventional vs Video-Assisted Laryngoscopy for Perioperative Endotracheal Intubations: A Randomized Clinical Trial, JAMA Open, 3 August 2026, [Link](https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2852394)
14. Comparison of anesthetic effects of different sedative drugs combined with remifentanil for general anesthesia in bronchoscopy: a randomized controlled trial, BMC Anesthesiology, 21 July 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04092-4)
### 4- Cardiovascular & Hemodynamics:
1. Timing of PCI in Patients Undergoing Transcatheter Aortic-Valve Implantation, NEJM, 30 August 2026, [Link](https://www.nejm.org/doi/full/10.1056/NEJMoa2606924)
2. Impact of Colloid Cardiopulmonary Bypass Priming Strategy on Perioperative Acid–Base Balance in Coronary Artery Bypass Surgery: Physiochemical Analysis of a Double–Blinded Randomised Controlled Study, Journal of Cardiothoracic and Vascular Anesthesia, 29 August 2026, [Link](https://www.sciencedirect.com/science/article/pii/S1053077026008682)
3. Renoprotective Effects of Dexmedetomidine Versus Dopamine in High-Risk Renal Patients Undergoing Off-Pump Coronary Artery Bypass Grafting: A Prospective, Randomized, Comparative Study, Journal of Cardiothoracic and Vascular Anesthesia, 21 August 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026008086)
4. Norepinephrine infusion for prophylaxis against spinal-induced hypotension in elderly patients undergoing hip surgery: a randomized controlled comparison of two doses, BMC Anesthesiology, 20 August, 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04174-3)
5. Sex Differences in Postoperative Recovery and Mortality After High‐Risk Cardiac Surgery: A Propensity Score–Matched Post Hoc Analysis of the SUSTAIN‐CSX Trial, Journal of the American Heart Association, 20 August, 2026, [Link](https://www.ahajournals.org/doi/10.1161/JAHA.126.049243)
6. Hypotension Prediction Index versus Mean Arterial Pressure Alarm for Preventing Intraoperative Hypotension in Elective Non-Cardiac Surgery: A Randomized Controlled Trial, Anesthesiology, 19 August 2026, [Link](https://www.ovid.com/jnls/anesthesiology/abstract/10.1097/aln.0000000000006338~hypotension-prediction-index-versus-mean-arterial-pressure)
7. Comparison of the effects of normal saline versus Plasma-Lyte® on acid–base balance during living donor kidney transplantation surgery using goal-directed fluid therapy based on pulse pressure variation: a randomised controlled trial, BMC Anesthesiology, 19 August, 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04148-5)
8. Hypotension Prediction Index versus High Mean Arterial Pressure Target for Preventing Intraoperative Hypotension: A Randomized Controlled Trial, Anesthesiology, 17 August 2026, [Link](https://www.ovid.com/jnls/anesthesiology/abstract/10.1097/aln.0000000000006335~hypotension-prediction-index-versus-high-mean-arterial)
9. Cold and Room-Temperature Platelets in Cardiac Surgery: The CHIPS Randomized Clinical Trial, JAMA, 17 August 2026, [Link](https://jamanetwork.com/journals/jama/article-abstract/2852953)
10. Elevated Cardiopulmonary Bypass Flow for Renal Protection in Cardiac Surgery: A Randomized Trial, Anesthesia & Analgesia, 10 August 2026, [Link](https://www.ovid.com/jnls/anesthesia-analgesia/fulltext/10.1213/ane.0000000000008196~elevated-cardiopulmonary-bypass-flow-for-renal-protection-in)
11. Effect of Pre-operative Intravenous Crystalloid Bolus on Post-Induction Blood Pressure – a randomized blinded intervention trial, Anesthesiology, 7 August, 2026, [Link](https://www.ovid.com/jnls/anesthesiology/fulltext/10.1097/aln.0000000000006308~effect-of-pre-operative-intravenous-crystalloid-bolus-on)
12. Multivessel coronary artery bypass grafting via small thoracotomy versus sternotomy (MIST): an investigator-initiated, international, open-label, randomised controlled trial, The Lancet, 31 July 2026, [Link](https://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2826%2901288-2/abstract)
13. Dapagliflozin and Acute Kidney Injury Following Cardiac Surgery: A Randomized Clinical Trial, JAMA, 30 July 2026, [Link](https://jamanetwork.com/journals/jama/article-abstract/2852324)
14. Continuous intra-arterial versus noninvasive blood pressure monitoring for preventing hypotension during anesthesia induction in patients aged ≥ 75 years undergoing noncardiac surgery: a randomized controlled trial, BMC Anesthesiology, 23 July 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04123-0)
15. Effectiveness of safety care and clinical nursing pathway in patients undergoing cardiovascular intervention: a randomized controlled trial, Perioperative Medicine, 17 July 2026, [Link](https://link.springer.com/article/10.1186/s13741-026-00718-w)
16. Pre‐ and Immediate Postoperative Prediction Model for Organ Dysfunction or Death Early After Cardiac Surgery: A Post Hoc Analysis of a Multicenter Randomized Trial, Journal of the American Heart Association, 17 July 2026, [Link](https://www.ahajournals.org/doi/10.1161/JAHA.125.044394)
### 5- Thoracic:
1. Stepwise versus one-step intubation strategy for tracheal injury in thoracic surgery: a multicenter randomized controlled trial protocol based on a combined visual lung isolation tube versus a video double-lumen tube, BMC Anesthesiology, 7 August 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04151-w)
2. Dexmedetomidine-based opioid-sparing anesthesia in video-assisted thoracoscopic surgery: a randomized controlled trial, BMC Anesthesiology, 24 July 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04070-w)
3. Hybrid 3D-Printed Manikin for Lung Isolation Training of Anesthesia Residents: A Randomized Controlled Trial, Journal of Cardiothoracic and Vascular Anesthesia, 18 July 2026, [Link](https://www.sciencedirect.com/science/article/pii/S105307702600618X)
### 6- Abdomen:
1. Comparative influence of opioid-free versus opioid-containing anesthetic techniques upon Th1/Th2 balance during laparoscopic colorectal cancer procedures: a randomized controlled trial, BMC Anesthesiology, 3 September 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04214-y)
2. The effect of musıc medıcıne wıth vırtual realıty glasses on patıents’ surgıcal anxıety and comfort durıng ureteroscopy: a randomızed controlled trıal, Perioperative Medicine, 8 August 2026, [Link](https://link.springer.com/article/10.1186/s13741-026-00729-7)
3. Quality of postoperative recovery in patients undergoing laparoscopic colorectal cancer resection as affected by transversus abdominis plane block combined with moderate neuromuscular blockade: a randomized controlled trial, BMC Anesthesiology, 3 August 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04145-8)
### 7- General:
1. Development and preliminary evaluation of a short web-based home multimodal prehabilitation program for patients undergoing major surgery: a single-arm clinical trial, Perioperative Medicine, 3 September 2026, [Link](https://link.springer.com/article/10.1186/s13741-026-00736-8)
2. Intraoperative corticosteroid administration and postoperative pulmonary complications: a secondary analysis of the iPROVE clinical trials, BJA, 26 August 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900583-0/abstract)
3. Total Intravenous vs Volatile Inhalational Anesthesia for Major Noncardiac Surgery: A Randomized Clinical Trial, JAMA, 12 August 2026, [Link](https://jamanetwork.com/journals/jama/article-abstract/2852741)
### 8- Obstetrics & Gynecology:
1. Remimazolam versus sevoflurane for maintenance of anesthesia and postoperative nausea and vomiting in laparoscopic gynecologic oncology surgery: a randomized controlled trial, BMC Anesthesiology, 21 September 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04251-7)
2. Intrauterine Mepivacaine Instillation vs Placebo for Pain During IUD Placement: A Randomized Clinical Trial, JAMA, 17 September 2026, [Link](https://jamanetwork.com/journals/jama/article-abstract/2854257)
3. A randomized, double-blind trial comparing the effects of prophylactic norepinephrine versus phenylephrine infusion on umbilical artery hemodynamics during spinal anesthesia for elective cesarean delivery, BMC Anesthesiology, 14 September 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04267-z)
4. Effect of low-dose esketamine on quality of recovery after gynecologic laparoscopic surgery: a randomized controlled trial, BMC Anesthesiology, 11 September 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04239-3)
5. A Double-Blinded Randomized Trial Comparing Dexamethasone to Ondansetron as the First-Line Antiemetic After Cesarean Delivery, Anesthesia & Analgesia, 10 September 2026, [Link](https://www.ovid.com/jnls/anesthesia-analgesia/abstract/10.1213/ane.0000000000008321~a-double-blinded-randomized-trial-comparing-dexamethasone-to)
6. Treatment of Shivering during Intrapartum Cesarean Delivery under Epidural Anesthesia: A Randomized Controlled Trial Comparing Dexmedetomidine and Meperidine, Anesthesiology, 4 September 2026, [Link](https://www.ovid.com/jnls/anesthesiology/abstract/10.1097/aln.0000000000006290~treatment-of-shivering-during-intrapartum-cesarean-delivery)
7. Comparison of a Modified Regimen of Prophylactic Phenylephrine Boluses Versus Variable Rate Infusion During Elective Cesarean Delivery Under Spinal Anesthesia: A Noninferiority Randomized Double-Blind Study, A&A Practice, September 2026, [Link](https://www.ovid.com/jnls/aacr/abstract/10.1213/xaa.0000000000002272~comparison-of-a-modified-regimen-of-prophylactic)
8. Determination of the 90% Effective Dose of the Initial Bolus of Norepinephrine Followed by a Continuous Infusion to Prevent Hypotension in Elective Cesarean Delivery: A Randomized, Double-Blind, Up–Down Study, Anesthesia & Analgesia, 10 August 2026, [Link](https://www.ovid.com/jnls/anesthesia-analgesia/abstract/10.1213/ane.0000000000008135~determination-of-the-90-effective-dose-of-the-initial-bolus)
9. Comparison of the anaesthetic efficacy and safety of different doses of esketamine combined with propofol in hysteroscopic surgery: a randomised, double-blind controlled trial, BMC Anesthesiology, 28 July 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04119-w)
10. Reduced-exposure neuromuscular blockade strategies for total laparoscopic hysterectomy within an ERAS pathway: a randomized controlled trial, BMC Anesthesiology, 23 July 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04107-0)
### 9- Pediatric:
1. Effects of Video-Guided Preoperative Simulation Training on Negative Postoperative Behavioral Changes in Children: A Randomized Controlled Trial, Anaesthesia Critical Care & Pain Medicine, 22 September 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2352556826001773)
2. Ultrasound-guided transverse abdominis plane versus ilioinguinal/iliohypogastric block for postoperative analgesia in pediatric inguinal surgery: a randomized comparative study, BMC Anesthesiology, 18 September 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04203-1)
3. Intranasal dexmedetomidine versus intravenous propofol for the prevention of pediatric emergence delirium following general anesthesia: A randomized controlled trial, BMC Anesthesiology, 7 September 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04205-z)
4. Safety and efficacy of low-dose dexmedetomidine combined with midazolam for MRI in children aged 1–3 years: a randomized controlled trial, BMC Anesthesiology, 12 August 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04161-8)
5. Non-inferiority trial of remimazolam versus propofol for fast-track anesthesia in children undergoing percutaneous closure of atrial septal defect, BMC Anesthesiology, 20 July 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04106-1)
### 10- Orthopedic:
1. Synergistic blood‑sparing effect of acute normovolemic hemodilution combined with intraoperative cell salvage in major orthopedic surgery: a randomized controlled trial, BMC Anesthesiology, 25 September 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04273-1)
### 11- Regional Anesthesia & Pain Management:
1. Programmed intermittent bolus erector spinae plane block exhibits progressive expansion of dermatomal spread but does not match the analgesic efficacy of paravertebral block: A sub-analysis of a randomized controlled trial, Trends in Anaesthesia and Critical Care, October 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2210844026000675)
2. Integrating Nonpharmacological Options Into Perioperative Pain Care: A Cluster Randomized Clinical Trial, JAMA Open, 25 September 2026, [Link](https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2854496)
3. Comparison of rectal diclofenac suppository with injectable tramadol for postoperative pain management in adult fistula-in-ano surgery: a randomized controlled trial, BMC Anesthesiology, 24 September 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04222-y)
4. Comparison of suprainguinal fascia iliaca compartment block and adductor canal block for postoperative analgesia in total knee arthroplasty: a randomized clinical trial, BMC Anesthesiology, 24 September 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04290-0)
5. Effects of ultrasound-guided ipsilateral internal jugular vein compression on catheter malposition during ultrasound-guided right infraclavicular subclavian venous catheterisation: a randomised controlled trial, Anaesthesia, 24 September 2026, [Link](https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/full/10.1111/anae.70419)
6. The impact of bilateral transversus abdominis plane block on early wound healing after cesarean delivery: a single-center randomized trial, BMC Anesthesiology, 21 September 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04283-z)
7. Serratus Posterior Superior Intercostal Plane Block versus Superficial Parasternal Intercostal Plane Block with Local Infiltration for Postoperative Analgesia in Open Cardiac Surgery: A Randomized Controlled Trial, Journal of Cardiothoracic and Vascular Anesthesia, 21 September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026009432)
8. Effect of thoracic paravertebral block with liposomal bupivacaine on quality of recovery after video-assisted thoracic surgery: a randomized controlled trial, BMC Anesthesiology, 21 September 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04282-0)
9. Periplexus versus intraplexus injection for interscalene brachial plexus block during arthroscopic rotator cuff repair: a randomized controlled trial, BMC Anesthesiology, 19 September 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04258-0)
10. Oliceridine- versus sufentanil-based postoperative PCIA after orthopedic fracture surgery: a target trial emulation study, BMC Anesthesiology, 12 September 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04250-8)
11. Virtual reality versus companion-delivered therapeutic touch for reducing pain and anxiety during suturing: a randomized controlled trial, International Journal of Emergency Medicine, 9 September 2026, [Link](https://link.springer.com/article/10.1186/s12245-026-01360-5)
12. Effect of Liposomal bupivacaine and ropivacaine on postoperative opioid usage for ultrasound-guided transversus abdominis plane blocks in laparoscopic colorectal resections: a randomized controlled study, Perioperative Medicine, 7 September 2026, [Link](https://link.springer.com/article/10.1186/s13741-026-00745-7)
13. Comparison of adding magnesium sulfate versus dexmedetomidine to intrathecal bupivacaine in patients undergoing total knee arthroplasty: a randomized double-blind clinical trial, BMC Anesthesiology, 7 September 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04234-8)
14. Efficacy of magnesium sulfate as an adjuvant to ropivacaine in transversus abdominis plane block for postoperative analgesia after laparoscopic radical gastrectomy: a double-blinded randomized controlled trial, Perioperative Medicine, 3 September 2026, [Link](https://link.springer.com/article/10.1186/s13741-026-00727-9)
15. Effect of dexmedetomidine as an adjuvant to ropivacaine in stellate ganglion block on postoperative sleep quality in patients undergoing thyroid cancer surgery: a randomized double-blind controlled trial, BMC Anesthesiology, 2 September 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04219-7)
16. Real-time vs. pre-procedural ultrasound guidance for lower thoracic epidural puncture: a randomised controlled trial, Anaesthesia, 1 September 2026, [Link](https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/ftr/10.1111/anae.70361)
17. A Novel Multiple Sensory Nerve Block Combination Using Ultrasound Guidance in Knee Arthroplasty: A Randomized Clinical Trial, A&A Practice, September 2026, [Link](https://www.ovid.com/jnls/aacr/abstract/10.1213/xaa.0000000000002274~a-novel-multiple-sensory-nerve-block-combination-using)
18. Comparison of the effectiveness of the SPB and TTP block combinations versus the PECS 2 block in modified radical mastectomy: a prospective randomized study, BMC Anesthesiology, 29 August 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04210-2)
19. Prolonged Continuous Theta Burst Stimulation With Transcranial Magnetic Stimulation Analgesic Effects and Corticospinal Excitability in Chronic Neuropathic Pain: A Randomized Clinical Trial, Anesthesia & Analgesia, 24 August 2026, [Link](https://www.ovid.com/jnls/anesthesia-analgesia/abstract/10.1213/ane.0000000000008253~prolonged-continuous-theta-burst-stimulation-with)
20. Anterior vs posterior approaches to suprascapular nerve block in arthroscopic shoulder surgery: a prospective randomised trial, BMC Anesthesiology, 21 August 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04184-1)
21. Arginine Therapy for Sickle Cell Disease Acute Pain Episodes: The STArT Randomized Clinical Trial, JAMA, 19 August 2026, [Link](https://jamanetwork.com/journals/jama/article-abstract/2853065)
22. Comparison of modified thoracoabdominal nerve block via perichondrial approach with serratus intercostal plane block and rectus sheath block combination in laparoscopic cholecystectomy: a randomized controlled trial, BMC Anesthesiology, 14 August 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04183-2)
23. Liposomal bupivacaine versus ropivacaine in four-in-one nerve block for total knee arthroplasty: a randomized controlled trial, BMC Anesthesiology, 13 August 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04036-y)
24. Comparison of QLB block and TAP block in morbidly obese patients: a randomized controlled study, BMC Anesthesiology, 13 August 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04163-6)
25. The efficacy of suprascapular nerve radiofrequency and intra-articular steroıd injectıon in frozen shoulder treatment: randomızed controlled trial, BMC Anesthesiology, 13 August 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04162-7)
26. Impact of rhomboid intercostal plane block on chronic pain incidence and acute pain scores after oncologic breast surgery: a randomized controlled trial, BMC Anesthesiology, 12 August 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04175-2)
27. The Effect of Repeated Bilateral Deep Parasternal Intercostal Plane Catheter Boluses on Analgesia After Cardiac Surgery: A Randomized Controlled Trial, Anesthesia & Analgesia, 11 August 2026, [Link](https://www.ovid.com/jnls/anesthesia-analgesia/fulltext/10.1213/ane.0000000000008211~the-effect-of-repeated-bilateral-deep-parasternal)
28. Association between pericapsular nerve group (PENG) block and postoperative inflammatory indices and analgesic outcomes in total hip arthroplasty: a randomized controlled trial, BMC Anesthesiology, 5 August 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04084-4)
29. Classical popliteal sciatic block versus Crosswise Approach to Popliteal Sciatic (CAPS) block for below-knee surgery: a randomised controlled trial, BMC Anesthesiology, 4 August 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04137-8)
30. Continuous inter-transverse process block versus continuous paravertebral block for postoperative analgesia after video-assisted thoracoscopic surgery: a randomized controlled trial, Journal of Cardiothoracic and Vascular Anesthesia, 3 August 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026006464)
31. Effects of Combined Pericapsular Nerve Group and Iliohypogastric Nerve Blocks on Postoperative Pain and Opioid Consumption After Total Hip Arthroplasty: A Randomized Clinical Trial, A&A Practice, August 2026, [Link](https://www.ovid.com/jnls/aacr/abstract/10.1213/xaa.0000000000002267~effects-of-combined-pericapsular-nerve-group-and)
32. Phase 2b Trial of a NaV1.8 Inhibitor for Acute Pain, NEJM, 29 July 2026, [Link](https://www.nejm.org/doi/full/10.1056/NEJMoa2602910)
33. Clavipectoral fascia block associated with intermediate cervical plexus block versus intermediate cervical plexus block alone in clavicle surgeries: a randomized clinical trial, BMC Anesthesiology, 24 July 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04127-w)
34. A non–inferiority randomized controlled trial comparing nebulized fentanyl and intravenous morphine for acute pain management in the emergency department, BMC Anesthesiology, 24 July 2026, [Link](https://link.springer.com/article/10.1186/s12873-026-01679-5)
35. Comparison of the 4-in-1 block technique with femoral and adductor canal blocks in arthroscopic anterior cruciate ligament reconstruction: a randomized controlled trial, BMC Anesthesiology, 22 July 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04109-y)
36. A prospective randomized controlled trial comparing subpectineal and interfascial obturator nerve block techniques in preventing adductor muscle spasm during transurethral resection of bladder tumors, BMC Anesthesiology, 22 July 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04091-5)
37. Femoral Nerve Block Versus Low-Dose Spinal Anesthesia for Ambulatory Endovenous Laser Ablation: A Prospective Randomized Trial, Journal of Cardiothoracic and Vascular Anesthesia, 21 July 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026006245)
38. Effect of Bilateral Pectointercostal Fascial Plane Block on Chronic Postsurgical Pain After Coronary Artery Bypass Grafting: A Randomized Clinical Trial, Journal of Cardiothoracic and Vascular Anesthesia, 19 July 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S105307702600621X)
### 12- Other:
1. Perioperative Depression and Anxiety Care in Older Patients: A Randomized Clinical Trial, JAMA Open, 9 September 2026, [Link](https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2853855)
2. Sugammadex versus neostigmine for reversal of neuromuscular blockade and postoperative pulmonary complications (SNaPP): an international, randomised, controlled, phase 4 trial, The Lancet: Respiratory Medicine, September 2026, [Link](https://www.thelancet.com/journals/lanres/article/PIIS2213-2600%2826%2900158-X/fulltext)
3. The comparison of total intravenous anesthesia and inhalation anesthesia effects on postoperative recovery by quality of recovery (QoR-40) in septorhinoplasty: a randomized trial, BMC Anesthesiology, 25 August 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04201-3)
4. Intravenous aprepitant for prevention of postoperative nausea and vomiting in adults at moderate-to-high risk in China: a multicenter, randomized, double-blind, placebo-controlled trial, Anesthesiology and Perioperative Science, 27 July 2026, [Link](https://link.springer.com/article/10.1007/s44254-026-00184-z)
5. Perineural or intravenous administration of dexmedetomidine combined with anterior quadratus lumborum block for analgesia after retroperitoneal laparoscopic surgery: a prospective, randomized controlled trial, BMC Anesthesiology, 18 July 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04103-4)
---
## ***Reviews:***
### 1- AI & Tech:
1. Technology fatigue, cognitive load, and clinician well-being in modern anesthesia practice, Current Opinion in Anaesthesiology, 4 September 2026, [Link](https://www.ovid.com/jnls/co-anesthesiology/abstract/10.1097/aco.0000000000001707~technology-fatigue-cognitive-load-and-clinician-well-being)
2. Anaesthesia and artificial intelligence: current applications and future directions, Anaesthesia & Intensive Care Medicine, September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926001499)
3. Artificial Intelligence in Perioperative Neuromuscular Blockade Monitoring and Management: State-of-the-Art and Future Directions, Current Anesthesiology Reports, 29 July 2026, [Link](https://link.springer.com/article/10.1007/s40140-026-00716-0)
### 2- Neuro:
1. Anesthesia and the Periprocedural Management of Large Vessel Occlusion Stroke Treated with Mechanical Thrombectomy: A Narrative Review, Anaesthesiology, 15 September 2026, [Link](https://www.ovid.com/jnls/anesthesiology/abstract/10.1097/aln.0000000000006250~anesthesia-and-the-periprocedural-management-of-large-vessel)
2. Postoperative delirium in ambulatory patients, Current Opinion in Anaesthesiology, 4 September 2026, [Link](https://www.ovid.com/jnls/co-anesthesiology/abstract/10.1097/aco.0000000000001708~postoperative-delirium-in-ambulatory-patients)
3. Anaesthesia for stroke thrombectomy, BJA Edu, 7 August 2026, [Link](https://www.bjaed.org/article/S2058-5349%2826%2900066-1/abstract)
4. Perioperative Hypoperfusion Stroke, Anesthesiology, 4 August 2026, [Link](https://www.ovid.com/jnls/anesthesiology/abstract/10.1097/aln.0000000000006142~perioperative-hypoperfusion-stroke)
5. Neuromuscular disorders: relevance to anaesthesia and intensive care, Anaesthesia & Intensive Care Medicine, August 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926001347)
6. Cervical spine disease and anaesthesia, Anaesthesia & Intensive Care Medicine, August 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926001323)
7. The value of a neuroanesthesiology division, Current Opinion in Anaesthesiology, 28 July 2026, [Link](https://www.ovid.com/jnls/co-anesthesiology/abstract/10.1097/aco.0000000000001694~the-value-of-a-neuroanesthesiology-division)
8. Anesthetic Considerations for Endovascular Treatment of Cerebral Vasospasm and Delayed Cerebral Ischemia, Anesthesiology, 20 July 2026, [Link](https://www.ovid.com/jnls/anesthesiology/abstract/10.1097/aln.0000000000006136~anesthetic-considerations-for-endovascular-treatment-of)
9. From State to Trait: A Narrative Review Refining Our Understanding of Perioperative Anxiety in the Context of Awake Neurosurgery, Journal of Neurosurgical Anesthesiology*,* 20 July 2026, [Link](https://www.ovid.com/jnls/jnsa/abstract/10.1097/ana.0000000000001154~from-state-to-trait-a-narrative-review-refining-our)
10. Viscoelastic Hemostatic Assays in Spine Surgery: A Scoping Review of Perioperative Transfusion Practices and Coagulation Assessment, Journal of Neurosurgical Anesthesiology*,* 3 July 2026, [Link](https://www.ovid.com/jnls/jnsa/abstract/10.1097/ana.0000000000001147~viscoelastic-hemostatic-assays-in-spine-surgery-a-scoping)
### 3- Airway & Mechanical Ventilation:
1. High-flow nasal oxygen in anesthesiology practice, Canadian Journal of Anesthesia, 11 September 2026, [Link](https://link.springer.com/article/10.1007/s12630-026-03166-8)
2. Airway emergencies in patients with laryngectomy and tracheostomy, Current Opinion in Anaesthesiology, 3 September 2026, [Link](https://www.ovid.com/jnls/co-anesthesiology/abstract/10.1097/aco.0000000000001706~airway-emergencies-in-patients-with-laryngectomy-and)
3. Unplanned postoperative reintubation: a narrative review of risk factors, predictive tools, and preventive strategies, BJA, 31 July 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900479-4/fulltext)
4. Airway Complications After Cervical Spine Surgery: A Focused Review on Recent Evidence and Perioperative Management, Journal of Neurosurgical Anesthesiology*,* 17 July 2026, [Link](https://www.ovid.com/jnls/jnsa/abstract/10.1097/ana.0000000000001152~airway-complications-after-cervical-spine-surgery-a-focused)
5. Anesthetic management for transoral robotic surgery, Current Opinion in Anaesthesiology, 15 July 2026, [Link](https://www.ovid.com/jnls/co-anesthesiology/abstract/10.1097/aco.0000000000001688~anesthetic-management-for-transoral-robotic-surgery)
### 4- Cardiovascular & Hemodynamics:
1. Anesthetic Management of Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair: When, How, and Why to Use Intraoperative Transesophageal Echocardiography. A Narrative Review and Practical Framework, Journal of Cardiothoracic and Vascular Anesthesia, 21 September 2026, [Link](https://www.sciencedirect.com/science/article/pii/S1053077026009419)
2. Intravenous Immunoglobulin Administration in Cardiac Surgery, Heart Transplantation and Infective Endocarditis: A Scoping Review, Journal of Cardiothoracic and Vascular Anesthesia, 17 September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026009262)
3. Transesophageal Echocardiography for Intraoperative Hemodynamic Assessment: A Physiology-Based, Phase-Oriented Practical Framework, Journal of Cardiothoracic and Vascular Anesthesia, 16 September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026009201)
4. Coronary artery bypass grafting. Part 1: preoperative assessment and surgical considerations, BJA Edu, 15 September 2026, [Link](https://www.bjaed.org/article/S2058-5349%2826%2900079-X/fulltext)
5. Cerebral arterial gas embolism in cardiovascular and aortic procedures - A narrative review of the mechanisms, diagnosis, management and prevention, Journal of Cardiothoracic and Vascular Anesthesia, 4 September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026008815)
6. Perioperative management of patients with cardiac implantable electronic devices, Anaesthesia & Intensive Care Medicine, September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926001414)
7. The 2026 American College of Cardiology Expert Consensus Decision Pathway for Heart Failure with Preserved Ejection Fraction: Implications for Cardiothoracic and Vascular Anesthesia, Journal of Cardiothoracic and Vascular Anesthesia, 28 August 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S105307702600861X)
8. Analysis of the 2025 European Society of Cardiology/European Association for Cardio-Thoracic Surgery Guidelines for the Management of Valvular Heart Disease, Journal of Cardiothoracic and Vascular Anesthesia, 23 August 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026008529)
9. Navigating intraoperative hypotension: rethinking traditional management for improved patient outcomes, Perioperative Medicine, 7 August 2026, [Link](https://link.springer.com/article/10.1186/s13741-026-00726-w)
10. Etomidate and Ciprofol for Induction in CABG Under Cardiopulmonary Bypass: Mechanistic Rationale, Evidence Gaps, and Future Trial Design, Journal of Cardiothoracic and Vascular Anesthesia, 29 July 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026006397)
11. Colchicine for Prevention of Postoperative Atrial Fibrillation After Coronary Artery Bypass Grafting: Mechanisms, Evidence, and Clinical Implications, Journal of Cardiothoracic and Vascular Anesthesia, 28 July 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S105307702600635X)
12. Right Heart Dysfunction and Postoperative Renal Injury: Venous Congestion, Renal Perfusion Pressure, and Perioperative Implications, Current Anesthesiology Reports, 25 July 2026, [Link](https://link.springer.com/article/10.1007/s40140-026-00713-3)
13. Frailty Assessment in Coronary Artery Bypass Grafting: A Review of Current Tools and Clinical Applications, Journal of Cardiothoracic and Vascular Anesthesia, 22 July 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026006269)
14. Advances in Cardiovascular Pharmacotherapy. X. Glucagon-Like Peptide-1 Receptor Agonists in Heart Failure and Mechanisms of Protection, Journal of Cardiothoracic and Vascular Anesthesia, 19 July 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026006154)
15. Advances in Cardiovascular Pharmacotherapy. IX. Protection Against Major Adverse Cardiovascular Events by Glucagon-like Peptide-1 Receptor Agonists in Type 2 Diabetes Mellitus and Obesity, Journal of Cardiothoracic and Vascular Anesthesia, 19 July 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026006142)
### 5- Thoracic:
1. Anaesthesia for diagnostic and therapeutic bronchoscopy, BJA Edu, 3 August 2026, [Link](https://www.bjaed.org/article/S2058-5349%2826%2900064-8/fulltext)
### 6- Abdomen:
1. Physiologic and Anesthetic Considerations in Robotic Liver Transplantation: Implications and Comparison with Conventional Liver Transplantation, Journal of Cardiothoracic and Vascular Anesthesia, 31 July 2026, [Link](https://www.sciencedirect.com/science/article/pii/S1053077026006403)
### 7- General:
1. Prevention of surgical site infection: focus on perioperative antimicrobial prophylaxis, Current Opinion in Anaesthesiology, 11 October 2026, [Link](https://www.ovid.com/jnls/co-anesthesiology/abstract/10.1097/aco.0000000000001703~prevention-of-surgical-site-infection-focus-on-perioperative)
2. Erratum to ‘Update on the perioperative management of diabetes mellitus’ \[BJA Education 24 (2024) 261–269\], BJA Edu, October 2026, [Link](https://www.bjaed.org/article/S2058-5349%2826%2900070-3/fulltext)
3. Prospective, randomized comparison of electromyographic neuromuscular responses from the adductor pollicis and abductor digiti minimi muscles during rocuronium-induced neuromuscular block, Anaesthesiology, 17 September 2026, [Link](https://www.ovid.com/jnls/anesthesiology/abstract/10.1097/aln.0000000000006381~prospective-randomized-comparison-of-electromyographic)
4. Ketamine in ambulatory anesthesia: dose-dependent effects on breathing and cortical function, Current Opinion in Anaesthesiology, 3 September 2026, [Link](https://www.ovid.com/jnls/co-anesthesiology/abstract/10.1097/aco.0000000000001705~ketamine-in-ambulatory-anesthesia-dose-dependent-effects-on)
5. Advances in anesthesia recovery assessment tools used in the post-anesthesia care unit, Perioperative Medicine, 3 September 2026, [Link](https://link.springer.com/article/10.1186/s13741-026-00743-9)
6. Potential of Remote Patient Monitoring in Perioperative Care: A Narrative Review, Anesthesiology, 25 August 2026, [Link](https://www.ovid.com/jnls/anesthesiology/fulltext/10.1097/aln.0000000000006217~potential-of-remote-patient-monitoring-in-perioperative-care)
7. Preoperative Medication Management in Ambulatory Surgery: Best Practices and Challenges, Current Anesthesiology Reports, 24 August 2026, [Link](https://link.springer.com/article/10.1007/s40140-026-00724-0)
8. Malnutrition before Surgery: A Reserve, Mechanism, and Trajectory-based Framework for Perioperative Care, Anesthesiology, 19 August 2026, [Link](https://www.ovid.com/jnls/anesthesiology/abstract/10.1097/aln.0000000000006182~malnutrition-before-surgery-a-reserve-mechanism-and)
9. Monitoring techniques: neuromuscular blockade and depth of anaesthesia, Anaesthesia & Intensive Care Medicine, August 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926001402)
10. The Association Between Transfusion of Blood Products and Postoperative Renal Impairment, Current Anesthesiology Reports, 22 July 2026, [Link](https://link.springer.com/article/10.1007/s40140-026-00714-2)
11. Exercise-centered Multimodal Prehabilitation for Major Cancer Surgery: Current Evidence, Delivery, and Future Directions, Current Anesthesiology Reports, 13 July 2026, [Link](https://link.springer.com/article/10.1007/s40140-026-00711-5)
### 8- Obstetrics & Gynecology:
1. Pregnancy-associated MINOCA: Diagnostic challenges and emergency management in young women, The American Journal of Emergency Medicine, December 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0735675726004961)
2. Hypertensive disorders of pregnancy: A review and updates for the emergency physician, The American Journal of Emergency Medicine, December 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S073567572600389X)
3. Perioperative Considerations of the Obstetric Patient with Heart Disease, Current Anesthesiology Reports, 14 September 2026, [Link](https://link.springer.com/article/10.1007/s40140-026-00732-0)
4. Cardiovascular disease in pregnancy: physiology, global burden, risk stratification, and opportunities in care, The Lancet, 5 September 2026, [Link](https://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2826%2901234-1/abstract)
5. The physiology of labour, BJA Edu, 25 August 2026, [Link](https://www.bjaed.org/article/S2058-5349%2826%2900068-5/abstract)
6. Nonpharmacological Adjuncts to Reduce Perioperative Anxiety and Pain for Awake Gynecological Procedures: A Scoping Review, Anesthesia &Analgesia, 10 August 2026, [Link](https://www.ovid.com/jnls/anesthesia-analgesia/abstract/10.1213/ane.0000000000008216~nonpharmacological-adjuncts-to-reduce-perioperative-anxiety)
7. Clinical Considerations in Management of Hypertrophic Cardiomyopathy in Pregnancy: *JACC* State-of-the-Art Review, JACC, 29 July 2026, [Link](https://www.jacc.org/doi/10.1016/j.jacc.2026.06.004)
### 9- Pediatric:
1. Perioperative management of kidney transplantation in children, BJA Edu, September 2026, [Link](https://www.bjaed.org/article/S2058-5349%2826%2900053-3/abstract)
2. Patient-reported outcomes in pediatric regional anesthesia trials: current use and limitations, Current Opinion in Anaesthesiology, October 2026, [Link](https://www.ovid.com/jnls/co-anesthesiology/abstract/10.1097/aco.0000000000001701~patient-reported-outcomes-in-pediatric-regional-anesthesia)
3. Measures of Quality of Recovery and Discharge-readiness Tools in the Pediatric Postanesthesia Care Unit, Anesthesiology, 28 July 2026, [Link](https://www.ovid.com/jnls/anesthesiology/fulltext/10.1097/aln.0000000000006193~measures-of-quality-of-recovery-and-discharge-readiness)
4. Anaesthesia for children undergoing surgical repair of anorectal malformations, BJA Edu, 27 July 2026, [Link](https://www.bjaed.org/article/S2058-5349%2826%2900059-4/abstract)
### 10- Regional Anesthesia & Pain Management:
1. The art and science of head nerve blocks in urgent care settings, International Journal of Emergency Medicine, 9 September 2026, [Link](https://link.springer.com/article/10.1186/s12245-026-01362-3)
2. Truncal Regional Analgesia for Thoracic Trauma, Current Anesthesiology Reports, 31 August 2026, [Link](https://link.springer.com/article/10.1007/s40140-026-00725-z)
3. Regional anaesthesia for breast surgery: a narrative review, Anaesthesia, 19 August 2026, [Link](https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/ftr/10.1111/anae.70341)
4. Practical aspects of ultrasound-guided regional anaesthesia, Anaesthesia & Intensive Care Medicine, August 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926001384)
5. Specific neurotoxicity of local anaesthetics revisited: An evidence-based narrative review, European Journal of Anaesthesiology, 28 July 2026, [Link](https://www.ovid.com/jnls/ejanaesthesiology/abstract/10.1097/eja.0000000000002461~specific-neurotoxicity-of-local-anaesthetics-revisited-an)
### 11- Other:
1. Perioperative care for patients with opioid exposure and opioid use disorder: screening and treatment strategies, Current Opinion in Anaesthesiology, October 2026, [Link](https://www.ovid.com/jnls/co-anesthesiology/abstract/10.1097/aco.0000000000001698~perioperative-care-for-patients-with-opioid-exposure-and)
2. Nonoperating room anesthesia in the ICU: current practice and considerations, Current Opinion in Anaesthesiology, October 2026, [Link](https://www.ovid.com/jnls/co-anesthesiology/abstract/10.1097/aco.0000000000001696~nonoperating-room-anesthesia-in-the-icu-current-practice-and)
3. Understanding care delivery within a universal healthcare system today, Current Opinion in Anaesthesiology, October 2026, [Link](https://www.ovid.com/jnls/co-anesthesiology/abstract/10.1097/aco.0000000000001699~understanding-care-delivery-within-a-universal-healthcare)
4. Anesthesiology Leadership in Global Health Security: Strengthening Perioperative Governance and Resilience, Current Anesthesiology Reports, 23 September 2026, [Link](https://link.springer.com/article/10.1007/s40140-026-00736-w)
5. The Art of Safe Anesthesia in Unsafe Environments, Current Anesthesiology Reports, 18 September 2026, [Link](https://link.springer.com/article/10.1007/s40140-026-00733-z)
6. Frailty in anaesthesia and intensive care, BJA Edu, 16 September 2026, [Link](https://www.bjaed.org/article/S2058-5349%2826%2900077-6/abstract)
7. Continuing Medical Education—Staying Current After Obtaining Board Certification, Anesthesiology Clinics, 15 September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1932227526000698)
8. Ambulatory Surgery: Procedure Selection and Emergency Ambulatory Surgery, Current Anesthesiology Reports, 10 September 2026, [Link](https://link.springer.com/article/10.1007/s40140-026-00731-1)
9. Preoperative Clinics: Do We Still Need Them? Reframing the Preoperative Period as a Treatment Window, Current Anesthesiology Reports, 3 September 2026, [Link](https://link.springer.com/article/10.1007/s40140-026-00728-w)
10. Effects of alcohol consumption on postoperative outcomes: a scoping review, Canadian Journal of Anesthesia, 3 September 2026, [Link](https://link.springer.com/article/10.1007/s12630-026-03184-6)
11. The role of the leader in navigating perioperative culture change, Current Opinion in Anaesthesiology, 1 September 2026, [Link](https://www.ovid.com/jnls/co-anesthesiology/abstract/10.1097/aco.0000000000001704~the-role-of-the-leader-in-navigating-perioperative-culture)
12. Pituitary disease and anaesthesia, Anaesthesia & Intensive Care Medicine, September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S147202992600144X)
13. Sustainability in anaesthetics and intensive care medicine, Anaesthesia & Intensive Care Medicine, September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926001463)
14. Building Strong Mentorship: Principles for Educators, Anesthesiology Clinics, 26 August 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1932227526000753)
15. Integrating educational theory and pedagogy for training technical skills in anaesthesia, BJA Edu, 25 August 2026, [Link](https://www.bjaed.org/article/S2058-5349%2826%2900069-7/abstract)
16. Diversity in Anesthesiology, a Critical Step Toward Equity in Perioperative Care, Current Anesthesiology Reports, 15 August 2026, [Link](https://link.springer.com/article/10.1007/s40140-026-00723-1)
17. Artificial Intelligence in Anesthesiology Education, Anesthesiology Clinics, 11 August 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1932227526000662)
18. Competency-Based Precision Education in Anesthesiology: Transforming Training Through Individualized Learning, Anesthesiology Clinics, 11 August 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1932227526000716)
19. Epigenetics, inflammation and postoperative complications: a scoping review, BJA, 5 August 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900481-2/fulltext)
20. The Role of the Anesthesiologist in Disasters and Large-Scale Emergencies: Lessons from a Potential Indo-Pacific Large-Scale Combat Operation, Current Anesthesiology Reports, 4 August 2026, [Link](https://link.springer.com/article/10.1007/s40140-026-00718-y)
21. Extended Reality (Augmented Reality, Virtual Reality, and Mixed Reality) in Teaching Technical Skills, Anesthesiology Clinics, 3 August 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1932227526000649)
22. Establishing and Sustaining Anesthesiology Education Scholarship Laboratories: A Strategic Framework for Academic Excellence, Anesthesiology Clinics, 1 August 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1932227526000686)
23. High-Stakes Assessment in Anesthesiology: The Design, Evidence, and Governance of American Board of Anesthesiology Certification, Anesthesiology Clinics, 1 August 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1932227526000704)
24. Managing the Stress of Teaching in the Clinical Setting: Balancing Patient Care, Learning, and Emotional Work, Anesthesiology Clinics, 1 August 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1932227526000741)
25. Malignant hyperthermia, Anaesthesia & Intensive Care Medicine, August 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926001396)
26. The Future of Anesthesiology Education: Trends, Challenges, and Opportunities, Anesthesiology Clinics, 31 July 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1932227526000728)
27. Simulation-Based Training in Anesthesiology, Anesthesiology Clinics, 30 July 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1932227526000674)
28. From Theory to Practice: Advancing Anesthesiology Education Through the Learning Sciences, Anesthesiology Clinics, 30 July 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S193222752600073X)
29. The implications of circadian rhythms for anaesthesia, BJA Edu, 23 July 2026, [Link](https://www.bjaed.org/article/S2058-5349%2826%2900058-2/fulltext)
---
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# **Critical Care:**
## ***Guidelines & Consensus:***
### 1- Cardiovascular & Hemodynamics:
1. Guidelines for the management of atrial fibrillation in adult patients admitted to an intensive care unit, Annals of Intensive Care, 14 September 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582026001949)
2. Criteria for the diagnosis of cardiogenic shock—European perspective: A Clinical Consensus Statement of the Association for Acute CardioVascular Care, the Heart Failure Association, and the European Association of Percutaneous Cardiovascular Interventions of the ESC, European Heart Journal. Acute Cardiovascular Care, 29 August 2026, [Link](https://academic.oup.com/ehjacc/article-abstract/15/8/634/8773245)
3. Fifth Universal Definition of Myocardial Infarction (2026), JACC, 27 August 2026, [Link](https://www.jacc.org/doi/10.1016/j.jacc.2026.07.025)
4. Use of landiolol in septic shock patients with new onset of atrial fibrillation: a European Delphi consensus, Critical Care, 07 August 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06200-9)
5. Inflammation in coronary syndromes in clinical practice: a clinical consensus statement of the Association for Acute Cardiovascular Care of the European Society of Cardiology, the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases, the European Society of Cardiology Council on Basic Cardiovascular Science, and the European Society of Cardiology Council for Cardiology Practice, European Heart Journal: Acute Cardiovascular Care, 31 July 2026, [Link](https://academic.oup.com/ehjacc/advance-article-abstract/doi/10.1093/ehjacc/zuag086/8748470)
6. Pulmonary Embolism Reporting and Data System (PE-RADS™) v2026 for the Diagnosis of Acute Pulmonary Embolism on CT and MR Angiography, Chest, 21 July 2026, [Link](https://www.sciencedirect.com/science/article/pii/S0012369226008676)
### 2- Thorax/Lungs/Airways/Mechanical ventilation:
1. Consensus statement for managing patients with ARDS in low-resource settings: a Delphi study, Annals of Intensive Care, 26 August 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582026001792)
2. Saudi expert consensus on the management of acute asthma and COPD exacerbations with algorithm of aerosol drug delivery device recommendations, International Journal of Emergency Medicine, 20 August 2026, [Link](https://link.springer.com/article/10.1186/s12245-026-01350-7)
### 3- Neuromuscular:
1. Treatment of Antithrombotic-Associated Intracranial Hemorrhage in Adults: A Focused Guideline Update from the Neurocritical Care Society and the Society of Critical Care Medicine, Neurocritical Care, 24 September 2026, [Link](https://link.springer.com/article/10.1007/s12028-026-02601-4)
2. Evidence Update for Minimally Invasive Surgical Evacuation of Supratentorial Spontaneous Intracerebral Hemorrhage: A Science Advisory From the American Heart Association, Stroke, 22 August 2026, [Link](https://www.ahajournals.org/doi/10.1161/STR.0000000000000529)
3. Guidelines for Seizure Prophylaxis in Patients with Aneurysmal Subarachnoid Hemorrhage: A Statement for Healthcare Professionals from the Neurocritical Care Society, Neurocritical Care, 4 August 2026, [Link](https://link.springer.com/article/10.1007/s12028-026-02614-z)
4. Implantation Standards for Intracranial Multimodal Monitoring (Neurocore-iMMM): An International Delphi Consensus, Neurocritical Care, 21 July 2026, [Link](https://link.springer.com/article/10.1007/s12028-026-02600-5)
### 4- Renal:
1. STARDaki: a consensus-based STARD extension for standardized reporting of diagnostic accuracy in acute kidney injury, Intensive Care Medicine, 28 July 20236, [Link](https://link.springer.com/article/10.1007/s00134-026-08549-5)
### 5- Blood & hemostasis:
1. Treatment of Antithrombotic-Associated Intracranial Hemorrhage in Adults: A Focused Guideline Update from the Neurocritical Care Society and the Society of Critical Care Medicine, Neurocritical Care, 24 September 2026, [Link](https://link.springer.com/article/10.1007/s12028-026-02601-4)
### 6- Infectious Diseases:
1. Infective Endocarditis: Diagnosis, Antibiotic Therapy, and Management: A Scientific Statement From the American Heart Association, Circulation, 8 September 2026, [Link](https://www.ahajournals.org/doi/10.1161/CIR.0000000000001466)
2. American Association for the Surgery of Trauma/American College of Surgeons Committee on Trauma clinical protocol for nutrition support in adult trauma, Journal of Trauma and Acute Care Surgery*,* 26 August 2026, [Link](https://www.ovid.com/jnls/jtrauma/fulltext/10.1097/ta.0000000000005160~american-association-for-the-surgery-of-traumaamerican)
3. IDSA/ACEP/ASM/PIDS/SCCM/SHEA/SHM/SIDP Multisociety Position Paper: Hospital Strategies to Improve Sepsis Outcomes, Clinical Infectious Diseases, 25 August 2026, [Link](https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciag438/8769592)
4. Consensus recommendations for patient selection and clinical implementation of polymyxin B hemoadsorption in endotoxic septic shock, Critical Care, 29 July 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06182-8)
### 7- Pediatric critical care:
1. Guideline update: Neonatal and infant airway management, The American Journal of Emergency Medicine, November 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0735675726003797)
2. Clinical practice guidelines: management of non-post-operative supraventricular tachycardia in neonates and children less than 18 years old hospitalized in a Pediatric Intensive Care Unit, Annals of Intensive Care, 16 September 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582026001950)
3. Surviving Pediatric Cardiogenic Shock: Clinical Approach, Improving Outcomes, and Future Directions: A Scientific Statement From the American Heart Association, Circulation, 6 August 2026, [Link](https://www.ahajournals.org/doi/10.1161/CIR.0000000000001461)
### 8- Other:
1. Social Media and Crisis Care Principles During Pandemics and Disasters: A Consensus Report From a Subgroup of the Task Force for Mass Critical Care, Chest, 15 September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0012369226065694)
##
---
## ***Systematic reviews & meta-analyses:***
### 1- AI & Tech:
1. Artificial intelligence–assisted point-of-care ultrasound training in novice learners: a systematic review and quality appraisal of controlled trials, Critical Care, 11 September 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06296-z)
### 2- Cardiovascular & Hemodynamics:
1. Dual direct current external cardioversion in refractory atrial fibrillation: a systematic review and single-arm meta-analysis, The American Journal of Emergency Medicine, December 2026, [Link](https://www.sciencedirect.com/science/article/pii/S0735675726004900)
2. Intravenous or intraosseous vascular access in cardiac arrest: an individual participant data meta-analysis, Resuscitation, November 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0300957226023518)
3. Safety of Age-Adjusted and Clinical Probability-Adjusted D-dimer Cut-offs in Suspected Pulmonary Embolism: A Systematic Review and Meta-Analysis, Chest, 25 September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0012369226067206)
4. Acute pharmacologic treatment versus observation for severe asymptomatic hypertension in emergency and acute care settings: a systematic review of short-term outcomes, BMC Emergency Medicine, 24 September 2026, [Link](https://link.springer.com/article/10.1186/s12873-026-01786-3)
5. Intra-arrest strategies to treat cardiac arrest due to a non-opioid toxicological causes in adults and children: a systematic review, Resuscitation Plus, 24 September 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2666520426002869)
6. Comparing High-Flow Nasal Cannula Therapy and Conventional Oxygen Therapy in Adult Patients Post-Cardiac Surgery: A Systematic Review and Meta-Analysis, Journal of Cardiothoracic and Vascular Anesthesia, 22 September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S105307702600892X)
7. Mortality Effect of Peripheral Perfusion-Guided Resuscitation in Vasodilatory Shock: A Systematic Review and Dual Frequentist-Bayesian Meta-Analysis of Randomized Trials, Critical Care Medicine, 11 September 2026, [Link](https://www.ovid.com/jnls/ccmjournal/abstract/10.1097/ccm.0000000000007364~mortality-effect-of-peripheral-perfusion-guided)
8. Dynamic EtCO₂/PETCO₂ changes for predicting fluid responsiveness during preload challenge in mechanically ventilated adults: a systematic review and meta-analysis, Critical Care, 11 September 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06320-2)
9. Fractional Flow Reserve in Acute Coronary Syndrome: An Updated Systematic Review and Bayesian Meta‐Analysis, Journal of the American Heart Association, 9 September 2026, [Link](https://www.ahajournals.org/doi/10.1161/JAHA.126.050265)
10. Prehospital versus in-hospital unfractionated heparin in ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: a systematic review and meta-analysis, European Journal of Emergency Medicine, 2 September 2026, [Link](https://www.ovid.com/jnls/euro-emergencymed/fulltext/10.1097/mej.0000000000001371~prehospital-versus-in-hospital-unfractionated-heparin-in)
11. Long-Term Mortality and Functional Outcomes After Extracorporeal Membrane Oxygenation in Critically Ill Adults: A Systematic Review and Meta-Analysis, Critical Care Medicine, 31 August 2026, [Link](https://www.ovid.com/jnls/ccmjournal/abstract/10.1097/ccm.0000000000007318~long-term-mortality-and-functional-outcomes-after)
12. ECMO Combined with Mechanical Thrombectomy Versus ECMO Alone for High-Risk Pulmonary Embolism: A Systematic Review and Meta-Analysis, Journal of Cardiothoracic and Vascular Anesthesia, 31 August 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026008748)
13. Variation of perfusion index to evaluate fluid responsiveness during the preload challenge tests: a systematic review and meta-analysis, Annals of Intensive Care, 20 August 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582026001718)
14. Serial cardiac ultrasound in acutely ill adults: a systematic review, BMC Emergency Medicine, 4 August 2026, [Link](https://link.springer.com/article/10.1186/s12873-026-01713-6)
15. Levosimendan During VA-ECMO for Cardiogenic Shock: An Updated Systematic Review and Meta-analysis Including the LEVOECMO Trial, Journal of Cardiothoracic and Vascular Anesthesia, 24 July 2026, [Link](https://www.sciencedirect.com/science/article/pii/S1053077026006348)
16. Hemoperfusion during extracorporeal membrane oxygenation: an updated systematic review and meta-analysis of 8,151 patients, Critical Care, 19 July 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06203-6)
### 3- Thorax/Lungs/Airways/Mechanical ventilation:
1. Revisiting vasodilator strategy in sympathetic crashing acute pulmonary edema: A meta-analysis of high-dose nitroglycerin efficacy and safety, The American Journal of Emergency Medicine, December 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S073567572600478X)
2. Supraglottic airway versus endotracheal intubation in out-of-hospital cardiac arrest: a systematic review and meta-analysis, Resuscitation Plus, November 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2666520426002766)
3. Ketamine *versus* Etomidate as an induction agent for tracheal intubation: An updated meta-analysis of randomized clinical trials, Anaesthesia Critical Care & Pain Medicine, 22 September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556826001682)
4. Conservative versus liberal oxygen therapy for mechanically ventilated adults: a systematic review with meta-analysis and trial sequential analysis, BMC Anesthesiology, 7 September 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04227-7)
5. Induction Agents for Tracheal Intubation of Critically Ill Patients: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials, Chest, 18 August 2026, [Link](https://www.sciencedirect.com/science/article/pii/S0012369226063506)
6. Predictive value of diaphragmatic ultrasound for weaning outcomes in mechanically ventilated patients with acute exacerbation of chronic obstructive pulmonary disease: a systematic review and meta-analysis, Critical Care, 8 August 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06240-1)
7. High-Flow Nasal Cannula Versus Noninvasive Ventilation for Prevention of Reintubation in High-Risk Critically Ill Patients (HIGH-FLOW OXY): An Informative Systematic Review and Meta-Analysis, Critical Care Explorations, August 2026, [Link](https://www.ovid.com/jnls/ccejournal/fulltext/10.1097/cce.0000000000001452~high-flow-nasal-cannula-versus-noninvasive-ventilation-for)
8. Outcomes in randomized trials of tracheal intubation in the critically ill: A systematic review, The American Journal of Emergency Medicine, 23 July 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0735675726003530)
9. Airway tracers and biomarkers for aspiration detection and VAP prediction in ICU patients with tracheal tubes: a systematic review and diagnostic accuracy meta-analysis, Annals of Intensive Care, 23 July 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582026001573)
### 4- Neuromuscular:
1. Diagnostic accuracy of delirium screening tools in the emergency department: A network meta-analysis, The American Journal of Emergency Medicine, December 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0735675726004481)
2. Neurocognitive outcomes in survivors of severe burn injuries: A systematic review, Burns, December 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0305417926003074)
3. Optic nerve sheath diameter for predicting neurological outcomes after cardiac arrest: a systematic review and meta-analysis, BMC Emergency Medicine, 23 September 2026, [Link](https://link.springer.com/article/10.1186/s12873-026-01790-7)
4. AMPA Receptor Antagonists in Preclinical Models of Traumatic Brain Injury: A Systematic Review and Meta-analysis of Animal Studies, Neurocritical Care, 11 September 2026, [Link](https://link.springer.com/article/10.1007/s12028-026-02640-x)
5. EEG Reactivity and Etiology as Prognostic Modifiers in Alpha and Theta Coma: A Systematic Review and Meta-analysis, Neurocritical Care, 8 September 2026, [Link](https://link.springer.com/article/10.1007/s12028-026-02646-5)
6. DexSAH: A Systematic Review and Meta-analysis of Dexmedetomidine in Aneurysmal Subarachnoid Hemorrhage, Neurocritical Care, 8 September 2026, [Link](https://link.springer.com/article/10.1007/s12028-026-02644-7)
7. Effect of positive end-expiratory pressure on intracranial pressure, cerebral perfusion pressure and brain-tissue oxygenation in acute brain injury: a systematic review and dose–response meta-analysis, Critical Care, 31 August 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06294-1)
8. Psychosocial coping with intensive care delirium: a mixed-methods systematic review of patient and family perspectives, Critical Care, 21 August 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06232-1)
9. Rethinking Muscle Wasting in Critical Illness: A Systematic Review and Meta-Analysis of Myofiber Size and Protein Turnover, Critical Care Medicine, 7 August 2026, [Link](https://www.ovid.com/jnls/ccmjournal/fulltext/10.1097/ccm.0000000000007288~rethinking-muscle-wasting-in-critical-illness-a-systematic)
10. Intravenous Thrombolysis Beyond the Conventional Time Window for Acute Ischemic Stroke: A Systematic Review and Meta-Analysis, JAMA Open, 6 August 2026, [Link](https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2852517)
11. Surgical Versus Medical Management in Older Adults with Traumatic Brain Injury: A Systematic Review and Meta-analysis, Neurocritical Care, 3 August 2026, [Link](https://link.springer.com/article/10.1007/s12028-026-02593-1)
12. Aggressive Versus Conservative Blood Pressure Reduction in Acute Intracerebral Hemorrhage: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Critical Care Medicine, 22 July 2026, [Link](https://www.ovid.com/jnls/ccmjournal/abstract/10.1097/ccm.0000000000007240~aggressive-versus-conservative-blood-pressure-reduction-in)
13. Flow Diversion for Anterior Communicating Artery Aneurysms: Systematic Review and Meta-Analysis, Stroke: Vascular and Interventional Neurology, 21 July 2026, [Link](https://www.ahajournals.org/doi/10.1161/SVIN.125.002259)
### 5- Renal & Metabolism:
1. Landscape of Biomarker Use in Critically Ill Patients: Systematic Evidence Map of Acute Kidney Injury and Implications for Practice, Critical Care Medicine, 11 September 2026, [Link](https://www.ovid.com/jnls/ccmjournal/abstract/10.1097/ccm.0000000000007362~landscape-of-biomarker-use-in-critically-ill-patients)
2. Diuretic therapy for critically ill patients: a systematic review and network meta-analysis, Annals of Intensive Care, 20 July 2026, [Link](https://www.sciencedirect.com/science/article/pii/S211058202600155X)
3. Sodium bicarbonate therapy in severe metabolic acidemia: an individual patient data meta-analysis of the BICAR-ICU and BICAR-ICU2 trials, Critical Care, 19 July 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06206-3)
### 6- Trauma:
1. Bromelain-based enzymatic debridement versus standard of care in deep partial- and full-thickness burns: A systematic review and meta-analysis of randomized controlled trials, Burns, November 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0305417926003062)
2. Comparative effectiveness of suction versus water seal following tube thoracostomy in traumatic pneumothorax and hemothorax: An updated systematic review and meta-analysis, The American Journal of Emergency Medicine, November 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0735675726003736)
### 7- Blood & hemostasis:
1. Calcium during prehospital trauma blood-product resuscitation: A meta-analysis, The American Journal of Emergency Medicine, December 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0735675726004985)
2. Efficacy and safety of prehospital whole blood resuscitation in traumatic haemorrhagic shock: a systematic review and meta-analysis, The American Journal of Emergency Medicine, November 2026, [Link](https://www.sciencedirect.com/science/article/pii/S0735675726003633)
3. Prehospital tranexamic acid in trauma and traumatic brain injury: a systematic review with meta-analysis of randomized comparative evidence, BMC Emergency Medicine, 22 August 2026, [Link](https://link.springer.com/article/10.1186/s12873-026-01735-0)
4. Effect on Mortality of Anticoagulant Reversal in Acute Intracranial Hemorrhage: A Systematic Review and Meta-analysis, Neurocritical Care, 20 July 2026, [Link](https://link.springer.com/article/10.1007/s12028-026-02588-y)
### 8- Nutrition:
1. Prebiotics, probiotics, and synbiotics therapy in critically ill patients: a systematic review and network meta-analysis, Annals of Intensive Care, 4 August 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582026001652)
2. Glycemic Control in Severe Acute Brain Injury: Systematic Review and Meta-analysis with Trial Sequential Analysis, Neurocritical Care, 20 July 2026, [Link](https://link.springer.com/article/10.1007/s12028-026-02592-2)
### 9- Infectious Diseases:
1. Comparative efficacy and safety of hydrocortisone-based regimens in septic shock: A network meta-analysis, Journal of Critical Care, February 2027, [Link](https://www.sciencedirect.com/science/article/abs/pii/S088394412600328X)
2. Echocardiography-guided resuscitation versus usual care for patients with sepsis: A systematic review and meta-analysis of randomized controlled trials, Chest Critical Care, 18 September 2026, [Link](https://www.sciencedirect.com/science/article/pii/S294978842600095X)
3. Drug Clearance and Dosing During CytoSorb Hemoadsorption: A Systematic Review: Erratum, Critical Care Explorations, September 2026, [Link](https://www.ovid.com/jnls/ccejournal/fulltext/10.1097/cce.0000000000001470~drug-clearance-and-dosing-during-cytosorb-hemoadsorption-a)
4. Correction to “Clinical effectiveness of procalcitonin- or C-reactive protein-guided antibiotic discontinuation protocols for adult patients who are critically ill with sepsis: a rapid systematic review and meta-analysis”, Anaesthesia, 14 August 2026, [Link](https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/full/10.1111/anae.70355)
5. IgM-Enriched Immunoglobulin As Adjunctive Therapy in Adult Sepsis and Septic Shock: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Critical Care Explorations, August 2026, [Link](https://www.ovid.com/jnls/ccejournal/fulltext/10.1097/cce.0000000000001451~igm-enriched-immunoglobulin-as-adjunctive-therapy-in-adult)
### 10- Pediatric critical care:
1. Pediatric Neurogenic Stunned Myocardium: A Systematic Review and Pooled Individual-Level Analysis, Neurocritical Care, 21 September 2026, [Link](https://link.springer.com/article/10.1007/s12028-026-02652-7)
2. Duration of Resuscitation and Survival of Pediatric Traumatic Cardiac Arrest: A Systematic Review of the Literature and Meta-Analysis, Pediatric Emergency Care, 16 September 2026, [Link](https://www.ovid.com/jnls/pec-online/abstract/10.1097/pec.0000000000003706~duration-of-resuscitation-and-survival-of-pediatric)
3. Venous thromboembolism in pediatric traumatic brain injury: A systematic review and meta-analysis, Journal of Trauma and Acute Care Surgery, 15 September 2026, [Link](https://www.ovid.com/jnls/jtrauma/fulltext/10.1097/ta.0000000000005170~venous-thromboembolism-in-pediatric-traumatic-brain-injury-a)
4. Prognostic Accuracy of the Phoenix Sepsis Criteria for Mortality in Children With Suspected Infection: A Systematic Review and Meta-Analysis, Critical Care Medicine, 5 August 2026, [Link](https://www.ovid.com/jnls/ccmjournal/abstract/10.1097/ccm.0000000000007312~prognostic-accuracy-of-the-phoenix-sepsis-criteria-for)
### 11- Other:
1. Ethical and Methodological Features of Cluster Randomized Trials in Critical Care Settings: A Systematic Review, Critical Care Medicine, 7 September 2026, [Link](https://www.ovid.com/jnls/ccmjournal/abstract/10.1097/ccm.0000000000007340~ethical-and-methodological-features-of-cluster-randomized)
2. Butyrylcholinesterase Activity as a Mortality Marker in ICU Patients: An Individual Participant Data Meta-Analysis, Critical Care Explorations, September 2026, [Link](https://www.ovid.com/jnls/ccejournal/fulltext/10.1097/cce.0000000000001476~butyrylcholinesterase-activity-as-a-mortality-marker-in-icu)
3. Psychological and cognitive support after cardiac arrest: a systematic review, Resuscitation Plus, September 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2666520426002353)
4. Impact of pre-admission functional status on intensive care patient outcomes: a systematic review and meta-analysis, BJA, 28 August 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900576-3/fulltext)
---
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## ***Clinical trials:***
### 1- Cardiovascular & Hemodynamics:
1. Early effects of bolus versus continuous infusion furosemide in acute decompensated heart failure: a randomized double-blind study, The American Journal of Emergency Medicine, December 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0735675726004055)
2. Intraosseous versus intravenous access in adult out-of-hospital cardiac arrest: a Bayesian secondary analysis of the Paramedic-3 randomised controlled trial, Resuscitation, 25 September 2026, [Link](https://www.sciencedirect.com/science/article/pii/S0300957226023828)
3. Prehospital extracorporeal cardiopulmonary resuscitation for refractory out-of-hospital cardiac arrest: a protocol for the Rapid Prehospital ACcess to ECPR in Prague (RACE Prague) single-arm pilot feasibility study, Resuscitation Plus, 24 September 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2666520426002900)
4. Comparing chest compression quality in 1-min vs. 2-min rescuer rotations with and without audiovisual feedback guidance during full adult advanced life support simulated scenarios: a randomized simulation study, Resuscitation Plus, September 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2666520426002080)
5. Hospital Costs of Microaxial Flow Pump Therapy in Cardiogenic Shock: A DanGer Shock Trial Analysis, JACC, 31 August 2026, [Link](https://www.jacc.org/doi/10.1016/j.jacc.2026.08.029)
6. Catheter-Directed Thrombolysis in Intermediate-High–Risk Pulmonary Embolism, NEJM, 31 August 2026, [Link](https://www.nejm.org/doi/full/10.1056/NEJMoa2608012)
7. Effect of In-Hospital Initiation of Dapagliflozin on Decongestion in Patients Hospitalized for Heart Failure: An Analysis of the DAPA ACT HF-TIMI 68 Trial, JACC: Heart Failure, 30 August 2026, [Link](https://www.jacc.org/doi/10.1016/j.jchf.2026.103366)
8. Aspirin Omission at the Time of Primary Percutaneous Coronary Intervention in STEMI, NEJM, 29 August 2026, [Link](https://www.nejm.org/doi/full/10.1056/NEJMoa2606997)
9. Prasugrel versus Ticagrelor in Acute Coronary Syndromes, NEJM, 29 August 2026, [Link](https://www.nejm.org/doi/full/10.1056/NEJMoa2609057)
10. Complete Revascularization Guided by Functional Coronary Angiography in STEMI, NEJM, 29 August 2026, [Link](https://www.nejm.org/doi/full/10.1056/NEJMoa2605373)
11. Targeted Use of Computed Tomographic Coronary Angiography in Acute Chest Pain, NEJM, 29 August 2026, [Link](https://www.nejm.org/doi/full/10.1056/NEJMoa2608903)
12. Safety and efficacy of the 0/1 h pathway for myocardial infarction in the emergency department: an international, pragmatic, stepped-wedge, cluster-randomised, controlled trial, The Lancet, 29 August 2026, [Link](https://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2826%2901654-5/abstract)
13. Bivalirudin Versus Heparin in Low and Non-Low Bleeding Risk Patients Undergoing Primary PCI for STEMI: The BRIGHT-4 Trial, JACC, 27 August 2026, [Link](https://www.jacc.org/doi/10.1016/j.jacc.2026.06.035)
14. Intravenous Nicorandil in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary PCI: The CLEAN Randomized Clinical Trial, JACC, 12 August 2026, [Link](https://www.jacc.org/doi/10.1016/j.jacc.2026.07.005)
15. Effect of an app-guided advanced cardiac life support algorithm on teamwork, non-technical skills, and workload in simulated in-hospital cardiac arrest: a randomized controlled feasibility trial, Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 12 August 2026, [Link](https://link.springer.com/article/10.1186/s13049-026-01673-7)
16. Protocol and Statistical Analysis Plan for the ECMO-Free Trial: A Multicenter Randomized Controlled Trial, Chest Critical Care, 11 August 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2949788426000845)
17. Duration of Therapeutic Hypothermia After Out-of-Hospital Cardiac Arrest: The ICECAP Randomized Clinical Trial, JAMA, 5 August 2026, [Link](https://jamanetwork.com/journals/jama/article-abstract/2852508)
18. Restrictive vs Liberal Transfusion Strategy After Myocardial Infarction: A Post Hoc Analysis of the MINT Randomized Clinical Trial, JAMA Open, 27 July 2026, [Link](https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2852120)
19. Lidocaine Versus Amiodarone in Patients With Shockable Out-of-Hospital Cardiac Arrest: A Target Trial Emulation, Critical Care Medicine, 15 July 2026, [Link](https://www.ovid.com/jnls/ccmjournal/fulltext/10.1097/ccm.0000000000007265~lidocaine-versus-amiodarone-in-patients-with-shockable)
20. YEARS Algorithm for Diagnosis of Suspected Pulmonary Embolism in Patients With Cancer: A Randomized Clinical Trial, JAMA, 12 July 2026, [Link](https://jamanetwork.com/journals/jama/article-abstract/2851621)
### 2- Thorax/Lungs/Airways/Mechanical ventilation:
1. Epithelial injury and inflammatory phenotypes for personalized ventilation in ARDS: Secondary analysis of the LIVE trial, Chest, 23 September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0012369226067073)
2. Multicomponent Pulmonary Rehabilitation for Prolonged Mechanical Ventilation in Patients Aged 80 Years or Older: A Randomized Controlled Trial, Chest, 19 September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0012369226066729)
3. Efficacy of Noninvasive Ventilatory Therapies Through Different Interfaces in the Postoperative Care of Cardiac Surgery Patients: A Randomized Controlled Trial, Journal of Cardiothoracic and Vascular Anesthesia, 6 September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026008840)
4. An augmented rehabilitation package incorporating immersive virtual reality during early recovery after ARDS: A randomized controlled trial, Annals of Intensive Care, 5 September 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582026001895)
5. Extracorporeal CO2 elimination for acute exacerbation of severe COPD requiring invasive mechanical ventilation: a randomized controlled trial (the X-COPD trial), Critical Care, 3 September 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06300-6)
6. Effectiveness of a standardized weaning protocol in tracheostomized patients with prolonged mechanical ventilation: a prospective single-arm interventional trial, Journal of Intensive Care, 2 September 2026, [Link](https://link.springer.com/article/10.1186/s40560-026-00935-x)
7. Accuracy of ventilation feedback devices compared with a reference standard during asynchronous ventilation with continuous chest compressions in a simulated cardiac arrest: a prospective non-randomized cross-over study, Resuscitation Plus, September 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2666520426002602)
8. Comparison of the effect of suction catheter and nelaton catheter in airway suctioning on hemodynamic status of patients in intensive care units, BMC Anesthesiology, 24 August 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04155-6)
9. Switching from controlled to assisted ventilation based on oxygenation thresholds and PEEP: a target trial emulation, Critical Care, 20 August 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06275-4)
10. Prophylactic high-flow nasal oxygen vs. conventional oxygen for prevention of postoperative respiratory complications: a randomized trial, Critical Care, 20 August 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06205-4)
11. Physiological comparison of high-flow oxygen via endotracheal tube and T-piece strategies during spontaneous breathing trials: a randomized crossover study, Critical Care, 18 August 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06266-5)
12. Impact of an ROX index-guided intubation strategy on mortality in patients receiving high-flow nasal cannula: a target trial emulation, Journal of Intensive Care, 14 August 2026, [Link](https://link.springer.com/article/10.1186/s40560-026-00927-x)
13. Bougie guided versus Endotracheal tube with stylet-guided intubation in critically injured patients with Difficult airway characteristics (BEST trial): randomised clinical trial, Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 10 August 2026, [Link](https://link.springer.com/article/10.1186/s13049-026-01670-w)
14. The impact of an intensive care telemedicine program on weaning from invasive ventilation: a secondary analysis of the ERIC trial, Critical Care, 7 August 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06234-z)
15. Accelerating tracheostomy decannulation with intermittent oro-esophageal feeding in neurogenic dysphagia: a multicenter randomized controlled trial, Critical Care, 4 August 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06235-y)
16. The Effect of Transpulmonary Pressure-Guided Positive End-Expiratory Pressure Titration on Pulmonary Arterial Compliance in Acute Respiratory Distress Syndrome Patients: A Single-Center, Randomized Controlled Pilot Pathophysiological Study, Critical Care Explorations, August 2026, [Link](https://www.ovid.com/jnls/ccejournal/fulltext/10.1097/cce.0000000000001461~the-effect-of-transpulmonary-pressure-guided-positive)
17. Patient-and Caregiver-Centered Outcomes in Survivors of Severe Stroke with Respiratory Failure at 6 Months: A Substudy of the SETPOINT2 Trial, Neurocritical Care, 20 July 2026, [Link](https://link.springer.com/article/10.1007/s12028-026-02591-3)
18. Effects of Abdominal Electrical Stimulation Combined With Airway Clearance Techniques in Tracheotomized Patients With Neurological Disorders: A Randomized, Controlled Trial, Critical Care Medicine, 17 July 2026, [Link](https://www.ovid.com/jnls/ccmjournal/fulltext/10.1097/ccm.0000000000007267~effects-of-abdominal-electrical-stimulation-combined-with)
### 3- Neuromuscular:
1. Neuroprotective effect of early remote ischaemic post-conditioning after out-of-hospital cardiac arrest (RIPOST-CA): study protocol for a randomized, single-blinded, monocentric, controlled trial, Resuscitation Plus, 24 September 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2666520426002894)
2. Tenecteplase Before Thrombectomy at 4.5 to 24 Hours for Basilar Artery Occlusion: The ATTENTION LATE Randomized Clinical Trial, JAMA, 23 September 2026, [Link](https://jamanetwork.com/journals/jama/article-abstract/2854449)
3. Loberamisal for Acute Ischemic Stroke: The LAIS Randomized Clinical Trial, JAMA, 10 September 2026, [Link](https://jamanetwork.com/journals/jama/article-abstract/2854043)
4. Restrictive vs Liberal Transfusion Strategy in Traumatic Brain Injury: A Secondary Analysis of the TRAIN Trial, JAMA Open, 8 September 2026, [Link](https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2853805)
5. Neuroprotection via optimizing cerebral blood flow after cardiac arrest (neuro-intact) study – A phase II proof-of-concept study protocol, Resuscitation Plus, September 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2666520426002158)
6. Tirofiban for Branch Atheromatous Disease–Related Stroke: The STRATEGY Randomized Clinical Trial, JAMA Neurology, 31 August 2026, [Link](https://jamanetwork.com/journals/jamaneurology/fullarticle/2853598)
7. Sex Differences in Treatment Effect of Adjunctive Intra‐Arterial Urokinase After Successful Thrombectomy: A Post Hoc Secondary Analysis of the POST‐UK Randomized Clinical Trial, Journal of the American Heart Association, 30 August 2026, [Link](https://www.ahajournals.org/doi/10.1161/JAHA.126.051642)
8. Body Weight in Relation to the Effectiveness of Intravenous Alteplase in Acute Ischemic Stroke: The ENCHANTED Trial, Stroke, 26 August 2026, [Link](https://www.ahajournals.org/doi/10.1161/STROKEAHA.125.053569)
9. Timing of Middle Meningeal Artery Embolization and Surgery: Analysis of the EMBOLISE Trial, Stroke: Vascular and Interventional Neurology, 13 August 20226, [Link](https://www.ahajournals.org/doi/10.1161/SVIN.126.002359)
10. Colchicine for the Prevention of Vascular Events After an Acute Intracerebral Hemorrhage: A Placebo-Controlled Trial, Stroke, 6 August 2026, [Link](https://www.ahajournals.org/doi/10.1161/STROKEAHA.126.055934)
11. One-Year Outcomes After Endovascular Treatment for Large Acute Ischemic Stroke: The TESLA Randomized Clinical Trial, JAMA, 3 August 2026, [Link](https://jamanetwork.com/journals/jama/fullarticle/2852448)
12. Mechanical Thrombectomy in Ischemic Stroke With a Medium or Distal Arterial Occlusion: The DISCOUNT Randomized Clinical Trial, JAMA, 22 July 2026, [Link](https://jamanetwork.com/journals/jama/article-abstract/2851954)
13. Tenecteplase Efficacy in Patients With Distal Occlusions: Secondary Analysis of the TASTE Randomized Clinical Trial, Stroke, 22 July 2026, [Link](https://www.ahajournals.org/doi/10.1161/STROKEAHA.126.056290)
14. Evaluating Utility-Weighted Modified Rankin Scale as an Outcome for Clinical Trials in Subarachnoid Hemorrhage: A SAHaRA Secondary Analysis, Neurocritical Care, 17 July 2026, [Link](https://link.springer.com/article/10.1007/s12028-026-02589-x)
### 4- Renal:
1. A multicenter randomized, double-blinded placebo-controlled phase 2 trial to evaluate safety and efficacy of ilofotase alfa in patients at risk for kidney injury following open-heart surgery, Intensive Care Medicine, 21 September 2026, [Link](https://link.springer.com/article/10.1007/s00134-026-08596-y)
2. Dapagliflozin and Acute Kidney Injury Following Cardiac Surgery: A Randomized Clinical Trial, JAMA, 30 July 2026, [Link](https://jamanetwork.com/journals/jama/article-abstract/2852324)
### 5- Trauma & Burns:
1. Short or Long Antibiotic Regimens in Orthopedics, NEJM, 16 September 2026, [Link](https://www.nejm.org/doi/full/10.1056/NEJMoa2506756)
2. A 360° virtual reality tool to reduce opioid consumption, pain, and anxiety during dressing changes after burn surgery – A Randomized Controlled Trial, Burns, 17 August 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0305417926003372)
### 6- Blood & hemostasis:
1. Restrictive vs Liberal Transfusion Strategy in Traumatic Brain Injury: A Secondary Analysis of the TRAIN Trial, JAMA Open, 8 September 2026, [Link](https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2853805)
2. Early red blood cell transfusion strategy in septic shock among patients with cancer: the TRANSPORT randomized controlled trial, Intensive Care Medicine, 19 August 2026, [Link](https://link.springer.com/article/10.1007/s00134-026-08582-4)
### 7- Nutrition & Metabolism:
1. Intranasal lidocaine spray during nasogastric tube placement: a randomized, double-blind, placebo-controlled trial, BMC Emergency Medicine, 25 September 2026, [Link](https://link.springer.com/article/10.1186/s12873-026-01795-2)
2. Association between age and outcomes of evidence-based feeding protocol versus usual care in critically ill patients: secondary analysis of a multicenter cluster-randomised controlled trial, Journal of Intensive Care, 21 September 2026, [**Link**](https://link.springer.com/article/10.1186/s40560-026-00942-y)
3. Indirect calorimetry-guided nutrition during weaning from prolonged mechanical ventilation: a double-blind randomized controlled trial, Critical Care, 28 August 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06272-7)
4. Effect of early versus delayed or no insulin therapy for moderate hyperglycemia in ICU patients: A target trial emulation, Chest, 16 August 2026, [Link](https://www.sciencedirect.com/science/article/pii/S001236922606352X)
### 8- Infectious Diseases:
1. Fluid-intolerance signals as bedside safety limits during early septic shock resuscitation: a multicenter randomized trial, Critical Care, 26 September 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06316-y)
2. Nurse-led respiratory care bundle and pneumonia prevention in critically ill patients with abdominal sepsis: a multicenter before-and-after controlled study, Critical Care, 14 September 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06304-2)
3. High blood pressure-targeted management associated with reduced benefits of higher body mass index in elderly patients with septic shock: a post hoc analysis of a multicenter randomized controlled trial, Annals of Intensive Care, 7 September 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582026001925)
4. Early multimodal vasopressor strategy in septic shock: results of the TRICYCLE randomized controlled trial, Critical Care, 7 September 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06323-z)
5. Response-Tailored or Standard-Duration Antibiotic Treatment for Infective Endocarditis, NEJM, 28 August 2026, [Link](https://www.nejm.org/doi/full/10.1056/NEJMoa2607887)
6. Effect of megadose vitamin C in patients with sepsis: the CEMVIS randomized clinical trial, Critical Care, 24 August 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06280-7)
7. Impact of a strategy using multiplex PCR on targeted antibiotic therapy for patients with suspected ventilator-associated pneumonia or hospital-acquired pneumonia requiring mechanical ventilation: a randomized, single-blind trial, Intensive Care Medicine, 20 August 2026, [Link](https://link.springer.com/article/10.1007/s00134-026-08591-3)
8. Predictive performance of kinetic eGFR, midregional proadrenomedullin, and H3.1 nucleosomes for acute kidney disease in sepsis: a secondary analysis of a large multicentre randomized controlled trial, Journal of Intensive Care, 19 August 2026, [Link](https://link.springer.com/article/10.1186/s40560-026-00926-y)
9. Postintensive Care Frailty of Older Patients With Septic Shock: A Post Hoc Analysis of a Multicenter Randomized Controlled Trial, Critical Care Medicine, 12 August 2026, [Link](https://www.ovid.com/jnls/ccmjournal/abstract/10.1097/ccm.0000000000007304~postintensive-care-frailty-of-older-patients-with-septic)
10. Ultra-early versus early adjunctive vasopressin initiation after norepinephrine escalation in septic shock: a target trial emulation, Intensive Care Medicine, 11 August 2026, [Link](https://link.springer.com/article/10.1007/s00134-026-08575-3)
11. Tigecycline pharmacokinetics in critically ill patients receiving extracorporeal membrane oxygenation: a prospective multicentre pilot study, BMC Anesthesiology, 6 August 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04114-1)
12. PCR-based syndromic tests for antibiotic stewardship in non-ventilated patients with hospital-acquired pneumonia: a multicentre randomized controlled trial, JAC-Antimicrobial Resistance, 4 August 2026, [Link ](https://academic.oup.com/jacamr/article/8/4/dlag154/8747238)
13. H3.1 Nucleosomes to Predict Renal Replacement Therapy and Mortality in Sepsis—A Secondary Analysis of the SISPCT Randomized Controlled Trial, Critical Care Medicine, 3 August 2026, [Link](https://www.ovid.com/jnls/ccmjournal/fulltext/10.1097/ccm.0000000000007270~h31-nucleosomes-to-predict-renal-replacement-therapy-and)
14. Effect of Early Administration of Shenfu Injection on Hemodynamics in Septic Patients: A Multicenter, Randomized, Controlled Trial, Critical Care Medicine, 15 July 2026, [Link](https://www.ovid.com/jnls/ccmjournal/abstract/10.1097/ccm.0000000000007269~effect-of-early-administration-of-shenfu-injection-on)
### 9- Sedation & analgesia:
1. Ketamine for Analgosedation in Mechanically Ventilated Adults: A Double-Blind Randomized Trial, Critical Care Medicine, 7 September 2026, [Link](https://www.ovid.com/jnls/ccmjournal/abstract/10.1097/ccm.0000000000007341~ketamine-for-analgosedation-in-mechanically-ventilated)
### 10- Pediatric critical care:
1. Increased ureagenesis revealing metabolic intolerance to enhanced nutrition in the PICU: a secondary analysis of the PEPaNIC RCT, Critical Care, 25 September 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06345-7)
2. Collaborative General Practitioner Shared Care Versus Self-Directed Care Following Critical Illness in Young Children: A Pilot Hybrid Effectiveness-Implementation Randomized Controlled Trial, Pediatric Critical Care Medicine, 26 August 2026, [Link](https://www.ovid.com/jnls/pccmjournal/abstract/10.1097/pcc.0000000000004024~collaborative-general-practitioner-shared-care-versus)
3. Bilevel Positive Airway Pressure and Continuous Albuterol for Pediatric Asthma Exacerbations: A Randomized Clinical Trial, JAMA Open, 26 August 2026, [Link](https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2853300)
4. Early albumin use and mortality in critically ill children with severe hypoalbuminemia: a target trial emulation study, Critical Care, 17 August 20226, [Link](https://link.springer.com/article/10.1186/s13054-026-06237-w)
5. Oral step-down, optimal drug, and total duration of antibiotic treatment in African children hospitalised with severe community-acquired pneumonia (PediCAP): a factorial randomised controlled trial, The Lancet, 8 August 2026, [Link](https://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2826%2900879-2/fulltext)
6. Oxygen saturation thresholds in children with acute respiratory distress (OxyKids): a multicentre, open, parallel-group, randomised clinical trial, The Lancet: Respiratory Medicine, August 2026, [Link](https://www.thelancet.com/journals/lanres/article/PIIS2213-2600%2826%2900087-1/abstract)
### 11- Other:
1. Early mobilization for mechanical ventilation for sepsis or acute respiratory failure (EVER): a multicenter randomized controlled trial with 12-month outcomes, Intensive Care Medicine,26 August 2026, [Link](https://link.springer.com/article/10.1007/s00134-026-08598-w)
2. Targeted Temperature Management at 35°C vs. 37°C for Heatstroke in ICU: A Pilot Randomized Controlled Trial, Critical Care Medicine, 6 August 2026, [Link](https://www.ovid.com/jnls/ccmjournal/abstract/10.1097/ccm.0000000000007266~targeted-temperature-management-at-35c-vs-37c-for-heatstroke)
3. A Co-Designed Post-ICU Follow-Up Pathway Is Feasible and May Be Associated With Improved Psychosocial Recovery for Patients and Their Caregivers: Outcomes From the IMPACT-ICU Single-Center Randomized Controlled Trial, Critical Care Explorations, August 2026, [Link](https://www.ovid.com/jnls/ccejournal/fulltext/10.1097/cce.0000000000001448~a-co-designed-post-icu-follow-up-pathway-is-feasible-and-may)
4. ICU-specific virtual reality for mental health after critical illness: an international three-arm randomized clinical trial, Critical Care, 24 July 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06186-4)
5. Facilitating Communication for Family Members of Critically Ill Patients During and Following a Hospital Stay: A Randomized Controlled Trial, Critical Care Medicine, 22 July 2026, [Link](https://www.ovid.com/jnls/ccmjournal/abstract/10.1097/ccm.0000000000007268~facilitating-communication-for-family-members-of-critically)
---
## ***Reviews:***
### 1- AI & Tech:
1. Responsible AI for Acute Stroke Management, Stroke, 17 September 2026, [Link](https://www.ahajournals.org/doi/10.1161/STROKEAHA.126.053795)
2. Effect of modern technologies on ICU resource management in disasters: a systematic review, Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 16 September 2026, [Link](https://link.springer.com/article/10.1186/s13049-026-01700-7)
3. Triple innovations in acute critical illness management: integrating AI early warning, precision biomarkers, and telemedicine, Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 14 September 2026, [Link](https://link.springer.com/article/10.1186/s13049-026-01701-6)
4. Artificial Intelligence in Burn Depth Assessment: From Pixel Classification to Surgical Decision-Making, Burns, 5 September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0305417926003645)
5. Intensive Monitoring, Big Data, and Artificial Intelligence in Critical Care, Critical Care Clinics, 4 September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070426000758)
6. Principles of pressure transducers, resonance and frequency and their clinical application in measuring arterial blood pressure, Anaesthesia & Intensive Care Medicine, September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926001475)
7. Artificial intelligence in emergency medicine: from algorithmic performance to real-world clinical integration — understanding the implementation gap, International Journal of Emergency Medicine, 31 August 2026, [Link](https://link.springer.com/article/10.1186/s12245-026-01333-8)
### 2- Cardiovascular & Hemodynamics:
1. Ventricular fibrillation waveform analysis for individualized defibrillation strategies, The American Journal of Emergency Medicine, December 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0735675726004110)
2. Optimizing the use of critical care echocardiography: from point-of-care tool to monitoring modality, Current Opinion in Critical Care, October 2026, [Link](https://www.ovid.com/jnls/co-criticalcare/abstract/10.1097/mcc.0000000000001423~optimizing-the-use-of-critical-care-echocardiography-from)
3. Transoesophageal echocardiography during cardiopulmonary resuscitation for cardiac arrest: a scoping review, Resuscitation, October 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0300957226003084)
4. Sex Differences Following Cardiac Arrest: A Conceptual Framework for Mechanisms and Translational Targets, Resuscitation, 25 September 2026, [Link](https://www.sciencedirect.com/science/article/pii/S030095722602383X)
5. Post-Operative Complications in Aboriginal and Torres Strait Islander People Undergoing Cardiac Surgery – A Scoping Review, Journal of Cardiothoracic and Vascular Anesthesia, 24 September 2026, [Link](https://www.sciencedirect.com/science/article/pii/S1053077026008918)
6. Critical Care Management of Patients with Acute Fulminant Myocarditis, Journal of Cardiothoracic and Vascular Anesthesia, 23 September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026009377)
7. Clinical relevance of ventriculo-arterial coupling and how to assess it at the bedside, Annals of Intensive Care, 23 September 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582026002050)
8. Acute Coronary Syndrome in Kawasaki Disease From Infancy to Adulthood, Circulation, 21 September 2026, [Link](https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.080727)
9. Therapeutic hypercapnia after cardiac arrest: still promising or time to move on?, Intensive Care Medicine Experimental, 18 September 2026, [Link](https://link.springer.com/article/10.1186/s40635-026-00974-6)
10. Therapeutic Strategies for Takotsubo Syndrome: A Comprehensive Clinical Review, Journal of the American Heart Association, 18 September 2026, [Link](https://www.ahajournals.org/doi/10.1161/JAHA.126.050906)
11. Beating the clock: time-targeted and individualized extracorporeal cardiopulmonary resuscitation, Current Opinion in Critical Care, 18 September 2026, [Link](https://www.ovid.com/jnls/co-criticalcare/abstract/10.1097/mcc.0000000000001432~beating-the-clock-time-targeted-and-individualized)
12. Defibrillation in refractory cardiac arrest: knowledge gaps and future priorities, Current Opinion in Critical Care, 18 September 2026, [Link](https://www.ovid.com/jnls/co-criticalcare/abstract/10.1097/mcc.0000000000001435~defibrillation-in-refractory-cardiac-arrest-knowledge-gaps)
13. Pump-controlled retrograde trial off in veno-arterial extracorporeal membrane oxygenation weaning: a scoping review of physiological rationale, protocol heterogeneity, and clinical application, Critical Care, 16 September 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06336-8)
14. Node-Based Framework for Regionalized Cardiogenic Shock Systems of Care: Evidence, Design, and Future Directions, Circulation: Heart Failure, 15 September 2026, [Link](https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.126.014188)
15. Next Generation Temporary Mechanical Circulatory Support for Cardiogenic Shock, Circulation: Heart Failure, 15 September 2026, [Link](https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.126.014202)
16. A Recovery-Focused Framework for the Management of Cardiogenic Shock, Circulation: Heart Failure, 15 September 2026, [Link](https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.126.014307)
17. Hypoperfusion-Shock Continuum in Acute Decompensated Heart Failure, Circulation: Heart Failure, 15 September 2026, [Link](https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.125.013797)
18. Cardiogenic Shock Management: A Framework for Individualized Microaxial Flow Pump Support, Circulation: Heart Failure, 15 September 2026, [Link](https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.125.014161)
19. Clinical Management of Myocardial Infarction, Circulation, 14 September 2026, [Link](https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.079317)
20. Physiology-informed management of peripheral VA ECMO in adults with cardiogenic shock: a narrative review and four-domain framework for integrated bedside assessment, Critical Care, 11 September 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06318-w)
21. Management of shock phenotypes after cardiac arrest: beyond cardiogenic shock, Current Opinion in Critical Care, 9 September 2026, [Link](https://www.ovid.com/jnls/co-criticalcare/abstract/10.1097/mcc.0000000000001434~management-of-shock-phenotypes-after-cardiac-arrest-beyond)
22. Overcoming Residual Congestion in Acute Heart Failure: Defining Targets and Identifying Diuretic Responders, Journal of the American Heart Association, 9 September 2026, [Link](https://www.ahajournals.org/doi/10.1161/JAHA.126.052271)
23. Point-of-care ultrasound in shock, BJA Edu, 8 September 2026, [Link](https://www.bjaed.org/article/S2058-5349%2826%2900072-7/abstract)
24. Hypertensive crisis in the critically ill, Annals of Intensive Care, 7 September 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582026001937)
25. Advanced hemodynamic monitoring during post-resuscitation care after out-of-hospital cardiac arrest: a scoping review, Resuscitation, September 2026, [Link](https://www.sciencedirect.com/science/article/pii/S0300957226002650)
26. Immune Checkpoint Inhibitor Myocarditis and Myotoxicity, Circulation, 31 August 2026, [Link](https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.081201)
27. Multi-omics biomarkers in post-cardiac arrest syndrome: From pathophysiological mechanisms to the potential prognostication, Shock, 31 August 2026, [Link](https://www.ovid.com/jnls/shockjournal/abstract/10.1097/shk.0000000000002933~multi-omics-biomarkers-in-post-cardiac-arrest-syndrome-from)
28. Atrial Tachycardia: A Novel Classification and Contemporary Management, JACC: Clinical Electrophysiology, 28 August 2026, [Link](https://www.jacc.org/doi/10.1016/j.jacep.2026.07.007)
29. Analyzing Heart Rate Variability in Critical Illness: Contemporary and Emerging Methods, Anesthesiology, 26 August 2026, [Link](https://www.ovid.com/jnls/anesthesiology/abstract/10.1097/aln.0000000000006168~analyzing-heart-rate-variability-in-critical-illness)
30. State-of-the-art review: ß-blockade in critical illness, Intensive Care Medicine, 26 August 2026, [Link](https://link.springer.com/article/10.1007/s00134-026-08574-4)
31. Vasoactive Agent Selection Strategies in the Management of Cardiogenic Shock, Circulation, 24 August 2026, [Link](https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.079463)
32. Assessing vascular barrier permeability in critically ill patients: what are we really measuring?, Critical Care, 20 August 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06250-z)
33. Designing a Cardiac Arrest System That Includes Extracorporeal Cardiopulmonary Resuscitation: A Contemporary Review, Journal of the American Heart Association, 20 August 2026, [Link](https://www.ahajournals.org/doi/10.1161/JAHA.126.051809)
34. The Postcardiac Arrest Inflammatory Response: Mechanisms and Therapeutic Targets, Circulation, 10 August 2026, [Link](https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.080096)
35. Right ventricular dysfunction in acute respiratory distress syndrome: from cardiopulmonary mechanisms to precision management—a narrative review, BJA, 30 July 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900480-0/abstract)
36. Starting Extracorporeal Membrane Oxygenation: A Review of the Ethical Issues and Recommended Approach, Chest, 25 July 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0012369226063038)
37. Paroxysmal Supraventricular Tachycardia Treatment: Evaluating the Evidence for Established and Newly Approved Options, JACC: Advances, 23 July 2026, [Link](https://www.jacc.org/doi/10.1016/j.jacadv.2026.103016)
38. Predicting Fluid Responsiveness in Mechanically Ventilated Adults: An Umbrella Review of Diagnostic Accuracy Meta-Analyses, Anesthesia & Analgesia, 15 July 2026, [Link](https://www.ovid.com/jnls/anesthesia-analgesia/abstract/10.1213/ane.0000000000008215~predicting-fluid-responsiveness-in-mechanically-ventilated)
### 3- Thorax/Lungs/Airways/Mechanical ventilation:
1. Cough function during mechanical ventilation, Chest, 25 September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0012369226067139)
2. The biological and physiological effects of spontaneous breathing in acute hypoxemic respiratory failure requiring invasive ventilation: A scoping review and narrative synthesis, Chest Critical Care, 18 September 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2949788426000936)
3. Prediction of Noninvasive Ventilation Failure: A Narrative Review, Annals of Intensive Care, 14 September 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582026001913)
4. Balancing lung and brain: physiological strategies for ARDS management in acute brain injury, Intensive Care Medicine, 27 August 2026, [Link](https://link.springer.com/article/10.1007/s00134-026-08595-z)
5. Pulmonary vascular dysfunction in ARDS: Pathophysiology and therapeutic implications, Annals of Intensive Care, 26 August 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582026001809)
6. ARDS management in trauma patients, Intensive Care Medicine, 26 August 2026, [Link](https://link.springer.com/article/10.1007/s00134-026-08581-5)
7. Lung-Protective Ventilation in Acute Respiratory Distress Syndrome and Non-acute Respiratory Distress Syndrome Patients: A Critical Appraisal of Its Benefits, Anesthesia & Analgesia, 25 August 2026, [Link](https://www.ovid.com/jnls/anesthesia-analgesia/abstract/10.1213/ane.0000000000008272~lung-protective-ventilation-in-acute-respiratory-distress)
8. Thoracic Ultrasound in Pleural Effusion: A Bedside Practical Approach: Introduction, Chest, 18 August 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0012369226063609)
9. ARDS management beyond the guidelines: a practical physiology-based approach to individualized care, Intensive Care Medicine, 18 August 2026, [Link](https://link.springer.com/article/10.1007/s00134-026-08563-7)
10. Dynamic reprogramming of alveolar epithelial-immune cell interactions in ARDS: from mechanisms to clinical translation, Critical Care, 16 August 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06265-6)
11. Corticosteroids in ARDS: old controversies, new insights, and future directions, Intensive Care Medicine, 13 August 2026, [Link](https://link.springer.com/article/10.1007/s00134-026-08567-3)
12. Hallmarks of Weaning from Mechanical Ventilation: A 3S Framework for Ventilator Liberation — A Narrative Review, Chest, 11 August 2026, [Link](https://www.sciencedirect.com/science/article/pii/S0012369226063385)
13. Why Passive Humidifier Testing Methods and Clinical Utilization Matter for Patient Safety and Need to Be Updated?, CHEST Critical Care, 4 August 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2949788426000730)
14. Right ventricular dysfunction in acute respiratory distress syndrome: from cardiopulmonary mechanisms to precision management—a narrative review, BJA, 30 July 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900480-0/abstract)
15. Considerations for emergency airway management and resuscitation in cancer patients: a review, International Journal of Emergency Medicine, 23 July 2026, [Link](https://link.springer.com/article/10.1186/s12245-026-01287-x)
16. Quantitative assessment of lung mechanical properties in ARDS using X-ray computed tomography, Intensive Care Medicine Experimental, 23 July 2026, [Link](https://link.springer.com/article/10.1186/s40635-026-00946-w)
17. Prone positioning in ARDS, Intensive Care Medicine, 20 July 2026, [Link](https://link.springer.com/article/10.1007/s00134-026-08543-x)
### 4- Neuromuscular:
1. Progress in Intra-Arterial Stem Cell Therapy for Ischemic Stroke: A Review, Stroke: Vascular and Interventional Neurology, 8 September 2026, [Link](https://www.ahajournals.org/doi/10.1161/SVIN.125.001648)
2. An update on management of subarachnoid haemorrhage, Anaesthesia & Intensive Care Medicine, September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926001645)
3. Traumatic brain injury, Anaesthesia & Intensive Care Medicine, September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926001438)
4. Intraarterial Thrombolysis: Past, Present, Future, Stroke, 17 August 2026, [Link](https://www.ahajournals.org/doi/10.1161/STROKEAHA.126.052342)
5. Publisher Correction: Non-invasive intracranial pressure estimation in the intensive care unit: narrative review of methods and clinical applications, Intensive Care Medicine, 11 August 2026, [Link](https://link.springer.com/article/10.1007/s00134-026-08588-y)
6. Understanding cerebral autoregulation and cerebrovascular reactivity: mechanistic perspectives and clinical insights from TBI, Critical Care, 4 August 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06207-2)
7. Update on the intensive care management of traumatic brain injury, BJA Edu, 3 August 2026, [Link](https://www.bjaed.org/article/S2058-5349%2826%2900065-X/abstract)
8. Neuromuscular disorders: relevance to anaesthesia and intensive care, Anaesthesia & Intensive Care Medicine, August 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926001347)
9. Postoperative care of neurosurgical patients: general principles, Anaesthesia & Intensive Care Medicine, August 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926001359)
10. Proposed Corrections to the 2026 Guideline for the Early Management of Patients With Acute Ischemic Stroke, Stroke, 31 July 2026, [Link](https://www.ahajournals.org/doi/10.1161/STROKEAHA.126.056478)
11. Response to Request for Modification of the 2026 AHA/ASA Acute Ischemic Stroke Guidelines: Endovascular Thrombectomy Imaging Selection in the 6- to 24-Hour Window, Stroke, 31 July 2026, [Link](https://www.ahajournals.org/doi/10.1161/STROKEAHA.126.056726)
12. Optimizing Acute Ischemic Stroke Systems of Care: Current State and Future Directions, Stroke, 30 July 2026, [Link](https://www.ahajournals.org/doi/10.1161/STROKEAHA.126.052584)
13. Intracranial pressure physiology, monitoring and individualized management in the acute brain injured patient, Intensive Care Medicine, 29 July 2026, [Link](https://link.springer.com/article/10.1007/s00134-026-08558-4)
14. Effects of Hypertonic Lactate Solutions on Intracranial Dynamics, Cerebral Oxygenation, and Metabolism in Patients with Acute Brain Injury: A Scoping Review, Neurocritical Care, 28 July 2026, [Link](https://link.springer.com/article/10.1007/s12028-026-02566-4)
15. Postoperative Neurocritical Care After Minimally Invasive Evacuation of Spontaneous Intracerebral Hemorrhage, Neurocritical Care, 27 July 2026, [Link](https://link.springer.com/article/10.1007/s12028-026-02598-w)
16. Neurocritical care in low- and middle-income countries, Current Opinion in Anaesthesiology, 22 July 2026, [Link](https://www.ovid.com/jnls/co-anesthesiology/abstract/10.1097/aco.0000000000001686~neurocritical-care-in-low--and-middle-income-countries)
17. Low-Field Magnetic Resonance Imaging in Critical Care of Stroke, Stroke, 21 July 2026, [Link](https://www.ahajournals.org/doi/10.1161/STROKEAHA.126.056517)
18. Rhabdomyolysis: What you need to know, Journal of Trauma and Acute Care Surgery, 20 July 2026, [Link](https://www.ovid.com/jnls/jtrauma/abstract/10.1097/ta.0000000000005141~rhabdomyolysis-what-you-need-to-know)
19. Recent advances and trends in critical care of neuro-infectious disease, Current Opinion in Critical Care, 17 July 2026, [Link](https://www.ovid.com/jnls/co-criticalcare/abstract/10.1097/mcc.0000000000001413~recent-advances-and-trends-in-critical-care-of)
### 5- Renal:
1. Harmonizing the diagnosis of citrate accumulation - a call for standardized criteria, Critical Care, 23 September 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06347-5)
2. Renal microcirculation in acute kidney injury: bridging haemodynamics, inflammation and repair, Annals of Intensive Care, 23 September 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582026002049)
3. The effects of hemoadsorption in patients with sepsis-associated persistent severe AKI who require CRRT: a prospective, randomized controlled pilot study, Annals of Intensive Care, 22 September 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582026002025)
4. Comparison of the approaches to combine Renal Replacement Therapy with Extracorporeal Membrane Oxygenation – a Scoping Review, Annals of Intensive Care, 21 September 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582026002001)
5. Monitoring and dose adjustment of regional citrate anticoagulation for continuous renal replacement therapy, Current Opinion in Critical Care, 19 September 2026, [Link](https://www.ovid.com/jnls/co-criticalcare/fulltext/10.1097/mcc.0000000000001433~monitoring-and-dose-adjustment-of-regional-citrate)
6. Kidney Failure in Cardiogenic Shock, Circulation: Heart Failure, 15 September 2026, [Link](https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.126.014189)
7. Managing fluid status in patients receiving renal replacement therapy, Current Opinion in Critical Care, 2 September 2026, [Link](https://www.ovid.com/jnls/co-criticalcare/abstract/10.1097/mcc.0000000000001426~managing-fluid-status-in-patients-receiving-renal)
8. Antimicrobial dosing in patients with renal dysfunction, Current Opinion in Critical Care, 2 September 2026, [Link](https://www.ovid.com/jnls/co-criticalcare/abstract/10.1097/mcc.0000000000001428~antimicrobial-dosing-in-patients-with-renal-dysfunction)
9. Albumin and the kidney, a friend or foe, Current Opinion in Critical Care, 31 August 2026, [Link](https://www.ovid.com/jnls/co-criticalcare/abstract/10.1097/mcc.0000000000001424~albumin-and-the-kidney-a-friend-or-foe)
10. Sodium bicarbonate for metabolic acidosis, Current Opinion in Critical Care, 31 August 2026, [Link](https://www.ovid.com/jnls/co-criticalcare/abstract/10.1097/mcc.0000000000001425~sodium-bicarbonate-for-metabolic-acidosis)
11. AKI as a systemic syndrome and its impact on other organ systems, Critical Care, 22 August 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06252-x)
12. Acute kidney injury and renal replacement therapy: a critical synthesis of metabolic derangements and nutritional implications, Critical Care, 13 August 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06245-w)
### 6- Trauma & Burns:
1. Mortality predictors, transfusion burden, and resuscitation decision-making in adult trauma patients receiving massive transfusion: A narrative review, Trends in Anaesthesia and Critical Care, October 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2210844026000663)
2. Large vascular blunt trauma injury: A multidisciplinary approach for early management, Anaesthesia Critical Care & Pain Medicine, 22 September 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2352556826001645)
3. Modern Management of Inferior Vena Cava Injuries: What You Need to Know, Journal of Trauma and Acute Care Surgery, 17 September 2026, [Link](https://www.ovid.com/jnls/jtrauma/abstract/10.1097/ta.0000000000005173~modern-management-of-inferior-vena-caval-injuries-what-you)
4. Factors influencing emergency medical services response to trauma during mass casualty incidents: a scoping review, Critical Care, 11 September 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06282-5)
5. Extremity compartment syndrome: What you need to know, Journal of Trauma and Acute Care Surgery, 7 September 2026, [Link](https://www.ovid.com/jnls/jtrauma/abstract/10.1097/ta.0000000000005169~extremity-compartment-syndrome-what-you-need-to-know)
6. Severe Burn Injury as a Chronic Immunometabolic Disease, Shock, 17 August 2026, [Link](https://www.ovid.com/jnls/shockjournal/abstract/10.1097/shk.0000000000002926~severe-burn-injury-as-a-chronic-immunometabolic-disease)
7. Perioperative Medications and Post-Traumatic Stress Disorder in Trauma Patients, Current Anesthesiology Reports, 12 August 2026, [Link](https://link.springer.com/article/10.1007/s40140-026-00717-z)
8. Complications of angioembolization in trauma: What you need to know, Journal of Trauma and Acute Care Surgery, 3 August 2026, [Link](https://www.ovid.com/jnls/jtrauma/abstract/10.1097/ta.0000000000005145~complications-of-angioembolization-in-trauma-what-you-need)
9. CT imaging of the cervical spine for trauma, Anaesthesia & Intensive Care Medicine, August 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926001335)
10. When Seconds Matter, Prioritization of Circulation Before Airway in Trauma Resuscitation, Current Anesthesiology Reports, 31 July 2026, [Link](https://link.springer.com/article/10.1007/s40140-026-00712-4)
11. Temperature Management in Trauma Patients, Current Anesthesiology Reports, 30 July 2026, [Link](https://link.springer.com/article/10.1007/s40140-026-00715-1)
12. Current Clinical Implications of Whole Blood in Trauma Resuscitation, Current Anesthesiology Reports, 30 July 2026, [Link](https://link.springer.com/article/10.1007/s40140-026-00719-x)
13. Management of carotid artery injuries: What you need to know, Journal of Trauma and Acute Care Surgery, 21 July 2026, [Link](https://www.ovid.com/jnls/jtrauma/abstract/10.1097/ta.0000000000005122~management-of-carotid-artery-injuries-what-you-need-to-know)
14. Western Trauma Association critical decisions in trauma: Lung injury, Journal of Trauma and Acute Care Surgery, 13 July 2026, [Link](https://www.ovid.com/jnls/jtrauma/abstract/10.1097/ta.0000000000005127~western-trauma-association-critical-decisions-in-trauma-lung)
### 7- Liver & GI:
1. Caustic ingestion in adult patients, what you should know, what is debated and what should come next, Anaesthesia Critical Care & Pain Medicine, 24 September 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2352556826001694)
2. Management of gastrointestinal oncologic emergencies for the acute care surgeon: What you need to know, Journal of Trauma and Acute Care Surgery, 3 August 2026, [Link](https://www.ovid.com/jnls/jtrauma/abstract/10.1097/ta.0000000000005155~management-of-gastrointestinal-oncologic-emergencies-for-the)
3. Bowel ischemia following extracorporeal cardiopulmonary resuscitation (ECPR): case reports and narrative review, International Journal of Emergency Medicine, 28 July 2026, [Link](https://link.springer.com/article/10.1186/s12245-026-01327-6)
### 8- Blood & hemostasis:
1. Is Ultramassive Transfusion Ever Futile in Trauma?, Current Anesthesiology Reports, 29 August 2026, [Link](https://link.springer.com/article/10.1007/s40140-026-00720-4)
2. The Use of Anticoagulation for Patients with Traumatic Brain Injury on Extracorporeal Membrane Oxygenation, Journal of Cardiothoracic and Vascular Anesthesia, 29 August 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026008670)
3. Coagulopathy and anticoagulation management in adult ECPR patients, Critical Care, 1 August 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06204-5)
### 9- Nutrition:
1. Individualising blood glucose control in ICU patients: evidence and practical implementations, Critical Care, 9 September 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06288-z)
2. Assessment of the effectiveness of protein in critical illness: the role of statistical shortcomings in explaining discrepancies between observational studies and randomized controlled trials, Critical Care, 22 August 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06273-6)
3. Tailored strategies for vitamin C, D, iron, and carnitine in critical illness, Critical Care, 22 August 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06276-3)
4. Providing appropriate response-contingent phase-specific nutrition therapy in critical illness, Current Opinion in Critical Care, 6 August 2026, [Link](https://www.ovid.com/jnls/co-criticalcare/abstract/10.1097/mcc.0000000000001419~providing-appropriate-response-contingent-phase-specific)
5. Physiology of starvation, exercise and stress response, Anaesthesia & Intensive Care Medicine, August 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926001372)
6. Hormonal control of metabolism: regulation of plasma glucose, Anaesthesia & Intensive Care Medicine, August 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926001360)
7. Individualizing post-ICU nutrition: from guideline intent to bedside practice, Current Opinion in Critical Care, 23 July 2026, [Link](https://www.ovid.com/jnls/co-criticalcare/fulltext/10.1097/mcc.0000000000001412~individualizing-post-icu-nutrition-from-guideline-intent-to)
### 10- Infectious Diseases:
1. The 2026 Surviving Sepsis Campaign Guidelines: The dissenting opinion, The American Journal of Emergency Medicine, December 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0735675726004894)
2. Necrotizing soft tissue infections: Challenges and opportunities to improve patient outcomes, Burns, December 2026, [Link](https://www.sciencedirect.com/science/article/pii/S0305417926003281)
3. Hantavirus: A focused review for the emergency medicine clinician, The American Journal of Emergency Medicine, December 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0735675726004225)
4. Dosing of anti-infective drugs in patients undergoing therapeutic plasma exchange – considerations for practical application: a narrative review, Critical Care, 24 September 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06306-0)
5. Practice changing articles: capillary refill time personalized hemodynamic resuscitation in patients with early septic shock, The American Journal of Emergency Medicine, 24 September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0735675726005012)
6. Beyond macrocirculatory targets: a multimodal framework for microcirculatory and organ perfusion monitoring in sepsis, Critical Care, 23 September 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06353-7)
7. The effects of hemoadsorption in patients with sepsis-associated persistent severe AKI who require CRRT: a prospective, randomized controlled pilot study, Annals of Intensive Care, 22 September 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582026002025)
8. Two decades of sepsis guidelines: Evolution of recommendation strength and evidence certainty in the surviving sepsis campaign, Journal of Critical Care, 20 September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0883944126003254)
9. The NLRP3 inflammasome in physiological and dysfunctional host response in human sepsis and critical illness: a narrative review, Critical Care, 19 September 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06315-z)
10. Intravenous Immunoglobulin Administration in Cardiac Surgery, Heart Transplantation and Infective Endocarditis: A Scoping Review, Journal of Cardiothoracic and Vascular Anesthesia, 17 September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026009262)
11. Phenotype-guided polymyxin B haemoadsorption in abdominal septic shock: a 2015–2026 evidence synthesis and proposed clinical pathway, Shock, 11 September 2026, [Link](https://www.ovid.com/jnls/shockjournal/abstract/10.1097/shk.0000000000002940~phenotype-guided-polymyxin-b-haemoadsorption-in-abdominal)
12. Timing of hemoadsorption in sepsis: redefining early through mediator-guided therapy, Journal of Intensive Care, 25 August 2026, [Link](https://link.springer.com/article/10.1186/s40560-026-00932-0)
13. Infection prevention and control strategies for multidrug-resistant Gram-negative bacteria in healthcare: a narrative review, JAC-Antimicrobial Resistance, 19 August 2026, [Link](https://academic.oup.com/jacamr/article/8/4/dlag176/8764254)
14. The evolution of biocontainment unit care for high-consequence infectious diseases: progress, lessons learned, and future directions, Critical Care, 15 August 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06259-4)
15. Eleven questions on Hantavirus cardiopulmonary syndrome management in the ICU, Critical Care, 9 August 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06233-0)
16. Invasive mold infections in intensive care in hematological patients, Current Opinion in Critical Care, 6 August 2026, [Link](https://www.ovid.com/jnls/co-criticalcare/fulltext/10.1097/mcc.0000000000001414~invasive-mold-infections-in-intensive-care-in-hematological)
17. Association Between Community-Level Social Determinants of Health and Sepsis Incidence and Mortality: A Scoping Review, Critical Care Explorations, August 2026, [Link](https://www.ovid.com/jnls/ccejournal/fulltext/10.1097/cce.0000000000001462~association-between-community-level-social-determinants-of)
18. Sepsis-related immunosuppression: a comprehensive review of current research breakthroughs, Critical Care, 24 July 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06168-6)
19. Severe community-acquired pneumonia: a paradigm shift toward precision diagnostics, microbiology, and targeted management, Current Opinion in Critical Care, 2 July 2026, [Link](https://www.ovid.com/jnls/co-criticalcare/abstract/10.1097/mcc.0000000000001410~severe-community-acquired-pneumonia-a-paradigm-shift-toward)
20. Septic shock, Current Opinion in Critical Care, 2 July 2026, [Link](https://www.ovid.com/jnls/co-criticalcare/abstract/10.1097/mcc.0000000000001409~septic-shock)
### 11- Pediatric critical care:
1. Intraosseous cannulation in children, Anaesthesia & Intensive Care Medicine, 21 September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926001669)
2. Paediatric cardiopulmonary arrest update: 2026, Anaesthesia & Intensive Care Medicine, 21 September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926001724)
3. Extracorporeal membrane oxygenation and mechanical support for the circulation, Anaesthesia & Intensive Care Medicine, 19 September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926001682)
4. Transporting critically ill children, Anaesthesia & Intensive Care Medicine, 18 September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926001700)
5. Trauma and burns in children, Anaesthesia & Intensive Care Medicine, 18 September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926001670)
6. Fluid and electrolyte balance in children, Anaesthesia & Intensive Care Medicine, 18 September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926001694)
7. Special considerations in paediatric intensive care, Anaesthesia & Intensive Care Medicine, 18 September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926001736)
### 12- Other:
1. Severity scoring systems in intensive care: new models, or continuous recalibration?, Current Opinion in Critical Care, October 2026, [Link](https://www.ovid.com/jnls/co-criticalcare/fulltext/10.1097/mcc.0000000000001416~severity-scoring-systems-in-intensive-care-new-models-or)
2. The poisoned patient, part 1: Interpreting vital signs through a Toxicologic Lens, The American Journal of Emergency Medicine, 22 September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0735675726005024)
3. Frailty in anaesthesia and intensive care, BJA Edu, 16 September 2026, [Link](https://www.bjaed.org/article/S2058-5349%2826%2900077-6/abstract)
4. Optimizing Team Integration of Critical Care Pharmacists: Where We Go Next, Critical Care Clinics, 16 September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070426000734)
5. Rehabilitation and the post-intensive care syndrome across the recovery continuum: a narrative review, Intensive Care Medicine, 9 September 2026, [Link](https://link.springer.com/article/10.1007/s00134-026-08600-5)
6. Administrative Harm and Workforce Strain Indicators, Critical Care Clinics, 8 September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070426000746)
7. Risk communication strategies during public health emergencies: a narrative review of frameworks, recent crises, and emerging challenges, International Journal of Emergency Medicine, 3 September 2026, [Link](https://link.springer.com/article/10.1186/s12245-026-01357-0)
8. Intensive Care Unit Staffing Ratios: Evidence, Experience, Economics, and Execution, Critical Care Clinics, 1 September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070426000667)
9. Moral Distress, Burnout, and the Intensive Care Unit Environment, Critical Care Clinics, 1 September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070426000710)
10. Optimizing Team Integration of Critical Care Pharmacists: A History of Critical Care Pharmacy Practice and Evolving Definition of “Optimal Practice”, Critical Care Clinics, 1 September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070426000722)
11. The Intensive Care Unit Team: Roles, Scope, and Interprofessional Interdependence in the Intensive Care Unit, Critical Care Clinics, 1 September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S074907042600076X)
12. Protein Quantification Platforms For Use In Critical Care Precision Medicine Trials: A Scoping Review, Critical Care Explorations, September 2026, [Link](https://www.ovid.com/jnls/ccejournal/fulltext/10.1097/cce.0000000000001477~protein-quantification-platforms-for-use-in-critical-care)
13. Sustainability in anaesthetics and intensive care medicine, Anaesthesia & Intensive Care Medicine, September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926001463)
14. Ethics of clinical trials, Anaesthesia & Intensive Care Medicine, September 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926001451)
15. The Microbiome in Critical Illness, Critical Care Medicine, 26 August 2026, [Link](https://www.ovid.com/jnls/ccmjournal/abstract/10.1097/ccm.0000000000007327~the-microbiome-in-critical-illness)
16. Prediction, Prescription, and Proactive Medication Management in the Intensive Care Unit, Critical Care Clinics, 26 August 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070426000679)
17. Culture and the Intensive Care Unit Team: Factors Driving Teamwork, Safety, Quality, and Well-Being, Critical Care Clinics, 26 August 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070426000680)
18. Redesigning Intensive Care Unit Workflows: A Learning Health System Approach to Improving Care Delivery, Critical Care Clinics, 26 August 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070426000709)
19. BEYOND PICS: a conceptual framework for post-ICU recovery stewardship, Critical Care, 26 August 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06285-2)
20. The COVID-19 Pandemic as a Stress Test of the Intensive Care Unit Workforce, Critical Care Clinics, 25 August 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070426000692)
21. Core concepts in statistics and research methods. Part 8: randomised trials, BJA Edu, 18 August 2026, [Link](https://www.bjaed.org/article/S2058-5349%2826%2900067-3/fulltext)
22. Conflict in intensive care units: a conceptual framework for patient, family, team, and inter-service disagreement, Critical Care, 15 August 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06248-7)
23. Genomic and integrative-based progression biomarker discovery in adult sepsis: toward clinical stratification and precision medicine, Annals of Intensive Care, 13 August 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582026001688)
24. Decades of intensive care medicine trials: what randomised evidence has changed, corrected, and still questions to resolve, Intensive Care Medicine, 13 August 2026, [Link](https://link.springer.com/article/10.1007/s00134-026-08579-z)
25. The Human Impact of Extracorporeal Membrane Oxygenation: Best Practices to Improve Experiences of Patients, Families, and Clinicians, CHEST, 28 July 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0012369226063051)
26. Environmental sustainability evidence in critical care medicine: a scoping review, Canadian Journal of Anesthesia, 23 July 2026, [Link](https://link.springer.com/article/10.1007/s12630-026-03142-2)
27. Predicting, describing, or measuring? How to align model purpose with validity and applicability in critical care outcome research, Current Opinion in Critical Care, 23 July 2026, [Link](https://www.ovid.com/jnls/co-criticalcare/fulltext/10.1097/mcc.0000000000001415~predicting-describing-or-measuring-how-to-align-model)
28. Physical restraint in the intensive care units: a narrative review of current practices and outcomes, Journal of Intensive Care, 21 July 2026, [Link](https://link.springer.com/article/10.1186/s40560-026-00913-3)
29. Key principles for rehabilitation of critically ill patients with obesity, Intensive Care Medicine, 17 July 2026, [Link](https://link.springer.com/article/10.1007/s00134-026-08541-z)
30. The impact of age, prior health status, and frailty on outcome prediction in critical care, Current Opinion in Critical Care, 7 July 2026, [Link](https://www.ovid.com/jnls/co-criticalcare/abstract/10.1097/mcc.0000000000001407~the-impact-of-age-prior-health-status-and-frailty-on-outcome)
31. Patient- and Family-Centered Care, Communication, and Relationship Development Along a Technological Continuum in the ICU: A Scoping Review, Critical Care Explorations, July 2026, [Link](https://www.ovid.com/jnls/ccejournal/fulltext/10.1097/cce.0000000000001429~patient--and-family-centered-care-communication-and)
32. From Opinions to Outcomes: Optimizing Survey Methods and Principles Applicable to the Delphi Process in Critical Care Research, Critical Care Explorations, July 2026, [Link](https://www.ovid.com/jnls/ccejournal/fulltext/10.1097/cce.0000000000001438~from-opinions-to-outcomes-optimizing-survey-methods-and)
---
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**Anecrit.com**
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Hundreds of anesthesia & critical care papers, distilled weekly.
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This week's highlight: three new AHA scientific statements on perioperative anemia and patient blood management in cardiac surgery, secondary prevention after CABG, and perinatal heart failure. Plus the usual roundup — 36 papers in anaesthesiology, 47 in critical care.
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# **Anesthesiology:**
## ***Guidelines & Consensus:***
### 1- Cardiovascular & Hemodynamics:
1. Perioperative Anemia and Patient Blood Management in Cardiac Surgery: A Scientific Statement From the American Heart Association, Circulation, 22 June 2026, [Link](https://www.ahajournals.org/doi/10.1161/CIR.0000000000001446)
2. Secondary Prevention After Coronary Artery Bypass Graft Surgery: 2026 Update: A Scientific Statement From the American Heart Association, Circulation, 13 May 2026, [Link](https://www.ahajournals.org/doi/10.1161/CIR.0000000000001434)
### 2- Obstetrics & Gynecology:
1. Heart Failure Occurring in the Perinatal Period: A Scientific Statement From the American Heart Association, Circulation, 24 June 2026, [Link](https://www.ahajournals.org/doi/10.1161/CIR.0000000000001450)
---
## ***Systematic reviews & meta-analyses:***
### 1- Neuro:
1. Remimazolam Versus Propofol for Anesthesia in Intracranial Neurosurgeries: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Journal of Neurosurgical Anesthesiology, 19 June 2026, [Link](https://journals.lww.com/jnsa/abstract/9900/remimazolam%5Fversus%5Fpropofol%5Ffor%5Fanesthesia%5Fin.247.aspx)
### 2- Cardiovascular & Hemodynamics:
1. Machine learning vs. traditional methods for predicting postoperative cardiac complications after non-cardiac surgery: a systematic review and Bayesian network meta-analysis, Anaesthesia, 22 June 2026, [Link](https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/ftr/10.1111/anae.70237)
2. Hemodynamic effects of dexmedetomidine versus propofol in cardiac surgery: a systematic review and meta-analysis, BMC Anesthesiology, 20 June 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04027-z)
### 3- Regional Anesthesia & Pain Management:
1. Effect of ultrasound-guided fascial plane block (UGPB) on pain control of rib fractures: a systematic review and meta-analysis, BMC Anesthesiology, 24 June 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04045-x)
2. Effects of single-injection vs. continuous brachial plexus blocks for shoulder surgeries on patient-reported outcomes: a systematic review and meta-analysis with trial sequential analysis of randomised controlled trials, Anaesthesia, 23 June 2026, [Link](https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/ftr/10.1111/anae.70249)
---
## ***Clinical trials:***
### 1- Airway & Mechanical Ventilation:
1. Respiration-Related Catheter Displacement and Physiological Tolerance of High-Frequency Very-Low Tidal Volume Ventilation with Peak Pressure Limitation During Atrial Fibrillation Ablation: A Prospective One-Way Crossover Pilot Study, Journal of Cardiothoracic and Vascular Anesthesia, 24 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026005100)
2. Hypotension and pulmonary atelectasis during general anaesthesia: a randomised crossover laboratory study, BJA, 24 June 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900361-2/fulltext)
3. Individualized PEEP titration guided by static lung compliance reduces postoperative atelectasis in elderly patients during laparoscopic Trendelenburg surgery: a randomized controlled trial, Perioperative Medicine, 19 June 2026, [Link](https://link.springer.com/article/10.1186/s13741-026-00708-y)
4. Stellate ganglion block for attenuating postoperative sore throat after double-lumen tube intubation in thoracic surgery: a randomized clinical study, Perioperative Medicine, 17 June 2026, [Link](https://link.springer.com/article/10.1186/s13741-026-00710-4)
### 2- Cardiovascular & Hemodynamics:
1. Effect of the orexin receptor antagonist, suvorexant, on sleep architecture in the early postoperative period following cardiac surgery: a randomized controlled trial, Critical Care, 23 June 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06151-1)
2. Perioperative intravenous fluid and chronic kidney disease: long-term follow-up of the Restrictive *versus* Liberal Fluid Therapy in Major Abdominal Surgery (RELIEF) randomised trial, BJA, 22 June 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900363-6/abstract)
### 3- Obstetrics & Gynecology:
1. Low-dose esketamine for postoperative fatigue after gynecological laparoscopic surgery: a randomized controlled trial, BMC Anesthesiology, 26 June 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04051-z)
2. Low-dose intrathecal morphine versus intrathecal fentanyl for post-caesarean analgesia in a resource-constrained setting: a pragmatic randomised trial, BMC Anesthesiology, 23 June 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04034-0)
3. Remimazolam vs. propofol for prevention of postoperative nausea and vomiting in laparoscopic gynecological surgery: a randomized non-inferiority trial, Perioperative Medicine, 16 June 2026, [Link](https://link.springer.com/article/10.1186/s13741-026-00713-1)
### 4- Regional Anesthesia & Pain Management:
1. Self-Directed vs Clinician-Delivered Cognitive Behavioral Therapy for Chronic Pain: A Randomized Clinical Trial, JAMA, 24 June 0226, [Link](https://jamanetwork.com/journals/jama/fullarticle/2850722)
2. Stellate ganglion block for attenuating postoperative sore throat after double-lumen tube intubation in thoracic surgery: a randomized clinical study, Perioperative Medicine, 17 June 2026, [Link](https://link.springer.com/article/10.1186/s13741-026-00710-4)
### 5- Other:
1. Intravenous lidocaine reduces propofol requirements during endoscopic ultrasound: a randomized, double-blinded, controlled trial, BMC Anesthesiology, 22 June 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04018-0)
---
## ***Reviews:***
### 1- Neuro:
1. Central nervous system stimulants: basic pharmacology and relevance to anaesthesia and critical care, Anaesthesia & Intensive Care Medicine, 24 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926000925)
### 2- Cardiovascular & Hemodynamics:
1. Preoperative cardiac optimization, Anaesthesia & Intensive Care Medicine, 24 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926001001)
2. Noninvasive Arterial Pressure Monitoring during Anesthesia, Anesthesiology, 18 June 2026, [Link](https://journals.lww.com/anesthesiology/citation/9900/noninvasive%5Farterial%5Fpressure%5Fmonitoring%5Fduring.1057.aspx)
### 3- Regional Anesthesia & Pain Management:
1. Eye-tracking technology applied to regional anaesthesia task performance, safety and skill acquisition: a scoping review, BJA, 25 June 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900392-2/fulltext)
2. Enhanced recovery pathways for patients with chronic pain: beyond standard protocols – a narrative review, Current Opinion in Anesthesiology, 23 June 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/enhanced%5Frecovery%5Fpathways%5Ffor%5Fpatients%5Fwith.441.aspx)
3. Novel technologies and innovations in postoperative follow-up after regional anesthesia, Current Opinion in Anesthesiology, 19 June 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/novel%5Ftechnologies%5Fand%5Finnovations%5Fin.440.aspx)
### 4- Other:
1. Prehabilitation, Anaesthesia & Intensive Care Medicine, 24 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926000937)
2. Confidentiality: a practical guide for anaesthetic and intensive care medicine practitioners, Anaesthesia & Intensive Care Medicine, 24 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926000962)
3. Conflict resolution, Anaesthesia & Intensive Care Medicine, 24 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926000998)
4. Suction devices, Anaesthesia & Intensive Care Medicine, 24 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926001013)
5. Omics and anaesthesia: pharmacogenomics, proteomics and metabolomics, Anaesthesia & Intensive Care Medicine, 24 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926001025)
6. Frailty assessment in the pre-operative setting, Anaesthesia & Intensive Care Medicine, 24 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926001062)
7. Gastric disorders: modifications of gastric content, antacids and drugs influencing gastric secretions and motility, Anaesthesia & Intensive Care Medicine, 24 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926000974)
8. Clinical aspects of hepatic disease, Anaesthesia & Intensive Care Medicine, 24 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926001037)
9. Drugs and the liver, Anaesthesia & Intensive Care Medicine, 24 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926001050)
10. European simulation-based education and training in anaesthesiology and intensive care: evidence, value and inevitable evolution, European Journal of Anaesthesiology, 22 June 2026, [Link](https://journals.lww.com/ejanaesthesiology/abstract/9900/european%5Fsimulation%5Fbased%5Feducation%5Fand%5Ftraining.436.aspx)
---
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# **Critical Care:**
## ***Guidelines & Consensus:***
### 1- Cardiovascular & Hemodynamics:
1. Heart Failure Occurring in the Perinatal Period: A Scientific Statement From the American Heart Association, Circulation, 24 June 2026, [Link](https://www.ahajournals.org/doi/10.1161/CIR.0000000000001450)
2. Perioperative Anemia and Patient Blood Management in Cardiac Surgery: A Scientific Statement From the American Heart Association, Circulation, 22 June 2026, [Link](https://www.ahajournals.org/doi/10.1161/CIR.0000000000001446)
3. Secondary Prevention After Coronary Artery Bypass Graft Surgery: 2026 Update: A Scientific Statement From the American Heart Association, Circulation, 13 May 2026, [Link](https://www.ahajournals.org/doi/10.1161/CIR.0000000000001434)
---
## ***Systematic reviews & meta-analyses:***
### 1- Cardiovascular & Hemodynamics:
1. The effectiveness of tissue-perfusion-guided resuscitation in shock: A systematic review and meta-analysis, Annals of Intensive Care, 25 June 2026, [Link](https://www.sciencedirect.com/science/article/pii/S211058202600141X)
### 2- Neuro-muscular:
1. Ventriculostomy-Related Infections by Country-Income Level: A Systematic Review and Bayesian Hierarchical Meta-analysis, Journal of Neurosurgical Anesthesiology, 15 June 2026, [Link](https://journals.lww.com/jnsa/abstract/9900/ventriculostomy%5Frelated%5Finfections%5Fby.246.aspx)
2. Association Between Intracranial Pressure Variability and Clinical Outcomes in Acute Brain Injury: A Systematic Review and Meta-Analysis, Journal of Neurosurgical Anesthesiology, 15 June 2026, [Link](https://journals.lww.com/jnsa/abstract/9900/association%5Fbetween%5Fintracranial%5Fpressure.241.aspx)
### 3- Trauma:
1. Acute intoxication and trauma severity in emergency department patients: a systematic review, BMC Emergency Medicine, 23 June 2026, [Link](https://link.springer.com/article/10.1186/s12873-026-01623-7)
2. Clinical outcomes of hemostatic interventions in patients with traumatic injury: A systematic review of randomized controlled trials, The Journal of Trauma and Acute Care Surgery, 15 June 2026, [Link](https://journals.lww.com/jtrauma/abstract/9900/clinical%5Foutcomes%5Fof%5Fhemostatic%5Finterventions%5Fin.1408.aspx)
### 4- Infectious Diseases:
1. Comparative efficacy and safety of extended versus continuous infusion of beta-lactam antibiotics for severe infection: a network meta-analysis of randomized trials, Critical Care, 20 June 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06142-2)
2. Diagnostic accuracy of presepsin for sepsis in adult patients according to the criteria of sepsis-3: systematic review and meta-analysis, BMC Anesthesiology, 19 June 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03983-w)
---
## ***Clinical trials:***
### 1- Cardiovascular & Hemodynamics:
1. Effect of the orexin receptor antagonist, suvorexant, on sleep architecture in the early postoperative period following cardiac surgery: a randomized controlled trial, Critical Care, 23 June 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06151-1)
### 2- Thorax/Lungs/Airways/Mechanical ventilation:
1. Standardized low-flow ventilation with PEEP maintenance during bronchoscopy in mechanically ventilated ICU patients: a pilot trial, Journal of Intensive Care, 21 June 2026, [Link](https://link.springer.com/article/10.1186/s40560-026-00895-2)
### 3- Neuro-muscular:
1. Safety and Efficacy of Nerinetide at Year 1 in Participants Enrolled in ESCAPE‐NEXT: A Multicenter, Double‐Blind, Randomized Controlled Trial, Journal of the American Heart Association, 23 June 2026, [Link](https://www.ahajournals.org/doi/10.1161/JAHA.125.044080)
2. CN-105 in Participants with Acute Supratentorial Intracerebral Hemorrhage Trial in Singapore (S-CATCH): A Phase 2b, Randomized, Double-blind, Placebo-Controlled Trial, Neurocritical Care, 23 June 2026, [Link](https://link.springer.com/article/10.1007/s12028-026-02563-7)
3. Concordance Between Bedside and Electronic Detection of Intracranial Pressure Crises: Insights From the Brain Tissue Oxygen Monitoring and Management in Severe Traumatic Brain Injury II Trial, Critical Care Medicine, 18 June 2026, [Link](https://journals.lww.com/ccmjournal/abstract/9900/concordance%5Fbetween%5Fbedside%5Fand%5Felectronic.892.aspx)
### 4- Trauma:
1. Prolonged tourniquet use in extremity trauma: What you need to know, The Journal of Trauma and Acute Care Surgery, 19 June 2026, [Link](https://journals.lww.com/jtrauma/abstract/9900/prolonged%5Ftourniquet%5Fuse%5Fin%5Fextremity%5Ftrauma%5F%5Fwhat.1416.aspx)
### 5- Infectious Diseases:
1. Benzylpenicillin versus flucloxacillin or cloxacillin for the treatment of penicillin-susceptible *Staphylococcus aureus* bacteraemia (SNAP): an international, multicentre, open-label, non-inferiority randomised controlled trial, The Lancet, 17 June 2026, [Link](https://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2826%2900761-0/fulltext)
---
## ***Reviews:***
### 1- Thorax/Lungs/Airways/Mechanical ventilation:
1. PEEP and alveolar recruitment after 60 years of acute respiratory distress syndrome, Intensive Care Medicine, 22 June 2026, [Link](https://link.springer.com/article/10.1007/s00134-026-08511-5)
2. The role of mechanical power in lung ventilation for the prevention of ventilator-induced lung injury: a narrative review, European Respiratory Review, 29 April 2026, [Link](https://publications.ersnet.org/content/errev/35/180/250283)
### 2- Neuro-muscular:
1. Central nervous system stimulants: basic pharmacology and relevance to anaesthesia and critical care, Anaesthesia & Intensive Care Medicine, 24 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926000925)
2. Beyond the Catheter: Contemporary Aspiration Pump Systems in Neurointerventional Stroke Therapy, Stroke: Vascular and Interventional Neurology, 22 June 2026, [Link](https://www.ahajournals.org/doi/10.1161/SVIN.126.002487)
3. Emerging Therapy Critique: Glibenclamide for Cerebral Edema—A Semi-CHARMed Treatment, Stroke, 22 June 2026, [Link](https://www.ahajournals.org/doi/10.1161/STROKEAHA.126.049690)
4. Early Autonomic Dysfunction Following TBI and Possible Interventions: A Narrative Review, Journal of Neurosurgical Anesthesiology, 18 June 2026, [Link](https://journals.lww.com/jnsa/abstract/9900/early%5Fautonomic%5Fdysfunction%5Ffollowing%5Ftbi%5Fand.248.aspx)
5. Immune System of the Ischemic Brain: Old Paradigms Revisited, Stroke, 27 May 2026, [Link](https://www.ahajournals.org/doi/10.1161/STROKEAHA.125.051471)
6. Taking a Glimpse Into the Brain’s Immune System: Imaging and Blood-Based Biomarkers of the Poststroke Immune Response, Stroke, 27 May 2026, [Link](https://www.ahajournals.org/doi/10.1161/STROKEAHA.125.051472)
7. Inflammation in Acute Ischemic Stroke: Translational Barriers and Implications for Treatment, Stroke, 27 May 2026, [Link](https://www.ahajournals.org/doi/10.1161/STROKEAHA.126.056147)
8. Thromboinflammation in Acute Stroke: From Pathophysiological Challenges to Emerging Therapeutic Opportunities, Stroke, 27 May 2026, [Link](https://www.ahajournals.org/doi/10.1161/STROKEAHA.125.051476)
9. Inflammation in Aneurysmal Subarachnoid Hemorrhage: Cause, Consequence, or Both? Focus on Pathogen Pattern Recognition, Stroke, 27 May 2026, [Link](https://www.ahajournals.org/doi/10.1161/STROKEAHA.125.051475)
10. Inflammation as a Key Driver for Chronic Subdural Hematomas, Stroke, 27 May 2026, [Link](https://www.ahajournals.org/doi/10.1161/STROKEAHA.126.055340)
### 3- Liver & GI:
1. Gastric disorders: modifications of gastric content, antacids and drugs influencing gastric secretions and motility, Anaesthesia & Intensive Care Medicine, 24 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926000974)
2. Drugs and the liver, Anaesthesia & Intensive Care Medicine, 24 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926001050)
### 4- Blood & hemostasis:
1. Mouse models to study von Willebrand factor in inflammation: a scoping review, Intensive Care Medicine Experimental, 24 June 2026, [Link](https://link.springer.com/article/10.1186/s40635-026-00935-z)
### 5- Nutrition:
1. Feeding under support in critical care illness: metabolic and nutritional management during extracorporeal membrane oxygenation and continuous renal replacement therapy, Current Opinion in Critical Care, 22 June 2026, [Link](https://journals.lww.com/co-criticalcare/abstract/9900/feeding%5Funder%5Fsupport%5Fin%5Fcritical%5Fcare%5Fillness%5F.372.aspx)
### 6- Infectious Diseases:
1. Bundibugyo Virus Disease in 2026 — Clinical and Public Health Responses, NEJM, 24 June 2026, [Link](https://www.nejm.org/doi/full/10.1056/NEJMra2607216)
2. Systemic corticosteroids for severe community-acquired pneumonia: a narrative review of mechanisms and critical appraisal of recent trials in ICU, European Respiratory Review, 24 June 2026, [Link](https://publications.ersnet.org/content/errev/35/180/250259)
3. Antimicrobial Resistance in Patients with Sepsis, Critical Care Clinics, 22 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070426000357)
4. Real-time Subgrouping of Sepsis and Systemic Inflammatory Syndromes, Critical Care Clinics, 22 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070426000370)
5. Post-Sepsis Syndrome after Critical Illness: Epidemiology and Long-term Outcomes, Critical Care Clinics, 22 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070426000400)
### 7- Pediatric critical care:
1. Hypodermoclysis for Fluid Administration in Hospitalized Pediatric Patients: A Scoping Review, Pediatric Emergency Care, 22 June 2026, [Link](https://journals.lww.com/pec-online/abstract/9900/hypodermoclysis%5Ffor%5Ffluid%5Fadministration%5Fin.856.aspx)
### 8- Other:
1. Neurocritical Care Fellowship Training in the USA: Challenges and Potential Solutions, Neurocritical Care, 26 June 2026, [Link](https://link.springer.com/article/10.1007/s12028-026-02574-4)
2. Consent, Anaesthesia & Intensive Care Medicine, 25 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926000950)
3. Immune-Mediated Inflammatory Diseases and the Critically Ill, Critical Care Clinics, 25 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070426000308)
4. Negligence, Anaesthesia & Intensive Care Medicine, 24 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926000949)
5. Confidentiality: a practical guide for anaesthetic and intensive care medicine practitioners, Anaesthesia & Intensive Care Medicine, 24 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926000962)
6. Conflict resolution, Anaesthesia & Intensive Care Medicine, 24 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926000998)
7. European simulation-based education and training in anaesthesiology and intensive care: evidence, value and inevitable evolution, European Journal of Anaesthesiology, 22 June 2026, [Link](https://journals.lww.com/ejanaesthesiology/abstract/9900/european%5Fsimulation%5Fbased%5Feducation%5Fand%5Ftraining.436.aspx)
8. Multinational collaborations in critical care research: feasible and useful?, Current Opinion in Critical Care, 22 June 2026, [Link](https://journals.lww.com/co-criticalcare/abstract/9900/multinational%5Fcollaborations%5Fin%5Fcritical%5Fcare.371.aspx)
---
### **Feedback & Suggestions**
Don't hesitate to share your thoughts and suggestions in the comments below; they'll be a great help in improving future issues of the newsletter.
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****Disclaimer:**
For educational use only; not a substitute for professional medical judgment. The papers shared in this newsletter are provided for informational purposes and do not necessarily reflect our views or clinical opinions.
See you next time :)
**Benhalima Othmane, MD.**
**Anecrit.com**
### Anecrit's Newsletter #36
URL: https://www.anecrit.com/newsletter-36/
Last updated: 2026-06-27T11:40:58.000Z
Hundreds of anesthesia & critical care papers, distilled weekly.
Free, concise, and read by clinicians in 20+ countries.
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Read, read, read... Sorry for the slight delay this week! The literature waited for no one, so let's get right to it.
###
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---
# **Anesthesiology:**
## ***Guidelines & Consensus:***
### 1- Cardiovascular & Hemodynamics:
1. Operator and Institutional Recommendations and Requirements for Tricuspid Interventions: 2026 ACC/AHA/ASE/HRS/STS Expert Consensus Systems of Care Document: A Joint Report of the American College of Cardiology, the American Heart Association, the American Society of Echocardiography, the Heart Rhythm Society, and the Society of Thoracic Surgeons, JACC, 25 March 2026, [Link](https://www.jacc.org/doi/10.1016/j.jacc.2026.02.5069)
### 2- Other:
1. Expert Consensus Statement on the Perioperative Management of Adult Patients Undergoing High-Risk Thyroidectomy from the Society for Head and Neck Anesthesia, Anesthesia & Analgesia, 10 June 2026, [Link](https://journals.lww.com/anesthesia-analgesia/citation/9900/expert%5Fconsensus%5Fstatement%5Fon%5Fthe%5Fperioperative.1819.aspx)
---
## ***Systematic reviews & meta-analyses:***
### 1- Cardiovascular & Hemodynamics:
1. Accuracy and precision of continuous, non-invasive blood pressure devices: a systematic review and meta-analyses, Anaesthesia, 15 June 2026, [Link](https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/full/10.1111/anae.70250)
2. Complications of controlled hypotension during functional endoscopic sinus surgery – a systematic review, BMC Anesthesiology, 13 June 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04021-5)
3. Is Faster Always Better? Ultra-Fast-Track Versus Fast-Track Extubation in Adult Cardiac Surgery: A Comprehensive Meta-Analysis with Meta-Regression, Journal of Cardiothoracic and Vascular Anesthesia, 11 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S105307702600488X)
### 2- Thoracic:
1. Impact of opioid free anesthesia on postoperative nausea and vomiting, chronic pain, and quality of recovery in patients undergoing video-assisted thoracoscopic surgery: a systematic review and meta-analysis of randomized controlled trials, BMC Anesthesiology, 16 June 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04028-y)
### 3- Orthopedic:
1. Impact of intraoperative dexmedetomidine on postoperative outcomes in shoulder arthroscopy: a systematic review and meta-analysis, BMC Anesthesiology, 13 June 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03798-9)
### 4- Regional Anesthesia & Pain Management:
1. The analgesic efficacy of intrathecal morphine compared to peripheral regional analgesia in total hip arthroplasty: A systematic review and meta-analysis, European Journal of Anaesthesiology, 18 June 2026, [Link](https://journals.lww.com/ejanaesthesiology/fulltext/9900/the%5Fanalgesic%5Fefficacy%5Fof%5Fintrathecal%5Fmorphine.434.aspx)
### 5- Other:
1. Intravenous Lidocaine as an Adjunct to Propofol Sedation for Endoscopic Retrograde Cholangiopancreatography: A Systematic Review and Meta-Analysis, Current Anesthesiology Reports, 19 May 2026, [Link](https://link.springer.com/article/10.1007/s40140-026-00707-1)
---
## ***Clinical trials:***
### 1- Neuro:
1. Tirofiban for Reduction of TEAR: A Phase 2, Randomized, Open-Label, Blinded End Point, Controlled Trial, Stroke, 12 June 2026, [Link](https://www.ahajournals.org/doi/10.1161/STROKEAHA.126.056558)
2. The Influence of Depth of Anesthesia on Motor Evoked Potentials Monitoring During Spinal Surgery in Youth: A Single-Center Prospective Study (SCOL Study), Anesthesia & Analgesia, 12 June 2026, [Link](https://journals.lww.com/anesthesia-analgesia/abstract/9900/the%5Finfluence%5Fof%5Fdepth%5Fof%5Fanesthesia%5Fon%5Fmotor.1824.aspx)
### 2- Airway & Mechanical Ventilation:
1. Impact of high *versus* low fraction of inspired oxygen for anaesthetic washout and extubation on postoperative pulmonary atelectasis formation and oxygenation: a randomised controlled trial, BJA, 16 June 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900349-1/abstract)
2. High-flow nasal oxygen versus conventional nasal cannula for gastroscopy with sedation in elderly patients at high altitudes: a partially-blinded randomized controlled trial in Tibet, China, BMC Anesthesiology, 15 June 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03968-9)
3. Effect of PEEP titration on the incidence of elevated driving pressure in laparoscopic bariatric surgery: a randomized superiority trial, BMC Anesthesiology, 13 June 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04026-0)
4. Comparison of esketamine combined with dexmedetomidine versus propofol combined with midazolam on drug-induced sleep endoscopy: a randomized controlled trial, BMC Anesthesiology, 13 June 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03987-6)
5. Efficacy of remimazolam besylate versus propofol on hemodynamics during anesthetic induction in elderly patients undergoing bronchoscopy: a randomized controlled trial, BMC Anesthesiology, 13 June 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03966-x)
### 3- Cardiovascular & Hemodynamics:
1. Superiority of Fibrinogen Concentrate vs Cryoprecipitate for Treatment of Bleeding in Cardiac Surgery Patients: a Secondary Analysis of the FIBRES Randomized Clinical Trial Stratified by Surgical Risk, Journal of Cardiothoracic and Vascular Anesthesia, 17 June 2026, [Link](https://www.sciencedirect.com/science/article/pii/S1053077026004957)
### 4- General:
1. Recommended intravenous infusion rate of sufentanil during induction of general anesthesia to prevent coughing: a randomized, single-blind, prospective clinical trials, BMC Anesthesiology, 16 June 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04014-4)
### 5- Obstetrics & Gynecology:
1. Prevention of maternal hypothermia after scheduled cesarean delivery under spinal anesthesia with active warming of intravenous fluids: an exploratory double-blind randomized controlled trial (CESAR-RESOL2), International Journal of Obstetric Anesthesia, 11 June 2026, [Link](https://www.sciencedirect.com/science/article/pii/S0959289X26003729)
### 6- Pediatric:
1. The efficacy and safety of weighted blankets to reduce agitation after cardiac catheterization and electrophysiology procedures in pediatric patients with congenital heart disease, Journal of Cardiothoracic and Vascular Anesthesia, 12 June 2026, [Link](https://www.sciencedirect.com/science/article/pii/S1053077026004933)
2. Effect of driving pressure-guided individualized PEEP in children undergoing right lateral thoracotomy cardiac surgery with cardiopulmonary bypass on postoperative atelectasis and oxygenation: a randomized controlled trial, BMC Anesthesiology, 11 June 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03947-0)
### 7- Orthopedic:
1. Patient-reported outcome measures-guided perioperative care versus standard of care in postoperative recovery: Randomised controlled trial in orthopaedic surgery, European Journal of Anaesthesiology, 9 June 2026, [Link](https://journals.lww.com/ejanaesthesiology/abstract/9900/patient%5Freported%5Foutcome%5Fmeasures%5Fguided.429.aspx)
### 8- Regional Anesthesia & Pain Management:
1. Comparison of the efficacy of Dexmedetomidine versus Ketamine as an adjunct to Ropivacaine for Scalp nerve block during Awake craniotomy surgery- A Randomised Controlled Trial, BMC Anesthesiology, 18 June 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04006-4)
2. Impact of liposomal bupivacaine parasternal block combined with rectus sheath block on postoperative pain in patients undergoing sternotomy for cardiac surgery: a randomized controlled trial, BMC Anesthesiology, 17 June 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03903-y)
3. Effects of external oblique intercostal plane block on postoperative pain and analgesic requirement in laparoscopic cholecystectomy: a prospective randomized controlled trial, BMC Anesthesiology, 17 June 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04029-x)
4. Association of Preoperative Cerebrospinal Fluid Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand With 1-Year Postsurgical Pain Severity in Older Adults: A Trial Secondary Analysis, Anesthesia & Analgesia, 16 June 2026, [Link](https://journals.lww.com/anesthesia-analgesia/citation/9900/association%5Fof%5Fpreoperative%5Fcerebrospinal%5Ffluid.1837.aspx)
5. Effect of Pericapsular Nerve Group Block on Prehabilitation in Femoral Neck Fractures: A Randomized, Double-Blind, Placebo-Controlled Trial, Anesthesia & Analgesia, 15 June 2026, [Link](https://journals.lww.com/anesthesia-analgesia/abstract/9900/effect%5Fof%5Fpericapsular%5Fnerve%5Fgroup%5Fblock%5Fon.1826.aspx)
6. Ultrasound versus nerve stimulation-guided interadductor approach for obturator nerve block: evaluation of injectate spread into the obturator canal in a randomized controlled trial, BMC Anesthesiology, 12 June 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04008-2)
7. Timing of a single dexmedetomidine bolus to attenuate remifentanil-induced hyperalgesia after thyroidectomy: a randomized controlled trial, BMC Anesthesiology, 11 June 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04001-9)
8. Superficial Cervical Plexus Block and Quality of Recovery after Thyroidectomy: A Randomized Clinical Trial, Anesthesiology, 10 June 2026, [Link](https://journals.lww.com/anesthesiology/abstract/9900/superficial%5Fcervical%5Fplexus%5Fblock%5Fand%5Fquality%5Fof.1049.aspx)
### 9- Other:
1. The effect of intraoperative dexamethasone on glycaemic responses in people with diabetes mellitus: a preplanned analysis of the Perioperative ADministration of Dexamethasone and Infection trial, BJA, 16 June 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900362-4/fulltext)
---
## ***Reviews:***
### 1- Cardiovascular & Hemodynamics:
1. Portal vein Doppler in peri-operative and critical care medicine, Physiology, measurement and clinical applications, European Journal of Anaesthesiology, 18 June 2026, [Link](https://journals.lww.com/ejanaesthesiology/fulltext/9900/portal%5Fvein%5Fdoppler%5Fin%5Fperi%5Foperative%5Fand%5Fcritical.435.aspx)
2. Causes, Predictors, and Treatment of Vasoplegia in Cardiac Surgery: A Narrative Review, Anesthesia & Analgesia, 8 June 2026, [Link](https://journals.lww.com/anesthesia-analgesia/abstract/9900/causes,%5Fpredictors,%5Fand%5Ftreatment%5Fof%5Fvasoplegia%5Fin.1816.aspx)
### 2- Obstetrics & Gynecology:
1. Postpartum haemorrhage: epidemiology, consequences, and missed opportunities, The Lancet, 12 June 2026, [Link](https://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2826%2900902-5/fulltext)
2. Prevention of postpartum haemorrhage: from evidence to implementation at scale, The Lancet, 12 June 2026, [Link](https://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2826%2900903-7/fulltext)
3. Diagnosis and treatment of postpartum haemorrhage: a race against time, The Lancet, 12 June 2026, [Link](https://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2826%2901031-7/fulltext)
4. Coagulopathy in obstetric bleeding: a narrative review and comparison with trauma-induced coagulopathy, BJA, 11 June 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900358-2/abstract)
### 3- Pediatric:
1. Ultrasound-guided peripheral vascular access in children, BJA Edu, 17 June 2026, [Link](https://www.bjaed.org/article/S2058-5349%2826%2900045-4/abstract)
### 4- Regional Anesthesia & Pain Management:
1. The glymphatic system in chronic pain: putative mechanisms and prospective therapeutic strategies, Anesthesiology and Perioperative Science, 17 June 2026, [Link](https://link.springer.com/article/10.1007/s44254-026-00180-3)
2. Regional anaesthesia and analgesia in surgical patients with chronic preoperative pain: mechanisms, evidence, and clinical implications, Current Opinion in Anesthesiology, 16 June 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/regional%5Fanaesthesia%5Fand%5Fanalgesia%5Fin%5Fsurgical.439.aspx)
3. Emerging technologies in interventional pain management: a scoping review on current innovations and future directions, BMC Anesthesiology, 11 June 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-04017-1)
4. An integrated systemic approach to chronic primary pain from epigenome to brain: a narrative review, BJA, 11 June 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900359-4/abstract)
5. Regional Anesthesia as a Modulator of Microcirculatory Function: Physiologic Mechanisms and Clinical Implications, Current Anesthesiology Reports, 26 May 2026, [Link](https://link.springer.com/article/10.1007/s40140-026-00709-z)
### 5- Other:
1. Thyroid, parathyroid hormones and calcium homeostasis, Anaesthesia & Intensive Care Medicine, 15 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926000779)
2. Recognition and management of phaeochromocytoma, Anaesthesia & Intensive Care Medicine, 13 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926000792)
3. Thyroid disease and thyroid surgery, Anaesthesia & Intensive Care Medicine, 13 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1472029926000731)
4. The Role of Gastric Ultrasound in Assessing Gastric Content and Aspiration Risk, Current Anesthesiology Reports, 26 May 2026, [Link](https://link.springer.com/article/10.1007/s40140-026-00706-2)
---
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# **Critical Care:**
## ***Systematic reviews & meta-analyses:***
### 1- AI:
1. Critical care delivery models in emergency departments: a systematic review of the literature and meta-analysis of related outcome effects, Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 14 June 2026, [Link](https://link.springer.com/article/10.1186/s13049-026-01647-9)
### 2- Cardiovascular & Hemodynamics:
1. Clinical Prediction Models for Prognostication After Out-of-Hospital Cardiac Arrest: A Systematic Review and Meta-Analysis, Critical Care Medicine, 11 June 2026, [Link](https://journals.lww.com/ccmjournal/abstract/9900/clinical%5Fprediction%5Fmodels%5Ffor%5Fprognostication.884.aspx)
### 3- Neuro-muscular:
1. Mechanical Thrombectomy as Stroke Management in Pregnancy: A Systematic Review, Stroke: Vascular and Interventional Neurology, 17 June 2026, [Link](https://www.ahajournals.org/doi/10.1161/SVIN.125.002101)
2. Effectiveness and safety of melatoninergic agonists in preventing delirium in the ICU: an updated dose‒response meta-analysis of randomized controlled trials, Critical Care, 17 June 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06047-0)
### 4- Pediatric critical care:
1. First-line vasopressor therapy in neonates with fluid-refractory septic shock: A systematic review and meta-analysis of randomized controlled trials, The American Journal of Emergency Medicine, 18 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0735675726003013)
2. Extracorporeal Membrane Oxygenation in the Interstage Period After Norwood and Related Stage I Palliations in Infants With Single Ventricle: A Systematic Review of Incidence, Risk Factors, and Outcomes, Journal of the American Heart Association, 15 June 2026, [Link](https://www.ahajournals.org/doi/10.1161/JAHA.125.047642)
---
## ***Clinical trials:***
### 1- Cardiovascular & Hemodynamics:
1. Early high-dose vitamin C for out-of-hospital cardiac arrest: the VITaCCA randomized clinical trial, Intensive Care Medicine, 16 June 2026, [Link](https://link.springer.com/article/10.1007/s00134-026-08492-5)
2. Sodium Bicarbonate for In-Hospital Cardiac Arrest: A Randomized Clinical Trial, JAMA, 11 June 2026, [Link](https://jamanetwork.com/journals/jama/fullarticle/2850405)
### 2- Neuro-muscular:
_This post is for subscribers only._
### Anecrit's Newsletter #35
URL: https://www.anecrit.com/newsletter-35/
Last updated: 2026-06-21T12:06:21.000Z
_This post is for subscribers only._
### Anecrit's Newsletter #34
URL: https://www.anecrit.com/newsletter-34/
Last updated: 2026-06-27T11:41:05.000Z
Hundreds of anesthesia & critical care papers, distilled weekly.
Free, concise, and read by clinicians in 20+ countries.
[Join for free ](#/portal/signup/free)
*Hey everyone,*
*May flew by — and so did the literature. This issue covers May 2 through June 5, with 109 papers from anesthesiology and 173 from critical care. Grab a coffee, there's a lot to dig into.*
###
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---
# **Anesthesiology:**
## ***Guidelines & Consensus:***
### 1- Neuro:
1. Guidelines for Seizure Prophylaxis in Patients Undergoing Supratentorial Neurosurgery: A Statement for Healthcare Professionals from the Neurocritical Care Society, Neurocritical Care, 5 May 2026, [Link](https://link.springer.com/article/10.1007/s12028-026-02522-2)
### 2- Pediatric:
1. Perioperative Considerations for Obese Pediatric Patients in the Ambulatory Setting: Guidance From the Society for Ambulatory Anesthesia, Anesthesia & Analgesia, 14 May 2026, [Link](https://journals.lww.com/anesthesia-analgesia/citation/9900/perioperative%5Fconsiderations%5Ffor%5Fobese%5Fpediatric.1781.aspx)
---
## ***Systematic reviews & meta-analyses:***
### 1- Neuro:
1. Efficacy of Dexmedetomidine in Preventing Postoperative Delirium in Patients Undergoing Brain Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Neurocritical Care, 18 May 2026, [Link](https://link.springer.com/article/10.1007/s12028-026-02533-z)
2. Association of postoperative elevation of biomarkers of neural injury in blood with postoperative neurocognitive disorders in adults receiving general anaesthesia: a systematic review, BJA, 11 May 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900277-1/abstract)
### 2- Airway & Mechanical Ventilation:
1. High-Flow Nasal Cannula Versus Conventional Oxygen Therapy During Bronchoscopy: A Meta-Analysis of Randomized Controlled Trials, Journal of Bronchology & Interventional Pulmonology, July 2026, [Link](https://journals.lww.com/bronchology/abstract/2026/07010/high%5Fflow%5Fnasal%5Fcannula%5Fversus%5Fconventional%5Foxygen.3.aspx)
2. Correlation between central venous oxygen saturation and mixed venous oxygen saturation in surgical patients: A systematic review and meta-analysis, Annals of Intensive Care, May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582026001111)
### 3- Cardiovascular & Hemodynamics:
1. Agreement of minimally invasive pulse wave analysis with pulmonary artery and transpulmonary thermodilution cardiac output measurements in perioperative and intensive care medicine: a systematic review and meta-analysis, BJA, 2 June 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900329-6/fulltext)
2. Perioperative dexmedetomidine is associated with improved respiratory outcomes in patients undergoing cardiac surgery: a systematic review and meta-analysis of randomized controlled trials, BMC Anesthesiology, 1 June 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03969-8)
3. Hydroxyethyl Starch and Perioperative Complications: a Systematic Review and Meta-analysis, Anesthesiology, 20 May 2026, [Link](https://journals.lww.com/anesthesiology/abstract/9900/hydroxyethyl%5Fstarch%5Fand%5Fperioperative.1024.aspx)
4. The Use of Methadone in Adult Cardiac Surgery: A Systematic Review With Narrative Synthesis, Anesthesia & Analgesia, 5 May 2026, [Link](https://journals.lww.com/anesthesia-analgesia/abstract/9900/the%5Fuse%5Fof%5Fmethadone%5Fin%5Fadult%5Fcardiac%5Fsurgery%5F%5Fa.1774.aspx)
5. Effect of individualised *versus* routine intraoperative blood pressure management on acute kidney injury in noncardiac surgery: a GRADE-assessed meta-analysis of randomised controlled trials, BJA, 1 May 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900186-8/abstract)
### 4- Thoracic:
1. Effect of erector spinae block on postoperative outcomes in patients undergoing lung surgical procedures: a systematic review and trial sequential analysis of randomized controlled trials, BMC Anesthesiology, 27 May 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03927-4)
2. Postoperative pain management after VATS for spontaneous pneumothorax - a systematic review, BMC Anesthesiology, 5 May 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03865-1)
### 5- Abdomen:
1. The role of esketamine in enhancing postoperative recovery and pain management in laparoscopic surgery: a meta-analysis of randomised controlled trials, European Journal of Anaesthesiology and Intensive Care, June 2026, [Link](https://journals.lww.com/ejaintensivecare/fulltext/2026/06000/the%5Frole%5Fof%5Fesketamine%5Fin%5Fenhancing%5Fpostoperative.4.aspx)
2. Opioid-free versus opioid-based anesthesia for postoperative nausea and vomiting in laparoscopic cholecystectomy: A Systematic Review with Meta-Analysis, Meta-Regression and Trial Sequential Analysis: Opioid-free for PONV in cholecystectomy, Anaesthesia Critical Care & Pain Medicine, 27 May 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556826001189)
### 6- General:
1. Effects of different warming strategies on intraoperative hypothermia: a systematic review and network meta-analysis of randomized controlled trials, BMC Anesthesiology, 29 May 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03960-3)
2. Multidimensional clinical evaluation of remimazolam versus propofol and dexmedetomidine: two systematic reviews and meta-analyses based on differentiated endpoints, BMC Anesthesiology, 28 May 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03951-4)
### 7- Obstetrics & Gynecology:
1. Post-dural Puncture Headache in Dural Puncture Epidural and Combined Spinal-Epidural Using 24- and 25-Gauge Needles Versus Conventional Epidural Labour Analgesia: A Systematic Review and Meta-analysis, Anesthesia & Analgesia, 19 May 2026, [Link](https://journals.lww.com/anesthesia-analgesia/abstract/9900/post%5Fdural%5Fpuncture%5Fheadache%5Fin%5Fdural%5Fpuncture.1786.aspx)Labour
### 8- Pediatric:
1. Comparative safety and sedation effectiveness of intranasal dexmedetomidine versus midazolam for preoperative anxiety reduction in pediatric surgical patients: an updated systematic review and meta-analysis, BMC Anesthesiology, 9 May 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03845-5)
### 9- Regional Anesthesia & Pain Management:
1. Multimodal opioid-free anesthesia containing esketamine versus opioid-based anesthesia: a systematic review and meta-analysis, BMC Anesthesiology, 4 June 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03975-w)
2. Effect of Pain Neuroscience Education on Pain, Sleep and Psychosocial factors in Chronic Musculoskeletal Pain Conditions: A Systematic Review and Meta-analysis, The Clinical Journal of Pain, 1 June 2026, [Link](https://journals.lww.com/clinicalpain/abstract/9900/effect%5Fof%5Fpain%5Fneuroscience%5Feducation%5Fon%5Fpain,.359.aspx)
3. Efficacy and safety of intravenous lidocaine in thyroidectomy: a systematic review and meta-analysis with trial sequential analysis and meta-regression, BMC Anesthesiology, 30 May 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03965-y)
4. Intraoperative low-dose ketamine for postoperative pain outcomes in opioid-naïve patients: a systematic review and meta-analysis, Anaesthesia Critical Care & Pain Medicine, 28 May 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556826001207)
5. Fascia iliaca compartment block for postoperative hip fracture pain: a systematic review and meta-analysis of randomized controlled trials, BMC Anesthesiology, 18 May 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03892-y)
6. Efficacy and safety of stellate ganglion block for postoperative pain management: a systematic review and meta-analysis of randomized controlled trials, BMC Anesthesiology, 11 May 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03901-0)
### 10- Other:
1. The Prevalence of Fibromyalgia in the General Population and At-Risk Subpopulations: A Systematic Review and Meta-Analysis, Anesthesia & Analgesia, 27 May 2026, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/the%5Fprevalence%5Fof%5Ffibromyalgia%5Fin%5Fthe%5Fgeneral.1799.aspx)
2. Efficacy and safety of perioperative dexmedetomidine infusion in thyroid surgery: a systematic review and meta-analysis of randomized controlled trials, BMC Anesthesiology, 26 May 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03944-3)
3. Automated end-tidal control versus manual regulation in low-flow volatile anesthesia: a systematic review and meta-analysis, BMC Anesthesiology, 11 May 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03878-w)
4. Genotype–phenotype relationships in butyrylcholinesterase deficiency: a systematic review, BJA, 12 May 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900276-X/abstract)
5. Patient Blood Management: a systematic review of current international guidelines, BJA, 11 May 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900273-4/fulltext)
6. Respiratory Depression after Perioperative Methadone Administration: A Systematic Review and Meta-analysis, Anesthesia & Analgesia, 8 May 2026, [Link](https://journals.lww.com/anesthesia-analgesia/abstract/9900/respiratory%5Fdepression%5Fafter%5Fperioperative.1779.aspx)
---
## ***Clinical trials:***
### 1- Neuro:
1. General Anesthesia Versus Non-General Anesthesia in Young Adults Undergoing Thrombectomy, Anaesthesia Critical Care & Pain Medicine, 5 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S235255682600127X)
2. Effect of Selective Scalp Block Compared With Fentanyl Infusion on Intraoperative Blood Pressure in Patients Undergoing Posterior Fossa Tumor Resection: A Randomized Controlled Trial, Journal of Neurosurgical Anesthesiology, 21 May 2026, [Link](https://journals.lww.com/jnsa/citation/9900/effect%5Fof%5Fselective%5Fscalp%5Fblock%5Fcompared%5Fwith.229.aspx)
3. Perioperative nebulized budesonide and L-Cysteine reduce pulmonary complications after posterior skull base tumor resection: a randomized controlled trial, BMC Anesthesiology, 20 May 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03928-3)
4. Clinical effectiveness of intravenous hypertonic sodium lactate infusion for intra-operative brain relaxation in supratentorial brain tumour surgery: A double-blind randomised phase II pilot study, European Journal of Anaesthesiology, 8 May 2026, [Link](https://journals.lww.com/ejanaesthesiology/abstract/9900/clinical%5Feffectiveness%5Fof%5Fintravenous%5Fhypertonic.423.aspx)
5. Choice of anesthesia in microelectrode recording-guided deep brain stimulation surgery for Parkinson’s disease (CHAMPION): A noninferiority randomized controlled trial, Anesthesiology, 8 May 2026, [Link](https://journals.lww.com/anesthesiology/abstract/9900/choice%5Fof%5Fanesthesia%5Fin%5Fmicroelectrode.1009.aspx)
### 2- Airway & Mechanical Ventilation:
1. Flexible Intubation Scope versus Flexible Intubation Scope and Video Laryngoscopy Combination: A Prospective Randomized Clinical Trial, Anesthesia & Analgesia, 2 June 2026, [Link](https://journals.lww.com/anesthesia-analgesia/abstract/9900/flexible%5Fintubation%5Fscope%5Fversus%5Fflexible.1813.aspx)
2. Jet ventilation and hemodynamic stability during pulmonary vein isolation: ventilatory and hemodynamic outcomes from a randomized controlled trial (Secondary analysis under EEG-Guided Total Intravenous Anesthesia), BMC Anesthesiology, 23 May 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03919-4)
3. Optimal dose of ciprofol combined with remifentanil for laryngeal mask placement without muscle relaxant: a biased-coin up-and-down sequential allocation trial, BMC Anesthesiology, 13 May 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03844-6)
### 3- Cardiovascular & Hemodynamics:
1. Magnesium Sulfate to Prevent Perioperative Atrial Fibrillation in Cardiac Surgery: A Randomized Clinical Trial, Critical Care Medicine, 28 May 2026, [Link](https://journals.lww.com/ccmjournal/fulltext/9900/magnesium%5Fsulfate%5Fto%5Fprevent%5Fperioperative%5Fatrial.847.aspx)
2. Opioid Free anesthesia in cardiac surgery: The OFACAR randomized clinical trial, Anesthesiology, 22 May 2026, [Link](https://journals.lww.com/anesthesiology/abstract/9900/opioid%5Ffree%5Fanesthesia%5Fin%5Fcardiac%5Fsurgery%5F%5Fthe.1027.aspx)
3. Early Enteral Levothyroxine as Rescue Therapy in Cardiac Surgery Patients with Delayed Neurological Recovery: A Randomized Trial, Journal of Cardiothoracic and Vascular Anesthesia, 11 May 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026003915)
4. Intervals For Oscillometric Arterial Pressure Monitoring During Noncardiac Surgery: the ‘2.5-Minute Versus 5-Minute’ Randomized Clinical Trial, Anesthesiology, 8 May 2026, [Link](https://journals.lww.com/anesthesiology/abstract/9900/intervals%5Ffor%5Foscillometric%5Farterial%5Fpressure.1008.aspx)
5. Anticholinergic Burden as a Modifiable Risk Factor in Cardiac Surgery: A Randomized Controlled Study, Journal of Cardiothoracic and Vascular Anesthesia, 8 May 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026003940)
6. Topical use of tranexamic acid for antifibrinolysis in cardiac surgery with cardiopulmonary bypass: a randomized clinical study, BMC Anesthesiology, 4 May 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03872-2)
### 4- Thoracic:
1. Perioperative dexmedetomidine nasal spray improves postoperative sleep in patients undergoing thoracoscopic lung surgery: a prospective, randomized controlled trial, BMC Anesthesiology, 13 May 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03906-9)
### 5- Abdomen:
1. Opioid-free versus opioid-based anesthesia in laparoscopic bariatric surgery: an exploratory randomized pilot trial, BMC Anesthesiology, 25 May 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03838-4)
2. Esketamine-led opioid-free anaesthesia reduces postoperative pulmonary complications in bariatric surgery patients: a prospective randomized controlled trial, BMC Anesthesiology, 6 May 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03886-w)
### 6- General:
1. Half-dose neostigmine and low dose sugammadex as a reversal agent for vecuronium: a pilot randomized trial, Anaesthesia Critical Care & Pain Medicine, 30 May 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556826001232)
2. Preoperative Olanzapine and Quality of Recovery after Ambulatory Surgery: A Randomized Clinical Trial, Anesthesiology, 20 May 2026, [Link](https://journals.lww.com/anesthesiology/abstract/9900/preoperative%5Folanzapine%5Fand%5Fquality%5Fof%5Frecovery.1023.aspx)
### 7- Obstetrics & Gynecology:
1. Randomized Double-Blinded Clinical Trial of Oxytocin Bolus versus Infusion in Elective Cesarean (INBOX Trial), Anesthesia & Analgesia, 2 June 2026, [Link](https://journals.lww.com/anesthesia-analgesia/abstract/9900/randomized%5Fdouble%5Fblinded%5Fclinical%5Ftrial%5Fof.1812.aspx)
2. Intraoperative remimazolam-nalbuphine infusion reduces visceral traction response during cesarean delivery: a randomised trial, BMC Anesthesiology, 18 May 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03909-6)
3. Effects of enhanced recovery after cesarean section on hospital length of stay and Obstetric Quality-of-Recovery score (ObsQoR-11): a randomized controlled trial, BMC Anesthesiology, 14 May 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03890-0)
### 8- Pediatric:
1. Effect of early lollipop sucking in the post-anesthesia care unit on recovery quality in children undergoing outpatient dental treatment under general anesthesia: a prospective randomized controlled trial, BMC Anesthesiology, 4 May 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03887-9)
### 9- Orthopedic:
1. Combined intrathecal fentanyl and morphine for postoperative analgesia after total knee arthroplasty: a randomised controlled trial, BMC Anesthesiology, 25 May 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03940-7)
2. The effect of dexmedetomidine on emergence agitation and pain in post-anesthesia recovery of patients undergoing upper limb elective orthopedic surgery: a double-blind randomized clinical trial, BMC Anesthesiology, 4 May 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03850-8)
### 10- Regional Anesthesia & Pain Management:
1. Increasing dose of esketamine for supplemental analgesia after complex spinal fusion surgery: a randomized and double-blind trial, BMC Anesthesiology, 2 June 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03962-1)
2. Association of pectoral nerve (PECS) and Serratus Anterior Plane (SAP) blocks with intraoperative left internal mammary artery free blood flow and hemodynamic responses in patients undergoing coronary artery bypass grafting: a randomized controlled trial, BMC Anesthesiology, 2 June 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03974-x)
3. The diaphragm-sparing effect of interscalene block with a low-volume of ropivacaine 0.1% vs. 0.5%: A double-blind, controlled, randomised trial, European Journal of Anaesthesiology and Intensive Care, June 2026, [Link](https://journals.lww.com/ejaintensivecare/fulltext/2026/06000/the%5Fdiaphragm%5Fsparing%5Feffect%5Fof%5Finterscalene%5Fblock.7.aspx)
4. Comparison of erector spinae plane block and paravertebral block on quality of recovery-15 after video-assisted thoracoscopic surgery: a prospective randomized study, BMC Anesthesiology, 29 May 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03939-0)
5. Dexmedetomidine Preemptive Analgesia on Intra- and Postoperative Pain in Noncardiac Surgery: A Randomized, Double-Blind, Controlled Study, Anesthesia & Analgesia, 28 May 2026, [Link](https://journals.lww.com/anesthesia-analgesia/pages/articleviewer.aspx?year=9900&issue=00000&article=01777&type=Fulltext)
6. Effects of dexmedetomidine nasal spray combined with thoracic paravertebral block on sleep and pain in herpes zoster neuralgia: a randomized controlled trial, BMC Anesthesiology, 28 May 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03904-x)
7. Dose-matched parasternal intercostal plane block with or without serratus anterior plane block for analgesia following cardiac surgery: A randomized controlled observer-blinded trial, Journal of Cardiothoracic and Vascular Anesthesia, 20 May 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026004453)
8. Pericapsular nerve group (PENG) block at 10 mL vs. 20 mL for postoperative analgesia after total hip arthroplasty: a randomized controlled trial, BMC Anesthesiology, 18 May 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03923-8)
9. The Efficacy of Erector Spinae Plane Block Versus Subcostal Transversus Abdominis Plane Block in Laparoscopic Nephrectomy: A Randomized Clinical Trial, The Clinical Journal of Pain, 18 May 2026, [Link](https://journals.lww.com/clinicalpain/abstract/9900/the%5Fefficacy%5Fof%5Ferector%5Fspinae%5Fplane%5Fblock%5Fversus.355.aspx)
10. Continuous Ultrasound-Guided Erector Spinae Plane Block Versus Thoracic Paravertebral Block for Postoperative Analgesia in Patients Undergoing Thoracotomy, The Clinical Journal of Pain, 18 May 2026, [Link](https://journals.lww.com/clinicalpain/abstract/9900/continuous%5Fultrasound%5Fguided%5Ferector%5Fspinae%5Fplane.354.aspx)
11. Erector spinae plane block for postoperative analgesia in patients undergoing flexible ureteroscopy: a randomized controlled trial, BMC Anesthesiology, 13 May 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03884-y)
12. Comparison of Paravertebral Block and Erector Spinae Plane Block in Thoracotomy Using Nociception Level Index Monitoring: A Prospective Randomized Trial, Journal of Cardiothoracic and Vascular Anesthesia, 12 May 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026004015)
13. Evaluation of the analgesic efficacy of ultrasound-guided bilateral high-volume recto-intercostal plane block in laparoscopic sleeve gastrectomy: a prospective randomized controlled trial, BMC Anesthesiology, 11 May 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03856-2)
14. Real-time artificial intelligence-based needle tracking for ultrasound-guided regional anesthesia training: a pilot prospective randomized controlled trial, BMC Anesthesiology, 6 May 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03867-z)
15. Continuous Erector Spinae Plane Blocks to Treat Pain Following Percutaneous Nephrolithotomy: *A Randomized, Triple-Masked, Placebo-Controlled Clinical Trial*, Anesthesiology, 4 May 2026, [Link](https://journals.lww.com/anesthesiology/abstract/9900/continuous%5Ferector%5Fspinae%5Fplane%5Fblocks%5Fto%5Ftreat.1001.aspx)
### 11- Other:
1. Impact of Intravenous Lidocaine, Dexmedetomidine, and Intrathecal Morphine on Metastasis-Related Biomarkers and Cellular Immune Profiles in Colorectal Surgery: A Prospective, Randomized Controlled Trial, Anesthesia & Analgesia, 2 June 2026, [Link](https://journals.lww.com/anesthesia-analgesia/abstract/9900/impact%5Fof%5Fintravenous%5Flidocaine,%5Fdexmedetomidine,.1811.aspx)
2. The Effect of Immersive Virtual Reality on Anterograde Amnesia and Subjective Pain During Procedures: A Within-Subject Randomized Controlled Study, Anesthesia & Analgesia, 15 May 2026, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/the%5Feffect%5Fof%5Fimmersive%5Fvirtual%5Freality%5Fon.1741.aspx)
---
## ***Reviews:***
### 1- Neuro:
1. Anaesthesia for cervical spine surgery part 2: emergency surgery, BJA Edu, 1 June 2026, [Link](https://www.bjaed.org/article/S2058-5349%2826%2900037-5/abstract)
2. EEG monitoring in the operating room: current uses and perspectives – a narrative review, Anaesthesia Critical Care & Pain Medicine, 30 May 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556826001190)
### 2- Airway & Mechanical Ventilation:
1. Pharmacological approach to awake tracheal intubation, Current Opinion in Anesthesiology, 2 June 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/pharmacological%5Fapproach%5Fto%5Fawake%5Ftracheal.435.aspx)
2. The Association Between Mechanical Power and Postoperative Pulmonary Complications: A Critical Narrative Review of Clinical Controversies, Journal of Cardiothoracic and Vascular Anesthesia, 8 May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S1053077026003873)
### 3- Cardiovascular & Hemodynamics:
1. Complex Patent Foramen Ovale: Anatomical Variants, Technical Considerations, and Outcomes, Journal of Cardiothoracic and Vascular Anesthesia, 4 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026004787)
2. Perioperative Management of Patients with Durable and Temporary Left Ventricular Assist Devices Undergoing Non-Cardiac Surgery: a Comprehensive Review, Journal of Cardiothoracic and Vascular Anesthesia, 28 May 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026004672)
3. Perioperative Challenges in Adults with Transposition of the Great Arteries, Anesthesiology, 28 May 2026, [Link](https://journals.lww.com/anesthesiology/citation/9900/perioperative%5Fchallenges%5Fin%5Fadults%5Fwith.1030.aspx)
4. Perioperative management of patients receiving renal replacement therapy undergoing major cardiac surgery: a narrative review, Journal of Cardiothoracic and Vascular Anesthesia, 22 May 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026004532)
5. Reading Between the Guidelines: Perioperative Implications of the 2025 AHA/ACC Hypertension Update, Journal of Cardiothoracic and Vascular Anesthesia, 13 May 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026003836)
6. Defining Perioperative Right Heart Failure in Cardiac Surgery: A Multiparametric Approach to Diagnosis and Management, Anesthesiology, 11 May 2026, [Link](https://journals.lww.com/anesthesiology/citation/9900/defining%5Fperioperative%5Fright%5Fheart%5Ffailure%5Fin.1010.aspx)
7. Perioperative management Heart Mate 3 Left Ventricular Assist Devices in Non-Cardiac Surgery, Journal of Cardiothoracic and Vascular Anesthesia, 6 May 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026003824)
8. Fluid therapy in adults having non-cardiac surgery: A narrative review, Annals of Intensive Care, May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582025020205)
### 4- Thoracic:
1. Perioperative Considerations of Neoadjuvant and Perioperative Chemo-Immunotherapy for Resectable Lung Cancer, Journal of Cardiothoracic and Vascular Anesthesia, 29 May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S1053077026004696)
2. Anesthetic Considerations for Percutaneous Transthoracic Needle Biopsy and Image-Guided Thermal Ablation of the Lung, Current Anesthesiology Reports, 23 April 2026, [Link](https://link.springer.com/article/10.1007/s40140-026-00705-3)
### 5- Abdomen:
1. Emerging concepts in anesthetic management for intestinal transplantation: a 2020–2025 narrative review, BMC Anesthesiology, 4 June 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03976-9)
2. Anesthetic considerations for advanced gastrointestinal procedures, Current Opinion in Anesthesiology, 29 May 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/anesthetic%5Fconsiderations%5Ffor%5Fadvanced.433.aspx)
### 6- General:
1. Managing Hyperkalemia amid Supramassive Hemorrhage and Transfusion, Anesthesiology, 28 May 2026, [Link](https://journals.lww.com/anesthesiology/citation/9900/managing%5Fhyperkalemia%5Famid%5Fsupramassive%5Fhemorrhage.1031.aspx)
### 7- Obstetrics & Gynecology:
1. Patient Blood Management in postpartum haemorrhage: a narrative review and expert opinion towards improving patient outcomes during pregnancy and childbirth, BJA, 26 May 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900294-1/fulltext)
2. Care of lactating patients in the nonoperating room anesthesia setting, Current Opinion in Anesthesiology, 6 May 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/care%5Fof%5Flactating%5Fpatients%5Fin%5Fthe%5Fnonoperating.428.aspx)
### 8- Pediatric:
1. Anesthesia workstation performance in pediatric ventilation – Part 1: Precision of ventilation, Anesthesiology, 13 May 2026, [Link](https://journals.lww.com/anesthesiology/abstract/9900/anesthesia%5Fworkstation%5Fperformance%5Fin%5Fpediatric.1018.aspx)
2. Anesthesia workstation performance in pediatric ventilation – Part 2: Characteristics during pressure support ventilation and oxygen rise times, Anesthesiology, 13 May 2026, [Link](https://journals.lww.com/anesthesiology/abstract/9900/anesthesia%5Fworkstation%5Fperformance%5Fin%5Fpediatric.1017.aspx)
3. Pediatric procedures in endoscopy and radiology: clinical considerations, Current Opinion in Anesthesiology, 12 May 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/pediatric%5Fprocedures%5Fin%5Fendoscopy%5Fand%5Fradiology%5F.429.aspx)
### 9- Orthopedic:
1. Anaesthesia and analgesia for total knee arthroplasty, BJA Edu, 21 May 2026, [Link](https://www.bjaed.org/article/S2058-5349%2826%2900035-1/abstract)
### 10- Regional Anesthesia & Pain Management:
1. Regional Anesthesia Approaches for Transcatheter Aortic Valve Implantation: When and Where Does It Add Value? A Narrative Review of Techniques by Access Route, Journal of Cardiothoracic and Vascular Anesthesia, 20 May 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026004404)
2. New long-acting local anesthetics: recent formulations and safety, Current Opinion in Anesthesiology, 13 May 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/new%5Flong%5Facting%5Flocal%5Fanesthetics%5F%5Frecent.430.aspx)
3. Digital health and telemedicine for perioperative pain management in patients with chronic pain, Current Opinion in Anesthesiology, 5 May 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/digital%5Fhealth%5Fand%5Ftelemedicine%5Ffor%5Fperioperative.427.aspx)
### 11- Other:
1. Building resilience in perioperative medicine: ensuring safe care for all: A white paper from the European society of anaesthesiology and intensive care (ESAIC), European Journal of Anaesthesiology, 4 June 2026, [Link](https://journals.lww.com/ejanaesthesiology/fulltext/9900/building%5Fresilience%5Fin%5Fperioperative%5Fmedicine%5F.427.aspx)
2. Preoperative considerations for nonoperating room anesthesia, Current Opinion in Anesthesiology, 29 May 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/preoperative%5Fconsiderations%5Ffor%5Fnonoperating%5Froom.434.aspx)
3. Crisis resource management in nonoperating room anesthesia, Current Opinion in Anesthesiology, 27 May 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/crisis%5Fresource%5Fmanagement%5Fin%5Fnonoperating%5Froom.432.aspx)
4. Anesthetic considerations for ambulatory and office-based otolaryngologic surgery, Current Opinion in Anesthesiology, 27 May 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/anesthetic%5Fconsiderations%5Ffor%5Fambulatory%5Fand.431.aspx)
5. Plastics in the Perioperative Period: Deleterious Health Effects on Patients and Providers, Anesthesiology, 27 May 2026, [Link](https://journals.lww.com/anesthesiology/abstract/9900/plastics%5Fin%5Fthe%5Fperioperative%5Fperiod%5F%5Fdeleterious.1028.aspx)
6. How to Innovate as an Anesthesiologist: Guidance From the American Society of Anesthesiologists Committee on Innovation, Anesthesia & Analgesia, 18 May 2026, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/how%5Fto%5Finnovate%5Fas%5Fan%5Fanesthesiologist%5F%5Fguidance.1776.aspx)
7. Advancing Perioperative Medicine: A Multistakeholder Perspective, Anesthesiology, 14 May 2026, [Link](https://journals.lww.com/anesthesiology/pages/articleviewer.aspx?year=9900&issue=00000&article=01019&type=Fulltext)
8. Consent and assessing capacity in perioperative and intensive care, BJA Edu, 8 May 2026, [Link](https://www.bjaed.org/article/S2058-5349%2826%2900028-4/abstract)
9. Neuronal Cell Death Modalities and Protective Mechanisms Induced By Sevoflurane: A Narrative Review, Anesthesia & Analgesia, 6 May 2026, [Link](https://journals.lww.com/anesthesia-analgesia/abstract/9900/neuronal%5Fcell%5Fdeath%5Fmodalities%5Fand%5Fprotective.1770.aspx)
10. Understanding Blood–Injection–Injury Phobia: Do Not Miss the Point, A&A Practice, May 2026, [Link](https://journals.lww.com/aacr/abstract/2026/05000/understanding%5Fblood%5Finjection%5Finjury%5Fphobia%5F%5Fdo.16.aspx)
---
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# **Critical Care:**
## ***Guidelines & Consensus:***
### 1- AI:
1. The IMPACT framework for evaluating generative AI in critical care: development and multinational consensus validation, Annals of Intensive Care, May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582026001135)
### 2- Cardiovascular & Hemodynamics:
1. Extracorporeal membrane oxygenation, acute kidney injury, fluid balance, and continuous renal replacement therapy: Acute Disease Quality Initiative (ADQI) and Extracorporeal Life Support Organization (ELSO) joint consensus conference, Intensive Care Medicine, 6 May 2026, [Link](https://link.springer.com/article/10.1007/s00134-026-08440-3)
2. Experts’ recommendations for the management of adult patients with cardiogenic shock, Annals of Intensive Care, May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582026000737)
### 3- Thorax/Lungs/Airways/Mechanical ventilation:
1. Expert consensus–based clinical practice guidelines for Care and weaning procedures in tracheostomized ICU patients after invasive mechanical ventilation: a joint statement by the Intensive Care Physiotherapy Society (SKR) and the French Intensive Care Society (SRLF), Annals of Intensive Care, May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582026000804)
2. Guidelines for the Initial Assessment of Respiratory Distress in the Emergency Department, Annals of Intensive Care, May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582025020199)
### 4- Neuro-muscular:
1. Guidelines for Seizure Prophylaxis in Patients Undergoing Supratentorial Neurosurgery: A Statement for Healthcare Professionals from the Neurocritical Care Society, Neurocritical Care, 5 May 2026, [Link](https://link.springer.com/article/10.1007/s12028-026-02522-2)
### 5- Renal:
1. Metabolic complications of citrate anticoagulation in continuous renal replacement therapy (crrt): a delphi consensus on indications, monitoring and management, Critical Care, 13 May 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06066-x)
2. Extracorporeal membrane oxygenation, acute kidney injury, fluid balance, and continuous renal replacement therapy: Acute Disease Quality Initiative (ADQI) and Extracorporeal Life Support Organization (ELSO) joint consensus conference, Intensive Care Medicine, 6 May 2026, [Link](https://link.springer.com/article/10.1007/s00134-026-08440-3)
### 6- Trauma:
1. American Association for the Surgery of Trauma/American College of Surgeons–Committee on Trauma Clinical Consensus Statement on the management of patients with rib fractures, The Journal of Trauma and Acute Care Surgery, 15 May 2026, [Link](https://journals.lww.com/jtrauma/citation/9900/american%5Fassociation%5Ffor%5Fthe%5Fsurgery%5Fof.1369.aspx)
### 7- Liver & GI:
1. Evidence-based, cost-effective management of upper gastrointestinal hemorrhage. An algorithm of the *Journal of Trauma and Acute Care Surgery* emergency general surgery algorithms work group, The Journal of Trauma and Acute Care Surgery, 25 May 2026, [Link](https://journals.lww.com/jtrauma/pages/articleviewer.aspx?year=9900&issue=00000&article=01347&type=Fulltext)
### 8- Blood & hemostasis:
1. Best practices on blood and blood products for a prehospital hemorrhage protocol: consensus from the 2025 Canadian prehospital transfusion summit, Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 3 June 2026, [Link](https://link.springer.com/article/10.1186/s13049-026-01630-4)
### 9- Pediatric critical care:
1. Diagnosis and management of Children with Post-Intensive Care Syndrome in Paediatrics: Clinical Practice Guidelines by the French National Authority for Health (HAS), Annals of Intensive Care, 2 June 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582026001329)
##
---
## ***Systematic reviews & meta-analyses:***
### 1- AI:
1. Artificial intelligence and computerized decision support in adult intensive care: A systematic review of randomized controlled trials, Journal of Critical Care, August 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0883944126001784)
2. Diagnostic accuracy of AI-assisted point-of-care ultrasound for abdominal free fluid detection in FAST trauma assessment: a systematic review and meta-analysis, BMC Emergency Medicine, 16 May 2026, [Link](https://link.springer.com/article/10.1186/s12873-026-01616-6)
### 2- Cardiovascular & Hemodynamics:
1. Delayed presentation of air embolism after removal of central venous catheters: A systematic review, Journal of Critical Care, August 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S088394412600184X)
2. Agreement of minimally invasive pulse wave analysis with pulmonary artery and transpulmonary thermodilution cardiac output measurements in perioperative and intensive care medicine: a systematic review and meta-analysis, BJA, 2 June 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900329-6/fulltext)
3. Outcomes in obese adult veno-arterial extracorporeal membrane oxygenation: A systematic review, Journal of Cardiothoracic and Vascular Anesthesia, 30 May 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026004684)
4. Efficacy and Safety of Prasugrel, Ticagrelor, or Clopidogrel After Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis, JAMA Cardiology, 27 May 2026, [Link](https://jamanetwork.com/journals/jamacardiology/article-abstract/2849614)
5. Invasive hemodynamic monitoring-guided resuscitation improves survival in shock: A systematic review and meta-analysis, Annals of Intensive Care, May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582026001068)
6. Echocardiographic assessment of left ventricular filling pressure compared to pulmonary artery catheter in mechanically ventilated patients: Systematic review and meta-analysis, Annals of Intensive Care, May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582025020382)
### 3- Thorax/Lungs/Airways/Mechanical ventilation:
1. Non-invasive respiratory supports and criteria for intubation in randomised trials of acute hypoxaemic respiratory failure: a systematic review and network meta-analysis, The Lancet Respiratory Medicine, June 2026, [Link](https://www.thelancet.com/journals/lanres/article/PIIS2213-2600%2826%2900039-1/abstract)
2. Technology-Enhanced Strategies to Optimize Positive End-Expiratory Pressure in Patients Receiving Invasive Mechanical Ventilation: A Systematic Review and Meta-Analysis, Critical Care Medicine, 29 May 2026, [Link](https://journals.lww.com/ccmjournal/fulltext/9900/technology%5Fenhanced%5Fstrategies%5Fto%5Foptimize.820.aspx)
3. Awake prone positioning reduces mortality, intubation, and hospital stay in acute hypoxemic respiratory failure: a systematic review and meta-analysis of 6,164 patients, BMC Anesthesiology, 28 May 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03963-0)
4. Nebulized Heparin in Adults With Acute Respiratory Failure: A Meta-Analysis of Randomized Trials, Critical Care Medicine, 18 May 2026, [Link](https://journals.lww.com/ccmjournal/abstract/9900/nebulized%5Fheparin%5Fin%5Fadults%5Fwith%5Facute%5Frespiratory.825.aspx)
5. The Association Between Mechanical Power and Mortality in Critically Ill Patients Receiving Invasive Mechanical Ventilation: A Systematic Review and Meta-Analysis, Critical Care Medicine, 18 May 2026, [Link](https://journals.lww.com/ccmjournal/abstract/9900/the%5Fassociation%5Fbetween%5Fmechanical%5Fpower%5Fand.826.aspx)
6. Definition and prognostic value of response to prone positioning in ARDS: a systematic review and meta-analysis, Critical Care, 15 May 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06081-y)
7. Induction agents for emergency tracheal intubation in critically ill adults: a systematic review and network meta-analysis, Critical Care, 12 May 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06067-w)
8. Personalized positive-end expiratory pressure using electrical impedance tomography in ARDS patients: a systematic review and meta-analysis, Annals of Intensive Care, May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582026000841)
### 4- Neuro-muscular:
1. Differences in intensive care outcomes between older adults with and without dementia: A systematic review and meta-analysis, Journal of Critical Care, August 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0883944126001310)
2. Diagnosis, Prevention, Management, and Prognostication of Delirium in Acute-Care Neurosurgical Patients: A Systematic Scoping Review, Neurocritical Care, 28 May 2026, [Link](https://link.springer.com/article/10.1007/s12028-026-02553-9)
3. Rehabilitation in the Intensive Care Unit for Adults with Traumatic Brain Injury: A Systematic Review and Meta-analysis, Neurocritical Care, 23 May 2026, [Link](https://link.springer.com/article/10.1007/s12028-026-02551-x)
4. Prognostic Value of Natriuretic Peptides for Delayed Cerebral Ischemia and Outcomes After Aneurysmal Subarachnoid Hemorrhage: An Updated-Systematic Review and Meta-Analysis, Neurocritical Care, 5 May 2026, [Link](https://link.springer.com/article/10.1007/s12028-026-02524-0)
5. Prophylactic Antiepileptic Drugs in Nontraumatic Intracerebral Hemorrhage: A Network Meta-Analysis, Neurocritical Care, 5 May 2026, [Link](https://link.springer.com/article/10.1007/s12028-026-02514-2)
6. Association between neurofilament light chain concentrations and outcomes in patients with moderate to severe traumatic brain injury: a systematic review and meta-analysis, Critical Care, 4 May 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06036-3)
7. Association of mortality and neurological outcomes with hypocapnia in adult patients with acute brain injury: an updated meta-analysis, Critical Care, 1 May 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06058-x)
### 5- Renal:
1. Sodium Bicarbonate for Acute Metabolic Acidosis in Critically Ill Adults: A Meta-Analysis of Randomized Clinical Trials, Critical Care Medicine, 22 May 2026, [Link](https://journals.lww.com/ccmjournal/abstract/9900/sodium%5Fbicarbonate%5Ffor%5Facute%5Fmetabolic%5Facidosis%5Fin.838.aspx)
### 6- Blood & hemostasis:
1. Temporal trends and prognostic factors in critically ill adult patients with acute leukemia: an individual participant data meta-analysis, Intensive Care Medicine, 4 May 2026, [Link](https://link.springer.com/article/10.1007/s00134-026-08449-8)
### 7- Nutrition:
1. Unclogging enteral feeding tubes: A systematic review, Nutrition in Clinical Practice, 19 May 2026, [Link](https://aspenjournals.onlinelibrary.wiley.com/doi/10.1002/ncp.70137)
### 8- Infectious Diseases:
1. Efficacy and Safety of Systemic Prophylactic Antibacterials in Mechanically Ventilated Patients: Systematic Review and Meta-Analysis, Critical Care Medicine, 1 June 2026, [Link](https://journals.lww.com/ccmjournal/fulltext/9900/efficacy%5Fand%5Fsafety%5Fof%5Fsystemic%5Fprophylactic.861.aspx)
2. Dexmedetomidine versus usual care in adult patients with septic shock receiving vasopressors: A systematic review and meta-analysis of randomised controlled trials, European Journal of Anaesthesiology and Intensive Care, June 2026, [Link](https://journals.lww.com/ejaintensivecare/fulltext/2026/06000/dexmedetomidine%5Fversus%5Fusual%5Fcare%5Fin%5Fadult.10.aspx)
3. Prognostic Factors Associated With Mortality Among Patients With Necrotizing Soft-Tissue Infection: A Systematic Review and Meta-Analysis, Critical Care Medicine, 15 May 2026, [Link](https://journals.lww.com/ccmjournal/abstract/9900/prognostic%5Ffactors%5Fassociated%5Fwith%5Fmortality%5Famong.824.aspx)
4. Prevalence and representation of comorbidities and multimorbidity in randomised controlled trials in sepsis or septic shock: a systematic review, Critical Care, 6 May 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06049-y)
5. The role of cytokines in septic myocardial dysfunction: a translational systematic review and meta-analysis, Annals of Intensive Care, May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582026000038)
### 9- Sedation & analgesia:
1. Association between opioid infusion use and duration of mechanical ventilation and related outcomes in critically ill adults: a systematic review and meta-analysis, Annals of Intensive Care, May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S211058202600124X)
### 10- Other:
1. Major publications in the critical care pharmacotherapy literature: 2025, Journal of Critical Care, August 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0883944126000869)
2. The Integrated Stress Response in Critical Illness: A Systematic Review, CHEST Critical Care, 3 June 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2949788426000559)
3. Post-obstructive pulmonary edema following near-hanging: a case report and systematic review of published cases, International Journal of Emergency Medicine, 2 May 2026, [Link](https://link.springer.com/article/10.1186/s12245-026-01242-w)
---
## ***Clinical trials:***
### 1- Cardiovascular & Hemodynamics:
1. “Pediatric versus adult self-inflating bags for cardiopulmonary resuscitation of adult patients with cardiac arrest - A non-randomized controlled trial”, Resuscitation Plus, 1 June 2026, [Link](https://www.sciencedirect.com/science/article/pii/S266652042600161X)
2. Red Cell Transfusion in Critically Ill and Noncritically Ill Patients With Acute Myocardial Infarction and Anemia—A Subanalysis of the Myocardial Ischemia and Transfusion (MINT) Trial, Critical Care Medicine, 25 May 2026, [Link](https://journals.lww.com/ccmjournal/abstract/9900/red%5Fcell%5Ftransfusion%5Fin%5Fcritically%5Fill%5Fand.846.aspx)
3. Accelerated Diagnostic Pathways for Suspected Acute Coronary Syndrome in Practice: A Randomized Trial of 0/1-Hour vs 0/3-Hour Troponin Testing, JACC, 20 May 2026, [Link](https://www.jacc.org/doi/10.1016/j.jacc.2026.02.5135)
4. Prehospital Resuscitation with Type O Whole Blood for Trauma and Hemorrhage, NEJM, 18 May 2026, [Link](https://www.nejm.org/doi/full/10.1056/NEJMoa2602167)
5. Short- and Long-Term Efficacy and Safety of Levosimendan in VA-ECMO Weaning: The WEANILEVO Randomized Double-Blind Multicenter Trial, Anesthesiology, 8 May 2026, [Link](https://journals.lww.com/anesthesiology/abstract/9900/short%5F%5Fand%5Flong%5Fterm%5Fefficacy%5Fand%5Fsafety%5Fof.1007.aspx)
6. Effectiveness of an Intervention to Improve Guideline‐Directed Medications for Patients With Acute Heart Failure: A Randomized Clinical Trial, Journal of the American Heart Association, 6 May 2026, [Link](https://www.ahajournals.org/doi/10.1161/JAHA.125.044747)
7. Prehospital resuscitative endovascular balloon occlusion of the aorta in non-traumatic out-of-hospital cardiac arrest (REBOARREST): an international, multicentre, open label, pragmatic, randomised, controlled trial, Critical Care, 5 May 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06057-y)
8. Fluid Management of Acute Heart Failure With the Reprieve System: The Randomized Controlled FASTR Trial, JACC: Heart Failure, 4 May 2026, [Link](https://www.jacc.org/doi/10.1016/j.jchf.2026.103062)
### 2- Thorax/Lungs/Airways/Mechanical ventilation:
1. Inferior vena cava dynamics during triggered breaths under different levels of pressure support and PEEP: A randomized crossover physiologic study, Journal of Critical Care, August 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0883944126001711)
2. Personalized automatic management of tracheal cuff pressure and subglottic secretions drainage to prevent pneumonia in critically ill intubated patients. The MICROINHALO multicenter randomized controlled trial, Intensive Care Medicine, 2 June 2026, [Link](https://link.springer.com/article/10.1007/s00134-026-08459-6)
3. Protocol and Statistical Analysis Plan for Efficacy of Local Anesthesia to the Trachea via a Subglottic Secretion Drainage Port in Orally Intubated Critically Ill Patients: A Single-Center Cluster-Crossover Phase 2 Randomized Controlled Trial, CHEST Critical Care, 19 May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S294978842600047X)
4. Effects of out-of-bed armchair positioning on oxygenation in spontaneously breathing ICU patients receiving respiratory support: a randomized controlled trial, Intensive Care Medicine, 18 May 2026, [Link](https://link.springer.com/article/10.1007/s00134-026-08453-y)
5. Elastance as a determinant of the effect of prone positioning on mortality in acute respiratory distress syndrome: a post hoc analysis of the PROSEVA trial, Critical Care, 16 May 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06060-3)
6. Anti-C5a antibody STSA-1002 for patients with acute respiratory distress syndrome due to viral pneumonia: a phase 1b/2, multicenter, randomized, double-blind, placebo-controlled trial, CHEST, 15 May 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0012369226006380)
7. Ivermectin for Critically and Noncritically Ill Hospitalized Patients With COVID-19: Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community-Acquired Pneumonia (REMAP-CAP), Critical Care Medicine, 8 May 2026, [Link](https://journals.lww.com/ccmjournal/pages/articleviewer.aspx?year=9900&issue=00000&article=00818&type=Fulltext)
8. Video versus direct laryngoscopy for tracheal intubation in trauma: A secondary analysis of the DEVICE trial, The Journal of Trauma and Acute Care Surgery, 7 May 2026, [Link](https://journals.lww.com/jtrauma/abstract/9900/video%5Fversus%5Fdirect%5Flaryngoscopy%5Ffor%5Ftracheal.1363.aspx)
9. Automated control of inspired oxygen in mechanically ventilated trauma and acute care surgery patients: A randomized controlled trial, The Journal of Trauma and Acute Care Surgery, 1 May 2026, [Link](https://journals.lww.com/jtrauma/abstract/9900/automated%5Fcontrol%5Fof%5Finspired%5Foxygen%5Fin.1344.aspx)
10. High-flow nasal cannula versus noninvasive ventilation in stabilized hypercapnic exacerbation: a physiological crossover trial, Annals of Intensive Care, May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582026001275)
11. High-flow nasal oxygen therapy via a single-prong cannula interface during bronchoscopy in patients with acute respiratory failure: a two-center, open-label, randomized controlled trial, Annals of Intensive Care, May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582026001160)
12. High-frequency oscillation improves mucus clearance and airway resistance in mechanically ventilated patients: a randomized clinical trial, Annals of Intensive Care, May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S211058202600097X)
13. Efficiency of neural respiratory drive changes during non-invasive ventilation and high-flow nasal cannula oxygen therapy in AECOPD patients with acute hypercapnic respiratory failure: A randomised cross-over study, Annals of Intensive Care, May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582025020333)
14. Health-related quality of life trajectories one year after COVID-19–induced ARDS: A secondary analysis of the CONFIDENT trial, Annals of Intensive Care, May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582025020230)
### 3- Neuro-muscular:
1. Standard-Dose Tenecteplase vs Low-Dose Alteplase for Acute Ischemic Stroke From Large-Vessel Occlusion: A Randomized Clinical Trial, JAMA Neurology, 1 June 2026, [Link](https://jamanetwork.com/journals/jamaneurology/fullarticle/2849793)
2. Endovascular treatment for medium or distal vessel occlusion stroke (DISTAL): 12-month outcomes of a multicentre, open-label, randomised trial, The Lancet Neurology, June 2026, [Link](https://www.thelancet.com/journals/laneur/article/PIIS1474-4422%2826%2900169-9/fulltext)
3. Promoting Consciousness Recovery in Patients with Acquired Brain Injury Through Multimodal Sensory Stimulation: A Randomized Controlled Trial of Median Nerve and Auricular Stimulation, Neuroctical Care, 28 May 2026, [Link](https://link.springer.com/article/10.1007/s12028-026-02543-x)
4. Impact of Ultra-Early Perioperative Antihypertensive Therapy in Acute Intracerebral Hemorrhage, Stroke, 24 May 2026, [Link](https://www.ahajournals.org/doi/10.1161/STROKEAHA.125.053989)
5. Effect of optimal operator positioning on transcranial Doppler acquisition: a randomized controlled trial, Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 21 May 2026, [Link](https://link.springer.com/article/10.1186/s13049-026-01619-z)
6. Effects of the ABCDEF Bundle on Delirium, Function, and Quality of Life in Australian ICU Patients: A Pragmatic Randomized Controlled Trial, Critical Care Medicine, 20 May 2026, [Link](https://journals.lww.com/ccmjournal/fulltext/9900/effects%5Fof%5Fthe%5Fabcdef%5Fbundle%5Fon%5Fdelirium,.828.aspx)
7. Location‐Specific Hematoma Volume Tolerance for Spontaneous Intracerebral Hemorrhage: A Pooled Analysis of INTERACT2 and ATACH II, Journal of the American Heart Association, 14 May 2026, [Link](https://www.ahajournals.org/doi/10.1161/JAHA.125.049096)
8. Endovascular Treatment of Medium-Vessel-Occlusion Strokes, NEJM, 13 May 2026, [Link](https://www.nejm.org/doi/full/10.1056/NEJMoa2514120)
9. Propranolol monotherapy versus combined propranolol-gabapentin for prevention of paroxysmal sympathetic hyperactivity after moderate-severe traumatic brain injury: a randomized controlled trial, BMC Anesthesiology, 8 May 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03802-2)
10. Intravenous Tenecteplase Prior to Endovascular Treatment for Ischemic Stroke at 4.5 to 24 Hours: The TNK-PLUS Randomized Clinical Trial, JAMA, 8 May 2026, [Link](https://jamanetwork.com/journals/jama/fullarticle/2848807)
11. Intravenous Tirofiban After Tenecteplase in Acute Ischemic Stroke: The INSTANT Randomized Clinical Trial, JAMA, 8 May 2026, [Link](https://jamanetwork.com/journals/jama/fullarticle/2848809)
12. Adjunctive Intra-Arterial Alteplase After Successful Thrombectomy for Acute Ischemic Stroke: The CHOICE-2 Randomized Clinical Trial, JAMA, 7 May 2026, [Link](https://jamanetwork.com/journals/jama/fullarticle/2848744)
### 4- Renal:
1. Discontinuation of continuous kidney replacement therapy in patients with acute kidney injury: A pilot study, Journal of Critical Care, August 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0883944126000833)
2. Effect of restrictive fluid balance in critically ill patients with acute kidney injury: a target trial emulation, Critical Care, 30 May 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06094-7)
3. Regional citrate anticoagulation for renal replacement therapy during venovenous ECMO: A randomized crossover pilot study, Annals of Intensive Care, May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S211058202600107X)
### 5- Trauma:
1. Prehospital Resuscitation with Type O Whole Blood for Trauma and Hemorrhage, NEJM, 18 May 2026, [Link](https://www.nejm.org/doi/full/10.1056/NEJMoa2602167)
### 6- Blood & hemostasis:
1. Prehospital Resuscitation with Type O Whole Blood for Trauma and Hemorrhage, NEJM, 18 May 2026, [Link](https://www.nejm.org/doi/full/10.1056/NEJMoa2602167)
### 7- Nutrition:
1. Enteral When Compared With IV Magnesium Replacement in the Critically Ill: A Noninferiority Randomized Clinical Trial, Critical Care Medicine, 1 June 2026, [Link](https://journals.lww.com/ccmjournal/abstract/9900/enteral%5Fwhen%5Fcompared%5Fwith%5Fiv%5Fmagnesium.864.aspx)
### 8- Infectious Diseases:
1. Targeted vs Standard Contact Precautions and Transmission of MRSA and VRE in Critically Ill Adults: A Pilot Clinical Trial, CHEST Critical Care, 25 May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2949788426000493)
2. Intrapulmonary penetration of ceftolozane/tazobactam and ceftazidime/avibactam administered by continuous infusion in critically ill patients with nosocomial pneumonia: a randomized pharmacokinetic trial, Critical Care, 13 May 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06075-w)
3. Polymyxin B haemoadsorption in endotoxic septic shock (Tigris): a multicentre, open-label, Bayesian, randomised, controlled, phase 3 trial, The Lancet Respiratory Medicine, May 2026, [Link](https://www.thelancet.com/journals/lanres/article/PIIS2213-2600%2826%2900047-0/fulltext)
4. Association between time to target mean arterial pressure and 90-day mortality in septic shock: a post hoc analysis of the OPTPRESS trial, Annals of Intensive Care, May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582026001238)
5. Relation between initial hypothermia, course of the hypothermia and mortality in patients with septic shock: a post-hoc analysis of the SEPSISPAM randomized trial, Annals of Intensive Care, May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582026000865)
6. Early mobilization with or without cycloergometry in patients with septic shock in Intensive Care Unit: a randomized controlled trial, Annals of Intensive Care, May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582026000695)
### 9- Sedation & analgesia:
1. Early inhaled isoflurane sedation in neurocritical patients with invasive intracranial pressure monitoring: the NEURO-CONDA randomized pilot trial, Critical Care, 28 May 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06101-x)
### 10- Pediatric critical care:
1. Adjunctive Mechanical Ventilation or Intravenous Hypertonic Saline in Malawian Children with Cerebral Malaria and Highly Increased Brain Volume: A Randomized, Phase 3 Clinical Trial, Neurocritical Care, 2 June 2026, [Link](https://link.springer.com/article/10.1007/s12028-026-02540-0)
2. Augmented Reality–Guided Decision Support in Simulated Pediatric Cardiac Arrest: A Randomized Clinical Trial, JAMA Open, 22 May 2026, [Link](https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2849287)
3. Effect of a liquid crystal vein locator on intravenous catheterization in young children: a randomized trial, European Journal of Emergency Medicine, 19 May 2026, [Link](https://journals.lww.com/euro-emergencymed/fulltext/9900/effect%5Fof%5Fa%5Fliquid%5Fcrystal%5Fvein%5Flocator%5Fon.243.aspx)
4. Extended Barrier Precautions vs Hand Hygiene Alone and Neonatal Sepsis in Intensive Care Patients: The BALTIC Cluster-Randomized Clinical Trial, JAMA Open, 15 May 2026, [Link](https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2849097)
5. Oxygen saturation thresholds in children with acute respiratory distress (OxyKids): a multicentre, open, parallel-group, randomised clinical trial, The Lancet Respiratory Medicine, 12 May 2026, [Link](https://www.thelancet.com/journals/lanres/article/PIIS2213-2600%2826%2900087-1/abstract)
6. Protocolized Evaluation of Permissive Blood Pressure Targets Versus Usual Care (PRESSURE): Statistical Analysis Plan for the PRESSURE Trial, Pediatric Critical Care Medicine, 7 May 2026, [Link](https://journals.lww.com/pccmjournal/pages/articleviewer.aspx?year=9900&issue=00000&article=00667&type=Fulltext)
7. Minimal Clinically Important Difference of the Functional Status Scale in Pediatric Neurocritical Care Patients: Post Hoc Analysis of a Randomized Controlled Trial, Neurocritical Care, 5 May 2026, [Link](https://link.springer.com/article/10.1007/s12028-026-02512-4)
### 11- Other:
1. Reducing Physical Restraint in the ICU: Multicenter Phase II Randomized Trial of a Novel Device Versus Traditional Wrist Restraints, Critical Care Medicine, 28 May 2026, [Link](https://journals.lww.com/ccmjournal/abstract/9900/reducing%5Fphysical%5Frestraint%5Fin%5Fthe%5Ficu%5F.848.aspx)
2. Clinical Performance in Critical Care Simulation Under Sleep Deprivation: Effects of Power Napping in the R-NAP Randomized Controlled Trial, Anesthesiology, 8 May 2026, [Link](https://journals.lww.com/anesthesiology/abstract/9900/clinical%5Fperformance%5Fin%5Fcritical%5Fcare%5Fsimulation.1005.aspx)
3. The predicted body weight equation overestimates lung sizes of female, critically ill patients: an analysis of randomized, controlled trials and real-world clinical data, Intensive Care Medicine, 7 May 2026, [Link](https://link.springer.com/article/10.1007/s00134-026-08442-1)
4. Efficacy and safety of ilaprazole for stress ulcer - associated upper gastrointestinal bleeding prophylaxis in critically ill patients: a randomized, double-blind, non-inferiority phase 3 trial, Annals of Intensive Care, May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582026000798)
---
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## ***Reviews:***
### 1- AI:
1. Development and Validation of an Integrated AI-Powered Clinical Decision Support Application for Cardiac Critical Care: Combining Coagulation Management, Blood Gas Analysis, Mechanical Ventilation, Hemodynamic Assessment, and Extracorporeal Membrane Oxygenation, Journal of Cardiothoracic and Vascular Anesthesia, 27 May 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026004635)
2. Machine Learning in Post-Cardiotomy Shock: Implications for Temporary Mechanical Circulatory Support, Journal of Cardiothoracic and Vascular Anesthesia, 7 May 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026003770)
### 2- Cardiovascular & Hemodynamics:
1. What every intensivist should know about the endothelial glycocalyx, Journal of Critical Care, August 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0883944126001875)
2. The 2026 Multisociety Acute Pulmonary Embolism Guidelines: An Expert Perspective, Journal of Cardiothoracic and Vascular Anesthesia, 3 June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S105307702600474X)
3. Contemporary Management of Acute Heart Failure: From Emergency Presentation to Long-Term Remission, JACC, 27 May 2026, [Link](https://www.jacc.org/doi/10.1016/j.jacc.2026.03.029)
4. Stellate Ganglion Block for the Treatment of Refractory Ventricular Tachycardia and Electrical Storm. A Narrative Review, Journal of Cardiothoracic and Vascular Anesthesia, 25 May 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026004544)
5. How I do it: Managing a Critically Ill Patient with Pulmonary Arterial Hypertension, CHEST, 22 May 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0012369226006513)
6. Reporting of Utstein-recommended variables in prehospital traumatic cardiac arrest: a scoping review, BMC Emergency Medicine, 18 May 2026, [Link](https://link.springer.com/article/10.1186/s12873-026-01609-5)
7. Phenotyping and biomarkers in cardiogenic shock, Current Opinion in Critical Care, 30 April 2026, [Link](https://journals.lww.com/co-criticalcare/abstract/9900/phenotyping%5Fand%5Fbiomarkers%5Fin%5Fcardiogenic%5Fshock.359.aspx)
8. How to perform fluid de-escalation in critical care, Annals of Intensive Care, May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S211058202600110X)
9. Unnecessary fluid therapy in patients with shock: Five classic fluid pitfalls and five ways to do it better, Annals of Intensive Care, May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582026001093)
10. Lactate in cardiogenic shock: pathophysiology, prognostic value, and clinical interpretation, Annals of Intensive Care, May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582026000968)
11. The time course of fluid responsiveness, Annals of Intensive Care, May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582026000713)
12. Remote ischemic conditioning in intensive care: From bench to bedside, Annals of Intensive Care, May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582025020321)
### 3- Thorax/Lungs/Airways/Mechanical ventilation:
1. Improving the safety of emergency tracheal intubation, Current Opinion in Critical Care, 21 May 2026, [Link](https://journals.lww.com/co-criticalcare/abstract/9900/improving%5Fthe%5Fsafety%5Fof%5Femergency%5Ftracheal.362.aspx)
2. Fluid responsiveness in ARDS: current evidence, knowledge gaps, and future directions — a scoping review of the literature, BMC Anesthesiology, 16 May 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03910-z)
3. The balance between classical and alternative renin–angiotensin system in ARDS: a narrative review, Journal of Intensive Care, 14 May 2026, [Link](https://link.springer.com/article/10.1186/s40560-026-00886-3)
4. Airway management in critically ill patients with obesity, Intensive Care Medicine, 13 May 2026, [Link](https://link.springer.com/article/10.1007/s00134-026-08454-x)
5. The lung in acute respiratory failure: insights from synchrotron radiation imaging, Intensive Care Medicine Experimental, 8 May 2026, [Link](https://link.springer.com/article/10.1186/s40635-026-00896-3)
6. When mechanical power remains high despite conventional lung-protective settings: a physiology-driven bedside framework, Annals of Intensive Care, May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582026001305)
7. Alveolar dysregulation of host response in pneumonia and ARDS: implications for immune modulation and infection, Annals of Intensive Care, May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582026001202)
8. Beyond the PaO2/FiO2 ratio: Rethinking ARDS severity through the Lens of physiology, Annals of Intensive Care, May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582026000920)
9. Management of hypercapnic acute respiratory failure with high-flow nasal cannula therapy: A narrative review, Annals of Intensive Care, May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582026000889)
10. The invasive and non-invasive monitoring of inspiratory effort and drive during assisted mechanical ventilation, Annals of Intensive Care, May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582025020175)
### 4- Neuro-muscular:
1. Past, present and future perspectives of traumatic brain injury, Journal of Critical Care, August 2026, [Link](https://www.sciencedirect.com/science/article/pii/S0883944126001036)
2. The Role of Microbiome-Associated Metabolites and Their Clinical Implications in Traumatic Brain Injury: A Scoping Review, Neurocritical Care, 5 June 2026, [Link](https://link.springer.com/article/10.1007/s12028-026-02562-8)
3. Delayed awakening after out-of-hospital cardiac arrest: a scoping review of definitions, determinants, and prognostic implications, Resuscitation, 20 May 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0300957226001905)
4. Brain neurovascular unit biomarkers: a hypothesis-driven paradigm to advance understanding of post-cardiac arrest cerebral injury, Annals of Intensive Care, May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582026000993)
### 5- Renal:
1. Renal replacement therapy in patients under extracorporeal membrane oxygenation: a narrative review, Critical Care, 2 May 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06033-6)
2. Renal congestion syndrome in critically ill patients: a neglected mechanism of acute kidney injury - A narrative review, Annals of Intensive Care, May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582026001184)
3. Renal replacement therapy in intensive care unit: a narrative review, Annals of Intensive Care, May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582026001159)
4. What new renal biomarkers tell us about renal physiology: Collection: physiology applied to ICU, Annals of Intensive Care, May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S211058202502031X)
### 6- Blood & Hemostasis:
1. Emerging role of nucleic acid aptamers in sepsis-induced coagulopathy: Future perspectives in diagnostics and therapeutics, Annals of Intensive Care, May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S211058202502028X)
2. Physiopathology of fibrinolysis in sepsis-induced disseminated intravascular coagulation: Emerging mechanisms and pharmacological targets, Annals of Intensive Care, May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582025020229)
### 7- Nutrition:
1. Nutrition support in the ICU: current evidence and evolving standards, Intensive Care Medicine, 2 June 2026, [Link](https://link.springer.com/article/10.1007/s00134-026-08474-7)
2. Nutrition and pharmacologic support to address metabolic demands following trauma: a narrative review, JPEN, 19 May 2026, [Link](https://aspenjournals.onlinelibrary.wiley.com/doi/10.1002/jpen.70108)
### 8- Infectious Diseases:
1. Recognition and Management of Infectious Biothreats and Emerging Pathogens, Critical Care Clinics, July 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070425001083)
2. Intensive Care Unit Management of Meningitis and Encephalitis, Critical Care Clinics, July 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070426000163)
3. The Global Intensive Care Unit: Human Immunodeficiency Virus, Tuberculosis, and Malaria, Critical Care Clinics, July 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070426000126)
4. Optimal Approach to Source Control in Intensive Care Unit Patients, Critical Care Clinics, July 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070425001095)
5. Lower Respiratory Tract Infections: Precision Diagnostics, Critical Care Clinics, July 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070425001101)
6. Recognizing and Managing Hemophagocytic Lymphohistiocytosis in Adults in the Intensive Care Unit, Critical Care Clinics, July 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070426000011)
7. Antibiotic Considerations in the Critically Ill: Empiric Choices and Dosing, Critical Care Clinics, July 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070426000138)
8. Infection Prevention and Control in the Intensive Care Unit, Critical Care Clinics, July 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070425001113)
9. Antibiotic Stewardship for the Intensivist, Critical Care Clinics, July 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S074907042600014X)
10. The Respiratory Triple Pandemic in the Intensive Care Unit: Epidemiology, Clinical Features and Management of COVID-19, Influenza and Respiratory Syncytial Virus, Critical Care Clinics, July 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070426000175)
11. Advances and Challenges in Sepsis Care in Low-Resource Settings, Critical Care Clinics, July 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070426000151)
12. Hyperlactatemia in sepsis and shock: a renal metabolic perspective, Critical Care, 3 June 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06095-6)
13. Innovation in sepsis trials: rethinking endpoints, statistics and patient stratification, Intensive Care Medicine Experimental, 1 June 2026, [Link](https://link.springer.com/article/10.1186/s40635-026-00911-7)
14. Rapid Microbiological Diagnostics for Sepsis: Narrative Review of Current and Prospective Approaches, Critical Care Explorations, June 2026, [Link](https://journals.lww.com/ccejournal/fulltext/2026/06000/rapid%5Fmicrobiological%5Fdiagnostics%5Ffor%5Fsepsis%5F.6.aspx)
15. Respiratory infections due to human common cold coronaviruses, SARS-CoV, MERS-CoV, and SARS-CoV-2: epidemiology, pathogenesis, clinical features, diagnostics, therapeutics, and vaccine landscapes, The Lancet Respiratory Medicine, June 2026, [Link](https://www.thelancet.com/journals/lanres/article/PIIS2213-2600%2826%2900049-4/abstract)
16. Ventilator-associated pneumonia: newer insights that can drive improved outcomes, Current Opinion in Critical Care, 15 May 2026, [Link](https://journals.lww.com/co-criticalcare/abstract/9900/ventilator%5Fassociated%5Fpneumonia%5F%5Fnewer%5Finsights.361.aspx)
17. Antibiotic use in serious infections, Current Opinion in Critical Care, 5 May 2026, [Link](https://journals.lww.com/co-criticalcare/abstract/9900/antibiotic%5Fuse%5Fin%5Fserious%5Finfections.360.aspx)
18. Clinical subphenotypes and molecular endotypes in sepsis: toward an integrated and dynamic framework, Annals of Intensive Care, May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582026000956)
19. Emerging role of nucleic acid aptamers in sepsis-induced coagulopathy: Future perspectives in diagnostics and therapeutics, Annals of Intensive Care, May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S211058202502028X)
20. Physiopathology of fibrinolysis in sepsis-induced disseminated intravascular coagulation: Emerging mechanisms and pharmacological targets, Annals of Intensive Care, May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582025020229)
21. Heat Shock Protein 90 In Sepsis-Induced Cardiomyopathy: Mechanistic Insights And Emerging Therapeutic Target, Shock, 21 April 2026, [Link](https://journals.lww.com/shockjournal/abstract/9900/heat%5Fshock%5Fprotein%5F90%5Fin%5Fsepsis%5Finduced.885.aspx)
### 9- Sedation & analgesia:
1. The impact of alarm sounds on patient sleep in the intensive care unit: A scoping review, Journal of Critical Care, August 2026, [Link](https://www.sciencedirect.com/science/article/pii/S0883944126001905)
2. Target-controlled infusion for analgesia and sedation in the intensive care unit: a scoping review, Annals of Intensive Care, May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2110582026000701)
### 10- Pediatric critical care:
1. Initial identification of severely injured pediatric trauma patients—Clinical signs, scoring systems, and anticipating acute intervention needs: What you need to know, The Journal of Trauma and Acute Care Surgery, 21 May 2026, [Link](https://journals.lww.com/jtrauma/abstract/9900/initial%5Fidentification%5Fof%5Fseverely%5Finjured.1374.aspx)
### 11- Other:
1. What every intensivist should know about low value care, Journal of Critical Care, August 2026, [Link](https://www.sciencedirect.com/science/article/pii/S0883944126000870)
2. Dual-energy and photon-counting computed tomography in critical care, Journal of Critical Care, August 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S088394412600167X)
3. Assessing the quality of consent discussions in intensive care unit research: A scoping review of outcome measures, Journal of Critical Care, August 2026, [Link](https://www.sciencedirect.com/science/article/pii/S0883944126001322)
4. Infectious complications of burns in the intensive care unit, Journal of Critical Care, August 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0883944126000973)
5. Update on chemical warfare agents, BJA Edu, 2 June 2026, [Link](https://www.bjaed.org/article/S2058-5349%2826%2900043-0/abstract)
6. Triple M overlap syndrome in the intensive care unit: differential diagnosis and management, Critical Care, 29 May 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-06106-6)
7. Impact of air pollution on exacerbations of respiratory and cardiovascular diseases for the intensivist: a narrative review, ICM Experimental, 13 May 2026, [Link](https://link.springer.com/article/10.1186/s40635-026-00908-2)
8. Consent and assessing capacity in perioperative and intensive care, BJA Edu, 8 May 2026, [Link](https://www.bjaed.org/article/S2058-5349%2826%2900028-4/abstract)
---
### **Feedback & Suggestions**
Don't hesitate to share your thoughts and suggestions in the comments below; they'll be a great help in improving future issues of the newsletter.
💡
****Disclaimer:**
For educational use only; not a substitute for professional medical judgment. The papers shared in this newsletter are provided for informational purposes and do not necessarily reflect our views or clinical opinions.
See you next time :)
**Benhalima Othmane, MD.**
**Anecrit.com**
### Anecrit's Newsletter #33
URL: https://www.anecrit.com/newsletter-33/
Last updated: 2026-06-21T12:06:38.000Z
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Hey! I’m back with an extensive roundup of the latest literature in anesthesiology and critical care. Dive in and enjoy the read!
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# **Anesthesiology:**
## ***Guidelines & Consensus:***
### 1- Airway & Mechanical Ventilation:
1. Anaesthesiologic management of patients at risk of pulmonary aspiration: a Swiss consensus statement, BMC Anesthesiology, 20 April 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03835-7)
### 2- Other:
1. Perioperative management of patients taking sodium-glucose cotransporter 2 inhibitors: Society for Perioperative Assessment and Quality Improvement (SPAQI) multidisciplinary consensus statement, BJA, 30 April 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900144-3/abstract)
2. Society for Ambulatory Anesthesia Position Statement on Risk Assessment and Prophylaxis for Prevention of Venous Thromboembolism After Ambulatory Surgery: A Simplified Approach, Anesthesia & Analgesia, 20 April 2026, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/society%5Ffor%5Fambulatory%5Fanesthesia%5Fposition.1752.aspx)
---
## ***Systematic reviews & meta-analyses:***
### 1- Neuro:
1. General Anesthesia Versus Conscious Sedation for Endovascular Thrombectomy in Patients With Acute Ischemic Stroke: Updated Systematic Review and Meta-analysis of Randomized Controlled Trials, Journal of Neurosurgical Anesthesiology, 1 April 2026, [Link](https://journals.lww.com/jnsa/abstract/9900/general%5Fanesthesia%5Fversus%5Fconscious%5Fsedation%5Ffor.221.aspx)
2. Effect of perioperative esketamine administration on the incidence of postoperative delirium: a systematic review and meta-analysis, BMC Anesthesiology, 1 April 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03785-0)
### 2- Airway & Mechanical Ventilation:
1. Closed-loop systems for automated hypnotic delivery during general anesthesia: a systematic review and meta-analysis, BJA, 20 April 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900175-3/abstract)
### 3- Cardiovascular & Hemodynamics:
1. Trending Ability and Accuracy of Minimally Invasive Pulse Wave Analysis Devices: A Systematic Review and Meta-Analysis, Anesthesia & Analgesia, 6 April 2026, [Link](https://journals.lww.com/anesthesia-analgesia/abstract/9900/trending%5Fability%5Fand%5Faccuracy%5Fof%5Fminimally.1745.aspx)
2. Hypotension Prediction Index-Guided Hemodynamic Management on Postoperative Organ Outcome: A Systematic Review and Meta-Analysis of Randomized Clinical Trials, A&A Practice, April 2026, [Link](https://journals.lww.com/aacr/abstract/2026/04000/hypotension%5Fprediction%5Findex%5Fguided%5Fhemodynamic.16.aspx)
3. Landiolol for the prevention of postoperative atrial fibrillation after cardiac surgery: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials, Anaesthesia Critical Care & Pain Medicine, 30 March 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556826001001)
### 4- Thoracic:
1. Incidence and Associations of Acute Kidney Injury after Lung Resection Surgery: A Systematic Review and Meta-Analysis, Journal of Cardiothoracic and Vascular Anesthesia, 25 April 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S105307702600354X)
2. Effects of perioperative intravenous lidocaine on postoperative recovery quality in thoracoscopic surgery: a systematic review and meta-analysis, BMC Anesthesiology, 31 March 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03794-z)
### 5- Abdomen:
1. Efficacy and Safety of Ketamine or Esketamine versus Fentanyl-Class Opioids as Adjuncts to Propofol for Gastrointestinal Endoscopy: A Systematic Review and Meta-Analysis, A&A Practice, April 2026, [Link](https://journals.lww.com/aacr/abstract/2026/04000/efficacy%5Fand%5Fsafety%5Fof%5Fketamine%5For%5Fesketamine.9.aspx)
### 6- General:
1. Remimazolam-based total intravenous vs. sevoflurane-based balanced general anesthesia on perioperative outcomes in adult surgical patients: a systematic review and meta-analysis, BMC Anesthesiology, 31 March 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03787-y)
### 7- Pediatric:
1. Postanesthesia Apnea in Former Preterm Infants for Inguinal Herniorrhaphy: An Update of Risk Factors from an Individual Participant Data Meta-analysis, Anesthesiology, 30 March 2026, [Link](https://journals.lww.com/anesthesiology/abstract/9900/postanesthesia%5Fapnea%5Fin%5Fformer%5Fpreterm%5Finfants%5Ffor.940.aspx)
### 8- Regional Anesthesia & Pain Management:
1. The multifaceted neural architecture of pain modulation by emotion and cognition: a systematic review and meta-analysis, BJA, 30 April 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900160-1/fulltext)
2. External Oblique Intercostal Plane Block for Postoperative Analgesia in Thoracoabdominal Procedures: A Systematic Review and meta-analysis, *The Clinical Journal of Pain*, 24 April 2026, [Link](https://journals.lww.com/clinicalpain/abstract/9900/external%5Foblique%5Fintercostal%5Fplane%5Fblock%5Ffor.351.aspx)
3. Comparison of liposomal bupivacaine and regular bupivacaine in the transversus abdominis plane for postoperative analgesia: an updated systematic review and meta-analysis, BMC Anesthesiology, 21 April 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03852-6)
4. Efficacy comparison of articaine versus lidocaine in dental anesthesia: a meta-analysis of randomized controlled trials, BMC Anesthesiology, 18 April 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03831-x)
5. Intranasal analgesia as an alternative to intravenous therapy for acute pain in adult emergency department patients: a systematic review, *European Journal of Emergency Medicine*, 13 April 2026, [Link](https://journals.lww.com/euro-emergencymed/abstract/9900/intranasal%5Fanalgesia%5Fas%5Fan%5Falternative%5Fto.233.aspx)
6. Transversus Abdominis Plane Block With Dexmedetomidine and Local Anesthetics compared with Local Anesthetics Isolated for Patients Undergoing Cesarean Section: A Systematic Review and Meta-Analysis, *The Clinical Journal of Pain*, 6 April 2026, [Link](https://journals.lww.com/clinicalpain/abstract/9900/transversus%5Fabdominis%5Fplane%5Fblock%5Fwith.346.aspx)
7. Analgesic Effects of Intravenous Lidocaine in Laparoscopic Surgery: A Systematic Review and Meta-analysis With Trial Sequential Analysis, *The Clinical Journal of Pain*, 2 April 2026, [Link](https://journals.lww.com/clinicalpain/abstract/9900/analgesic%5Feffects%5Fof%5Fintravenous%5Flidocaine%5Fin.344.aspx)
### 9- Other:
1. Pharmacotherapeutic interventions to improve postoperative sleep quality in older adult patients: a systematic review and meta-analysis, BJA, 15 April 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900156-X/abstract)
---
## ***Clinical trials:***
### 1- Neuro:
1. Efficacy and safety evaluation of intravenous esketamine in alleviating perioperative depressive symptoms in Parkinson’s disease: a randomized controlled trial, BMC Anesthesiology, 15 April 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03839-3)
2. Apolipoprotein E Mimetic Peptide CN-105 and Postoperative Delirium in Older Patients: The Phase 2 MARBLE Randomized Clinical Trial, JAMA Open, 3 April 2026, [Link](https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2847294)
### 2- Airway & Mechanical Ventilation:
1. Evaluation of clinical impact of ultra fast-track versus conventional extubation in patients undergoing nonemergency cardiac surgery: ‘CARDU-FAST’: A randomised clinical trial, European Journal of Anaesthesiology, 28 April 2026, [Link](https://journals.lww.com/ejanaesthesiology/abstract/9900/evaluation%5Fof%5Fclinical%5Fimpact%5Fof%5Fultra%5Ffast%5Ftrack.418.aspx)
2. Effect of different administration times of dexmedetomidine on the ED50 of sufentanil to inhibit the cardiovascular response in elderly patients with double lumen tracheal intubation: a randomized controlled trial, BMC Anesthesiology, 28 April 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03747-6)
3. Videolaryngoscopy *versus* direct laryngoscopy for double-lumen tube intubation: the DOuble-Lumen intubation with VIdeolaryngoscopy (DOLVI) multicentre randomised trial, BJA, 24 April 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900207-2/abstract)
4. EIT-guided individualized PEEP titration versus conventional lung-protective ventilation to prevent pulmonary complications in laparoscopic bariatric surgery: a study protocol for a randomized controlled trial, BMC Anesthesiology, 24 April 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03853-5)
5. Comparison of hemodynamic responses to endotracheal intubation with oliceridine and sufentanil during induction: a randomized controlled trial, BMC Anesthesiology, 23 April 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03825-9)
6. Effect of intermittent recruitment manoeuvre combined with PEEP on postoperative atelectasis in obese patients: a randomized controlled trial, BMC Anesthesiology, 13 April 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03808-w)
7. Individualised positive end-expiratory pressure to minimize driving pressure and postoperative pulmonary complications in minimally invasive thoracic and abdominal surgery: a systematic review and meta-analysis, BJA, 10 April 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900161-3/fulltext)
8. High-Flow Nasal Oxygen Therapy After Cardiac Surgery: A Randomized Clinical Trial, JAMA Open, 8 April 2026, [Link](https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2847515)
9. Effects of different pneumoperitoneum pressures on the upper airway assessed by ultrasonography: a prospective, randomized, observer-blinded clinical study, BMC Anesthesiology, 6 April 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03801-3)
10. Hemodynamic Response to Intubation with Four Different Laryngoscopes in CABG Surgery: A Randomized Trial, Journal of Cardiothoracic and Vascular Anesthesia, 5 April 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S105307702600282X)
11. Comparison of Time for Endotracheal Intubation with Flexible Tip Bougie Versus Standard Bougie During Videolaryngoscopy in Simulated Cervical Spine Immobilization in Adult Patients - A Randomized Control Trial, Anaesthesia Critical Care & Pain Medicine, 1 April 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556826001013)
### 3- Cardiovascular & Hemodynamics:
1. Effect of two-session remote ischaemic preconditioning on myocardial injury after noncardiac surgery in patients undergoing abdominal surgery: randomised clinical trial, BJA, 21 April 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900187-X/abstract)
2. Methemoglobin Formation Reflects Systemic Nitric Oxide Uptake: The Critical Role of Delivery Method. Results from Secondary Analysis of a Randomized Controlled Trial, Journal of Cardiothoracic and Vascular Anesthesia, 17 April 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026003484)
3. Preemptive noradrenaline infusion: a game-changer against post-induction hypotension in surgical sepsis: a randomized double blind trial, BMC Anesthesiology, 11 April 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03783-2)
4. High-Flow Nasal Oxygen Therapy After Cardiac Surgery: A Randomized Clinical Trial, JAMA Open, 8 April 2026, [Link](https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2847515)
5. Comparing Clinical Outcomes in Cardiac Surgical Patients Who Receive Sugammadex Versus Placebo: A Prospective Randomized Blinded Controlled Trial, Critical Care Explorations, April 2026, [Link](https://journals.lww.com/ccejournal/pages/articleviewer.aspx?year=2026&issue=04000&article=00014&type=Fulltext)
### 4- Thoracic:
1. Two-Lung Ventilation Attenuates Systemic Inflammatory and Oxidative Stress Responses During Thoracic Surgery: A Randomized Clinical Trial, Journal of Cardiothoracic and Vascular Anesthesia, 24 April 2026, [Link](https://www.sciencedirect.com/science/article/pii/S1053077026003538)
2. Effect of different lung recruitment maneuvers on postoperative respiratory outcomes and lung aeration, assessed by lung ultrasound, in patients undergoing thoracoscopic sympathectomy: a randomized controlled trial, BMC Anesthesiology, 30 March 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03790-3)
### 5- Abdomen:
1. Effect of dexmedetomidine on recovery of postoperative gastrointestinal function in patients with adhesive bowel obstruction: a single-center randomized clinical trial, BMC Anesthesiology, 1 April 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03732-z)
### 6- General:
1. Feasibility pilot trial for the Trajectories of Recovery after Intravenous propofol versus inhaled VolatilE anesthesia (THRIVE) Pragmatic Randomized Clinical Trial, Anesthesiology, 8 April 2026, [Link](https://journals.lww.com/anesthesiology/abstract/9900/feasibility%5Fpilot%5Ftrial%5Ffor%5Fthe%5Ftrajectories%5Fof.958.aspx)
### 7- Obstetrics & Gynecology:
1. The effect of intravenous ondansetron on maternal spinal-induced hypotension in preeclamptic patients undergoing caesarean delivery: A randomised, controlled clinical trial, European Journal of Anaesthesiology, 30 April 2026, [Link](https://journals.lww.com/ejanaesthesiology/abstract/9900/the%5Feffect%5Fof%5Fintravenous%5Fondansetron%5Fon%5Fmaternal.419.aspx)
2. Impact of maltodestrin intake in elective cesarean section: A randomized study, Clinical Nutrition ESPEN, 29 April 2026, [Link](https://www.clinicalnutritionespen.com/article/S2405-4577%2826%2900404-3/fulltext)
3. Impact of esketamine-based opioid-free anesthesia on quality of recovery after laparoscopic hysterectomy: a randomized controlled trial using the QoR-40 questionnaire, BMC Anesthesiology, 29 April 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03863-3)
4. High-dose *versus* low-dose dexamethasone for postoperative analgesia after Caesarean delivery: a randomised, double-blind, two-centre trial, BJA, 13 April 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900093-0/abstract)
5. Comparison of fractionated versus bolus administration of different doses of hyperbaric bupivacaine combined with opioids in spinal anesthesia for caesarean section – a prospective, randomized, participant-blind clinical trial, BMC Anesthesiology, 7 April 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03813-z)
6. Effect of Local Anesthetic Solution at Different Temperatures for Epidural Labor Analgesia on Intrapartum Fever: A Randomized Clinical Trial, Anesthesia & Analgesia, 6 April 2026, [Link](https://journals.lww.com/anesthesia-analgesia/abstract/9900/effect%5Fof%5Flocal%5Fanesthetic%5Fsolution%5Fat%5Fdifferent.1744.aspx)
### 8- Pediatric:
1. Symptom-Based Dosing for Neonatal Opioid Withdrawal: The OPTimize NOW Randomized Clinical Trial, JAMA, 25 April 2026, [Link](https://jamanetwork.com/journals/jama/article-abstract/2848412)
2. Effective doses of remimazolam for sedation in paediatric magnetic resonance imaging following dexmedetomidine premedication: a dose-finding study, BMC Anesthesiology, 20 April 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03848-2)
3. Effect of General Anesthesia Combined With Single-Shot, Single-Level Thoracic Paravertebral Block on Postoperative Analgesia in Children Undergoing Thoracoscopic Mediastinal Tumour Resection: A Randomized Controlled Trial, Journal of Cardiothoracic and Vascular Anesthesia, 15 April 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026003393)
4. Comparing pericapsular nerve group block and fascia iliaca compartment block for intraoperative and postoperative analgesia in hip surgeries in pediatrics: a randomized controlled trial, BMC Anesthesiology, 15 April 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03810-2)
5. Palonosetron and dexamethasone for the prophylaxis of nausea and vomiting in children undergoing strabismus surgery: A randomised, double-blind clinical trial, European Journal of Anaesthesiology, 3 April 2026, [Link](https://journals.lww.com/ejanaesthesiology/citation/9900/palonosetron%5Fand%5Fdexamethasone%5Ffor%5Fthe%5Fprophylaxis.412.aspx)
6. Median effective dose (ED50) of esketamine combined with different doses of propofol for children to inhibit the response to gastroscope insertion: a prospective dose–response clinical study, BMC Anesthesiology, 2 April 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03793-0)
### 9- Orthopedic:
1. Intrawound Tobramycin Plus Vancomycin to Prevent Surgical Site Infection in Tibial Fractures: The TOBRA Randomized Clinical Trial, JAMA, 15 April 2026, [Link](https://jamanetwork.com/journals/jama/fullarticle/2847582)
2. The effect of preemptive intravenous paracetamol-mannitol on postoperative analgesia and quality of recovery in elderly patients undergoing total hip arthroplasty, BMC Anesthesiology, 9 April 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03815-x)
### 10- Regional Anesthesia & Pain Management:
1. Effect of 16-gauge needle as needle-over-needle guidance introducer in single-operator real-time ultrasound-guided spinal anesthesia: a randomized controlled trial, BMC Anesthesiology, 14 April 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03822-y)
2. Safety and efficacy of dexmedetomidine in combination with ropivacaine for lumbar paravertebral block in posterior lumbar surgery: a randomized controlled trial, BMC Anesthesiology, 7 April 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03782-3)
3. Comparison of ultrasound-guided erector spinae plane block and transversus abdominis plane block for postoperative analgesia after laparoscopic hysterectomy: a prospective randomized non-inferiority clinical trial, BMC Anesthesiology, 2 April 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03799-8)
4. Efficacy of coadministration of calcitonin and hyperbaric bupivacaine in spinal anesthesia for unilateral open inguinal hernia repair in tramadol abuse patients: a randomized controlled trial, BMC Anesthesiology, 28 March 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03736-9)
### 11- Other:
1. A comparison of ciprofol-nalbuphine versus propofol-nalbuphine on safety and efficacy during gastrointestinal endoscopy: a randomized controlled trial, BMC Anesthesiology, 24 April 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03860-6)
2. Effect of intraoperative CO₂-targeted ventilation on postoperative grip strength recovery in older patients undergoing open abdominal surgery: a randomized controlled trial, BMC Anesthesiology, 15 April 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03795-y)
3. 3D models and simulations training improves TEE performance on pediatric patients with simple valvular congenital heart disease compared to traditional apprenticeship training: a clinical randomized controlled trial, BMC Anesthesiology, 29 March 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03769-0)
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---
## ***Reviews:***
### 1- AI:
1. Generative Artificial Intelligence in Anesthesiology: Current Evidence, Clinical Applications, and the Emerging Role of Small Models, Anesthesiology, 6 April 2026, [Link](https://journals.lww.com/anesthesiology/citation/9900/generative%5Fartificial%5Fintelligence%5Fin.948.aspx)
2. Personalizing anesthetic management in trauma patients using machine learning, Current Opinion in Anesthesiology, 23 March 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/personalizing%5Fanesthetic%5Fmanagement%5Fin%5Ftrauma.414.aspx)
### 2- Neuro:
1. Intraoperative electroencephalographic burst suppression: a narrative review and clinical framework for interpretation and management, BJA, 20 April 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900143-1/abstract)
### 3- Airway & Mechanical Ventilation:
1. Airway ultrasound in anesthesia training: a scoping review, BJA, 22 April 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900167-4/abstract)
2. Practical integration of bedside real-time lung ultrasound and electrical impedance tomography for guiding personalized perioperative lung protective ventilation in cardiothoracic and vascular anesthesia, Journal of Cardiothoracic and Vascular Anesthesia, 28 March 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026002818)
### 4- Cardiovascular & Hemodynamics:
1. 2025 Update on Vascular Anesthesia, Journal of Cardiothoracic and Vascular Anesthesia, 25 April 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026003575)
2. “Sinus of Valsalva Aneurysm: An Anesthesiologist’s Perspective and Narrative Review”, Journal of Cardiothoracic and Vascular Anesthesia, 22 April 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026003551)
3. The Year in Perioperative Echocardiography: Selected Highlights from 2025, Journal of Cardiothoracic and Vascular Anesthesia, 18 April 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026003368)
4. Physiology, monitoring, and optimization of perioperative tissue oxygenation: a narrative review, BJA, 13 April 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900120-0/fulltext)
5. Atrial Functional Mitral Regurgitation: Contemporary Mechanisms, Imaging, and Perioperative Implications for Cardiothoracic Anesthesiologists and Intensivists, Journal of Cardiothoracic and Vascular Anesthesia, 7 April 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026002983)
6. Postoperative Cognitive Dysfunction and Analgesic Outcomes in Cardiac Surgery: Evaluating the Role of Nerve Block Techniques, The Clinical Journal of Pain, 3 April 2026, [Link](https://journals.lww.com/clinicalpain/abstract/9900/postoperative%5Fcognitive%5Fdysfunction%5Fand%5Fanalgesic.345.aspx)
7. Perioperative management of adults with heart valve disease having noncardiac surgery: a narrative review, Current Opinion in Anesthesiology, 19 March 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/perioperative%5Fmanagement%5Fof%5Fadults%5Fwith%5Fheart.413.aspx)
8. Coronary vasomotor dysfunction and anesthesia management in noncardiac surgery, Current Opinion in Anesthesiology, 19 March 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/coronary%5Fvasomotor%5Fdysfunction%5Fand%5Fanesthesia.412.aspx)
### 5- General:
1. Viscoelastic Coagulation Testing in the Perioperative Period – Pros and Cons, Current Anesthesiology Reports, 14 April 2026, [Link](https://link.springer.com/article/10.1007/s40140-026-00704-4)
2. Perioperative Cardiovascular Medication Management for Noncardiac Surgery, JAMA, 31 March 2026, [Link](https://jamanetwork.com/journals/jama/article-abstract/2846882)
3. Perioperative anesthesia care for patients with diabetes mellitus: a review of current literature with focus on oral antidiabetic medication, Current Opinion in Anesthesiology, 19 March 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/perioperative%5Fanesthesia%5Fcare%5Ffor%5Fpatients%5Fwith.411.aspx)
4. Liver disease and general anesthesia: what the anesthesiologist needs to know, Current Opinion in Anesthesiology, 17 March 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/liver%5Fdisease%5Fand%5Fgeneral%5Fanesthesia%5F%5Fwhat%5Fthe.408.aspx)
5. Glucagon-like peptide-1 drugs, gastrointestinal function and critical illness, Current Opinion in Critical Care, 4 March 2026, [Link](https://journals.lww.com/co-criticalcare/abstract/9900/glucagon%5Flike%5Fpeptide%5F1%5Fdrugs,%5Fgastrointestinal.349.aspx)
### 6- Obstetrics & Gynecology:
1. Maternal cardiac arrest: a simulation-based review of anesthetic protocols and perimortem cesarean delivery, Current Opinion in Anesthesiology, June 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/2026/06000/maternal%5Fcardiac%5Farrest%5F%5Fa%5Fsimulation%5Fbased%5Freview.7.aspx)
2. Left ventricular cardiomyopathies in pregnancy: clinical challenges, diagnosis, and management, Current Opinion in Anesthesiology, 17 March 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/left%5Fventricular%5Fcardiomyopathies%5Fin%5Fpregnancy%5F.410.aspx)
### 7- Pediatric:
1. The future of pediatric airway management, Current Opinion in Anesthesiology, June 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/2026/06000/the%5Ffuture%5Fof%5Fpediatric%5Fairway%5Fmanagement.17.aspx)
2. Let’s talk about Leadership in Pediatric Anesthesia!, Current Opinion in Anesthesiology, June 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/2026/06000/let%5Fs%5Ftalk%5Fabout%5Fleadership%5Fin%5Fpaediatric.19.aspx)
3. Anaesthesia for paediatric liver transplantation, BJA Edu, 29 April 2026, [Link](https://www.bjaed.org/article/S2058-5349%2826%2900021-1/abstract)
4. Remimazolam in pediatric sedation and anesthesia: current perspectives and clinical considerations, Journal of Intensive Care, 15 April 2026, [Link](https://link.springer.com/article/10.1186/s40560-026-00881-8)
5. Prevalence, Expression, Assessment, Mechanisms, and Management of Pain in Autistic Children: A Scoping Review, *A & A Practice*, April 2026, [Link](https://journals.lww.com/aacr/abstract/2026/04000/prevalence,%5Fexpression,%5Fassessment,%5Fmechanisms,.6.aspx)
6. Pediatric anesthesia as a navigator: current practice and hot topics in preoperative assessment, *Current Opinion in Anesthesiology*, 17 March 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/pediatric%5Fanesthesia%5Fas%5Fa%5Fnavigator%5F%5Fcurrent.407.aspx)
7. Current controversies in pediatric regional anesthesia, Current Opinion in Anesthesiology, 17 March 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/current%5Fcontroversies%5Fin%5Fpaediatric%5Fregional.409.aspx)
### 8- Regional Anesthesia & Pain Management:
1. Beyond Unconsciousness: Optimizing Antinociception during General Anesthesia, Anesthesiology, 29 April 2026, [Link](https://journals.lww.com/anesthesiology/abstract/9900/beyond%5Funconsciousness%5F%5Foptimizing%5Fantinociception.990.aspx)
2. Interventions for managing pain after traumatic peripheral nerve injury, BJA Edu, 9 April 2026, [Link](https://www.bjaed.org/article/S2058-5349%2826%2900020-X/abstract)
### 9- Other:
1. Frailty in anesthesia, Current Opinion in Anesthesiology, June 2026, [Link](https://journals.lww.com/co-anesthesiology/fulltext/2026/06000/frailty%5Fin%5Fanesthesia.27.aspx)
2. Improving efficiency and workflows in the nonoperating room anesthesia setting, Current Opinion in Anesthesiology, 27 April 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/improving%5Fefficiency%5Fand%5Fworkflows%5Fin%5Fthe.422.aspx)
3. Traditional learning meets adaptive learning: the present and future of education in nonoperating room anesthesia, *Current Opinion in Anesthesiology*, 27 April 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/traditional%5Flearning%5Fmeets%5Fadaptive%5Flearning%5F%5Fthe.426.aspx)
4. Applying enhanced recovery after surgery principles to the nonoperating room anesthesia environment: rationale, current evidence, and future directions, Current Opinion in Anesthesiology, 27 April 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/applying%5Fenhanced%5Frecovery%5Fafter%5Fsurgery.424.aspx)
5. Anesthetic techniques and outcomes in nonoperating room anesthesia, Current Opinion in Anesthesiology, 27 April 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/anesthetic%5Ftechniques%5Fand%5Foutcomes%5Fin%5Fnonoperating.425.aspx)
6. Defining estimands in anesthesia clinical trials: a scoping review and framework, BJA, 20 April 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900183-2/fulltext)
7. Sustainable Anesthesia: A Scoping Review of Carbon Reduction Strategies, Anesthesia & Analgesia, 20 April 2026, [Link](https://journals.lww.com/anesthesia-analgesia/abstract/9900/sustainable%5Fanesthesia%5F%5Fa%5Fscoping%5Freview%5Fof%5Fcarbon.1753.aspx)
8. How team debriefings can transform anesthesia culture, BJA Edu, 9 April 2026, [Link](https://www.bjaed.org/article/S2058-5349%2826%2900019-3/fulltext)
9. Intravenous iron for perioperative anemia: recent advances, practical considerations, and future directions, Current Opinion in Anesthesiology, 31 March 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/intravenous%5Firon%5Ffor%5Fperioperative%5Fanemia%5F%5Frecent.416.aspx)
10. Dexmedetomidine: an update, Current Opinion in Anesthesiology, 31 March 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/dexmedetomidine%5F%5Fan%5Fupdate.417.aspx)
11. Xenon anesthesia: shedding light on brain dynamics and clinical niches, Current Opinion in Anesthesiology, 31 March 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/xenon%5Fanesthesia%5F%5Fshedding%5Flight%5Fon%5Fbrain%5Fdynamics.415.aspx)
---
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# **Critical Care:**
## ***Guidelines & Consensus:***
### 1- AI:
1. AI Models for Surgical Decision Support in Spontaneous Intracerebral Hemorrhage: A Systematic Review in Relation to Trials and Guidelines, Neurocritical Care, 6 April 2026, [Link](https://link.springer.com/article/10.1007/s12028-026-02501-7)
### 2- Thorax/Lungs/Airways/Mechanical ventilation:
1. Defining the Resolution of Acute Respiratory Distress Syndrome: A Delphi Consensus Study, Critical Care Medicine, 2 April 2026, [Link](https://journals.lww.com/ccmjournal/abstract/9900/defining%5Fthe%5Fresolution%5Fof%5Facute%5Frespiratory.804.aspx)
### 3- Neuro-muscular:
1. Consensus statement from the 2025 Delphi panel on cerebral microdialysis in critical care, Critical Care, 13 April 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-05993-z)
2. Guidelines for Neuroprognostication in Critically ill Adults with Acute Ischemic Stroke, Neurocritical Care, 6 April 2026, [Link](https://link.springer.com/article/10.1007/s12028-026-02486-3)
3. Teleneurocritical Care (TeleNCC) Consensus Statement: The American Academy of Neurology (AAN), the American Association of Neurological Surgeons (AANS), and the Congress of Neurological Surgeons (CNS) affirm the value of this statement. Endorsed by the American Telemedicine Association (ATA), Neurocritical Care, 6 April 2026, [Link](https://link.springer.com/article/10.1007/s12028-025-02445-4)
4. A Modified Delphi Consensus-Based Comprehensive Checklist and Angoff Standard for Assessment of Competency in Brain Death/Death by Neurologic Criteria Determination, Critical Care Medicine, 30 March 2026, [Link](https://journals.lww.com/ccmjournal/abstract/9900/a%5Fmodified%5Fdelphi%5Fconsensus%5Fbased%5Fcomprehensive.797.aspx)
### 4- Blood & hemostasis:
1. Revised French military transfusion doctrine for large-scale combat operations: a consensus framework, Critical Care, 10 April 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-05862-9)
### 5- Kidney:
1. KDIGO 2026 Clinical practice guidelines for acute kidney injury (AKI) and acute kidney disease (AKD): Public review draft, March 2026, [Link](https://kdigo.org/wp-content/uploads/2026/03/KDIGO-2026-AKI-AKD-Guideline-Public-Review-Draft-March-2026.pdf)
### 6- Pediatric critical care:
1. Determining a Consensus-Based Measure for Critical Illness and Injury for Children Cared for By Emergency Medical Services, Pediatric Emergency Care, 20 April 2026, [Link](https://journals.lww.com/pec-online/abstract/9900/determining%5Fa%5Fconsensus%5Fbased%5Fmeasure%5Ffor%5Fcritical.826.aspx)
2. Evaluation and Management of the Child With Acute Decompensated Heart Failure: A Scientific Statement From the American Heart Association, Circulation, 6 April 2026, [Link](https://www.ahajournals.org/doi/10.1161/CIR.0000000000001428)
3. Consensus-based criteria for actionable hemorrhage in pediatric trauma: A Delphi study, The Journal of Trauma and Acute Care Surgery, 24 March 2026, [Link](https://journals.lww.com/jtrauma/abstract/9900/consensus%5Fbased%5Fcriteria%5Ffor%5Factionable%5Fhemorrhage.1291.aspx)
### 7- Other:
1. Challenges and Recommendations for Integrating Circadian Medicine in Critical Care: A Roadmap, CHEST, April 2026, [Link](https://www.sciencedirect.com/science/article/pii/S0012369225059318)
##
---
## ***Systematic reviews & meta-analyses:***
### 1- AI:
1. Use of Artificial Intelligence to Predict Outcomes in Critically Ill Patients Receiving Extracorporeal Membrane Oxygenation: A Systematic Review, Journal of Cardiothoracic and Vascular Anesthesia, 29 March 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026002806)
2. A Systematic Review Of Machine Learning Models For Sepsis Prediction: An Appraise-AI Approach, Shock, 20 March 2026, [Link](https://journals.lww.com/shockjournal/abstract/9900/a%5Fsystematic%5Freview%5Fof%5Fmachine%5Flearning%5Fmodels%5Ffor.866.aspx)
### 2- Cardiovascular & Hemodynamics:
1. The use of supplemental oxygen during cardiopulmonary resuscitation – A systematic review of the literature, Resuscitation Plus, 27 April 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2666520426001189)
2. An overview of reviews of Angiotensin II in distributive shock, BMC Anesthesiology, 6 April 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03797-w)
3. A Meta-Analytic Perspective on Echocardiographic Signs of Long-Term Cardiac Dysfunction After Burns, Sepsis, and Trauma, Shock, 3 April 2026, [Link](https://journals.lww.com/shockjournal/abstract/9900/a%5Fmeta%5Fanalytic%5Fperspective%5Fon%5Fechocardiographic.875.aspx)
4. Mechanical versus manual chest compression in cardiac arrest: a systematic review, Resuscitation Plus, 1 April 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2666520426000962)
5. Percutaneous Decannulation versus Open Surgical Decannulation in Patients Weaned from Venoarterial Extracorporeal Membrane Oxygenation: A Systematic Review and Meta-Analysis, Journal of Cardiothoracic and Vascular Anesthesia, 3 April 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S105307702600251X)
6. Resuscitative endovascular balloon occlusion of the aorta versus resuscitative thoracotomy for noncompressible torso hemorrhage: A systematic review and meta-analysis, The Journal of Trauma and Acute Care Surgery, 26 March 2026, [Link](https://journals.lww.com/jtrauma/abstract/9900/resuscitative%5Fendovascular%5Fballoon%5Focclusion%5Fof.1297.aspx)
### 3- Thorax/Lungs/Airways/Mechanical ventilation:
1. Ventilation parameters during adult cardiopulmonary resuscitation: a systematic review, Resuscitation Plus, May 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2666520426000846)
2. Non-invasive respiratory supports and criteria for intubation in randomized trials of acute hypoxaemic respiratory failure: a systematic review and network meta-analysis, The Lancet Respiratory Medicine, 22 April 2026, [Link](https://www.thelancet.com/journals/lanres/article/PIIS2213-2600%2826%2900039-1/abstract)
3. Overuse of imaging for pulmonary embolism in emergency departments: a systematic review and meta-analysis, International Journal of Emergency Medicine, 17 April 2026, [Link](https://link.springer.com/article/10.1186/s12245-026-01228-8)
4. Noninvasive respiratory support strategies in chest trauma: A systematic review and network meta-analysis, The Journal of Trauma and Acute Care Surgery, 16 April 2026, [Link](https://journals.lww.com/jtrauma/abstract/9900/noninvasive%5Frespiratory%5Fsupport%5Fstrategies%5Fin.1319.aspx)
5. Neuromuscular blocking agents for tracheal intubation of critically ill adults: a systematic review and meta-analysis, European Journal of Emergency Medicine, 9 April 2026, [Link](https://journals.lww.com/euro-emergencymed/abstract/9900/neuromuscular%5Fblocking%5Fagents%5Ffor%5Ftracheal.232.aspx)
6. Ketamine *versus* alternative agents to prevent postinduction hemodynamic instability during tracheal intubation of critically ill adults: a systematic review and meta-analysis, BJA, 7 April 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900132-7/fulltext)
7. Efficacy of video laryngoscopy versus direct laryngoscopy for critically Ill adults undergoing tracheal intubation: a trial sequential analysis and meta-analysis, BMC Anesthesiology, 6 April 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03788-x)
8. Complications in acute respiratory distress syndrome: a systematic review and meta-analysis, Critical Care, 29 March 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-05978-y)
### 4- Neuro-muscular:
1. Association Between Sex and Mortality After Traumatic Brain Injury: A Systematic Review and Meta-Analysis, Neurocritical Care, 24 April 2026, [Link](https://link.springer.com/article/10.1007/s12028-026-02521-3)
2. Blood-based biomarkers and delirium in critically ill adults in the ICU: a systematic review, Intensive Care Medicine Experimental, 20 April 2026, [Link](https://link.springer.com/article/10.1186/s40635-026-00894-5)
3. Stereotactic Drainage Treatment is Associated with Improved Long-Term Neurological Recovery in Small-to-Moderate Volume Basal Ganglia Hemorrhages: A Systematic Review and Meta-Analysis, Neurocritical Care, 20 April 2026, [Link](https://link.springer.com/article/10.1007/s12028-026-02527-x)
4. Intensive Versus Standard Blood Pressure Control After Endovascular Thrombectomy in Acute Ischemic Stroke: A Meta‐Analysis of Randomized Controlled Trials, Journal of the American Heart Association
, 16 April 2026, [Link](https://www.ahajournals.org/doi/10.1161/JAHA.125.045503)
5. Remote Ischemic Conditioning After Subarachnoid Hemorrhage: A Systematic Review and Meta-analysis, Neurocritical Care, 13 April 2026, [Link](https://link.springer.com/article/10.1007/s12028-026-02497-0)
6. Effect of immunomodulation on post-cardiac arrest brain injury: A systematic review and meta-analysis, Resuscitation, 11 April 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0300957226001371)
7. Red blood cell transfusion in neurocritical patients: an updated systematic review and meta-analysis, BMC Anesthesiology, 31 March 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03796-x)
8. Effects of lactate-based therapies on intracranial pressure and brain metabolism of patients with acute brain injury: a systematic review, Critical Care, 27 March 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-05973-3)
### 5- Renal:
1. Implementation of a kidney protection strategy to prevent acute kidney injury after major surgery in high-risk patients identified by biomarkers: a systematic review and individual participant data meta-analysis of randomized controlled trials, Intensive Care Medicine, 20 April 2026, [Link](https://link.springer.com/article/10.1007/s00134-026-08399-1)
### 6- Trauma:
1. End-tidal carbon dioxide as a predictor of mortality in trauma patients: A systematic review and meta-analysis, The Journal of Trauma and Acute Care Surgery, 24 March 2026, [Link](https://journals.lww.com/jtrauma/abstract/9900/end%5Ftidal%5Fcarbon%5Fdioxide%5Fas%5Fa%5Fpredictor%5Fof.1292.aspx)
### 7- Blood & hemostasis:
1. Clinical Outcomes of Different Heparin Anticoagulation Monitoring Targets in Extracorporeal Membrane Oxygenation: A Systematic Review and Meta-Analysis, Journal of Cardiothoracic and Vascular Anesthesia, 20 April 2026, [Link](https://www.sciencedirect.com/science/article/pii/S1053077026003277)
### 8- Nutrition:
1. Comparison of the effects of different types of nasointestinal tube placement techniques for ICU patients: a Bayesian network meta-analysis, BMC Anesthesiology, 14 April 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03828-6)
2. Ultrasound assessment of muscle atrophy and its association with functional outcomes in critically ill patients: a systematic review and meta-analysis, Critical Care, 31 March 2026, [Link](https://link.springer.com/article/10.1186/s13054-025-05825-6)
### 9- Pediatric critical care:
1. Ketamine for Analgosedation in Critically Ill Mechanically Ventilated Children: A Systematic Review and Meta-Analysis, Critical Care Explorations, May 2026, [Link](https://journals.lww.com/ccejournal/fulltext/2026/05000/ketamine%5Ffor%5Fanalgosedation%5Fin%5Fcritically%5Fill.2.aspx)
2. First attempt Success rate of Intraosseous Access in Preterm Infants and Neonates: A Systematic Review, Resuscitation Plus, 16 April 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2666520426001190)
### 10- Other:
1. Representation and reporting of patients with cancer in mortality-focused adult ICU randomized trials: a systematic review, BMC Anesthesiology, 20 April 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03840-w)
---
## ***Clinical trials:***
_This post is for subscribers only._
### Anecrit's Newsletter #32
URL: https://www.anecrit.com/newsletter-32/
Last updated: 2026-06-21T12:06:47.000Z
Hey there!
The past two weeks have been remarkably productive for new publications. Between the 2026 Surviving Sepsis Campaign guidelines and several high-impact clinical trials, there is a lot to cover. Enjoy the read! **P.S.** I haven’t forgotten the second part of our previous clinical case—I’ve got you covered.
###
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---
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# **Anesthesiology:**
## ***Guidelines & Consensus:***
### 1- AI:
1. Contextualizing AI Evaluation in Anesthesiology: Interpreting Predictive Modeling and Reinforcement Learning Metrics Across Clinical Use Cases—An Expert Statement From the Society of Technology in Anesthesia, *Anesthesia & Analgesia*, 12 March 2026, [Link](https://journals.lww.com/anesthesia-analgesia/citation/9900/contextualizing%5Fai%5Fevaluation%5Fin%5Fanesthesiology%5F.1716.aspx)
### 2- General:
1. Guidelines on Preventing Medication Errors in Anaesthesia and Intensive Care, Anaesthesia Critical Care & Pain Medicine, April 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556825002504)
---
## ***Systematic reviews & meta-analyses:***
### 1- General:
1. Comparative safety of esketamine in procedural sedation and analgesia: a systematic review and network meta-analysis, BMC Anesthesiology, 14 March 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03673-7)
2. The involvement of anaesthetists and other healthcare professionals with surgeons in shared decision-making for adult patients contemplating surgery: a systematic review and narrative analysis, BJA Open, March 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2772609626000171)
### 2- Cardiovascular & Hemodynamics:
1. Impact of hypotension prediction index-guided management on intraoperative hypotension and postoperative outcomes in abdominal surgery: A meta-analysis of randomized controlled trials, Anaesthesia Critical Care & Pain Medicine, April 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2352556825001882)
### 3- Obstetrics & Gynecology:
1. Does peripartum intravenous calcium administration reduce the occurrence of uterine atony in caesarean sections? A systematic review and meta-analysis, *European Journal of Anaesthesiology*, 24 March 2026, [Link](https://journals.lww.com/ejanaesthesiology/citation/9900/does%5Fperipartum%5Fintravenous%5Fcalcium%5Fadministration.411.aspx)
### 4- Pediatric:
1. The effect of esketamine on emergence delirium or agitation in children after anesthesia: a systematic review and meta-analysis, BMC Anesthesiology, 16 March 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03748-5)
### 5- Regional Anesthesia & Pain Management:
1. Ketamine’s Immediate Analgesia and Opioid-Sparing Benefits in Laparoscopic Cholecystectomy: A Meta-Analysis of Time Points, Anesthesia Protocols, and Bolus/Infusion Strategies, *The Clinical Journal of Pain*, 19 March 2026, [Link](https://journals.lww.com/clinicalpain/abstract/9900/ketamine%5Fs%5Fimmediate%5Fanalgesia%5Fand%5Fopioid%5Fsparing.339.aspx)
2. Comparison of neuraxial anesthesia and analgesia strategies for obese parturients: a systematic review and network meta-analysis, BMC Anesthesiology, 18 March 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03761-8)
3. Effect of ultrasound-guided quadratus lumborum block with dexmedetomidine as an adjuvant on postoperative analgesia for gynecological laparoscopic surgery: a randomized controlled trial, BMC Anesthesiology, 17 March 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03765-4)
---
## ***Clinical trials:***
### 1- General:
1. Comparison of effects of remimazolam and propofol on mask ventilation during general anaesthesia induction: A randomised controlled trial, Anaesthesia Critical Care & Pain Medicine, April 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556825002358)
2. Continuous vs Intermittent Postoperative Vital Sign Monitoring: A Cluster Randomized Crossover Trial, JAMA Open, 26 March 2026, [Link](https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2846961)
3. Dynamic effects of low- and high-pressure pneumoperitoneum on optic nerve sheath diameter during laparoscopic cholecystectomy: a prospective, randomized, observer-blinded clinical trial, BMC Anesthesiology, 19 March 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03762-7)
### 2- Airway & Mechanical Ventilation:
1. Jiancheng dual-channel *vs.* i-gel laryngeal mask airway for fiberoptic bronchoscopy: A randomized trial, Anaesthesia Critical Care & Pain Medicine, April 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2352556825002310)
2. Provu video stylet-assisted intubation under direct laryngoscopy and video laryngoscopy in high Arne score patients: a randomized clinical trial, BMC Anesthesiology, 18 March 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03754-7)
3. Sugammadex, neostigmine, and postoperative pulmonary complications: protocol of the SNaPP multicentre randomised controlled trial, BJA Open, March 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2772609626000055)
### 3- Cardiovascular & Hemodynamics:
1. Efficacy of surgeon-administered regional anesthesia in cardiac surgery –A double-blind, two-center, randomized, placebo-controlled trial, Journal of Cardiothoracic and Vascular Anesthesia, 27 March 2026, [Link](https://www.sciencedirect.com/science/article/pii/S1053077026002715)
2. Invasive blood pressure monitoring by ultrasound-guided artery cannulation through the distal radial artery approach at the anatomical snuffbox compared with the conventional artery approach: a randomised controlled trial, Journal of Cardiothoracic and Vascular Anesthesia, 25 March 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026002697)
3. Effect of ciprofol with etomidate on the occurrence of hypotension in elderly patients undergoing upper gastrointestinal endoscopy: a prospective randomized controlled study, BMC Anesthesiology, 24 March 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03767-2)
4. Effect of exercise prehabilitation on days alive and out of hospital after cardiac surgery: a secondary analysis of the randomised PRE-habilitation for improving QUality of recovery after ELective cardiac surgery trial, BJA Open, March 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2772609626000146)
### 4- Neuro:
1. Effect of Preoperative Intravenous Ferric Carboxymaltose on Postoperative Transfusion Reduction in Iron Deficiency Anemia Patients Scheduled for Clipping Surgery for Unruptured Intracranial Aneurysms: The PICASA Trial — A Single Center, Single-Blind Randomized Clinical Trial, Anaesthesia Critical Care & Pain Medicine, April 2026, [Link](https://www.sciencedirect.com/science/article/pii/S235255682500178X)
2. Impact of Ultraearly Perioperative Antihypertensive Therapy in Acute Intracerebral Hemorrhage, Stroke, 24 March 2026, [Link](https://www.ahajournals.org/doi/10.1161/STROKEAHA.125.053989)
### 5- Obstetrics & Gynecology:
1. Effect of intraoperative remimazolam infusion on postoperative sleep disturbance in elderly patients after gynecological laparoscopy: A randomized clinical trial, Anaesthesia Critical Care & Pain Medicine, 20 March 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556826000731), April 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2352556825001572)
2. HSK21542 for Postoperative Analgesia in Gynecological Surgery: A Pooled Post-Hoc Analysis of Two Phase III Randomized Controlled Trials, Anesthesia & Analgesia, 23 March 2026, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/hsk21542%5Ffor%5Fpostoperative%5Fanalgesia%5Fin.1720.aspx)
3. Opioid-Free Versus Opioid-Based Anesthesia for Quality of Recovery Following Laparoscopic Hysterectomy: A Randomized Controlled Non-Inferiority Trial, Anaesthesia Critical Care & Pain Medicine, 20 March 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556826000731)
4. Comparison of supine vs head-elevated position on sensory block height following combined spinal epidural anaesthesia in Class III obese parturients undergoing elective caesarean delivery- a randomized controlled trial, BMC Anesthesiology, 16 March 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03756-5)
### 6- Regional Anesthesia & Pain Management:
1. Comfort-Focused Assessment and Patient-Reported Experience After Regional versus General Anaesthesia: Post Hoc Analysis of a Cluster-Randomised Trial, Anaesthesia Critical Care & Pain Medicine, April 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2352556825001924)
2. Evaluation of the postoperative quality of recovery score in radical prostatectomy with erector spinae plane block: a randomised controlled trial, BMC Anesthesiology, 21 March 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03749-4)
3. Effect of Paroxetine or Escitalopram Co-administered with Oxycodone vs Oxycodone Alone on Ventilation During Hypercapnia: A Randomized Clinical Trial, Anesthesiology, 18 March 2026, [Link](https://journals.lww.com/anesthesiology/abstract/9900/effect%5Fof%5Fparoxetine%5For%5Fescitalopram.928.aspx)
4. Superior autonomic regulation with ropivacaine over lidocaine in stellate ganglion block for chronic insomnia: a randomized controlled trial, BMC Anesthesiology, 17 March 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03763-6)
---
## ***Reviews:***
### 1- AI & Tech:
1. From Cuffs to Code: Machine Learning in Non-Invasive Blood Pressure Monitoring, Anaesthesia Critical Care & Pain Medicine, April 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2352556825001870)
2. Using head-mounted augmented and virtual reality devices for anaesthesia education: a scoping review, BJA Open, March 2026, [Link](https://www.sciencedirect.com/science/article/pii/S277260962600016X)
### 2- General:
1. Anaesthetic considerations for patient blood management in cancer surgery: a narrative review, Anaesthesia Critical Care & Pain Medicine, April 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556825001833)
2. Core concepts in statistics and research methods. Part 7: regression, BJA Edu, 20 March 2026, [Link](https://www.bjaed.org/article/S2058-5349%2826%2900018-1/fulltext)
### 3- Airway & Mechanical Ventilation:
1. High-Flow Nasal Oxygen in the Perioperative Setting: A Narrative Review, Anaesthesia Critical Care & Pain Medicine, 26 March 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556826000755)
### 4- Cardiovascular & Hemodynamics:
1. Selected 2025 Highlights in Congenital Cardiac Anesthesia, Journal of Cardiothoracic and Vascular Anesthesia, 25 March 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026002685)
2. Rethinking Lactate in Cardiac Surgery and Intensive Care, Journal of Cardiothoracic and Vascular Anesthesia, 14 March 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026002107)
3. Advances in the understanding and management of hospital-acquired anemia, *Current Opinion in Anesthesiology*, 13 March 2026, [Link](https://journals.lww.com/co-anesthesiology/fulltext/9900/advances%5Fin%5Fthe%5Funderstanding%5Fand%5Fmanagement%5Fof.405.aspx)
4. Updates to perioperative and anesthetic management of the left ventricular assist device patient presenting for noncardiac surgery, *Current Opinion in Anesthesiology*, 11 March 2026, [Link](https://journals.lww.com/co-anesthesiology/fulltext/9900/updates%5Fto%5Fperioperative%5Fand%5Fanesthetic%5Fmanagement.401.aspx)
5. Safety in electroconvulsive therapy: a narrative review of cardiopulmonary complications, *Current Opinion in Anesthesiology*, 9 March 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/safety%5Fin%5Felectroconvulsive%5Ftherapy%5F%5Fa%5Fnarrative.398.aspx)
### 5- Obstetrics & Gynecology:
1. Beyond postdural puncture headache: headache and the puerperium, *Current Opinion in Anesthesiology*, 9 March 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/beyond%5Fpostdural%5Fpuncture%5Fheadache%5F%5Fheadache%5Fand.397.aspx)
### 6- Pediatric:
1. The impact of social determinants of health on paediatric perioperative adverse events – a narrative review, Anaesthesia Critical Care & Pain Medicine, 20 March 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2352556826000718)
2. Neuromuscular block in paediatric patients undergoing airway management: a narrative review, *Current Opinion in Anesthesiology*, 13 March 2026, [Link](https://journals.lww.com/co-anesthesiology/fulltext/9900/neuromuscular%5Fblock%5Fin%5Fpaediatric%5Fpatients.406.aspx)
3. Overview and anesthetic management of fetal vessel anomalies and umbilical cord emergencies, *Current Opinion in Anesthesiology*, 12 March 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/overview%5Fand%5Fanesthetic%5Fmanagement%5Fof%5Ffetal%5Fvessel.403.aspx)
4. Update on total intravenous anesthesia in children, *Current Opinion in Anesthesiology*, 12 March 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/update%5Fon%5Ftotal%5Fintravenous%5Fanesthesia%5Fin%5Fchildren.404.aspx)
5. Promoting safe anaesthesia for every child: the SAFETOTS initiative and beyond, *Current Opinion in Anesthesiology*, 11 March 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/promoting%5Fsafe%5Fanaesthesia%5Ffor%5Fevery%5Fchild%5F%5Fthe.399.aspx)
### 7- Regional Anesthesia & Pain Management:
1. Specialised invasive techniques for cancer-related pain, BJA Edu, 19 March 2026, [Link](https://www.bjaed.org/article/S2058-5349%2826%2900017-X/abstract)
2. Latest conceptual, methodological, and clinical advances in chronic pain, *Current Opinion in Anesthesiology*, 11 March 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/latest%5Fconceptual,%5Fmethodological,%5Fand%5Fclinical.400.aspx)
---
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# **Critical Care:**
### 1- Cardiovascular & Hemodynamics:
1. Current practice, training and skill assessment of central venous access device insertion: Perspectives of intensive care trainees in adult intensive care units across Australia and New Zealand and their recommendations for improvement: **C**entral Venous **L**ines **I**nsertion: **P**ractice, **E**ducation, **R**ecommendation 2.0 **(CLIPER 2.0)**, Critical Care and Resuscitation, March 2026, [Link](https://www.sciencedirect.com/science/article/pii/S1441277225000638)
2. Evidence-based guidelines for the use of extracorporeal membrane oxygenation in Australia and New Zealand using GRADE methodology series part 1: Venovenous extracorporeal membrane oxygenation (VV ECMO) indications and management, Critical Care and Resuscitation, March 2026, [Link](https://www.sciencedirect.com/science/article/pii/S1441277226000025)
### 2- Infectious Diseases:
1. Evidence-based, cost-effective management of necrotizing soft tissue infection: An algorithm of the Journal of Trauma and Acute Care Surgery emergency general surgery algorithms work group, *Journal of Trauma and Acute Care Surgery*, April 2026, [Link](https://journals.lww.com/jtrauma/fulltext/2026/04000/evidence%5Fbased,%5Fcost%5Feffective%5Fmanagement%5Fof.3.aspx)
2. Clinical Criteria for the Definition of Refractory Septic Shock: A Joint Delphi Consensus from the Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM), *Critical Care Medicine*, 24 March 2026, [Link](https://journals.lww.com/ccmjournal/fulltext/9900/clinical%5Fcriteria%5Ffor%5Fthe%5Fdefinition%5Fof%5Frefractory.787.aspx)
3. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2026, *Critical Care Medicine*, 23 March 2026, [Link](https://journals.lww.com/ccmjournal/fulltext/9900/surviving%5Fsepsis%5Fcampaign%5F%5Finternational.786.aspx)
4. Executive Summary: Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2026, *Critical Care Medicine*, 23 March 2026, [Link](https://journals.lww.com/ccmjournal/fulltext/9900/executive%5Fsummary%5F%5Fsurviving%5Fsepsis%5Fcampaign%5F.781.aspx)
5. Gaps and Strategies for Management of Sepsis in Low-Resource Settings: Expert Consensus Statements Using a Delphi Method, *Critical Care Medicine*, 20 March 2026, [Link](https://journals.lww.com/ccmjournal/fulltext/9900/gaps%5Fand%5Fstrategies%5Ffor%5Fmanagement%5Fof%5Fsepsis%5Fin.780.aspx)
### 3- Sedation & analgesia:
1. Updated European Society for Emergency Medicine Guidelines for acute pain management in emergency departments and prehospital care, *European Journal of Emergency Medicine*, 11 March 2026, [Link](https://journals.lww.com/euro-emergencymed/abstract/9900/updated%5Feuropean%5Fsociety%5Ffor%5Femergency%5Fmedicine.227.aspx)
### 4- Pediatric critical care:
1. Surviving Sepsis Campaign International Guidelines for the Management of Sepsis and Septic Shock in Children 2026, Intensive Care Medicine, 23 March 2026, [Link](https://link.springer.com/article/10.1007/s00134-026-08360-2)
### 5- Other:
1. Executive Summary: Society of Critical Care Medicine Guidelines on Caring for Older Adults in the ICU, *Critical Care Medicine*, 20 March 2026, [Link](https://journals.lww.com/ccmjournal/fulltext/9900/executive%5Fsummary%5F%5Fsociety%5Fof%5Fcritical%5Fcare.774.aspx)
2. Society of Critical Care Medicine Guidelines on Caring for Older Adults in the ICU, *Critical Care Medicine*, 20 March 2026, [Link](https://journals.lww.com/ccmjournal/fulltext/9900/society%5Fof%5Fcritical%5Fcare%5Fmedicine%5Fguidelines%5Fon.785.aspx)
##
---
## ***Systematic reviews & meta-analyses:***
### 1- AI:
1. Closed-loop and Artificial intelligence guided cardiopulmonary resuscitation using real-time physiological signals: a systematic review and meta-analysis, BMC Anesthesiology, 14 March 2026, [Link](https://link.springer.com/article/10.1186/s12873-026-01544-5)
### 2- Cardiovascular & Hemodynamics:
1. Lung ultrasound-guided decongestion in heart failure patients: A systematic review and meta-analysis of randomized controlled trials, Journal of Critical Care, June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0883944126000134)
2. Volume Therapy for Cardiac Arrest: A Systematic Review and Meta-Analysis, Resuscitation Plus, 25 March 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2666520426000858)
### 3- Thorax/Lungs/Airways/Mechanical ventilation:
1. Percutaneous dilatational tracheostomy with versus without bronchoscopic guidance: a systematic review and meta-analysis of randomized controlled trials, BMC Anesthesiology, 17 March 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03759-2)
### 4- Neuro-muscular:
1. Operator and Modality-Dependent Limitations of Optic Nerve Sheath Diameter Sonography for Raised ICP in TBI: A Meta-Regression of Diagnostic Accuracy, Neurocritical Care, 25 March 2026, [Link](https://link.springer.com/article/10.1007/s12028-026-02493-4)
2. Resumption of Warfarin After Intracranial Hemorrhage in Patients With Mechanical Heart Valves: A Systematic Review and Meta‐Analysis, Journal of the American Heart Association, 13 March 2026, [Link](https://www.ahajournals.org/doi/10.1161/JAHA.125.041301)
### 5- Renal:
1. Clinical utility of proenkephalin A 119-159 for prediction of worsening renal function and prognosis in patients with sepsis –results of a patient-level meta-analysis, Critical Care, 24 March 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-05947-5)
### 6- Blood & hemostasis:
1. Anti-Xa Levels With Venous Thromboembolism Prophylaxis in Critical Care: A Systematic Review and Meta-Analysis, *Critical Care Medicine*, 11 March 2026, [Link](https://journals.lww.com/ccmjournal/abstract/9900/anti%5Fxa%5Flevels%5Fwith%5Fvenous%5Fthromboembolism.767.aspx)
### 7- Infectious Diseases:
1. The Association Between Socioeconomic Position and Mortality in Patients With Sepsis and Septic Shock—A Systematic Review and Meta-Analysis, *Critical Care Medicine*, 20 March 2026, [Link](https://journals.lww.com/ccmjournal/fulltext/9900/the%5Fassociation%5Fbetween%5Fsocioeconomic%5Fposition%5Fand.769.aspx)
2. Inhaled Antibiotics to Treat Ventilator-Associated Pneumonia: A Systematic Review and Meta-Analysis, *Critical Care Medicine*, 16 March 2026, [Link](https://journals.lww.com/ccmjournal/abstract/9900/inhaled%5Fantibiotics%5Fto%5Ftreat%5Fventilator%5Fassociated.778.aspx)
3. Prevalence, treatment, and outcomes of sepsis during rapid response team calls: A systematic review and meta-analysis, Critical Care and Resuscitation, March 2026, [Link](https://www.sciencedirect.com/science/article/pii/S1441277226000116)
---
## ***Clinical trials:***
### 1- Cardiovascular & Hemodynamics:
1. Cardiac Arrest and Outcome in Patients With Cardiogenic Shock Complicating Acute Myocardial Infarction: A Pooled Analysis of Randomized Controlled Trials, JACC, 25 March 2026, [Link](https://www.jacc.org/doi/10.1016/j.jacc.2026.01.068)
2. Ultrasound guidance versus conventional technique for radial arterial puncture in patients with shock in the emergency department: a randomized controlled trial, BMC Anesthesiology, 19 March 2026, [Link](https://link.springer.com/article/10.1186/s12873-026-01538-3)
3. Efficacy of Vericiguat in Acute Heart Failure: A Target Trial Emulation Study, Journal of the American Heart Association, 18 March 2026, [Link](https://www.ahajournals.org/doi/10.1161/JAHA.125.046168)
4. Prehospital Whole Blood in Traumatic Hemorrhage — a Randomized Controlled Trial, NEJM, 17 March 2026, [Link](https://www.nejm.org/doi/full/10.1056/NEJMoa2516043)
### 2- Thorax/Lungs/Airways/Mechanical ventilation:
1. Dipeptidyl peptidase-3 to predict respiratory outcomes in patients hospitalized with COVID-19: A secondary analysis of a multicenter randomized trial, Journal of Critical Care, June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0883944126000560)
2. Performance of the new Laryngeal tube LT®evo during simulated resuscitation: a randomised crossover manikin study, International Journal of Emergency Medicine, 24 March 2026, [Link](https://link.springer.com/article/10.1186/s12245-026-01163-8)
3. Congestive heart failure in patients with acute respiratory distress syndrome: a secondary analysis of large randomized controlled trials, Anaesthesia Critical Care & Pain Medicine, 20 March 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556826000767)
4. The impact of bronchoscopy on the safety of percutaneous tracheostomy: a randomized controlled trial, Critical Care, 18 March 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-05912-2)
5. High-Flow or Standard Oxygen in Acute Hypoxemic Respiratory Failure, NEJM, 17 March 2026, [Link](https://www.nejm.org/doi/full/10.1056/NEJMoa2516087)
### 3- Neuro-muscular:
1. Evaluation of a Novel Automated Cerebral Ventricular Drainage System for Intracranial Pressure Monitoring and Cerebrospinal Fluid Drainage in Neurocritical Care Patients: A Prospective, Randomized Clinical Study, Neurocritical Care, 23 March 2026, [Link](https://link.springer.com/article/10.1007/s12028-026-02477-4)
### 4- Infectious Diseases:
1. Quantifying immune dysregulation in pneumonia and sepsis with a parsimonious machine-learning model: a multicohort analysis across care settings and reanalysis of a hydrocortisone randomised controlled trial, The Lancet Respiratory Medicine, 16 March 2026, [Link](https://www.thelancet.com/journals/lanres/article/PIIS2213-2600%2825%2900429-1/abstract)
2. Ceragenin-Coated Endotracheal Tubes for the Reduction of Ventilator-Associated Pneumonia: A Prospective, Longitudinal, Crossover, Interrupted Time, Implementation Study (CEASE VAP Study), Critical Care Explorations, April 2026, [Link](https://journals.lww.com/ccejournal/pages/articleviewer.aspx?year=2026&issue=04000&article=00002&type=Fulltext)
### 5- Sedation & analgesia:
1. Efficacy and Safety of Remimazolam Tosylate versus Propofol for Sedation of Postoperative Mechanically Ventilated Patients in Intensive Care Units: a Multicenter, Randomized, Single-blind, Non-inferiority, Phase 3 trial, Anesthesiology, 19 March 2026, [Link](https://journals.lww.com/anesthesiology/abstract/9900/efficacy%5Fand%5Fsafety%5Fof%5Fremimazolam%5Ftosylate%5Fversus.931.aspx)
2. Restrictive vs Liberal Physical Restraint Strategies in Critically Ill Patients: The R2D2-ICU Randomized Clinical Trial, JAMA, 17 March 2026, [Link](https://jamanetwork.com/journals/jama/fullarticle/2846726)
1. Restrictive vs Liberal Physical Restraint Strategies in Critically Ill Patients: Research Summary, JAMA, 17 March 2026, [Link](https://jamanetwork.com/journals/jama/fullarticle/2846725)
2. Physical Restraint Use in Critical Care: Balancing Safety and Harm, JAMA, 17 March 2026, [Link](https://jamanetwork.com/journals/jama/fullarticle/2846727)
3. A pilot, parallel-group, blinded, placebo-controlled, randomise**D**, p**R**agmatic clinical trial investigating the **E**ffect of temazep**AM** on objective and subjective measures of sleep in critically ill patients (the DREAM trial), Critical Care and Resuscitation, March 2026, [Link](https://www.sciencedirect.com/science/article/pii/S1441277226000086)
4. Protocol for a multicentre target trial emulation comparing ketamine and propofol in critically ill adults undergoing emergency intubation, Critical Care and Resuscitation, March 2026, [Link](https://www.sciencedirect.com/science/article/pii/S1441277226000104)
### 6- Pediatric critical care:
1. Effect of Adjunctive Train-of-Four Monitoring Using Peripheral Nerve Stimulation on Neuromuscular Blocking Agent Dose in PICU Patients: A Randomized Crossover Study, *Pediatric Critical Care Medicine*, 16 March 2026, [Link](https://journals.lww.com/pccmjournal/fulltext/9900/effect%5Fof%5Fadjunctive%5Ftrain%5Fof%5Ffour%5Fmonitoring.646.aspx)
2. Sweep Gas Nitric Oxide During Extracorporeal Membrane Oxygenation in Neonates and Children (NECTAR Trial): A Single-Center, Pilot Randomized Controlled Trial, *Pediatric Critical Care Medicine*, 11 March 2026, [Link](https://journals.lww.com/pccmjournal/abstract/9900/sweep%5Fgas%5Fnitric%5Foxide%5Fduring%5Fextracorporeal.636.aspx)
### 7- Other:
1. Effects of a Combined Lifestyle Intervention on Recovery of ICU Survivors: A Randomized Controlled Trial, *Critical Care Medicine*, 16 March 2026, [Link](https://journals.lww.com/ccmjournal/abstract/9900/effects%5Fof%5Fa%5Fcombined%5Flifestyle%5Fintervention%5Fon.775.aspx)
---
## ***Reviews:***
### 1- AI:
1. Machine learning in ARDS: an intensivist’s guide to artificial intelligence applications, Critical care, 13 March 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-05928-8)
### 2- Cardiovascular & Hemodynamics:
1. Current perspectives in cardiogenic shock, Journal of Critical Care, June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0883944126000493)
2. Critical closing pressure in the circulation: Understanding the vascular waterfall phenomenon, Journal of Critical Care, June 2026, [Link](https://www.sciencedirect.com/science/article/pii/S0883944126000638)
3. Albumin 20% in surgical and critically ill patients; a comprehensive review, Critical Care, 24 March 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-05959-1)
4. The Effective Management of Shock: Moving From Physiology to Guidelines to Personalized Medicine, Critical Care Medicine, 17 March 2026, [Link](https://journals.lww.com/ccmjournal/abstract/9900/the%5Feffective%5Fmanagement%5Fof%5Fshock%5F%5Fmoving%5Ffrom.779.aspx)
5. Rethinking Lactate in Cardiac Surgery and Intensive Care, Journal of Cardiothoracic and Vascular Anesthesia, 14 March 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026002107)
6. Critical Care Ultrasonography for Cardiogenic Shock: A Scoping Review, *Critical Care Explorations*, March 2026, [Link](https://journals.lww.com/ccejournal/fulltext/2026/03000/critical%5Fcare%5Fultrasonography%5Ffor%5Fcardiogenic.9.aspx)
### 3- Thorax/Lungs/Airways/Mechanical ventilation:
1. What every intensivist should know about extracorporeal CO₂ removal in ARDS, Journal of Critical Care, June 2026, [Link](https://www.sciencedirect.com/science/article/pii/S0883944126000535)
2. Physiological rationale and clinical use of lateral positioning in ARDS, Journal of Critical Care, June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0883944126000584)
3. Acute respiratory distress syndrome and acute kidney injury in critically ill patients: A scoping review on this lung-kidney crosstalk, Journal of Critical Care, June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0883944126000237)
4. Subphenotypes in acute respiratory distress syndrome: A scoping review across clinical, biological, computational, imaging, omics, and artificial intelligence approaches, Journal of Critical Care, June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0883944126000195)
5. Characterizing heterogeneity and subphenotyping acute respiratory distress syndrome with computed tomography, Intensive Care Medicine Experimental, 26 March 2026, [Link](https://link.springer.com/article/10.1186/s40635-026-00880-x)
6. Ventilator Weaning and Extubation in Acute Brain Injury: Challenges and Evidence-Based Approaches, Anaesthesia Critical Care & Pain Medicine, 20 March 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556826000743)
### 4- Neuro-muscular:
1. Abnormal pupils at the bedside: rapid recognition of neurologic and systemic emergencies in acute care settings, International Journal of Emergency Medicine, 25 March 2026, [Link](https://link.springer.com/article/10.1186/s12245-026-01195-0)
### 5- Renal:
1. Acute respiratory distress syndrome and acute kidney injury in critically ill patients: A scoping review on this lung-kidney crosstalk, Journal of Critical Care, June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0883944126000237)
### 6- Trauma:
1. Dose-reduction strategies in whole-body CT for injured patients in the emergency department: a scoping review, International Journal of Emergency Medicine, 16 March 2026, [Link](https://link.springer.com/article/10.1186/s12245-026-01181-6)
### 7- Infectious Diseases:
1. Left ventricular-arterial coupling in septic shock: A physiological review, Journal of Critical Care, June 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S088394412600064X)
2. Incidence and outcomes of influenza-associated pulmonary aspergillosis and the role of antifungal prophylaxis: a structured literature review, Critical Care, 256 March 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-05975-1)
3. Ten Steps to Improve Sepsis Care in Low-Resource Settings, *Critical Care Medicine*, 20 March 2026, [Link](https://journals.lww.com/ccmjournal/fulltext/9900/ten%5Fsteps%5Fto%5Fimprove%5Fsepsis%5Fcare%5Fin%5Flow%5Fresource.765.aspx)
4. The Frame of Survival for Sepsis: A Practical Systems Framework for Time-Sensitive Critical Illness in Low-Resource Settings, *Critical Care Medicine*, 20 March 2026, [Link](https://journals.lww.com/ccmjournal/fulltext/9900/the%5Fframe%5Fof%5Fsurvival%5Ffor%5Fsepsis%5F%5Fa%5Fpractical.783.aspx)
5. Targeting Myeloid-Derived Suppressor Cells in Sepsis: Pathophysiology, Duality, and Therapeutic Frontiers, Shock, 13 March 2026, [Link](https://journals.lww.com/shockjournal/abstract/9900/targeting%5Fmyeloid%5Fderived%5Fsuppressor%5Fcells%5Fin.835.aspx)
### 8- Pediatric critical care:
1. Pediatric trauma management in low-resource emergency departments: from first contact to safe disposition – a narrative review, International Journal of Emergency Medicine, 24 March 2026, [Link](https://link.springer.com/article/10.1186/s12245-026-01189-y)
### 9- Other:
1. Post-anaphylaxis observation in the ED: a decade of data challenging the traditional 24-hour rule, International Journal of Emergency Medicine, 14 March 2026, [Link](https://link.springer.com/article/10.1186/s12245-026-01175-4)
---
### **Feedback & Suggestions**
Don't hesitate to share your thoughts and suggestions in the comments below; they'll be a great help in improving future issues of the newsletter.
**Disclaimer**
💡
****Disclaimer:**
The is for educational and informational purposes only and is not intended to replace professional medical advice, diagnosis, or treatment.
See you next time :)
**Benhalima Othmane.**
**Anecrit.com**
### Anecrit's Newsletter #31
URL: https://www.anecrit.com/newsletter-31/
Last updated: 2026-06-21T12:06:55.000Z
###
Hey there! I hope you’re all doing well. A warm welcome to our newcomers! This past week, I encountered a case that was too intriguing not to share. Below, I’ve detailed the presentation and initial investigations. I’ll leave the definitive diagnosis and management for next week’s edition—see if you can crack the case before then!
### 1\. Patient History
A 30-year-old female was brought to the Emergency Department (ED) by paramedics after being found unconscious outside a store. No collateral information was available (identity and medical history unknown), and there were no visible signs of trauma or external injury.
### 2\. Clinical Presentation
Upon arrival, the patient was in a deep coma with a **Glasgow Coma Scale (GCS) of 6/15**. However, the clinical team noted a striking set of paradoxical symptoms:
- **CNS Depression:** The patient was completely unresponsive to verbal commands.
- **No Focal Signs:** A neurological exam revealed **no signs of CNS localization** (no lateralizing signs or focal deficits), suggesting a global rather than a structural brain insult.
- **Hyperexcitability:** Despite the coma, she exhibited intense, generalized **myoclonic jerks** triggered by any physical contact or loud noises in the room with bilateral Babinski sign.
- **Respiratory Status:** RR 18, SpO2 90% on room air. Lungs were clear on auscultation with **no signs of hypersecretion**.
- **Autonomic/Vitals:** Temperature was 36.5°C, pupils were miotic, BP was 95/60 mmHg, and HR was 62 bpm.
- **Other:** Notably, there were no signs of tongue biting or urinary incontinence, making a typical post-ictal state less likely.
### 3\. Diagnostic Findings
Initial lab work was surprisingly unremarkable, adding to the mystery:
- **Labs:** CBC, electrolytes (Na+, K+, Cl\-), blood glucose, urea, creatinine, and hemostasis were all within normal limits.
- **Toxicology:** Standard screens for opioids, benzodiazepines, and alcohol were negative.
- **Imaging:** A CT scan of the head showed no acute intracranial pathology.
**The Challenge:**
Our team considered several possibilities, but it took a specific clinical 'clue' (and some vital history from the family! :) ) to provide the definitive answer.
**What’s your top differential?** Comment below or wait until next week for the conclusion!
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---
# **Anesthesiology:**
## ***Systematic reviews & meta-analyses:***
### 1- General:
1. Validation status of definitive airway management simulators: a systematic review, BJA, 12 March 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900053-X/fulltext)
### 2- Airway & Mechanical Ventilation:
1. High-Flow Nasal Oxygen and the Risk of Gastric Insufflation: A Systematic Review and Meta-Analysis Supplemented by Narrative Synthesis, A&A, 5 March 2026, [Link](https://journals.lww.com/anesthesia-analgesia/abstract/9900/high%5Fflow%5Fnasal%5Foxygen%5Fand%5Fthe%5Frisk%5Fof%5Fgastric.1696.aspx)
---
## ***Clinical trials:***
### 1- General:
1. Comparing Black Coffee to Coffee With Creamer in Gastric Emptying Time: A Nonrandomized Control Trial, A&A Practice, March 2026, [Link](https://journals.lww.com/aacr/fulltext/2026/03000/comparing%5Fblack%5Fcoffee%5Fto%5Fcoffee%5Fwith%5Fcreamer%5Fin.8.aspx)
2. Postoperative Urinary Retention After Reversal of Neuromuscular Block by Neostigmine versus Sugammadex in Patients Undergoing Laparoscopic Cholecystectomy: A Randomized Controlled Trial, A&A, 6 March 2026, [Link](https://journals.lww.com/anesthesia-analgesia/abstract/9900/postoperative%5Furinary%5Fretention%5Fafter%5Freversal%5Fof.1715.aspx)
### 2- Airway & Mechanical Ventilation:
1. The effect of high-flow nasal cannula oxygen therapy on preventing hypoxemia during deep sedation extubation after laparoscopic surgery: a prospective randomized controlled trial, BMC Anesthesiology, 11 March 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03735-w)
### 3- Cardiovascular & Hemodynamics:
1. Sivelestat and Incidence of Acute Respiratory Distress Syndrome After Cardiovascular Surgery: A Randomized Clinical Trial, JAMA Open, 11 March 2026, [Link](https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2846209)
### 4- Thoracic:
1. Intravenous lidocaine reduces systemic inflammation but not myocardial injury following thoracic surgery for lung cancer: a randomized controlled trial, BMC Anesthesiology, 7 March 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03733-y)
### 5- Neuro:
1. Multisensory virtual reality reduces postoperative delirium in elderly patients undergoing laparoscopic gastrointestinal surgery: A single-centre randomised controlled trial, EJA, 12 March 2026, [Link](https://journals.lww.com/ejanaesthesiology/pages/articleviewer.aspx?year=9900&issue=00000&article=00407&type=Fulltext)
### 6- Obstetrics & Gynecology:
1. Transthoracic echocardiographic evaluation of maternal cardiac output: colloid preload versus crystalloid coload during cesarean delivery under spinal anesthesia: randomized clinical trial, BMC Anesthesiology, 12 March 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03702-5)
### 7- Pediatric:
1. The efficacy of gabapentin in reducing perioperative opioid requirements in pediatric open-heart surgery: a randomized double-blinded controlled study, Journal of Cardiothoracic and Vascular Anesthesia, 6 March 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026002053)
### 8- Orthopedic:
1. Effects of perioperative probiotic supplementation on postoperative gastrointestinal recovery in elderly hip fracture patients: a randomized controlled trial, BMC Anesthesiology, 6 March 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03746-7)
### 9- Regional Anesthesia & Pain Management:
1. Analgesic efficacy of liposomal bupivacaine adductor canal block combined with periarticular infiltration after total knee arthroplasty: a prospective, double-blind, randomized controlled trial, BMC Anesthesiology, 12 March 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03742-x)
2. Effect of preoperative ultrasound-guided stellate ganglion block on pain thresholds and postoperative nausea and vomiting in gynecological laparoscopy: a randomised clinical trial, BMC Anesthesiology, 11 March 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03752-9)
3. Analgesic efficacy of blocking nerve to vastus lateralis muscle versus lateral femoral cutaneous nerve after knee surgeries: a randomized trial, BMC Anesthesiology, 7 March 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03680-8)
4. Efficacy and safety of liposomal bupivacaine versus bupivacaine for retrolaminar block for postoperative analgesia in patients undergoing posterior lumbar interbody fusion: a randomized controlled trial, BMC Anesthesiology, 7 March 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03721-2)
5. Comparison of erector spinae plane block and rhomboid intercostal block for postoperative pain management in patients undergoing unilateral breast surgery, BMC Anesthesiology, 6 March 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03655-9)
---
## ***Reviews:***
### 1- AI:
1. Automation software for transesophageal echocardiography in cardiac patients: a scoping review, Journal of Cardiothoracic and Vascular Anesthesia, 11 March 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026002211)
### 2- General:
1. Prophylaxis and treatment of postoperative nausea and vomiting, BJA Edu, 11 March 2026, [Link](https://www.bjaed.org/article/S2058-5349%2826%2900015-6/fulltext)
2. 2025 Clinical Update in Liver Transplantation, Journal of Cardiothoracic and Vascular Anesthesia, 10 March 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026001771)
### 3- Neuro:
1. Anesthesia for patients with movement disorders, *Current Opinion in Anesthesiology*, 11 March 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/anesthesia%5Ffor%5Fpatients%5Fwith%5Fmovement%5Fdisorders.402.aspx)
### 4- Obstetrics & Gynecology:
1. Strategies for preventing nerve injuries in obstetric anesthesia: a review, *Current Opinion in Anesthesiology*, 3 March 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/strategies%5Ffor%5Fpreventing%5Fnerve%5Finjuries%5Fin.396.aspx)
### 5- Pediatric:
1. Ecological sustainability in pediatric anesthesia: current evidence and future directions, *Current Opinion in Anesthesiology*, 26 February 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/ecological%5Fsustainability%5Fin%5Fpediatric%5Fanesthesia%5F.395.aspx)
2. Patient-reported outcome and experience measures in pediatric perioperative care, *Current Opinion in Anesthesiology*, 26 February 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/patient%5Freported%5Foutcome%5Fand%5Fexperience%5Fmeasures.394.aspx)
---
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# **Critical Care:**
## ***Guidelines & Consensus:***
### 1- Pediatric critical care:
1. Pediatric Intensive Care Core Outcomes–a modified Delphi consensus process (PIC-CO), Critical Care, 9 March 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-05878-1)
---
## ***Systematic reviews & meta-analyses:***
### 1- Cardiovascular & Hemodynamics:
1. Extracorporeal Life Support Use During Severe Anaphylaxis: A Systematic Review and Pooled Analysis of Individual Patient Data, Journal of Cardiothoracic and Vascular Anesthesia, 9 March 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026002077)
### 2- Neuro-muscular:
1. Surgical Interventions for Super-Refractory Status Epilepticus: A Systematic Review, Neurocritical Care, 12 March 2026, [Link](https://link.springer.com/article/10.1007/s12028-026-02448-9)
---
## ***Clinical trials:***
### 1- Cardiovascular & Hemodynamics:
1. Sivelestat and Incidence of Acute Respiratory Distress Syndrome After Cardiovascular Surgery: A Randomized Clinical Trial, JAMA Open, 11 March 2026, [Link](https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2846209)
2. Bleeding Risk with Apixaban vs. Rivaroxaban in Acute Venous Thromboembolism, NEJM, 11 March 2026, [Link](https://www.nejm.org/doi/full/10.1056/NEJMoa2510703)
3. Effect of Low-Dose Dobutamine Infusion on N-Terminal Pro–B-Type Natriuretic Peptide in At-Risk Patients With Acute Myocardial Infarction (DOBERMANN-D): A Randomized Clinical Trial, JACC, 8 March 2026, [Link](https://www.jacc.org/doi/10.1016/j.jacc.2026.01.020)
4. Effect of Tocilizumab on Pro–B-Type Natriuretic Peptide and Infarct Size in Patients With Acute Myocardial Infarction at Risk of Cardiogenic Shock (DOBERMANN-T), JACC, 8 March 2026, [Link](https://www.jacc.org/doi/10.1016/j.jacc.2026.01.019)
### 2- Thorax/Lungs/Airways/Mechanical ventilation:
1. Effect of the extubation predictive score (ExPreS) on reintubation in the ICU: a randomized controlled trial, Critical Care, 12 March 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-05861-w)
2. Effect of Continuous High-Frequency Oscillation Therapy on Lung Aeration in Mechanically Ventilated Patients With Impaired Consciousness: A Multicenter Randomized Controlled Trial, CHEST, March 2026, [Link](https://www.sciencedirect.com/science/article/pii/S0012369225052638)
### 3- Neuro-muscular:
1. Targeted Multidomain Treatment for Mild Traumatic Brain Injury: A Randomized Clinical Trial, JAMA Open, 12 March 2026, [Link](https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2846291)
2. Serum biomarkers of postanoxic encephalopathy in relation to ghrelin treatment. A secondary analysis of the GRECO trial, Resuscitation, March 2026, [Link](https://www.sciencedirect.com/science/article/pii/S0300957226000250)
### 4- Pediatric critical care:
1. High-Frequency Oscillation vs Mechanical Ventilation for Neonatal Acute Respiratory Distress Syndrome: A Randomized Clinical Trial, JAMA Open, 9 March 2026, [Link](https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2846024)
### 5- Other:
1. Barriers to adopting evidence from Bayesian adaptive clinical trials in critical care: a randomized experiment in United States intensivists, CHEST Critical Care, 7 March 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2949788426000316)
---
## ***Reviews:***
### 1- Thorax/Lungs/Airways/Mechanical ventilation:
1. Mechanical ventilation in ARDS: navigating the fine line with real-time monitoring, Critical Care, 7 March 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-05895-0)
### 2- Nutrition:
1. Feeding the injured brain: nutrients, dose, timing, and monitoring, Intensive Care Medicine, 9 March 2026, [Link](https://link.springer.com/article/10.1007/s00134-026-08324-6)
### 3- Infectious Diseases:
1. Antibiotic Considerations in the Critically Ill: Empiric Choices and Dosing, Critical Care Clinics, 9 March 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070426000138)
2. Research progress of sepsis immunotherapy: a bibliometric analysis, Shock, 26 February 2026, [Link](https://journals.lww.com/shockjournal/abstract/9900/research%5Fprogress%5Fof%5Fsepsis%5Fimmunotherapy%5F%5Fa.840.aspx)
### 4- Pediatric critical care:
1. Corrective steps during neonatal mask ventilation – a narrative review of the evidence behind the MR SOPA acronym, Resuscitation Plus, 12 March 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2666520426000731)
### 5- Other:
1. Critical Care Organization as an Acute Care Learning Health System: Integrating Clinical and Academic Research Missions, Critical Care Clinics, April 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070425000788)
2. The Future of Critical Care, Critical Care Clinics, April 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070425001058)
3. Organization and Management of Critical Care Services: Unexpected Challenges in Leading a Critical Care Organization, Critical Care Clinics, April 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070425000983)
4. How to Start and Sustain a System-Based High-Reliability Medicine Venture for Your Critical Care Organization, Critical Care Clinics, April 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S074907042500106X)
5. Intensive Care Unit Quality Metrics: Leveraging Advancing Analytics for Meaningful Improvement, Critical Care Clinics, April 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070425000971)
6. Critical Care Billing: Doing it Right, Every Time, Critical Care Clinics, April 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070425001009)
7. ICU Capacity Management and Surge Preparedness, Critical Care Clinics, April 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070425001046)
8. Innovation, Technology, and Telemedicine in Critical Care, Critical Care Clinics, April 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S074907042500096X)
9. Regionalization of Critical Care in Community Settings, Critical Care Clinics, April 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070425001022)
10. Pharmacists in Interprofessional Critical Care: Optimizing Medication Management, Critical Care Clinics, April 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070425000958)
11. Advanced Practice Provider Leadership in Critical Care: Building High-performance Teams, Improving Outcomes, and Future Planning, Critical Care Clinics, April 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070425000946)
12. Assessing Workforce Competencies for Physicians and Advanced Practice Providers, Critical Care Clinics, April 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070425001010)
13. Challenges in Creating a Critical Care Organization at Your Institution, Critical Care Clinics, April 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070425001034)
14. Principles of Critical Care Organization and Management, Critical Care Clinics, April 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070425000995)
---
### **Feedback & Suggestions**
Don't hesitate to share your thoughts and suggestions in the comments below; they'll be a great help in improving future issues of the newsletter.
**Disclaimer**
💡
****Disclaimer:**
The is for educational and informational purposes only and is not intended to replace professional medical advice, diagnosis, or treatment.
See you next time :)
**Benhalima Othmane.**
**Anecrit.com**
### Anecrit's Newsletter #30
URL: https://www.anecrit.com/newsletter-30/
Last updated: 2026-06-21T12:07:03.000Z
****Get concise anesthesia & Critical Care updates, every week.**
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Welcome back! It’s amazing to see this community expanding. I hope you love today’s read. By the way, if you enjoy what you see, please consider sharing this with a friend who might find it useful!
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---
# **Anesthesiology:**
## ***Guidelines & Consensus:***
### 1- AI:
1. Responsible use of large language models in manuscript authorship, peer review, and editorial processes: a Delphi consensus among editors-in-chief of anesthesia and pain medicine journals (RULE-AP), BJA, 25 February 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900055-3/fulltext)
### 2- General:
1. Professional practice guidelines: Eco-Responsible Optimization of Choice and use of Drugs and Medical Devices in Operating Theatres or interventional sector, Anaesthesia Critical Care & Pain Medicine, 17 February 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2352556826000305)
### 3- Thoracic:
1. Monitoring in Thoracic Anesthesia: EACTAIC Consensus Document, Journal of Cardiothoracic and Vascular Anesthesia, March 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025011292)
### 4- Neuro:
1. Consensus document on electroencephalography education in anaesthesiology: defining learning outcomes: A modified four-round Delphi study, EJA, 19 February 2026, [Link](https://journals.lww.com/ejanaesthesiology/pages/articleviewer.aspx?year=9900&issue=00000&article=00398&type=Fulltext)
### 5- Obstetrics & Gynecology:
1. Pain management in childbirth: neuraxial analgesia and drug alternatives, Anesthesia Critical Care & Pain Medicine, 17 February 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556826000299)
### 6- Pediatric:
1. Multimodality Approach to Coronary Ischemic Testing in Pediatric Patients: A Scientific Statement From the American Heart Association, JAHA, 26 February 2026, [Link](https://www.ahajournals.org/doi/10.1161/JAHA.125.047790)
### 7- Regional Anesthesia & Pain Management:
1. Defining the need for analgesia in the emergency department: an international consensus statement, *European Journal of Emergency Medicine*, 25 February 2026, [Link](https://journals.lww.com/euro-emergencymed/pages/articleviewer.aspx?year=9900&issue=00000&article=00223&type=Fulltext)
---
## ***Systematic reviews & meta-analyses:***
### 1- General:
1. A systematic review of efforts to predict day of surgery cancellation, EJA, 25 February 2026, [Link](https://journals.lww.com/ejanaesthesiology/fulltext/9900/a%5Fsystematic%5Freview%5Fof%5Fefforts%5Fto%5Fpredict%5Fday%5Fof.400.aspx)
2. Antibiotic Prophylaxis Strategies and Surgical Site Infections in Colorectal Surgery: A Systematic Review and Network Meta-Analysis, JAMA Open, 19 February 2026, [Link](https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2845266)
### 2- Cardiovascular & Hemodynamics:
1. The Effects of Tranexamic Acid on Renal Outcomes in Patients Undergoing Cardiovascular Surgery: A Systematic Review and Meta-Analysis Compliant With Preferred Reporting Items for Systematic Reviews and Meta-Analyses, Journal of Cardiothoracic and Vascular Anesthesia, March 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025011462)
2. Sex-related Incidence of Stroke After Left Ventricular Assist Device Implantation: A Systematic Review and Meta-analysis, Journal of Cardiothoracic and Vascular Anesthesia, March 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025008092)
3. Evaluating Topical Antifibrinolytics in Cardiac Surgery: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis, Journal of Cardiothoracic and Vascular Anesthesia, March 2026, [Link](https://www.sciencedirect.com/science/article/pii/S1053077025011085)
4. Benefits of nitric oxide administration during cardiopulmonary bypass on postoperative outcomes in adult patients: a meta-analysis and systematic review, BMC Anesthesiology, 25 February 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03707-0)
5. Preoperative and Intraoperative Risk Factors for Postoperative Pneumonia After Cardiac Surgery: An Ancillary Study of the STERNOCAT (Catheter Outcomes With Sternotomy Cardiac Operated) Randomized Trial and a Systematic Review With Meta-Analysis, Critical Care Medicine, 11 February 2026, [Link](https://journals.lww.com/ccmjournal/abstract/9900/preoperative%5Fand%5Fintraoperative%5Frisk%5Ffactors%5Ffor.744.aspx)
### 3- Neuro:
1. Psychological factors associated with postoperative cognitive outcomes in older adults: a systematic review and meta-analysis, BJA, 27 February 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900060-7/fulltext)
2. Impaired Cognitive Domains in Surgical Patients: A Systematic Review and Meta-Analysis, A&A, 16 February 2026, [Link](https://journals.lww.com/anesthesia-analgesia/abstract/9900/impaired%5Fcognitive%5Fdomains%5Fin%5Fsurgical%5Fpatients%5F%5Fa.1669.aspx)
### 4- Obstetrics & Gynecology:
1. The impact of neuraxial labour analgesia on neurodevelopmental disorders in offspring: a systematic review and meta-analysis, BJA, 3 March 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900061-9/abstract)
### 5- Pediatric:
1. Effectiveness of parental presence during induction of anaesthesia in managing perioperative anxiety in children: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials, BMC Anesthesiology, 23 February 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03717-y)
2. Early Versus Late Extubation After Pediatric Cardiac Surgery: A Systematic Review and Meta-analysis, Journal of Cardiothoracic and Vascular Anesthesia, 19 February 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026001394)
### 6- Regional Anesthesia & Pain Management:
1. The effect of adding a second multimodal analgesic component to anesthesia regimens on acute postoperative pain outcomes: a systematic review and meta-analysis, BMC Anesthesiology, 4 March 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03714-1)
****Get concise anesthesia & Critical Care updates, every week.**
Join the growing community of anesthesiologists and intensivists staying current on the latest evidence.
[Join for Free ](#/portal/signup/free)
---
## ***Clinical trials:***
### 1- General:
1. Intranasal low-dose dexmedetomidine alleviates propofol-associated postoperative sleep disturbance in female hysteroscopy patients: a randomized controlled trial, BMC Anesthesiology, 27 February 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03720-3)
2. Ciprofol versus propofol and the risk of hemodynamic adverse events: a meta-analysis with trial sequential analysis of randomized controlled trials, BMC Anesthesiology, 27 February 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03648-8)
3. Dexmedetomidine reduces pulmonary complications in older patients undergoing abdominal laparoscopic surgery: a prospective, single-blinded, randomized controlled trial, BMC Anesthesiology, 14 February 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03633-1)
### 2- Airway & Mechanical Ventilation:
1. Combination of COMBO endoscopy oropharyngeal airway and high-flow nasal cannula oxygenation in sedated gastrointestinal endoscopy for morbidly obese patients: a Simon two-stage trial, BMC Anesthesiology, 19 February 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03708-z)
### 3- Cardiovascular & Hemodynamics:
1. Effect of Subcutaneous vs Topical nitroglycerin on the radial artery dimensions in pediatric patients undergoing surgery: A randomized non-inferiority trial, Journal of Cardiothoracic and Vascular Anesthesia, 4 March 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S105307702600203X)
2. Perioperative Multimodal General Anesthesia Focusing on Specific Central Nervous System Targets Does Not Reduce Postoperative Interleukin-6 and Neurofilament Light Levels in Patients Undergoing Cardiac Surgeries: A Randomized Controlled Trial, Journal of Cardiothoracic and Vascular Anesthesia, March 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025011279)
### 4- Thoracic:
1. Effects of preconditioning with one-lung ventilation on perioperative oxygenation and oxidative stress in thoracoscopic surgery: a prospective single-center randomized controlled clinical trial, BMC Anesthesiology, 28 February 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03709-y)
2. Right lateral decubitus as a strategy to improve left bronchial blocker placement in thoracic operations: a randomized clinical trial, BMC Anesthesiology, 23 February 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03658-6)
3. Effect of oliceridine versus morphine on the quality of early recovery after thoracoscopic surgery: a randomized, controlled clinical trial, BMC Anesthesiology, 13 February 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03674-6)
### 5- Obstetrics & Gynecology:
1. The 90% effective dose (ED90) of esketamine for inhibiting responses to intraoperative motor stimulation during ambulatory hysteroscopy: a biased-coin up-and-down sequential allocation trial, BMC Anesthesiology, 14 February 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03687-1)
### 6- Pediatric:
1. The effect of preoperative remimazolam application on emergence delirium in children under sevoflurane anesthesia based on electroencephalogram analysis: a randomized, double-blind, placebo-controlled study, BMC Anesthesiology, 5 March 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03727-w)
2. Clinical effectiveness of transversus abdominis plane block versus local anaesthesia wound infiltration for postoperative pain relief after laparoscopic appendicectomy in children: A multicentre, double-blind, randomised, controlled phase III trial, EJA, 4 March 2026, [Link](https://journals.lww.com/ejanaesthesiology/abstract/9900/clinical%5Feffectiveness%5Fof%5Ftransversus%5Fabdominis.402.aspx)
3. A novel dexmedetomidine nasal spray for gastrointestinal recovery in pediatric laparoscopic hernia repair: a randomized controlled trial, BMC Anesthesiology, 18 February 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03712-3)
4. Effectiveness of McGRATH MAC Video Laryngoscopy for First-Attempt Intubation by Anesthesia Trainees in Infants: A Randomized Controlled Trial, A&A, 16 February 2026, [Link](https://journals.lww.com/anesthesia-analgesia/abstract/9900/effectiveness%5Fof%5Fmcgrath%5Fmac%5Fvideo%5Flaryngoscopy.1670.aspx)
5. Lung Ultrasound Evaluation of the Impact of Inspired Oxygen Fraction on Atelectasis During Induction of General Anesthesia in Pediatric Patients: A Randomized Controlled Trial, Shock, 31 December 2025, [Link](https://journals.lww.com/shockjournal/abstract/9900/lung%5Fultrasound%5Fevaluation%5Fof%5Fthe%5Fimpact%5Fof.815.aspx)
### 7- Orthopedic:
1. Impact of a thermal care bundle on perioperative hypothermia, surgical site infection, and readmissions in osteosynthesis patients: A randomized controlled trial, EJA, 17 February 2026, [Link](https://journals.lww.com/ejanaesthesiology/abstract/9900/impact%5Fof%5Fa%5Fthermal%5Fcare%5Fbundle%5Fon%5Fperioperative.396.aspx)
### 8- Regional Anesthesia & Pain Management:
1. Modified longitudinal intermediate cervical plexus block for supraclavicular nerve analgesia: a randomized, double-blind trial in healthy volunteers, BMC Anesthesiology, 28 February 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03723-0)
2. Respiratory effects of rectus sheath block in patients undergoing major upper abdominal surgery: a randomized controlled trial, BMC Anesthesiology, 26 February 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03666-6)
3. Morphine Plus Placebo vs Morphine Plus Acetaminophen for Acute Pain in the Emergency Department: A Randomized Clinical Trial, JAMA Open, 24 February 2026, [Link](https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2845448)
4. Quadratus lumborum block versus femoral nerve block in total hip arthroplasty: a randomized clinical trial, BMC Anesthesiology, 24 February 2026, [Link](https://link.springer.com/article/10.1186/s12871-025-03586-x)
5. Ultrasound-guided retro-superior costotransverse ligament space block (RSSB) versus subcostal transversus abdominis plane block (TAPB) for postoperative analgesia in gastric cancer patients undergoing laparoscopic gastrectomy : a prospective randomized controlled trial, BMC Anesthesiology, 23 February 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03700-7)
6. Impact of preoperative continuous supra-inguinal fascia iliaca block or anterior quadratus lumborum block versus conventional analgesia on quality of recovery after hip fracture surgery: a three-arm randomized clinical trial, BMC Anesthesiology, 23 February 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03696-0)
7. Application of anterior sciatic nerve block with liposomal bupivacaine in lower leg fracture surgery: a randomized clinical trial, BMC Anesthesiology, 23 February 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03719-w)
8. CYP2D6-Guided Opioid Management and Postoperative Pain Control: A Randomized Clinical Trial, JAMA Open, 20 February 2026, [Link](https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2845325)
9. Reduced movement-evoked pain with liposomal bupivacaine versus ropivacaine in transversus abdominis plane block for laparoscopic colorectal surgery: a randomized controlled trial, BMC Anesthesiology, 17 February 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03695-1)
10. Comparison of sympathetic block and hemodynamic effects of erector spinae plane block and thoracic epidural analgesia in breast surgery: a randomised controlled trial, BMC Anesthesiology, 14 February 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03694-2)
---
## ***Reviews:***
### 1- AI:
1. Machine learning for hemodynamic instability prediction and hemorrhage management in trauma and perioperative care, *Current Opinion in Anesthesiology*, April 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/2026/04000/machine%5Flearning%5Ffor%5Fhemodynamic%5Finstability.4.aspx)
2. Real-time, artificial intelligence–guided intraoperative resuscitation and fluid management in trauma anesthesia, *Current Opinion in Anesthesiology*, April 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/2026/04000/real%5Ftime,%5Fartificial%5Fintelligence%5Fguided.5.aspx)
3. Data integration and systems interoperability: the prerequisite for artificial intelligence in anesthesiology, *Current Opinion in Anesthesiology*, April 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/2026/04000/data%5Fintegration%5Fand%5Fsystems%5Finteroperability%5F%5Fthe.8.aspx)
4. Artificial intelligence and predictive analytics in obstetric anesthesia: early warning for maternal complications, *Current Opinion in Anesthesiology*, 11 February 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/artificial%5Fintelligence%5Fand%5Fpredictive%5Fanalytics.386.aspx)
### 2- General:
1. Perioperative Acute Kidney Injury: What’s New in 2025?, Journal of Cardiothoracic and Vascular Anesthesia, March 2026, [Link](https://www.sciencedirect.com/science/article/pii/S1053077025010286)
2. Optimizing Perioperative Management of Sarcoidosis in Noncardiac Surgery: A Focused Review and Practical Framework, Anesthesiology, 17 February 2026, [Link](https://journals.lww.com/anesthesiology/citation/9900/optimizing%5Fperioperative%5Fmanagement%5Fof%5Fsarcoidosis.900.aspx)
### 3- Cardiovascular & Hemodynamics:
1. The Year in Coagulation and Transfusion: Selected Highlights, Journal of Cardiothoracic and Vascular Anesthesia, 4 March 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026002041)
2. Advances in Cardiovascular Pharmacotherapy. VI. Sacubitril-Valsartan, An Angiotensin Receptor-Neprilysin Inhibitor, Journal of Cardiothoracic and Vascular Anesthesia, March 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025012042)
3. Respiratory Reactivation of Herpes Simplex Virus-1 Following Cardiac Surgery in Immunocompetent Individuals, Journal of Cardiothoracic and Vascular Anesthesia, March 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025007591)
4. Management of Liver Cirrhosis in Percutaneous and Surgical Cardiac Interventions, JAHA, 24 February 2026, [Link](https://www.ahajournals.org/doi/10.1161/JAHA.125.045147)
5. Intraoperative blood pressure management in noncardiac surgery: a narrative review based on current evidence, Intensive Care Medicine, 17 February 2026, [Link](https://link.springer.com/article/10.1007/s00134-026-08326-4)
### 4- Thoracic:
1. Perioperative Anesthetic Management of Giant Mediastinal Tumours: Current Advances and Evidence-Based Strategies, Journal of Cardiothoracic and Vascular Anesthesia, 20 February 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026001485)
### 5- Neuro:
1. Timing of Surgery After Ischemic Stroke, *Journal of Neurosurgical Anesthesiology*, April 2026, [Link](https://journals.lww.com/jnsa/abstract/2026/04000/timing%5Fof%5Fsurgery%5Fafter%5Fischemic%5Fstroke.3.aspx)
### 6- Regional Anesthesia & Pain Management:
1. Suzetrigine, a novel nonopioid analgesic for acute pain, *Current Opinion in Anesthesiology*, 17 February 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/suzetrigine,%5Fa%5Fnovel%5Fnonopioid%5Fanalgesic%5Ffor%5Facute.391.aspx)
2. Pain management of adults in the prehospital setting: a scoping review, BMC Emergency Medicine, 17 February 2026, [Link](https://link.springer.com/article/10.1186/s12873-026-01491-1)
3. Common interventional techniques for cancer-related pain, BJA Edu, 13 February 2026, [Link](https://www.bjaed.org/article/S2058-5349%2826%2900006-5/abstract)
---
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# **Critical Care:**
## ***Guidelines & Consensus:***
### 1- Cardiovascular & Hemodynamics:
1. 2026 AHA/ACC/ACCP/ACEP/CHEST/SCAI/SHM/SIR/SVM/SVN Guideline for the Evaluation and Management of Acute Pulmonary Embolism in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines, Circulation, 19 February 2026, [Link](https://www.ahajournals.org/doi/10.1161/CIR.0000000000001415)
1. 2026 Acute Pulmonary Embolism Guideline-at-a-Glance, JACC, 23 February 2026, [Link](https://www.jacc.org/doi/10.1016/j.jacc.2025.12.023)
### 2- Trauma:
1. Western Trauma Association critical decisions in trauma: Significant blunt cardiac injury, *Journal of Trauma and Acute Care Surgery*, 20 February 2026, [Link](https://journals.lww.com/jtrauma/citation/9900/western%5Ftrauma%5Fassociation%5Fcritical%5Fdecisions%5Fin.1267.aspx)
2. Executive summary of the Brain Trauma Foundation Guidelines for the Management of Penetrating Traumatic Brain Injury, Second Edition, *Journal of Trauma and Acute Care Surgery*, March 2026, [Link](https://journals.lww.com/jtrauma/abstract/2026/03000/executive%5Fsummary%5Fof%5Fthe%5Fbrain%5Ftrauma%5Ffoundation.4.aspx)
### 3- Blood & hemostasis:
1. An American College of Surgeons Committee on Trauma Stop the Bleed guideline on the use of improvised tourniquets for trauma patients with life-threatening extremity hemorrhage 2025, *Journal of Trauma and Acute Care Surgery*, 20 February 2026, [Link](https://journals.lww.com/jtrauma/citation/9900/an%5Famerican%5Fcollege%5Fof%5Fsurgeons%5Fcommittee%5Fon.1266.aspx)
### 4- Nutrition:
1. Correction: The Japanese Critical Care Nutrition Guideline 2024, Journal of Intensive Care, 28 February 2026, [Link](https://link.springer.com/article/10.1186/s40560-026-00856-9)
##
---
## ***Systematic reviews & meta-analyses:***
### 1- AI:
1. Evaluating the impact of artificial intelligence tools on the detection of chest injuries from medical imaging: A systematic review and meta-analysis, *Journal of Trauma and Acute Care Surgery*, 12 February 2026, [Link](https://journals.lww.com/jtrauma/fulltext/9900/evaluating%5Fthe%5Fimpact%5Fof%5Fartificial%5Fintelligence.1264.aspx)
### 2- Cardiovascular & Hemodynamics:
1. Prevalence and outcomes of in-hospital cardiac arrest in the intensive care unit: a systematic review and meta-analysis, Critical Care, 27 February 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-05880-7)
2. Intraosseous and intravenous vascular access during adult cardiac arrest: a systematic review and meta-analysis, Resuscitation, 26 February 2026, [Link](https://www.sciencedirect.com/science/article/pii/S0300957226000614)
3. The Use of Extracorporeal Membrane Oxygenation in Traumatic Brain Injury and Neurosurgical Patients: A Single-Center Analysis and Systematic Review, Neurocritical Care, 26 February 2026, [Link](https://link.springer.com/article/10.1007/s12028-026-02449-8)
4. Percutaneous Mechanical Aspiration for Tricuspid Valve Infective Endocarditis: A Systematic Review and Meta-Analysis, Journal of Cardiothoracic and Vascular Anesthesia, 13 February 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026001357)
### 3- Thorax/Lungs/Airways/Mechanical ventilation:
1. Effect of driving pressure-limiting strategies on outcomes of patients with ARDS: a meta-analysis of randomized controlled trials, Critical Care, 5 March 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-05876-3)
### 4- Trauma:
1. Comparative efficacy of prehospital resuscitation strategies on mortality for patients with major trauma: a network meta-analysis, *European Journal of Emergency Medicine*, 9 February 2026, [Link](https://journals.lww.com/euro-emergencymed/abstract/9900/comparative%5Fefficacy%5Fof%5Fprehospital%5Fresuscitation.220.aspx)
### 5- Infectious Diseases:
1. Venoarterial Extracorporeal MembraneOxygenation in Septic Shock and/or Sepsis-induced Cardiomyopathy: A Systematic Review of Fifteen Studies, Journal of Cardiothoracic and Vascular Anesthesia, March 2026, [Link](https://www.sciencedirect.com/science/article/pii/S1053077025010079)
2. Prognostic Factors Associated with Pneumonia in Patients with Traumatic Brain Injury: A Systematic Review and Meta-analysis, Neurocritical Care, 26 February 2026, [Link](https://link.springer.com/article/10.1007/s12028-026-02459-6)
3. Chlorhexidine vs Povidone-Iodine and Incidence of Catheter-Related Infections: A Systematic Review and Meta-Analysis, JAMA Open, 12 February 2026, [Link](https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2844975)
### 6- Other:
1. Effects of digital communication tools on patients, family members and health care professionals in adult ICUs: a mixed-methods systematic review, Critical Care, 3 March 2026, [Link](https://link.springer.com/article/10.1186/s13054-025-05826-5)
---
## ***Clinical trials:***
### 1- Cardiovascular & Hemodynamics:
1. Low-Dose Rivaroxaban to Prevent Left Ventricular Thrombosis After Anterior Myocardial Infarction: The APERITIF Randomized Clinical Trial, JAM, 25 February 2026, [Link](https://jamanetwork.com/journals/jamacardiology/fullarticle/2845590)
2. The effect of plasma versus crystalloids on intravascular volume, tissue perfusion and tissue oxygenation: a randomized controlled trial in a human endotoxemia model, Critical CXare, 24 February 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-05885-2)
3. Evaluating hands-free carotid Doppler ultrasound for real-time return of spontaneous circulation detection in in-hospital cardiac arrest: a multicenter randomized controlled study, Resuscitation, 18 February 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0300957226000626)
4. Comparison of the European Society of Cardiology 0/1-Hour and High-Sensitivity Troponin in the Evaluation of Patients With Suspected Acute Coronary Syndrome 0/2-or-0/3-Hour Algorithms for Rapid Myocardial Infarction Diagnosis: A Prospective Multicenter Study, JACC, 18 February 2026, [Link](https://www.jacc.org/doi/10.1016/j.jacc.2025.12.056)
### 2- Thorax/Lungs/Airways/Mechanical ventilation:
1. Blade Size and Outcomes with Standard-Geometry Video Laryngoscopy in Emergency Tracheal Intubations: Secondary Analysis of Two Randomized Controlled Trials, CHEST Critical Care, 5 March 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2949788426000249)
2. Fiberoptic Bronchoscopy Monitoring During Percutaneous Dilatational Tracheostomy: A Multicenter, Randomized, Controlled Trial. The FIBERTRACH Randomized Clinical Trial, *Critical Care Medicine*, 26 February 2026, [Link](https://journals.lww.com/ccmjournal/abstract/9900/fiberoptic%5Fbronchoscopy%5Fmonitoring%5Fduring.754.aspx)
3. Comparison of two different recruitment maneuver patterns in ARDS patients, Intensive Care Medicine Experimental, 14 February 2026, [Link](https://link.springer.com/article/10.1186/s40635-026-00854-z)
### 3- Neuro-muscular:
1. Head Down Position Before Endovascular Treatment for Large Vessel Occlusion: Clinical Trial Design, JAHA, 4 March 2026, [Link](https://www.ahajournals.org/doi/10.1161/JAHA.125.046853)
2. Feasibility of Calculating and Maintaining Near-Infrared Spectroscopy-Guided Personalized Mean Arterial Pressure Targets in Adults With Critical Illness: A Pilot Clinical Study, *Critical Care Explorations*, March 2026, [Link](https://journals.lww.com/ccejournal/fulltext/2026/03000/feasibility%5Fof%5Fcalculating%5Fand%5Fmaintaining.2.aspx)
3. Critical illness–related corticosteroid insufficiency after acute brain hemorrhage surgery: a prospective cohort study with a randomized trial of hydrocortisone, Critical Care, 24 February 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-05915-z)
4. Safety and Efficacy of Early Aspirin Administration After Intravenous Thrombolysis for Acute Ischemic Stroke (TREND‐IVT): Rationale and Design of a Multicenter, Randomized, Placebo‐Controlled Clinical Trial, JAHA, 20 February 2026, [Link](https://www.ahajournals.org/doi/10.1161/JAHA.125.045180)
### 4- Renal:
1. Prognosis of critically ill patients with severe acute kidney injury and high circulating dipeptidyl peptidase 3: a *post hoc* analysis of the AKIKI 2 trial, 3 March 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-05910-4)
2. Association of duration of amino acids infusion and renal protection: a secondary analysis of the PROTECTION trial, BJA, 24 February 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900046-2/abstract)
### 5- Trauma:
1. Influence of multiple trauma on the effect of transfusion strategies in patients with traumatic brain injury: a sub-study of the HEMOTION trial, Intensive Care Medicine, 3 March 2026, [Link](https://link.springer.com/article/10.1007/s00134-025-08290-5)
### 6- Nutrition:
1. The Impact of Early Enteral Nutrition on Ventilator- and Vasopressor-Free Days in Mechanically Ventilated Patients with Septic Shock: A Secondary Analysis of a Pilot Randomized Controlled Trial, CHEST Critical Care, 26 February 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2949788426000225)
### 7- Infectious Diseases:
1. Albumin Replacement Therapy in Septic Shock: A Randomized Clinical Trial, JAMA Open, 19 February 2026, [Link](https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2845268)
2. Effect of Neostigmine on Attenuation of Proinflammatory Cytokines When Given as an Adjuvant Therapy in Septic Shock: A Randomized Controlled Trial, Critical Care Medicine, 12 February 2026, [Link](https://journals.lww.com/ccmjournal/abstract/9900/effect%5Fof%5Fneostigmine%5Fon%5Fattenuation%5Fof.746.aspx)
3. Clinical and Immunologic Effects of Extracorporeal Cytokine Removal in Patients with Septic Shock: A Randomized Controlled Trial, Shock, 4 February 2026, [Link](https://journals.lww.com/shockjournal/abstract/9900/clinical%5Fand%5Fimmunologic%5Feffects%5Fof%5Fextracorporeal.824.aspx)
### 8- Sedation & analgesia:
1. Eyecontrol coMmunication platform for dEliRium manaGemEnt in intensive care units (EMERGE): Protocol for a Multicentre Randomized Controlled Trial, CHEST Critical Care, 26 February 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2949788426000213)
2. Association between ABCDE bundle compliance and long-term outcomes: a secondary longitudinal analysis, Intensive Care Medicine, 25 February 2026, [Link](https://link.springer.com/article/10.1007/s00134-026-08346-0)
### 9- Pediatric critical care:
1. Protocol for a Randomized Clinical Trial to Evaluate Not Routinely Measuring Gastric Residual Volume to Guide Enteral Feeding Versus Routine Measurement in Mechanically Ventilated Critically Ill Children (GASTRIC-PICU), *Pediatric Critical Care Medicine*, 26 February 2026, [Link](https://journals.lww.com/pccmjournal/pages/articleviewer.aspx?year=9900&issue=00000&article=00631&type=Fulltext)
---
## ***Reviews:***
### 1- Cardiovascular & Hemodynamics:
1. Advances in cardiovascular pharmacotherapy. VII. Soluble guanylate cyclase stimulators in pulmonary hypertension and heart failure, Journal of Cardiothoracic and Vascular Anesthesia, 25 February 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S105307702600176X)
2. Extracorporeal cardiopulmonary resuscitation in adult patients following in-hospital and out-of-hospital refractory cardiac arrest: A Narrative Review, Journal of Cardiothoracic and Vascular Anesthesia, 24 February 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026001783)
3. Prehospital diagnosis and management of supraventricular tachycardia – a scoping review, Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 21 February 2026, [Link](https://link.springer.com/article/10.1186/s13049-026-01583-8)
4. Revisiting *Commotio Cordis*: Novel Insight Into Clinical Variability, Diagnosis, Epidemiology, and Prevention, JAHA, 20 February 2026, [Link](https://www.ahajournals.org/doi/10.1161/JAHA.125.045115)
5. Left Ventricular Outflow Tract Obstruction in Critically Ill Patients: from Pathophysiology and diagnosis to the management with the “LVOTO” Bundle, Anaesthesia Critical Care & Pain Medicine, 17 February 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556826000287)
6. Cardiogenic Shock Detection Using Electronic Medical Records: A Review and Blueprint for Clinical Implementation and Future Research, JAHA, 11 February 2026, [Link](https://www.ahajournals.org/doi/10.1161/JAHA.125.047049)
### 2- Thorax/Lungs/Airways/Mechanical ventilation:
1. Prediction of high-flow nasal cannula failure in critically ill patients: a narrative review, Journal of Intensive Care, 3 March 2026, [Link](https://link.springer.com/article/10.1186/s40560-026-00871-w)
2. Sex-specific considerations for mechanical ventilation in acute respiratory distress syndrome: implications for female patients in the intensive care unit, a narrative review, BJA, 24 February 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900048-6/abstract)
3. The ISHLT Consensus Statement on the Perioperative Use of ECLS in Lung Transplantation: Highlights and Perioperative Implications, Journal of Cardiothoracic and Vascular Anesthesia, 18 February 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S105307702600145X)
### 3- Neuro-muscular:
1. Diagnosis of death using neurological criteria in adults, BJA Edu, 4 March 2026, [Link](https://www.bjaed.org/article/S2058-5349%2826%2900014-4/abstract)
2. Neuroprognostication in Extracorporeal Membrane Oxygenation Patients After Cardiac Arrest: A Narrative Review, Journal of Cardiothoracic and Vascular Anesthesia, March 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025010274)
3. Posterior reversible encephalopathy syndrome (PRES): A narrative review of pathophysiology, clinical insights, and advances in management, International Journal of Emergency Medicine, 19 February 2026, [Link](https://link.springer.com/article/10.1186/s12245-026-01138-9)
### 4- Renal:
1. Mitigating Risk of Kidney Dysfunction After Heart Transplantation and Therapeutic Approaches, Circulation: Heart Failure, 23 February 2026, [Link](https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.125.013747)
2. Urinary oxygen partial pressure as a potential biomarker for acute kidney injury: a narrative review, Shock, 23 December 2025, [Link](https://journals.lww.com/shockjournal/abstract/9900/urinary%5Foxygen%5Fpartial%5Fpressure%5Fas%5Fa%5Fpotential.811.aspx)
### 5- Trauma:
1. Emergency care for avalanche-buried patients - a narrative review, Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 20 February 2026, [Link](https://link.springer.com/article/10.1186/s13049-026-01543-2)
### 6- Blood & hemostasis:
1. Recognizing and Managing Hemophagocytic Lymphohistiocytosis in Adults in the Intensive Care Unit, Critical Care Clinics, 18 February 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070426000011)
### 7- Nutrition:
1. Preexisting malnutrition in the ICU, *Current Opinion in Critical Care*, April 2026, [Link](https://journals.lww.com/co-criticalcare/abstract/2026/04000/preexisting%5Fmalnutrition%5Fin%5Fthe%5Ficu.17.aspx)
2. Macronutrient excess in critical illness: too much of a good thing?, *Current Opinion in Critical Care*, April 2026, [Link](https://journals.lww.com/co-criticalcare/abstract/2026/04000/macronutrient%5Fexcess%5Fin%5Fcritical%5Fillness%5F%5Ftoo%5Fmuch.18.aspx)
3. Advances and Challenges in Sepsis Care in Low-Resource Settings, Critical Care Clinics, 6 March 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070426000151)
4. The poikilothermic hypothesis of sepsis, Critical Care, 5 March 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-05879-0)
5. Malnutrition and Cachexia in Inpatients With Acute Cardiac Conditions: A Scientific Statement From the American Heart Association, Circulation, 24 February 2026, [Link](https://www.ahajournals.org/doi/10.1161/CIR.0000000000001405)
### 8- Infectious Diseases:
1. Immunocompromised host pneumonia: a shifting landscape of risk, *Current Opinion in Pulmonary Medicine*, 4 March 2026, [Link](https://journals.lww.com/co-pulmonarymedicine/abstract/9900/immunocompromised%5Fhost%5Fpneumonia%5F%5Fa%5Fshifting.320.aspx)
### 9- Pediatric critical care:
1. Analgesia and sedation in mechanically ventilated critically ill children, BJA Edu, 25 February 2026, [Link](https://www.bjaed.org/article/S2058-5349%2826%2900005-3/abstract)
---
### **Feedback & Suggestions**
Don't hesitate to share your thoughts and suggestions in the comments below; they'll be a great help in improving future issues of the newsletter.
**Disclaimer**
💡
****Disclaimer:**
The is for educational and informational purposes only and is not intended to replace professional medical advice, diagnosis, or treatment.
See you next time :)
**Benhalima Othmane.**
**Anecrit.com**
### Anecrit's Newsletter #29
URL: https://www.anecrit.com/newsletter-29/
Last updated: 2026-06-21T12:07:10.000Z
###
_This post is for subscribers only._
### Anecrit's Newsletter #28
URL: https://www.anecrit.com/newsletter-28/
Last updated: 2026-06-21T12:07:17.000Z
###
## Welcome!
**Hey! Just popping in on time for once. Just kidding.** **You’ll be seeing me every Friday or Saturday from here on out. Hope you enjoy the read—I kept it short and sweet for you.**
Follow me on Facebook and LinkedIn:
- [Facebook](https://www.facebook.com/profile.php?id=61576540237541)
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---
# **Anesthesiology:**
## ***Guidelines & Consensus:***
### 1- General:
1. Guidelines on Antibiotic Prophylaxis in Surgery 2024, Anaesthesia Critical Care & Pain Medicine, 31 January 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S235255682600007X)
1. Antibiotic prophylaxis in ear, nose, throat, stomato-maxillo-facial and ophtalmologic surgeries, Anaesthesia Critical Care & Pain Medicine, 31 January 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556826000093)
2. Antibiotic prophylaxis in cardiac surgery, structural heart disease, interventional cardiology and vascular surgery, Anaesthesia Critical Care & Pain Medicine, 31 January 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S235255682600010X)
3. Antibioprophylaxis in thoracic surgery, thoracic endoscopy, and interventional radiology, Anaesthesia Critical Care & Pain Medicine, 31 January 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2352556826000111)
4. Gynaecological surgery, Assisted Reproductive Technology (ART), Obstetrics, and Interventional Gynaecological and Obstetrical Radiology, Anaesthesia Critical Care & Pain Medicine, 31 January 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2352556826000135)
5. Digestive and bariatric surgery, digestive endoscopy and interventional radiology, Anaesthesia Critical Care & Pain Medicine, 31 January 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556826000159)
6. Antibioprophylaxis in neurosurgery, Anaesthesia Critical Care & Pain Medicine, 31 January 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556826000081)
### 2- Cardiovascular & Hemodynamics:
1. Management of Direct Oral Anticoagulants in Adult Patients Undergoing Cardiac Surgery: A Joint Consensus Statement by the Society of Cardiovascular Anesthesiologists and the Society of Thoracic Surgeons, A&A, 29 January 2026, [Link](https://journals.lww.com/anesthesia-analgesia/abstract/9900/management%5Fof%5Fdirect%5Foral%5Fanticoagulants%5Fin%5Fadult.1637.aspx)
---
## ***Systematic reviews & meta-analyses:***
### 1- General:
1. Perioperative Ketamine or Esketamine for Acute Postoperative Pain after Laparoscopic Cholecystectomy: A Systematic Review and Meta-analysis with Meta-regression, Anaesthesia Critical Care & Pain Medicine, 5 February 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556826000202)
2. Quantification of emergency operating theatre process performance: a systematic review of clinical studies, BJA, 3 February 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900008-5/fulltext)
3. Sugammadex and intraocular pressure: systematic review with meta-analysis and trial sequential analysis, BMC Anesthesiology, 2 February 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03661-x)
4. Hypoalbuminemia contributes to postoperative pulmonary complications and mortality: a systematic review and meta-analysis, BMC Anesthesiology, 30 January 2026, [Link](https://link.springer.com/article/10.1186/s12871-025-03329-y)
5. Evidence on Enhanced Recovery After Surgery Protocols in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis of Postoperative Outcomes, A&A, 29 January 2026, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/evidence%5Fon%5Fenhanced%5Frecovery%5Fafter%5Fsurgery.1641.aspx)
### 2- Airway & Mechanical Ventilation:
1. Tracheal intubation in adult patients with anticipated difficult airway: Hyperangulated *versus* Macintosh blade videolaryngoscopy: a comprehensive systematic review, Anaesthesia Critical Care & Pain Medicine, 6 February 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556826000196)
### 3- Thoracic:
1. Intravenous Lidocaine in Video-Assisted Thoracoscopic Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Journal of Cardiothoracic and Vascular Anesthesia, 4 February 2026, [Link](https://www.sciencedirect.com/science/article/pii/S1053077026001084)
2. Comparative efficacy and safety of remimazolam versus propofol in bronchoscopic procedures: a GRADE-assessed systematic review and meta-analysis, BMC Anesthesiology, 31 January 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03634-0)
### 4- Pediatric:
1. Effects of avoidance versus use of neuromuscular blocking agents for facilitation of tracheal intubation in children and infants: A systematic review with meta-analysis and trial sequential analysis, EJA, 3 February 2026, [Link](https://journals.lww.com/ejanaesthesiology/pages/articleviewer.aspx?year=9900&issue=00000&article=00394&type=Abstract)
### 5- Regional Anesthesia & Pain Management:
1. Methodological quality of systematic reviews on the erector spinae plane block: a systematic review, Anaesthesia Critical Care & Pain Medicine, 6 February 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S235255682600024X)
2. Perioperative clinical outcomes of remimazolam in regional anesthesia: a systematic review of sedation and safety parameters, BMC Anesthesiology, 3 February 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03669-3)
---
## ***Clinical trials:***
### 1- General:
1. Regional Anesthesia Combined with Respiratory Physiotherapy Improves Postoperative PaO₂/FiO₂ Ratio and Pulmonary Atelectasis in Thoracolaparoscopic Esophagectomy: A Randomized Controlled Trial, Journal of Cardiothoracic and Vascular Anesthesia, 30 January 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026000960)
### 2- Airway & Mechanical Ventilation:
1. Effect of individualized PEEP guided by EIT vs. conventional fixed PEEP on postoperative pulmonary complications in adult patients with preoperative cardiopulmonary dysfunction undergoing CRS/HIPEC: a randomized clinical trial, BMC Anesthesiology, 2 February 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03650-0)
2. Paratracheal pressure reduces the incidence of moderate-to-severe coughing during endoscopic esophageal iodine staining: a prospective, randomized controlled trial, BMC Anesthesiology, 2 February 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03644-y)
3. High-flow nasal oxygen versus face-mask ventilation for rapid sequence induction in non-elective surgical patients: a randomized controlled trial, BMC Anesthesiology, 31 January 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03654-w)
### 3- Neuro:
1. General Anesthesia Versus Conscious Sedation for Mechanical Thrombectomy in Patients With Acute Ischemic Stroke in the MOST Trial, Journal of the American Heart Association, 3 February 2026, [Link](https://www.ahajournals.org/doi/10.1161/JAHA.125.044874)
2. Transcranial Motor Evoked Potential Monitoring Using Propofol-Fentanyl Versus Desflurane-Dexmedetomidine Anesthesia During Spinal Cord Tumour Resection: A Randomized Controlled Trial, *Journal of Neurosurgical Anesthesiology*, 26 January 2026, [Link](https://journals.lww.com/jnsa/abstract/9900/transcranial%5Fmotor%5Fevoked%5Fpotential%5Fmonitoring.205.aspx)
### 4- Obstetrics & Gynecology:
1. Effects of Preoperative Pain Education on Postoperative Pain and Postpartum Depression following Elective Cesarean Sections: A Randomized Controlled Trial, *The Clinical Journal of Pain,* 30 January 2026, [Link](https://journals.lww.com/clinicalpain/abstract/9900/effects%5Fof%5Fpreoperative%5Fpain%5Feducation%5Fon.319.aspx)
### 5- Regional Anesthesia & Pain Management:
1. Ultrasound-guided percutaneous versus trans-nasal pterygopalatine fossa block in endoscopic trans-sphenoidal pituitary gland surgery: a randomized controlled trial, BMC Anesthesiology, 2 February 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03618-0)
---
## ***Reviews:***
### 1- AI:
1. Artificial intelligence in airway management: a narrative review, BJA, 4 February 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900002-4/fulltext)
### 2- General:
1. Ethical and Practical Barriers to Consent in Acute Care and Anaesthetic Clinical Trials: A Scoping Review, Anaesthesia Critical Care & Pain Medicine, 6 February 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556826000251)
### 3- Cardiovascular & Hemodynamics:
1. Does Language Matter? The Impact of English Proficiency on Healthcare Outcomes After Cardiac Surgery: A Scoping Review, A&A, 29 January 2026, [Link](https://journals.lww.com/anesthesia-analgesia/abstract/9900/does%5Flanguage%5Fmatter%5F%5Fthe%5Fimpact%5Fof%5Fenglish.1639.aspx)
### 4- Neuro:
1. Targeting γ-aminobutyric acid type A receptors to mitigate perioperative neurocognitive disorders: a narrative review, BJA, 3 February 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900006-1/fulltext)
2. Genetic and epigenetic insights into perioperative neurocognitive disorders: a narrative review, BJA, 30 January 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900933-X/abstract)
### 5- Obstetrics & Gynecology:
1. Liver disease in pregnancy, BJA Edu, 4 February 2026, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900118-0/abstract)
### 6- Regional Anesthesia & Pain Management:
1. Pathophysiology of Chronic Pain, *The Clinical Journal of Pain,* 2 February 2026, [Link](https://journals.lww.com/clinicalpain/abstract/9900/pathophysiology%5Fof%5Fchronic%5Fpain.320.aspx)
---
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# **Critical Care:**
## ***Guidelines & Consensus:***
### 1- Cardiovascular & Hemodynamics:
1. Acute Coronary Syndromes in Premenopausal Women: A Scientific Statement From the American Heart Association, Circulation, 3 February 2026, [Link](https://www.ahajournals.org/doi/10.1161/CIR.0000000000001416)
---
## ***Systematic reviews & meta-analyses:***
### 1- AI:
1. Machine Learning Models for Predicting Stroke-Associated Pneumonia: A Systematic Review and Meta-Analysis, Neurocritical Care, 3 February 2026, [Link](https://link.springer.com/article/10.1007/s12028-026-02450-1)
2. Prognostic value of machine learning for brain computed tomography as a predictor of neurologic outcomes after cardiac arrest: a systematic review and meta-analysis, Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 30 January 2026, [Link](https://link.springer.com/article/10.1186/s13049-026-01565-w)
### 2- Cardiovascular & Hemodynamics:
1. Efficacy and safety of ultrasound-guided infraclavicular axillary vein cannulation for centrally inserted central catheter placement in critically ill patients: systematic review with meta-analysis and trial sequential analysis, Critical Care, 30 January 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-05869-2)
### 3- Neuro-muscular:
1. Diagnostic accuracy of transcranial Doppler for cerebral vasospasm in aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis, Critical Care, 2 February 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-05849-6)
### 4- Pediatric critical care:
1. Nutritional interventions and outcomes after severe traumatic brain injury in children: a systematic review and meta-analysis, Clinical Nutrition, 31 January 2026, [Link](https://www.clinicalnutritionjournal.com/article/S0261-5614%2826%2900018-X/fulltext)
---
## ***Clinical trials:***
### 1- Cardiovascular & Hemodynamics:
1. Immediate vs Delayed Coronary Angiography After Cardiac Arrest Without ST-Segment Elevation: 5-Year Outcomes From the COACT Randomized Trial, JACC, 4 February 2026, [Link](https://www.jacc.org/doi/10.1016/j.jacc.2025.12.018)
2. Emergency total extracorporeal life support versus standard advanced cardiac life support with rescue extracorporeal membrane oxygenation for refractory out-of-hospital cardiac arrest: protocol for the ECLS-OHCA randomized trial, Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 3 February 2026, [Link](https://link.springer.com/article/10.1186/s13049-026-01557-w)
### 2- Neuro-muscular:
1. Tenecteplase for Acute Non–Large Vessel Occlusion 4.5 to 24 Hours After Ischemic Stroke: The OPTION Randomized Clinical Trial, JAMA, 5 February 2026, [Link](https://jamanetwork.com/journals/jama/fullarticle/2844754)
1. Tenecteplase for Acute Non–Large Vessel Occlusion Ischemic Stroke: Research Summary, JAMA, 5 February 2026, [Link](https://jamanetwork.com/journals/jama/fullarticle/2844753)
2. Head Down Tilt 15° to Increase Collateral Flow in Acute Ischemic Stroke: Rationale and Study Protocol of a Multicenter, Randomized, Proof-of-Concept, Phase 2a/b Trial in Patients Treated With Mechanical Thrombectomy (DOWN-SUITE), Stroke: Vascular and Interventional Neurology, 4 February 2026, [Link](https://www.ahajournals.org/doi/10.1161/SVIN.125.002221)
### 3- Renal:
1. The comparison of circuit lifespan between integration and separation approach in extracorporeal membrane oxygenation patients requiring continuous renal replacement therapy support: a randomized controlled trial (E-CRRT Trial), Intensive Care Medicine, 5 February 2026, [Link](https://link.springer.com/article/10.1007/s00134-026-08302-y)
---
## ***Reviews:***
### 1- Thorax/Lungs/Airways/Mechanical ventilation:
1. Respiratory muscle motor control in mechanically ventilated patients: A scoping review, CHEST Critical Care, 5 February 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2949788426000146)
### 2- Neuro-muscular:
1. Consensus Review of Perioperative Immune Modulation for Endovascular Thrombectomy Following Ischemic Stroke, Stroke, 2 February 2026, [Link](https://www.ahajournals.org/doi/10.1161/STROKEAHA.125.051556)
2. Acute management of spontaneous intracerebral hemorrhage (ICH) in the emergency department, International Journal of Emergency Medicine, 30 January 2026, [Link](https://link.springer.com/article/10.1186/s12245-026-01126-z)
3. Disorders of consciousness in the ICU: gaps in establishing and communicating the prognosis, *Current Opinion in Critical Care*, 29 January 2026, [Link](https://journals.lww.com/co-criticalcare/abstract/9900/disorders%5Fof%5Fconsciousness%5Fin%5Fthe%5Ficu%5F%5Fgaps%5Fin.343.aspx)
4. Omics-based approaches for acute brain injury research, *Current Opinion in Critical Care*, 29 January 2026, [Link](https://journals.lww.com/co-criticalcare/abstract/9900/omics%5Fbased%5Fapproaches%5Ffor%5Facute%5Fbrain%5Finjury.342.aspx)
### 3- Liver:
1. Acalculous cholecystitis in the critically ill: evolving insights into diagnosis and management, *Current Opinion in Critical Care*, 29 January 2026, [Link](https://journals.lww.com/co-criticalcare/abstract/9900/acalculous%5Fcholecystitis%5Fin%5Fthe%5Fcritically%5Fill%5F.341.aspx)
### 4- Nutrition:
1. Parenteral nutrition in the ICU, Clinical Nutrition Open, 30 January 2026, [Link](https://www.clinicalnutritionopenscience.com/article/S2667-2685%2826%2900011-2/fulltext)
### 5- Infectious Diseases:
1. Current evidence on septic shock in patients with cirrhosis, *Current Opinion in Critical Care*, 5 February 2026, [Link](https://journals.lww.com/co-criticalcare/abstract/9900/current%5Fevidence%5Fon%5Fseptic%5Fshock%5Fin%5Fpatients%5Fwith.345.aspx)
2. The therapeutic potential of high-dose inhaled nitric oxide for antimicrobial effects: a narrative review and future directions, ICM Experimental, 5 February 2026, [Link](https://link.springer.com/article/10.1186/s40635-026-00852-1)
3. Severe community-acquired pneumonia: an integral approach, Journal of Intensive Care, 31 January 2026, [Link](https://link.springer.com/article/10.1186/s40560-026-00854-x)
4. Clinical applications for the endotoxin activity assay in sepsis: a scoping review, Critical Care, 30 January 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-05868-3)
5. Rethinking pneumonia in terms of the lung microbiome, *Current Opinion in Pulmonary Medicine*, 30 January 2026, [Link](https://journals.lww.com/co-pulmonarymedicine/abstract/9900/rethinking%5Fpneumonia%5Fin%5Fterms%5Fof%5Fthe%5Flung.301.aspx)
### 6- Pediatric critical care:
1. Characteristics, Management, and Outcomes of Perioperative Cardiac Arrest in Children Undergoing Noncardiac Surgery Procedures: A Scoping Review, Resuscitation Plus, 5 February 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2666520426000433)
### 7- Other:
1. Immunometabolism, an emerging field in perioperative and critical care medicine: a narrative review, BJA, 3 February 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2826%2900005-X/fulltext)
---
### **Feedback & Suggestions**
Don't hesitate to share your thoughts and suggestions in the comments below; they'll be a great help in improving future issues of the newsletter.
**Disclaimer**
💡
****Disclaimer:**
The is for educational and informational purposes only and is not intended to replace professional medical advice, diagnosis, or treatment.
See you next time :)
**Benhalima Othmane, MD.**
**Anecrit.com**
### Anecrit's Newsletter #27
URL: https://www.anecrit.com/newsletter-27/
Last updated: 2026-06-21T12:07:24.000Z
## Welcome!
Hey there!
There are more of you here every day, and honestly? It’s the best kind of motivation. I’ve been writing less than I’d like lately, but the spark is back. Your inbox is about to get a lot more **anecrit** in the next few weeks. Thanks for sticking with me—hope you love this issue!
---
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---
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Join the growing community of anesthesiologists and intensivists staying current on the latest evidence.
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# **Anesthesiology:**
## ***Guidelines & Consensus:***
### 1- General:
1. The definition and aims of Anesthesia: a Delphi-based consensus statement, Anaesthesia Critical Care & Pain Medicine, January 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2352556825001468)
### 2- Cardiovascular & Hemodynamics:
1. Management of anaesthesia for transfemoral transcatheter aortic valve implantation: an Italian interdisciplinary consensus statement, BJA, 2 January 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900801-3/abstract)
2. Perioperative hemodynamic optimization - Adults including obstetrics, Anaesthesia Critical Care & Pain Medicine, January 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2352556825001948)
### 3- Obstetrics & Gynecology:
1. Prevention and Treatment of Maternal Stroke in Pregnancy and Postpartum: A Scientific Statement From the American Heart Association, Stroke, 28 January 2026, [Link](https://www.ahajournals.org/doi/10.1161/STR.0000000000000514)
### 4- Pediatric:
1. Perioperative hemodynamic optimization - Paediatrics, Anaesthesia Critical Care & Pain Medicine, January 2026, [Link](https://www.sciencedirect.com/science/article/pii/S235255682500195X)
---
## ***Systematic reviews & meta-analyses:***
### 1- General:
1. Prevalence of perioperative functional disability using WHODAS 2.0 and associated adverse outcomes in surgical populations: A systematic review and meta-analysis, Anaesthesia Critical Care & Pain Medicine, January 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2352556825001559)
2. Eight strategic elements that support successful implementation of beneficial nutritional interventions in the perioperative setting: A systematic review, Clinical Nutrition, Janaury 2026, [Link](https://www.clinicalnutritionjournal.com/article/S0261-5614%2825%2900327-9/fulltext)
### 2- Airway & Mechanical Ventilation:
1. Efficacy of High-Flow Nasal Cannula Oxygen Therapy During Bronchoscopy: A Systematic Review and Meta-Analysis, *Journal of Bronchology & Interventional Pulmonology*, April 2026, [Link](https://journals.lww.com/bronchology/abstract/2026/04010/efficacy%5Fof%5Fhigh%5Fflow%5Fnasal%5Fcannula%5Foxygen%5Ftherapy.4.aspx)
### 3- Cardiovascular & Hemodynamics:
1. Topical versus Intravenous Tranexamic Acid in Cardiac Surgery: A Meta-analysis of Randomized Controlled Trials, Journal of Cardiothoracic and Vascular Anesthesia, 20 January 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S105307702600039X)
2. Acute normovolaemic haemodilution after cardiac surgery: a meta-analysis of randomised controlled trials, BJA, 19 January 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900871-2/abstract)
3. Cognitive Outcomes in Randomized Controlled Trials of Coronary Artery Bypass Graft Surgery From 2005 to 2025: A Systematic Review, Journal of the American Heart Association, 14 January 2026, [Link](https://www.ahajournals.org/doi/10.1161/JAHA.125.041946)
4. Efficacy of Hemoadsorption in Cardiac Surgery with Cardiopulmonary Bypass: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Journal of Cardiothoracic and Vascular Anesthesia, 14 January 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026000406)
### 4- Neuro:
1. Effects of EEG-guided anesthetic depth monitoring on delirium incidence across different age groups: a systematic review and meta-analysis, BMC Anesthesiology ,28 January 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03631-3)
### 5- Pediatric:
1. Erector spinae plane block in pediatric surgery: a systematic review and meta-analysis, BMC Anesthesiology, 17 January 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03617-1)
2. Intranasal esketamine plus dexmedetomidine versus dexmedetomidine alone for emergence delirium in pediatric patients: a systematic review and meta-analysis of randomized controlled trials, BMC Anesthesiology, 17 January 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03628-y)
3. Perioperative Monitoring of Regional Oxygen Saturation in Congenital Heart Disease: Systematic Review of Literature up to 2023, *Pediatric Critical Care Medicine*, 12 January 2026, [Link](https://journals.lww.com/pccmjournal/fulltext/9900/perioperative%5Fmonitoring%5Fof%5Fregional%5Foxygen.612.aspx)
4. Impact of preoperative fasting duration on perioperative complications in elective paediatric procedures: a systematic review and meta-analysis, BJA, January 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900775-5/fulltext)
### 6- Regional Anesthesia & Pain Management:
1. Superficial parasternal intercostal plane block for analgesia after cardiac surgery: an updated meta-analysis of randomized controlled trials with meta-regression and trial sequential analysis, Journal of Cardiothoracic and Vascular Anesthesia, 19 January 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026000431)
2. Analgesic efficacy of multiple regional nerve block techniques in laparoscopic hepatectomy: a systematic review and meta-analysis, BMC Anesthesiology, 17 January 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03630-4)
3. The effect of fascia Iliaca compartment block in patients with total hip arthroplasty under general vs. spinal anesthesia: a meta-analysis of randomized controlled trials, BMC Anesthesiology, 13 January 2026, [Link](https://link.springer.com/article/10.1186/s12871-025-03564-3)
4. Dexmedetomidine for opioid-sparing postoperative analgesia: a systematic review and meta-analysis, BMC Anesthesiology, 13 January 2026, [Link](https://link.springer.com/article/10.1186/s12871-025-03606-w)
5. Transversus abdominis plane block for postoperative pain management and opioid sparing: a systematic review and meta-analysis of randomised controlled trials, BJA, January 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900753-6/fulltext)
6. Safety of clonidine and dexmedetomidine in peripheral nerve blocks: a systematic review of preclinical evidence, BJA, January 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900700-7/fulltext)
7. Comparative Efficacy of Adductor Canal Block in Total Knee Arthroplasty: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, A&A practice, January 2026, [Link](https://journals.lww.com/aacr/abstract/2026/01000/comparative%5Fefficacy%5Fof%5Fadductor%5Fcanal%5Fblock%5Fin.17.aspx)
---
## ***Clinical trials:***
### 1- General:
1. Effect of low-dose propofol infusion with sevoflurane versus propofol-only total intravenous anesthesia on postoperative nausea and vomiting in high-risk patients: a single-blind randomized controlled clinical trial, BMC Anesthesiology, 28 January 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03649-7)
2. Could Taurine supplementation improve graft functions after liver transplantation? A randomized clinical trial among liver transplant Recipients, Clinical Nutrition ESPEN, 26 January 2026, [Link](https://www.clinicalnutritionespen.com/article/S2405-4577%2826%2900015-X/abstract)
3. Dose-dependent effects of esketamine on the prevention of propofol-induced injection pain: a randomized controlled trial, BMC Anesthesiology, 17 January 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03636-y)
4. Low dose of sugammadex versus neostigmine for reversal of rocuronium-induced moderate neuromuscular block: a randomized controlled trial, BMC Anesthesiology, 17 January 2026, [Link](https://link.springer.com/article/10.1186/s12871-025-03581-2)
5. Conscious analgesia with oxycodone improves the efficacy and safety in patients at high risk of aspiration during gastroscopy: a randomized double-blind trial, BMC Anesthesiology, 14 January 2026, [Link](https://link.springer.com/article/10.1186/s12871-025-03595-w)
6. Novel Immune-Modulating Formula Versus Standard Formula for Gastrointestinal Cancer Patients at Risk of Malnutrition Undergoing Surgery: A Pilot Randomized Controlled Trial, Clinical Nutrition ESPEN, 26 January 2026, [Link](https://www.clinicalnutritionespen.com/article/S2405-4577%2826%2900004-5/abstract)
7. A single-centre, randomised comparison of the performance and safety of a novel mechanomyography sensor with electromyography, BJA, 7 January 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900830-X/fulltext)
### 2- Airway & Mechanical Ventilation:
1. Effect of supraglottic endotracheal tube inserted transorally on preventing hypoxemia in obese patients undergoing sedated bidirectional endoscopy: a prospective randomized controlled clinical trial, BMC Anesthesiology, 9 January 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03608-2)
### 3- Cardiovascular & Hemodynamics:
1. Comparison of performance characteristics of flexible bronchoscopy or video laryngoscopy-assisted versus blind insertion of transesophageal echocardiography probe in adults undergoing cardiac surgery: A randomized controlled study, Journal of Cardiothoracic and Vascular Anesthesia, 21 January 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026000571)
2. Impaired endotoxin inactivation, rather than gut translocation, is associated with organ injury in cardiac surgery with cardiopulmonary bypass: An ancilliary analysis of a randomised control trial, EJA, 14 January 2026, [Link](https://journals.lww.com/ejanaesthesiology/abstract/9900/impaired%5Fendotoxin%5Finactivation,%5Frather%5Fthan%5Fgut.387.aspx)
3. Evaluation of the Effect of Intravenous Lidocaine on the Systemic Inflammatory Response Associated with Cardiopulmonary Bypass in Valvular and/or Coronary Cardiac Surgery: Protocol for a Double-Blind Randomised Clinical Trial, Journal of Cardiothoracic and Vascular Anesthesia, 10 January 2026, [Link](https://www.sciencedirect.com/science/article/pii/S1053077026000352)
4. Impact of continuing renin–angiotensin–aldosterone system inhibitors before surgery on intraoperative hypotensive events: a secondary analysis of the STOP-or-NOT Trial, BMC Anesthesiology, 8 January 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900860-8/abstract)
5. Individualized intraoperative blood pressure control with norepinephrine reduces kidney injury biomarkers but not creatinine-defined acute kidney injury in older patients with hypertension undergoing major abdominal surgery: a single-center randomized controlled trial, BMC Anesthesiology, 6 January 2026, [Link](https://link.springer.com/article/10.1186/s12871-025-03588-9)
6. Low dose of landiolol does not prevent postoperative atrial fibrillation after cardiac surgery in non-Asian patients: a multicentre randomised study, BJA, January 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900669-5/abstract)
7. Effects of Dexmedetomidine on Outcomes After Cardiac Surgery (DOCS): a randomised double-blind, placebo-controlled trial, BJA, January 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900691-9/abstract)
### 4- Thoracic:
1. Lateral Decubitus Strategy is Superior to Ventilatory Strategy in Preventing Atelectasis From Obscuring Targets During Robotic Bronchoscopy, Leading to Improved Procedural Outcomes (Lateral Decubitus Strategy vs Ventilatory Strategy to Prevent Atelectasis Trial), CHEST, 8 January 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0012369225058350)
### 5- Neuro:
1. Opioid-free Anesthesia for Craniotomy in Supratentorial Tumors: An Open-labeled Single-blinded Randomized Controlled Study, *Journal of Neurosurgical Anesthesiology*, 15 January 2026, [Link](https://journals.lww.com/jnsa/abstract/9900/opioid%5Ffree%5Fanesthesia%5Ffor%5Fcraniotomy%5Fin.199.aspx)
### 6- Obstetrics & Gynecology:
1. Prophylactic esketamine to reduce postpartum depression in primiparae: A multicentre, double-blind, randomised clinical trial, EJA, 29 Janaury 2026, [Link](https://journals.lww.com/ejanaesthesiology/fulltext/9900/prophylactic%5Fesketamine%5Fto%5Freduce%5Fpostpartum.392.aspx)
### 7- Pediatric:
1. High-Flow Nasal Oxygenation in Infants Undergoing Tracheal Intubation: A Single-center Randomized Controlled Trial, Anesthesiology, 20 January 2026, [Link](https://journals.lww.com/anesthesiology/abstract/9900/high%5Fflow%5Fnasal%5Foxygenation%5Fin%5Finfants%5Fundergoing.883.aspx)
2. Comparison of oral versus rectal NSAIDs for perioperative analgesia in pediatric circumcision using a disposable circumcision suture device: a randomized controlled trial, BMC Anesthesiology, 8 January 2026, [Link](https://link.springer.com/article/10.1186/s12871-025-03587-w)
3. Optimal remimazolam dosage for pediatric painless gastrointestinal endoscopy: a randomized controlled trial comparing efficacy and safety of three doses combined with sufentanil and propofol, BMC Anesthesiology, 2 January 2026, [Link](https://link.springer.com/article/10.1186/s12871-025-03511-2)
### 8- Orthopedic:
1. Effect of continuous intraoperative intravenous dexmedetomidine infusion on postoperative delirium in elderly patients undergoing lower extremity orthopedic surgery under neuraxial anesthesia: a prospective single-center controlled clinical trial, BMC Anesthesiology, 20 January 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03609-1)
### 9- Regional Anesthesia & Pain Management
1. Oblique subcostal transversus abdominis plane block versus transmuscular quadratus lumborum block for postoperative analgesia and quality of recovery in laparoscopic gynecological surgery: a prospective randomized controlled double-blind trial, BMC Anesthesiology, 24 January 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03643-z)
2. Dexmedetomidine as adjuvant of transversus abdominal plane block for cesarean delivery under multimodal analgesia: a randomized clinical trial, BMC Anesthesiology, 23 January 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03642-0)
3. Effect of Combined Deep and Superficial Serratus Anterior Plane Block versus Deep Serratus Anterior Plane Block on Postoperative Pain After Video-Assisted Thoracoscopic Surgery: A Prospective Randomized Trial, Journal of Cardiothoracic and Vascular Anesthesia, 21 January 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026000595)
4. Comparison of the analgesic efficacy of superficial and deep serratus anterior plane blocks in patients undergoing breast cancer surgery: a prospective randomized single blind study, BMC Anesthesiology, 15 January 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03627-z)
5. Perineural injection or intravenous infusion of dexmedetomidine in ultrasound-guided erector spinae plane block combined with serratus anterior plane block for analgesia after thoracoscopic surgery: a randomized controlled study, BMC Anesthesiology, 14 January 2026, [Link](https://link.springer.com/article/10.1186/s12871-025-03599-6)
6. Impact of interscalene versus superior trunk blocks as sole anesthetics on respiratory outcomes for shoulder arthroscopy: a randomized controlled trial, BMC Anesthesiology, 14 January 2026, [Link](https://link.springer.com/article/10.1186/s12871-025-03575-0)
7. Different local anesthetic volumes for unilateral spinal anesthesia in varicose vein surgery: a prospective randomized clinical trial, BMC Anesthesiology, 10 January 2026, [Link](https://link.springer.com/article/10.1186/s12871-026-03619-z)
8. Intravenous Esketamine Versus Erector Spinae Plane Block for Postoperative Recovery Quality Following Video-Assisted Thoracoscopic Surgery: A Randomized Controlled Non-Inferiority Trial, Journal of Cardiothoracic and Vascular Anesthesia, 3 January 2026, [Link](https://www.sciencedirect.com/science/article/pii/S1053077025012480)
---
## ***Reviews:***
### 1- General:
1. Preoperative Evaluation of Patients Undergoing Cataract Surgery: Recommendations, Challenges, and Ethical Considerations, Anesthesiology, 26 Janaury 2026, [Link](https://journals.lww.com/anesthesiology/abstract/9900/preoperative%5Fevaluation%5Fof%5Fpatients%5Fundergoing.885.aspx)
2. Beyond observational data: understanding anaesthesia research better with causal diagrams: An introductory review, EJA, 20 January 2026, [Link](https://journals.lww.com/ejanaesthesiology/abstract/9900/beyond%5Fobservational%5Fdata%5F%5Funderstanding.390.aspx)
3. Climate resilience as a strategic lever for long-term healthcare sustainability: a narrative review, BJA, January 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900609-9/fulltext)
4. The role of the anaesthetist in mitigating the environmental impacts of nitrous oxide: a narrative review, BJA, January 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900613-0/fulltext)
### 2- Cardiovascular & Hemodynamics:
1. Cardiac surgery-associated acute kidney injury, BJA Edu, February 2026, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900098-8/fulltext)
2. Management of Chronic Antihypertensive Medications in the Perioperative Period: A Clinical Focus Review, Anesthesiology, 27 Janaury 2026, [Link](https://journals.lww.com/anesthesiology/citation/9900/management%5Fof%5Fchronic%5Fantihypertensive%5Fmedications.887.aspx)
3. Perioperative Neurocognitive Disorders in Elderly Patients Undergoing Cardiac Surgery: Mechanisms, Biomarkers, and Prevention, Journal of Cardiothoracic and Vascular Anesthesia, 21 January 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026000534)
4. Echocardiography in structural heart disease, *Current Opinion in Anesthesiology*, 9 January 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/echocardiography%5Fin%5Fstructural%5Fheart%5Fdisease.382.aspx)
5. Current Affairs of the Heart: Hydration Status in Cardiac Patients Assessed by Bioelectrical Impedance Analysis, Journal of Cardiothoracic and Vascular Anesthesia, 6 January 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026000030)
### 3- Neuro:
1. Anaesthesia for cervical spine surgery. Part 1: elective surgery, BJA Edu, February 2026, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900105-2/fulltext)
2. Targeting glycolysis and maintaining glucose homeostasis for treating perioperative neurocognitive disorder: a narrative review, BJA, January 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900738-X/fulltext)
### 4- Obstetrics & Gynecology:
1. Enhanced recovery after Caesarean delivery. Part 2: postoperative considerations and quality indicators, BJA Edu, 27 January 2026, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900117-9/abstract)
2. Enhanced recovery after Caesarean delivery. Part 1: preoperative and intraoperative considerations, BJA Edu, 20 January 2026, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900110-6/abstract)
### 5- Pediatric:
1. Anaesthesia for children with cervical spine anomalies, BJA Edu, 27 January 2026, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900116-7/abstract)
### 6- Regional Anesthesia & Pain Management
1. Intraoperative methadone: promise and pitfalls, *Current Opinion in Anesthesiology*, 9 January 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/intraoperative%5Fmethadone%5F%5Fpromise%5Fand%5Fpitfalls.381.aspx)
2. Stellate ganglion block in perioperative practice: a narrative review, BJA, January 2026, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900606-3/abstract)
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# **Critical Care:**
## ***Guidelines & Consensus:***
### 1- Cardiovascular & Hemodynamics:
1. American Association for the Surgery of Trauma—World Society of Emergency Surgery Guidelines on the diagnosis and management of cervical vascular injuries, *Journal of Trauma and Acute Care Surgery*, 13 January 2026, [Link](https://journals.lww.com/jtrauma/fulltext/9900/american%5Fassociation%5Ffor%5Fthe%5Fsurgery%5Fof.1211.aspx)
### 2- Thorax/Lungs/Airways/Mechanical ventilation:
1. American Association for the Surgery of Trauma–World Society of Emergency Surgery guidelines on the diagnosis and management of major thoracic vascular injuries, *Journal of Trauma and Acute Care Surgery,* February 2026, [Link](https://journals.lww.com/jtrauma/pages/articleviewer.aspx?year=2026&issue=02000&article=00020&type=Fulltext)
2. Guidelines 2024: Emergency intubation of an adult outside the operating room and intensive care unit, Anaesthesia Critical Care & Pain Medicine, 22 January 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2352556826000020)
### 3- Neuro-muscular:
1. 2026 Guideline for the Early Management of Patients With Acute Ischemic Stroke: A Guideline From the American Heart Association/American Stroke Association, Stroke, 26 January 2026, [Link](https://www.ahajournals.org/doi/10.1161/STR.0000000000000513)
2. Guidelines for Neuroprognostication in Critically Ill Adults with Status Epilepticus, Neurtocritical Care, 8 January 2026, [Link](https://link.springer.com/article/10.1007/s12028-025-02425-8)
### 4- Renal:
1. Multidisciplinary guidelines on renal replacement therapy in intensive care medicine, Critical Care, 14 January 2026, [Link](https://link.springer.com/article/10.1186/s13054-025-05817-6)
### 5- Infectious Diseases:
1. A consensus of international experts on definition, sampling, treatment, and prevention of peripheral extracorporeal membrane oxygenation cannula-site infection obtained by the Delphi method: the SAVECMO study, Intensive Care Medicine, 8 Janaury 2026, [Link](https://link.springer.com/article/10.1007/s00134-025-08269-2)
### 6- Other:
1. Proceedings of an International Summit on Frailty in the Critically Ill: A Consensus on Future Research Directions, CHEST Critical care, 28 Janaury 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2949788426000109)
##
---
## ***Systematic reviews & meta-analyses:***
### 1- Cardiovascular & Hemodynamics:
1. Prognostic Factors Among Patients Receiving Microaxial Flow Pump for Acute Myocardial Infarction-Related Cardiogenic Shock: A Systematic Review and Meta-Analysis, Critical Care Medicine, 8 January 2026, [Link](https://journals.lww.com/ccmjournal/abstract/9900/prognostic%5Ffactors%5Famong%5Fpatients%5Freceiving.719.aspx)
2. Multi-omics in cardiac arrest: a systematic review, Resuscitation Plus, January 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2666520425003078)
3. Incidence and prognostic impact of delirium after cardiac arrest: a systematic review and meta-analysis, Resuscitation Plus, January 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2666520425003327)
4. Intravenous magnesium administration errors, attributing factors and associated respiratory or cardiopulmonary arrest in obstetric and non-obstetric patients—A systematic review, Anaesthesia Critical Care & Pain Medicine, January 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556825001535)
### 2- Thorax/Lungs/Airways/Mechanical ventilation:
1. Tracheal Intubation using Video Laryngoscopy as Compared to Direct Laryngoscopy During Cardiopulmonary Resuscitation: A Systematic Review and Meta-analysis, Resuscitation, 20 January 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0300957226000262)
2. Approaches to Converting Spo2/Fio2 Ratio to Pao2/Fio2 Ratio for Assessment of Respiratory Failure in Critically Ill Patients: A Systematic Review, Critical Care Medicine, 6 January 2026, [Link](https://journals.lww.com/ccmjournal/abstract/9900/approaches%5Fto%5Fconverting%5Fspo2%5Ffio2%5Fratio%5Fto.714.aspx)
3. Inhaled nitric oxide for acute respiratory distress syndrome in adults: a systematic review and meta-analysis, Journal of Intensive Care, 2 January 2026, [Link](https://link.springer.com/article/10.1186/s40560-025-00845-4)
### 3- Neuro-muscular:
1. Neuroprognostication After Cardiac Arrest Using Glial Fibrillary Acidic Protein: A Systematic Review and Meta-Analysis, Critical Care Medicine, 15 January 2026, [Link](https://journals.lww.com/ccmjournal/abstract/9900/neuroprognostication%5Fafter%5Fcardiac%5Farrest%5Fusing.729.aspx)
2. Systematic Review of Direct Hospital Costs Associated with Aneurysmal Subarachnoid Hemorrhage Management, Neurtocritical Care, 15 January 2026, [Link](https://link.springer.com/article/10.1007/s12028-025-02439-2)
### 4- Blood & hemostasis:
1. Should platelet transfusion be used to reverse preinjury antiplatelet agents in traumatic brain injury? A systematic review and meta-analysis, *Journal of Trauma and Acute Care Surgery*, 12 January 2026, [Link](https://journals.lww.com/jtrauma/abstract/9900/should%5Fplatelet%5Ftransfusion%5Fbe%5Fused%5Fto%5Freverse.1205.aspx)
### 5- Infectious Diseases:
1. The diagnostic accuracy of serum procalcitonin for sepsis in critically ill adults. A systematic review and diagnostic meta-analysis, Journal of Critical Care, April 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0883944125003892)
2. Low-dose corticosteroids in cirrhotic patients with septic shock or vasopressor-dependent shock: A systematic review and meta-analysis, Journal of Critical Care, April 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0883944125003922)
3. Effects on mortality of blood purification techniques in severe septic shock patients. An updated Bayesian network meta-analysis of randomized controlled trials, Journal of Critical Care, April 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S088394412500317X)
4. Prognostic factors associated with mortality in septic shock: a systematic review and meta-analysis, The Lancet Respiartory Medicine, 28 Janauary 2026, [Link](https://www.thelancet.com/journals/lanres/article/PIIS2213-2600%2825%2900397-2/abstract)
### 6- Sedation & analgesia:
1. Continuous ketamine infusion for surgical patients in the intensive care unit: a systematic review and meta-analysis of randomized controlled trials with GRADE assessment, Critical Care, 23 January 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-05858-5)
### 7- Pediatric critical care:
1. Video Versus Direct Laryngoscopy for Pediatric Intubation During Cardiopulmonary Resuscitation: A Systematic Review and Meta-analysis of Simulation-based Trials, *Pediatric Emergency Care*, 21 January 2026, [Link](https://journals.lww.com/pec-online/abstract/9900/video%5Fversus%5Fdirect%5Flaryngoscope%5Ffor%5Fpediatric.780.aspx)
### 8- Other:
1. Discovery of data quality issues in electronic health records: profound consequences for critical care medicine applications – a systematized review, Critical Care, 8 January 2026, [Link](https://link.springer.com/article/10.1186/s13054-025-05677-0)
---
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## ***Clinical trials:***
### 1- Cardiovascular & Hemodynamics:
1. Effects of mild hypercapnia on myocardial injury among ST-elevation myocardial infarction patients after out-of-hospital cardiac arrest: A exploratory post-hoc study of the TAME trial, Resuscitation, 21 January 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0300957226000274)
2. Prehospital transesophageal echocardiography versus conventional advanced life support in out-of-hospital cardiac arrest (PHTEE–OHCA) – a randomized controlled pilot study, Critical care, 23 January 2026, [Link](https://link.springer.com/article/10.1186/s13054-025-05805-w)
3. Vasopressin, steroids, and epinephrine in out-of-hospital cardiac arrest – a protocol for a randomized controlled trial (OHCA REVIVES trial), Resuscitation Plus, January 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2666520425003005)
### 2- Thorax/Lungs/Airways/Mechanical ventilation:
1. Ventilator settings for fiberoptic bronchoscopy during mechanical ventilation: a randomized adjudicator-blinded controlled trial VentSetFib, Critical Care, 27 January 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-05847-8)
2. Lung perfusion estimation by saline-contrast EIT without breath hold: a randomized cross-over trial, Critical care, 5 January 2026, [Link](https://link.springer.com/article/10.1186/s13054-025-05823-8)
### 3- Neuro-muscular:
1. Properties of testosterone transdermal gel in restoring serum testosterone levels in critically ill patients: the TestICU-1 pilot study, Journal of Critical Care, April 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0883944125003260)
2. Serum biomarkers of postanoxic encephalopathy in relation to ghrelin treatment. A secondary analysis of the GRECO trial, Resuscitation, 20 January 2026, [Link](https://www.sciencedirect.com/science/article/pii/S0300957226000250)
3. Efficacy of suspension-based lower-limb rehabilitation device in enhancing lower limb function among patients with ICU-acquired weakness: a self-controlled randomized clinical trial, Critical Care, 16 January 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-05840-1)
### 4- Renal:
1. Association between anemia and trauma-related severe acute kidney injury in trauma patients at risk of major bleeding: A post-hoc analysis of the RESTRIC trial, Journal of Critical Care, April 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S088394412500351X)
### 5- Nutrition:
1. Early Supplemental Parenteral Nutrition Shortens Ventilation and Intensive Care Unit Stay in ICU Patients Aged ≥60 Years Requiring Mechanical Ventilation: A Randomized Controlled Trial, Clinical Nutrition ESPEN, 19 January 2026, [Link](https://www.clinicalnutritionespen.com/article/S2405-4577%2826%2900028-8/abstract)
### 6- Infectious Diseases:
1. Seven days versus extended duration antibiotic therapy for multidrug-resistant gram-negative bacterial infections in critically ill patients: A pooled analysis of the OPTIMISE and REGARD-VAP trials, Journal of Critical Care, April 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S088394412500348X)
2. Early Methylene Blue for Mortality Reduction in High-Dose VasoPREssor-Dependent Septic Shock (EMPRESS): protocol for a multicenter randomized controlled trial, Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 24 January 2026, [Link](https://link.springer.com/article/10.1186/s13049-026-01563-y)
3. Impact of renal vein doppler ultrasound-guided CVP titration in sepsis: a pilot randomized controlled trial, Critical Care, 24 January 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-05842-z)
4. Causal effects of serum testosterone on septic shock mortality: a Mendelian randomization study, Critical Care, 23 January 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-05860-x)
5. Hospital-adapted inhaled phage therapy for ventilator-associated pneumonia caused by multidrug-resistant *Klebsiella pneumoniae*: a comparative pilot study, Critical care, 13 January 2026, [Link](https://link.springer.com/article/10.1186/s13054-026-05839-8)
6. Ceftriaxone to Prevent Early-Onset Pneumonia in Comatose Patients Following Out-of-Hospital Cardiac Arrest: A Pilot Randomized Controlled Trial and Resistome Assessment (PROTECT), CHEST, January 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0012369225051347)
### 7- Sedation & analgesia:
1. Remimazolam Besylate Versus Dexmedetomidine As a Sedative in ICU Patients Undergoing Mechanical Ventilation: A Multicenter, Single-blinded, Randomized, Noninferiority Trial, Critical Care Medicine, 12 January 2026, [Link](https://journals.lww.com/ccmjournal/fulltext/9900/remimazolam%5Fbesylate%5Fversus%5Fdexmedetomidine%5Fas%5Fa.722.aspx)
### 8- Other:
1. Cyclosporine versus placebo pretreatment of brain-dead donors and kidney graft function (Cis-A-Rein trial): a multicenter, double-blind, randomized, controlled trial, Intensive Care Medicine, 8 Janauary 2026, [Link](https://link.springer.com/article/10.1007/s00134-025-08265-6)
---
## ***Reviews:***
### 1- Cardiovascular & Hemodynamics:
1. Cardiogenic Shock: Current Evidence, Guideline Perspectives, and Outcomes, Journal of Cardiothoracic and Vascular Anesthesia, 24 January 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077026000546)
2. Diagnosis of occlusion myocardial infarction, *Current Opinion in Critical Care*, 20 January 2026, [Link](https://journals.lww.com/co-criticalcare/abstract/9900/diagnosis%5Fof%5Focclusion%5Fmyocardial%5Finfarction.336.aspx)
3. Early management of acute heart failure, *Current Opinion in Critical Care*, 20 January 2026, [Link](https://journals.lww.com/co-criticalcare/abstract/9900/early%5Fmanagement%5Fof%5Facute%5Fheart%5Ffailure.333.aspx)
4. Femoral vein Doppler ultrasound for assessing venous congestion and right heart function: a scoping review, ICM Experimental, 14 January 2026, [Link](https://link.springer.com/article/10.1186/s40635-026-00856-x)
5. Extracorporeal membrane oxygenation support for tropical infections: a scoping review, Journal of Intensive Care, 12 January 2026, [Link](https://link.springer.com/article/10.1186/s40560-025-00843-6)
6. Extracorporeal cardiopulmonary resuscitation following cardiac surgery: a scoping review, Resuscitation Plus, January 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2666520425003479)
7. Key physiological indicators and technological trends in physiology-directed cardiopulmonary resuscitation: A narrative review, Resuscitation Plus, January 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2666520425003170)
8. Artificial Intelligence in cardiopulmonary resuscitation training – A scoping review, Resuscitation Plus, January 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2666520425003121)
9. Effects of *peri*\-arrest hypertonic/hyperoncotic fluid treatment on clinical outcomes in non-trauma-related resuscitation – A scoping review, Resuscitation Plus, January 2026, [Link](https://www.sciencedirect.com/science/article/pii/S266652042500308X)
_This post is for subscribers only._
### Anecrit's Newsletter #15-26
URL: https://www.anecrit.com/newsletter-15-26/
Last updated: 2026-06-21T12:07:34.000Z
**Issue #\[15-26\] | \[10/10/2025\] - \[01/01/2026\]**
## Welcome!
Hey! Long time no see. I know, I know—it’s been a while, since October 2025! But we’re back today, January 3rd, 2026, and I promise I’m not going to “time-skip” over the incredible papers published while I was away.
This issue is a bit of a long read because I’ve gathered the very best from the past few months. Think of it as a buffet of articles: pick and choose what interests you most, and enjoy the feast!**,** And a huge welcome to the new readers who joined us during the break—I’m thrilled to have you here for your first issue!
---
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---
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# **Anesthesiology:**
## ***Guidelines & Consensus:***
### 1- General:
1. European Malignant Hyperthermia Group 2025 guidelines for the investigation of malignant hyperthermia susceptibility, BJA, 31 December 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900797-4/abstract)
2. SFAR & SFPC recommendations for professional practice in the prevention of medication errors in anaesthesia and intensive care, Anaesthesia Critical Care & Pain Medicine, 26 November 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556825002504)
3. Fifth Consensus Guidelines for the Management of Postoperative Nausea and Vomiting: Executive Summary, A&A, 14 November 2025, [Link](https://journals.lww.com/anesthesia-analgesia/pages/articleviewer.aspx?year=9900&issue=00000&article=01547&type=Fulltext)
4. Chinese clinical practice guidelines for total intravenous anaesthesia: a systematic review and expert consensus-based recommendations, BJA, 13 November 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900706-8/fulltext)
5. ESPEN guideline on clinical nutrition in surgery – Update 2025, Clinical Nutrition, October 2025, [Link](https://www.clinicalnutritionjournal.com/article/S0261-5614%2825%2900243-2/fulltext)
### 2- Airway & Mechanical Ventilation:
1. Difficult Airway Society 2025 guidelines for management of unanticipated difficult tracheal intubation in adults, BJA, 6 November 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900693-2/fulltext)
### 3- Cardiovascular & Hemodynamics:
1. Perioperative hemodynamic optimization - Adults including obstetrics, Anaesthesia Critical Care & Pain Medicine, January 2026, [Link](https://www.sciencedirect.com/science/article/pii/S2352556825001948)
2. 2025 ACC/AHA/HRS/ISACHD/SCAI Guideline for the Management of Adults With Congenital Heart Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines, JACC, 18 December 2025, [Link](https://www.jacc.org/doi/10.1016/j.jacc.2025.09.006)
3. Management of Ischemic Heart Disease in Patients With Heart Failure: *JACC: Heart Failure* Position Statement, JACC: Heart Failure, 1 December 2025, [Link](https://www.jacc.org/doi/10.1016/j.jchf.2025.102731)
4. Executive Summary of the American College of Cardiology/American Heart Association Joint Committee (2024) on Clinical Practice for Cardiac Evaluation and Management of Patients Having Noncardiac Surgeries, A&A, 25 November 2025, [Link](https://journals.lww.com/anesthesia-analgesia/citation/9900/executive%5Fsummary%5Fof%5Fthe%5Famerican%5Fcollege%5Fof.1573.aspx)
### 4- Thoracic:
1. Monitoring in Thoracic Anesthesia: EACTAIC Consensus Document, Journal of Cardiothoracic and Vascular Anesthesia, 18 December 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025011292)
2. European Respiratory Society and European Society of Thoracic Surgeons clinical practice guideline on fitness for curative intent treatment of lung cancer, European Respiratory Journal, 13 November 2025, [Link](https://publications.ersnet.org/content/erj/66/5/2500156)
3. Airway Management in Thoracic Anesthesia: EACTAIC Consensus Document, Journal of Cardiothoracic and Vascular Anesthesia, 5 December 2025, [Link](https://www.sciencedirect.com/science/article/pii/S1053077025011309)
### 5- Pediatric:
1. Perioperative hemodynamic optimization - Paediatrics, Anaesthesia, Critical Care & Pain Medicine, January 2026, [Link](https://www.sciencedirect.com/science/article/pii/S235255682500195X)
### 6- Orthopedic:
1. Pain management after hallux valgus repair surgery: an updated systematic review and procedure-specific postoperative pain management (PROSPECT) recommendations, EJA, January 2025, [Link](https://journals.lww.com/ejanaesthesiology/fulltext/2026/01000/pain%5Fmanagement%5Fafter%5Fhallux%5Fvalgus%5Frepair.2.aspx)
### 7- Regional Anesthesia & Pain Management
1. Pain management for laparoscopic sleeve gastrectomy: An update of the systematic review and procedure-specific postoperative pain management (PROSPECT) recommendations, EJA, 13 October 2025, [Link](https://journals.lww.com/ejanaesthesiology/abstract/9900/pain%5Fmanagement%5Ffor%5Flaparoscopic%5Fsleeve.362.aspx)
---
## ***Systematic reviews & meta-analyses:***
### 1- AI:
1. Artificial intelligence in airway management: A systematic review and meta-analysis, Anaesthesia Critical Care & Pain Medicine, November 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556825001213)
### 2- General:
1. Pooled Efficacy and Exploration of Effect Modifiers of Exercise Prehabilitation: A Systematic Review and Meta-regression Analysis of Randomized Controlled Trials, A&A, 16 December 2025, [Link](https://journals.lww.com/anesthesia-analgesia/abstract/9900/pooled%5Fefficacy%5Fand%5Fexploration%5Fof%5Feffect.1603.aspx)
2. Eight strategic elements that support successful implementation of beneficial nutritional interventions in the perioperative setting: A systematic review, Clinical Nutrition, 15 December 2025, [Link](https://www.clinicalnutritionjournal.com/article/S0261-5614%2825%2900327-9/fulltext)
3. Effects of perioperative benzodiazepine administration on postoperative patient-reported outcomes: a systematic review and meta-analysis of randomised controlled trials, BJA, December 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900663-4/fulltext)
4. Effects of perioperative benzodiazepine administration on postoperative patient-reported outcomes: a systematic review and meta-analysis of randomised controlled trials, BJA, December 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900663-4/fulltext)
5. Effect of dexmedetomidine on postoperative mortality and prognosis: a systematic review and meta-analysis of randomized controlled trials, BMC Anesthesiology, 24 November 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03514-z)
6. Soluble urokinase plasminogen activator receptor and perioperative complications: a systematic review, BMC Anesthesiology, 13 November 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03350-1)
7. The economic burden of anesthetic-related adverse events: a systematic review and empirical analysis, BMC Anesthesiology, 6 November 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03376-5)
8. Use of prothrombin complex concentrates in liver transplantation: a systematic review and meta-analysis, BJA, November 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900536-7/fulltext)
9. Immunonutrition in minimally invasive major abdominal surgery: A systematic review and meta-analysis of randomized clinical trials, Clinical Nutrition, November 2025, [Link](https://www.clinicalnutritionjournal.com/article/S0261-5614%2825%2900265-1/abstract)
10. Omega-3 fatty acid supplementation in solid organ transplant recipients: A systematic review and meta-analysis of randomized controlled trials, Clinical Nutrition ESPEN, October 2025, [Link](https://www.clinicalnutritionespen.com/article/S2405-4577%2825%2902921-3/abstract)
### 3- Airway & Mechanical Ventilation:
1. A comparison of McGrath video laryngoscope versus macintosh laryngoscope for intubation undergoing general anesthesia: a meta-analysis, BMC Anesthesiology, 20 December 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03498-w)
### 4- Cardiovascular & Hemodynamics:
1. Association of Preoperative Frailty and Postoperative Outcomes in Older Adults Undergoing Major Cardiac Procedures: A Systematic Review and Meta-Analysis, A&A, 23 December 2025, [Link](https://journals.lww.com/anesthesia-analgesia/abstract/9900/association%5Fof%5Fpreoperative%5Ffrailty%5Fand.1605.aspx)
2. Stellate ganglion block for preventing perioperative arrhythmias: a systematic review and meta-analysis, BJA, 16 December 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900821-9/abstract)
3. Remimazolam compared to dexmedetomidine on the incidence of hypotension in middle aged and elderly patients undergoing general anesthesia: a systematic review and meta-analysis, BMC Anesthesiology, 5 December 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03532-x)
4. Intraoperative Hemoadsorption and Acute Kidney Injury in Cardiac Surgery: Systematic Review and Meta-Analysis, Journal of Cardiothoracic and Vascular Anesthesia, 4 December 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025011668)
5. Definitions for Vasoplegia Associated With On-Pump Cardiac Surgery: A Systematic Review With Meta-Analysis, Critical Care Explorations, December 2025, [Link](https://journals.lww.com/ccejournal/fulltext/2025/12000/definitions%5Ffor%5Fvasoplegia%5Fassociated%5Fwith%5Fon%5Fpump.14.aspx)
6. Intraoperative electroencephalogram-derived measures and their association with postoperative delirium: a systematic review and meta-analysis, BJA, December 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900604-X/fulltext)
7. Effects of Volatile Sedation Versus Propofol on Time to Extubation in the Intensive Care Unit After Cardiac Surgery: A Systematic Review and Meta-analysis, Journal of Cardiothoracic and Vascular Anesthesia, December 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025006718)
8. Multivariable Prediction Models for Atrial Fibrillation after Cardiac Surgery: A Systematic Review and Critical Appraisal, Anesthesiology, December 2025, [Link](https://journals.lww.com/anesthesiology/abstract/2025/12000/multivariable%5Fprediction%5Fmodels%5Ffor%5Fatrial.26.aspx)
9. The Effects of Daytime Variation on Short-Term Outcomes of Cardiac Surgical Patients: A PRISMA-Compliant Systemic Review and Meta-Analysis, Journal of Cardiothoracic and Vascular Anesthesia, 25 November 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025011656)
10. The Effects of Tranexamic Acid on Renal Outcomes in Patients Undergoing Cardiovascular Surgery: A Systematic Review and Meta-Analysis Compliant With Preferred Reporting Items for Systematic Reviews and Meta-Analyses, Journal of Cardiothoracic and Vascular Anesthesia, 15 November 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025011462)
11. Impact of Hypotension Prediction Index-Guided Management on Intraoperative Hypotension and Postoperative Outcomes in Abdominal Surgery: A Meta-Analysis of Randomized Controlled Trials, Anaesthesia Critical Care & Pain Medicine, 30 October 2025, [Link](https://www.sciencedirect.com/science/article/pii/S2352556825001882)
12. Evaluating Topical Antifibrinolytics in Cardiac Surgery: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis, Journal of Cardiothoracic and Vascular Anesthesia, 30 October 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025011085)
13. The organ protective effects of penehyclidine hydrochloride (PHC) in patients undergoing cardiac surgery: a systematic review and meta-analysis, BMC Anesthesiology, 22 October 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03396-1)
### 5- Neuro:
1. Comparative efficacy of sphenopalatine ganglion block versus scalp block for hemodynamic stability during craniotomy: a systematic review and meta-analysis, BMC Anesthesiology, 26 November 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03523-y)
2. The effects of preoperative carbohydrate loading on postoperative outcomes in neurosurgery: a systematic review and meta-analysis, BMC Anesthesiology, 19 November 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03468-2)
3. Effect of Bundled Care on External VentricularDrain Infections: A Systematic Review and Meta-analysis, *Journal of Neurosurgical Anesthesiology*, 17 November 2025, [Link](https://journals.lww.com/jnsa/abstract/9900/effect%5Fof%5Fbundled%5Fcare%5Fon%5Fexternal.186.aspx)
### 6- Obstetrics & Gynecology:
1. Nebulized dexmedetomidine for post-dural puncture headache after cesarean delivery: a systematic review and meta-analysis, BMC Anesthesiology, 21 October 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03339-w)
### 7- Pediatric:
1. Efficacy of dexmedetomidine in preventing emergence agitation in children undergoing tonsillectomy and/or adenoidectomy: a meta-analysis and systematic review, BMC Anesthesiology, 30 December 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03512-1)
2. Effect of neuromuscular blocking agents on tracheal intubation quality in paediatric patients: a systematic review using network meta-analysis and meta-regression, BJA, December 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900602-6/fulltext)
3. Impact of preoperative fasting duration on perioperative complications in elective paediatric procedures: a systematic review and meta-analysis, BJA, 27 November 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900775-5/fulltext)
4. Oral Prednisolone for Postoperative Analgesia Management in Paediatric Tonsillectomy: A Meta-Analysis of Published Studies, Anaesthesia Critical Care & Pain Medicine, 27 November 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556825002383)
5. Bispectral index-guided anesthesia in children: A systematic review and meta-analysis, Anaesthesia Critical Care & Pain Medicine, November 2025, [Link](https://www.sciencedirect.com/science/article/pii/S2352556825001390)
6. Effect of neuromuscular blocking agents on tracheal intubation quality in paediatric patients: a systematic review using network meta-analysis and meta-regression, BJA, 10 October 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900602-6/fulltext)
### 8- Orthopedic:
1. Single-shot perineural femoral nerve block and falls after lower limb orthopaedic surgery: a systematic review and meta-analysis, BJA, 31 December 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900820-7/abstract)
2. Effectiveness of gabapentinoids in orthopedic surgeries: a systematic review and meta-analysis of postoperative pain, and opioid-sparing effects, BMC Anesthesiology, 14 November 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03291-9)
### 9- Regional Anesthesia & Pain Management
1. The analgesic efficacy of erector spinae plane block for percutaneous nephrolithotomy: a systematic review and meta-analysis of randomized controlled trials, BMC Anesthesiology, 26 December 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03425-z)
2. Comparative efficacy of chest wall fascial plane blocks for cardiac surgery via median sternotomy: a network meta-analysis, BMC Anesthesiology, 5 December 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03529-6)
3. Breathing new life into pain management: a systematic review of nebulised ketamine for analgesia, Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 4 December 2025, [Link](https://link.springer.com/article/10.1186/s13049-025-01501-4)
4. Transversus abdominis plane block for postoperative pain management and opioid sparing: a systematic review and meta-analysis of randomised controlled trials, BJA, 2 December 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900753-6/abstract)
5. The association between preoperative anxiety and chronic post-surgical pain after general anaesthesia, a systematic review and meta-analysis, BJA Open, December 2025, [Link](https://www.sciencedirect.com/science/article/pii/S277260962500111X)
6. Identifying predictors of neuropathic pain medication prescribing, adherence, and discontinuation: a systematic review and meta-analysis, BJA, 27 November 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900787-1/fulltext)
7. Efficacy and safety of co-administered bupivacaine and liposomal bupivacaine in interscalene brachial plexus block for shoulder surgery: a systematic review and meta-analysis, BMC Anesthesiology, 27 November 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03494-0)
8. Comparative efficacy of sphenopalatine ganglion block versus scalp block for hemodynamic stability during craniotomy: a systematic review and meta-analysis, BMC Anesthesiology, 26 November 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03523-y)
9. The effect of low-dose ketamine compared to morphine on the severity of acute pain in emergency situations: a systematic review and meta-analysis, Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 26 November 2025, [Link](https://link.springer.com/article/10.1186/s13049-025-01500-5)
10. Ultrasound-Guided Versus Conventional Radioscopic–Guided Transforaminal Epidural Steroid Injections for Cervical Radicular Pain: A Systematic Review and Meta-analysis, A&A, 24 November 2025, [Link](https://journals.lww.com/anesthesia-analgesia/abstract/9900/ultrasound%5Fguided%5Fversus%5Fconventional.1563.aspx)
11. Efficacy and safety of hydromorphone for preemptive analgesia in patients undergoing laparoscopic cholecystectomy: a systematic review and meta-analysis, BMC Anesthesiology, 17 November 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03420-4)
12. Safety of clonidine and dexmedetomidine in peripheral nerve blocks: a systematic review of preclinical evidence, BJA, 31 October 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900700-7/fulltext)
13. Esmolol as an Adjunct in Multimodal Anesthesia: A Systematic Review and Meta-Analysis of Its Opioid-Sparing and Analgesic Effects, A&A, 24 October 2025, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/esmolol%5Fas%5Fan%5Fadjunct%5Fin%5Fmultimodal%5Fanesthesia%5F%5Fa.1507.aspx)
14. Efficacy and Safety of Serratus Anterior Plane Block and Erector Spinae Plane Block for Rib Fracture Pain: A Systematic Review and meta-analysis, *The Clinical Journal of Pain,* 16 October 2025, [Link](https://journals.lww.com/clinicalpain/abstract/9900/efficacy%5Fand%5Fsafety%5Fof%5Fserratus%5Fanterior%5Fplane.294.aspx)
15. Complications Associated with use of Peripheral Nerve Stimulators for Pain Management, *The Clinical Journal of Pain,* 16 October 2025, [Link](https://journals.lww.com/clinicalpain/abstract/9900/complications%5Fassociated%5Fwith%5Fuse%5Fof%5Fperipheral.293.aspx)
16. Comparison of perioperative analgesic efficacy between serratus anterior plane block and thoracic paravertebral block in adult patients undergoing thoracic and breast surgeries: a systematic review and meta-analysis, BMC Anesthesiology, 14 October 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03343-0)
---
## ***Clinical trials:***
### 1- General:
1. Individualised Perioperative Blood Pressure and Fluid Therapy in Oesophagectomy: *a prospective, single-blind, randomised controlled trial,* Anesthesiology, 26 December 2025, [Link](https://journals.lww.com/anesthesiology/abstract/9900/individualised%5Fperioperative%5Fblood%5Fpressure%5Fand.857.aspx)
2. Comparative efficacy of modified nasopharyngeal airway and nasal cannula for oxygenation in deeply sedated patients undergoing endoscopic retrograde cholangiopancreatography: a randomized controlled trial, BMC Anesthesiology, 11 December 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03515-y)
3. Longitudinal changes in haemoglobin, iron stores, and inflammatory markers following surgery and in critical illness: an analysis from the Practical Anaemia Bundle for Sustained Blood Recovery randomised clinical trial, BJA, 8 December 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900789-5/abstract)
4. Integrated analysis of metabolomics combined and net-work pharmacology reveals the effects of dexmedetomidine on early postoperative cognitive dysfunction in elderly patients: randomized controlled trial, BMC Anesthesiology, 8 December 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03379-2)
5. Effect of silicone and PVC tube intubation on postoperative sore throat after thyroid surgery: a randomized controlled trial, BMC Anesthesiology, 7 December 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03542-9)
6. Neck extension during thyroidectomy: effects on early postoperative cognitive function and optic nerve sheath diameter- a randomized controlled trial, BMC Anesthesiology, 1 December 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03507-y)
7. Phenylephrine Vs. Norepinephrine on the Renin–Angiotensin–Aldosterone System and Postoperative Complications in Acute Abdomen Emergency Surgery: A Randomized Controlled Trial, *Critical Care Medicine*, December 2025, [Link](https://journals.lww.com/ccmjournal/fulltext/2025/12000/phenylephrine%5Fvs%5F%5Fnorepinephrine%5Fon%5Fthe.22.aspx)
8. The effect of corticosteroids on early recovery after major surgery in elderly patients: the CORTERAS trial: Study protocol for a double-blind randomised controlled trial, EJAIC, December 2025, [Link](https://journals.lww.com/ejaintensivecare/fulltext/2025/12000/the%5Feffect%5Fof%5Fcorticosteroids%5Fon%5Fearly%5Frecovery.2.aspx/)
9. IMpact of PerioperAtive KeTamine on Enhanced Recovery After abdominal Surgery (IMPAKT ERAS): a pragmatic randomised single-cluster trial, BJA, December 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900508-2/fulltext)
10. Discharge with a smartphone application for follow-up after day care surgery: a randomised controlled trial, BJA Open, December 2025, [Link](https://www.sciencedirect.com/science/article/pii/S2772609625001133)
11. Comparative study between nalbuphine and dexmedetomidine for conscious sedation in patients undergoing colonoscopy: randomized comparative trial, BMC Anesthesiology, 28 November 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03482-4)
12. Comparative effects of remimazolam and propofol on hemodynamic stability during sedation for painless gastroscopy: a randomized clinical trial, BMC Anesthesiology, 25 November 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03484-2)
13. Comparison of effects of remimazolam and propofol on mask ventilation during general anaesthesia induction: A randomised controlled trial, Anaesthesia Critical Care & Pain Medicine, 20 November 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556825002358)
14. Benefits in adults allowed to drink clear liquids before anaesthesia until called to the operating room: A randomised pilot study, EJA, 19 November 2025, [Link](https://journals.lww.com/ejanaesthesiology/fulltext/9900/benefits%5Fin%5Fadults%5Fallowed%5Fto%5Fdrink%5Fclear%5Fliquids.375.aspx)
15. Effect of remimazolam on inflammatory reaction after ureteroscopic lithotripsy: a randomised controlled trial, BMC Anesthesiology, 14 November 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03445-9)
16. The effects of ciprofol and propofol on hypoxemia during gastrointestinal endoscopy in overweight and obese patients: a randomized controlled trial, BMC Anesthesiology, 6 November 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03428-w)
17. Butorphanol premedication improves postoperative lung function and analgesic outcomes in laparoscopic surgery: a randomized dose-response study, BMC Anesthesiology, 5 November 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03414-2)
18. Effects of Ultrasound-Guided Oblique Subcostal Transversus Abdominis Block Combined with Patient-Controlled Intravenous Analgesia on Analgesia and Early Recovery after Open Hepatectomy: A Randomized Controlled Clinical Trial, *The Clinical Journal of Pain*, 3 November 2025, [Link](https://journals.lww.com/clinicalpain/abstract/9900/effects%5Fof%5Fultrasound%5Fguided%5Foblique%5Fsubcostal.296.aspx)
19. Effect of perioperative dexmedetomidine on acute kidney injury after partial nephrectomy: a single-centre, randomised, double-blind, placebo-controlled trial, BJA, November 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900547-1/abstract)
20. Argipressin for prevention of blood loss in hepatic resection: a randomised, placebo-controlled, double-blind trial, BJA, 30 October 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900672-5/fulltext)
21. Esketamine attenuates hemodynamic oscillations during anesthesia induction in elderly gastrointestinal surgical patients: a randomized trial, BMC Anesthesiology, 17 October 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03384-5)
22. Intraoperative tight blood glucose control reduces the incidence of postoperative pneumonia in minimally invasive esophagectomy: a randomized clinical trial, Anaesthesia Critical Care & Pain Medicine, 15 October 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556825001778)
### 2- Airway & Mechanical Ventilation:
1. Video laryngoscope versus disposcope endoscope for anticipated laryngeal tumor related difficult intubation in patients undergoing general anesthesia: a randomized controlled trial, BMC Anesthesiology, 26 December 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03566-1)
2. A randomised controlled trial comparing of the efficacy and safety of left lung isolation for minimally invasive direct coronary artery surgery using video-imaging double-lumen endobronchial tube with a bronchial blocker paced through a video-imaging single-lumen tracheal tube, BMC Anesthesiology, 26 December 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03578-x)
3. Tramadol and postoperative sore throat after tracheal intubation in thyroid surgery - a randomized controlled trial, BMC Anesthesiology, 22 December 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03487-z)
4. Mechanical power and the association with postoperative impaired oxygenation and pulmonary complications in orthopedic patients: post hoc analysis of a cluster factorial randomized trial, Anesthesiology, 18 December 2025, [Link](https://journals.lww.com/anesthesiology/abstract/9900/mechanical%5Fpower%5Fand%5Fthe%5Fassociation%5Fwith.852.aspx)
5. Preoxygenation with high-flow nasal oxygen at various flow rates in elective surgical patients: a prospective, randomised, single-blind clinical trial, BJA, 18 December 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900816-5/fulltext)
6. Subglottic jet ventilation versus supraglottic jet ventilation for flexible bronchoscopy: a randomized controlled trial, BMC Anesthesiology, 5 December 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03535-8)
7. Intraoperative Driving Pressure–Guided High PEEP vs Standard Low PEEP for Postoperative Pulmonary Complications, JAMA, 3 December 2025, [Link](https://jamanetwork.com/journals/jama/article-abstract/2842476)
1. Intraoperative Driving Pressure–Guided High PEEP vs Standard Low PEEP for Postoperative Pulmonary Complications: Research Summary, JAMA, 3 December 2025, [Link](https://jamanetwork.com/journals/jama/article-abstract/2842475)
8. Effect of head-elevated versus neutral position on tracheal intubation using a hyper-angulated video laryngoscope under cervical spine immobilization: a randomised crossover trial, Anaesthesia Critical Care & Pain Medicine, 3 December 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556825002528)
9. Association of intraoperative end-tidal CO2 levels with postoperative outcomes: a patient-level analysis of two randomised clinical trials, BJA, December 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900529-X/fulltext)
10. Driving pressure guided ventilation versus conventional lung protective strategy in morbid obese patients undergoing laparoscopic bariatric surgery: a prospective randomized controlled study, BMC Anesthesiology, 20 November 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03431-1)
11. Jiancheng Dual-Channel *vs.* i-gel Laryngeal Mask Airway for Fiberoptic Bronchoscopy: A Randomized Trial, Anaesthesia Critical Care & Pain Medicine, 19 November 2025, [Link](https://www.sciencedirect.com/science/article/pii/S2352556825002310)
12. Quality of intubation using remifentanil in obese patients (OBEREM): a randomised, double-blind pilot trial, Anaesthesia Critical Care & Pain Medicine, 7 November 2025, [Link](https://www.sciencedirect.com/science/article/pii/S235255682500205X)
13. The effect of oxygen reserve index guided oxygen titration on oxidative stress in rhinoplasty surgery: a randomized controlled trial, BMC Anesthesiology, 4 November 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03424-0)
14. Applying positive end-expiratory pressure to facemask ventilation improves post-induction lung atelectasis: a three-arm randomized controlled trial, BMC Anesthesiology, 17 October 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03352-z)
### 3- Cardiovascular & Hemodynamics:
1. Safety and efficacy of 6% hydroxyethyl starch in patients undergoing major surgery: The randomised controlled PHOENICS trial, EJA, January 2026, [Link](https://journals.lww.com/ejanaesthesiology/fulltext/2026/01000/safety%5Fand%5Fefficacy%5Fof%5F6%5F%5Fhydroxyethyl%5Fstarch%5Fin.1.aspx)
2. Reversal of neuromuscular blockade after coronary artery bypass grafting: a randomized control trial, BMC Anesthesiology, 23 December 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03456-6)
3. Pressure monitoring-augmented long-axis in-plane vs. long-axis in-plane alone for ultrasound-guided radial artery catheterization in elderly patients undergoing coronary artery bypass grafting: A randomized prospective trial, Journal of Cardiothoracic and Vascular Anesthesia, 17 December 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025012261)
4. Effect of Goal-Directed Intraoperative Blood Pressure Management on Postoperative Delirium in Older Patients Undergoing Hip Fracture Surgery: A Randomized Controlled Trial, A&A, 16 December 2025, [Link](https://journals.lww.com/anesthesia-analgesia/abstract/9900/effect%5Fof%5Fgoal%5Fdirected%5Fintraoperative%5Fblood.1602.aspx)
5. Prophylactic norepinephrine infusion to reduce severe hypotension during induction of anaesthesia in patients undergoing cardiac surgery: a randomised controlled single-centre clinical trial, BJA, 10 December 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900795-0/abstract)
6. Cryopreserved vs Liquid-Stored Platelets for the Treatment of Surgical Bleeding: The CLIP-II Randomized Noninferiority Clinical Trial, JAMA, 8 December 2025, [Link](https://jamanetwork.com/journals/jama/fullarticle/2842479)
1. Cost-Effectiveness of Cryopreserved vs Liquid-Stored Platelets for Managing Surgical Bleeding, JAMA Open, 8 December 2025, [Link](https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2842477)
2. Cryopreserved vs Liquid-Stored Platelets for the Treatment of Surgical Bleeding: Research Summary, JAMA, 8 December 2025, [Link](https://jamanetwork.com/journals/jama/fullarticle/2842478)
3. An Oasis in the Platelet Desert?, JAMA, 8 December 2025, [Link](https://jamanetwork.com/journals/jama/fullarticle/2842480)
7. Pain as a Driver of Myocardial Injury in Hip Fracture Patients: A Hip Fracture Accelerated Surgical Treatment and Care Track (HIP ATTACK) Trial Secondary Analysis, Anesthesiology, 4 December 2025, [Link](https://journals.lww.com/anesthesiology/abstract/9900/pain%5Fas%5Fa%5Fdriver%5Fof%5Fmyocardial%5Finjury%5Fin%5Fhip.796.aspx)
8. Impact of propofol or sevoflurane on the renoprotective effect of remote ischaemic preconditioning in cardiac surgery: the HypnoRenalRIP randomised clinical trial, BJA, December 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900632-4/fulltext)
9. Restrictive *versus* liberal oxygenation in patients undergoing cardiopulmonary bypass-assisted heart surgery: a randomised controlled trial, BJA, December 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900533-1/fulltext)
10. A Single-blind, Randomized Controlled Trial Comparing Postoperative Analgesic Effects of Superficial and Deep Parasternal Intercostals Blocks in Patients Undergoing Coronary Artery Bypass Grafting Surgery, Journal of Cardiothoracic and Vascular Anesthesia, December 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025006196)
11. Effects of Preoperative Oral Carbohydrates on Insulin Resistance and Postoperative Recovery in Diabetic Patients Undergoing Coronary Artery Bypass Grafting: A Preliminary Prospective, Single-Blinded, Randomized Controlled Trial, Journal of Cardiothoracic and Vascular Anesthesia, December 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025006317)
12. Ultrasound-Guided In-Plane Subclavian Vein Puncture versus Prior Ultrasound and Landmark Technique: A Randomized Controlled Trial, A&A, 25 November 2025, [Link](https://journals.lww.com/anesthesia-analgesia/pages/articleviewer.aspx?year=9900&issue=00000&article=01574&type=Fulltext)
13. Influence of Pre-emptive Haptoglobin on Postoperative Acute Kidney Injury in Cardiac Surgical Patients: A Randomized Controlled Trial, A&A, 21 November 2025, [Link](https://journals.lww.com/anesthesia-analgesia/abstract/9900/influence%5Fof%5Fpre%5Femptive%5Fhaptoglobin%5Fon.1552.aspx)
14. Cost-utility of point-of-care viscoelastic hemostatic assays in the management of bleeding during cardiac surgery: a single-blinded prospective multicenter stepped wedge cluster randomized trial in French context, Anaesthesia Critical Care & Pain Medicine, 20 November 2025, [Link](https://www.sciencedirect.com/science/article/pii/S235255682500236X)
15. Individualized Flow-Controlled versus Pressure-Controlled Ventilation in Cardiac Surgery: A Randomized Controlled Trial, Anesthesiology, 17 November 2025, [Link](https://journals.lww.com/anesthesiology/abstract/9900/individualized%5Fflow%5Fcontrolled%5Fversus.814.aspx)
16. Dynamic needle tip positioning in short-axis versus long-axis ultrasound-guided arterial cannulation: a randomised controlled trial, BMC Anesthesiology, 14 November 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03413-3)
17. Effects of Dexmedetomidine on Outcomes After Cardiac Surgery (DOCS): a randomised double-blind, placebo-controlled trial, BJA, 13 November 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900691-9/abstract)
18. Liberal or Restrictive Postoperative Transfusion in Patients at High Cardiac Risk: The TOP Randomized Clinical Trial, JAMA, 7 November 2025, [Link](https://jamanetwork.com/journals/jama/article-abstract/2841245)
1. Postoperative Transfusion in Patients at High Cardiac Risk: Evidence, Uncertainty, and Nuance, JAMA, 7 November 2025, [Link](https://jamanetwork.com/journals/jama/article-abstract/2841246)
19. Low dose of landiolol does not prevent postoperative atrial fibrillation after cardiac surgery in non-Asian patients: a multicentre randomised study, BJA, 6 November 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900669-5/abstract)
20. Perioperative Multimodal General Anesthesia Focusing on Specific Central Nervous System Targets Does Not Reduce Postoperative Interleukin-6 and Neurofilament Light Levels in Patients Undergoing Cardiac Surgeries: A Randomized Controlled Trial, Journal of Cardiothoracic and Vascular Anesthesia, 5 November 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025011279)
21. A Combined Intravenous and Oral Metoprolol Regimen to Reduce Perioperative Myocardial Injury: The ORION Trial, A&A, 17 October 2025, [Link](https://journals.lww.com/anesthesia-analgesia/citation/9900/a%5Fcombined%5Fintravenous%5Fand%5Foral%5Fmetoprolol%5Fregimen.1502.aspx)
22. Proactive vs Reactive Treatment of Hypotension During Surgery: The PRETREAT Randomized Clinical Trial, JAMA, 12 October 2025, [Link](https://jamanetwork.com/journals/jama/fullarticle/2840159)
1. Perioperative Outcomes—The Limits of Blood Pressure–Centered Strategies, JAMA, 12 October 2025, [Link](https://jamanetwork.com/journals/jama/article-abstract/2840161)
23. Individualized Perioperative Blood Pressure Management in Patients Undergoing Major Abdominal Surgery: The IMPROVE-multi Randomized Clinical Trial, JAMA, 12 October 2025, [Link](https://jamanetwork.com/journals/jama/article-abstract/2840160)
1. Perioperative Outcomes—The Limits of Blood Pressure–Centered Strategies, JAMA, 12 October 2025, [Link](https://jamanetwork.com/journals/jama/article-abstract/2840161)
### 4- Thoracic:
1. Effect of thoracic paravertebral block with ropivacaine and compound betamethasone on postoperative pain after thoracoscopic surgery: A randomized, double-blind, controlled trial, Medicine, 26 December 2025, [Link](https://journals.lww.com/md-journal/fulltext/2025/12260/effect%5Fof%5Fthoracic%5Fparavertebral%5Fblock%5Fwith.59.aspx/)
2. Effects of rhomboid intercostal and sub-serratus plane block on perioperative analgesic efficacy and diaphragm excursion in video-assisted thoracic surgery: a prospective, randomized controlled trial, BMC Anesthesiology, 18 December 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03556-3)
3. Efficacy of opioid-free anesthesia in reducing postoperative adverse events for thoracoscopic pulmonary surgery: a randomized controlled trial, BMC Anesthesiology, 12 December 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03497-x)
4. Dexmedetomidine versus ketamine as adjuvants in external oblique intercostal plane block for post thoracotomy pain: a randomised trial, BMC Anesthesiology, 26 November 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03476-2)
5. Driving Pressure–Guided Tidal Volume Titration Reduces Lung Injury in Thoracic Surgery With One-Lung Ventilation: A Randomized Clinical Trial, Journal of Cardiothoracic and Vascular Anesthesia, 19 November 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025011553)
6. Effects of intraoperative higher versus lower positive end-expiratory pressure during one-lung ventilation for thoracic surgery on postoperative pulmonary complications (PROTHOR): a multicentre, international, randomised, controlled, phase 3 trial, The Lancet Respiratory Medicine, 12 November 2025, [Link](https://www.thelancet.com/journals/lanres/article/PIIS2213-2600%2825%2900330-3/abstract)
7. Comparative effects of flow- versus volume-controlled one-lung ventilation on gas exchange and respiratory system mechanics in thoracic surgery: A randomised controlled clinical trial, EJA, 7 November 2025, [Link](https://journals.lww.com/ejanaesthesiology/abstract/9900/comparative%5Feffects%5Fof%5Fflow%5F%5Fversus.369.aspx)
8. Efficacy and safety of remimazolam tosilate in elderly patients undergoing general anesthesia for bronchoscopy. A randomized controlled trial, BMC Anesthesiology, 4 November 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03318-1)
9. The Effects of Nonintubated Anesthesia onNeutrophil-to-Lymphocyte Ratio and Tumor Markers Among Patients Undergoing Thoracoscopic Lung Resection: A Randomized Controlled Trial, Journal of Cardiothoracic and Vascular Anesthesia, 1 November 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025011127)
10. Effect of intraoperative paravertebral or intravenous lidocaine infusion on postoperative complications and inflammation after lung resection surgery: a randomised controlled trial, BJA, November 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900452-0/abstract)
11. Impact of acupressure combined with flexible pressure sensor manometry on anesthesia recovery in patients undergoing Bronchoalveolar lavage: a randomized controlled trial, BMC Anesthesiology, 28 October 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03404-4)
12. Feasibility and safety evaluation of remimazolam in geriatric patients during bronchoscopy: a single-centre randomized controlled trial, BMC Anesthesiology, 13 October 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03349-8)
### 5- Neuro:
1. Impact of desflurane versus isoflurane on early cognitive function of the elderly undergoing lumbar surgery: a randomized clinical trial, BMC Anesthesiology, 9 December 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03493-1)
2. The Impact of Preoperative Positive Suggestions on Dreaming With Intravenous Sedation: A Randomized Controlled, Blinded Trial, A&A, 25 November 2025, [Link](https://journals.lww.com/anesthesia-analgesia/abstract/9900/the%5Fimpact%5Fof%5Fpreoperative%5Fpositive%5Fsuggestions%5Fon.1572.aspx)
3. Comparison of the Effect of Low-dose and Standard-dose Dexmedetomidine Infusion on Neurological Outcomes in Patients With Aneurysmal Subarachnoid Hemorrhage Undergoing Aneurysmal Neck Clipping: a Randomized Controlled Trial, *Journal of Neurosurgical Anesthesiology*, 17 November 2025, [Link](https://journals.lww.com/jnsa/abstract/9900/comparison%5Fof%5Fthe%5Feffect%5Fof%5Flow%5Fdose%5Fand.187.aspx)
4. Opioid-Sparing Anesthesia Technique for Supratentorial Craniotomy in Geriatric Patients: A Randomized Open-Labeled Preliminary Study, A&A, 3 November 2025, [Link](https://journals.lww.com/anesthesia-analgesia/citation/9900/opioid%5Fsparing%5Fanesthesia%5Ftechnique%5Ffor.1521.aspx)
5. Comparison of Enhanced Recovery After Surgery Protocol Versus Conventional Care in Patients Undergoing Craniotomy for Intracranial Aneurysms: A Randomized Controlled Trial, A&A Practice, November 2025, [Link](https://journals.lww.com/aacr/abstract/2025/11000/comparison%5Fof%5Fenhanced%5Frecovery%5Fafter%5Fsurgery.2.aspx)
6. The effect of raw EEG implementation for assessing depth of anaesthesia on patient quality of recovery: A multicentre, double-blind, randomised controlled trial, EJA, 31 October 2025, [Link](https://journals.lww.com/ejanaesthesiology/abstract/9900/the%5Feffect%5Fof%5Fraw%5Feeg%5Fimplementation%5Ffor%5Fassessing.368.aspx)
7. Preoperative Pregabalin and the Cp50 for Skin Incision During Target-Controlled Propofol Infusion: A Randomized, Placebo-Controlled, Double-Blind Clinical Trial, A&A, 29 October 2025, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/preoperative%5Fpregabalin%5Fand%5Fthe%5Fcp50%5Ffor%5Fskin.1516.aspx)
8. Effects of transcutaneous electrical acupoint stimulation on recovery after internal spinal fixation: a randomised controlled trial, BMC Anesthesiology, 29 October 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03400-8)
9. Effect of perioperative intranasal insulin on postoperative delirium in elderly hip fracture patients undergoing general anesthesia: a randomized controlled study, BMC Anesthesiology, 27 October 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03406-2)
10. Sedation vs General Anesthesia for Endovascular Therapy in Acute Ischemic Stroke: The SEGA Randomized Clinical Trial, JAMA Neurology, 13 October 2025, [Link](https://jamanetwork.com/journals/jamaneurology/article-abstract/2839838)
### 6- Obstetrics & Gynecology:
1. Esketamine as an opioid-sparing adjuvant for epidural labour analgesia: a randomised, double-blind trial evaluating postpartum depression, BMC Anesthesiology, 29 December 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03590-1)
2. Intrathecal morphine versus transversalis fascia and transversus abdominis plane blocks combination on obstetric quality of recovery after cesarean delivery: a randomized controlled trial, BMC Anesthesiology, 17 December 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03559-0)
3. Comparison of analgesia efficacy between single-orifice and multiorifice wire-reinforced catheters for labour analgesia with the dural puncture epidural technique: A double-blind randomised controlled trial, *European Journal of Anaesthesiology*, 8 December 2025, [Link](https://journals.lww.com/ejanaesthesiology/abstract/9900/comparison%5Fof%5Fanalgesia%5Fefficacy%5Fbetween.380.aspx)
4. Effects of a multistage virtual reality intervention on perioperative anxiety and recovery in patients undergoing elective gynecological surgery: a prospective single-blind randomized controlled trial, BMC Anesthesiology, 6 December 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03474-4)
5. Effects of penehyclidine hydrochloride or droperidol combined with dexamethasone on preventing postoperative nausea and vomiting after remimazolam-alfentanil general anesthesia for gynecological day surgery, BMC Anesthesiology, 4 December 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03530-z)
6. Effects of remimazolam versus propofol on the optic nerve sheath diameter in patients undergoing laparoscopic hysterectomy: a randomized controlled trial, BMC Anesthesiology, 29 November 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03525-w)
7. Dural puncture epidural technique with 23-, 25- or 27-gauge pencil point spinal needles versus standard epidural technique for labor analgesia: a randomized trial, BMC Anesthesiology, 26 November 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03463-7)
8. Effects of different bupivacaine concentrations with dural puncture epidural technique for labor analgesia: a prospective randomized controlled trial, BMC Anesthesiology, 26 November 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03486-0)
9. Effect of intraoperative intravenous infusion of dexmedetomidine on postoperative ileus in parturients undergoing cesarean section with combined spinal-epidural anesthesia: a single center, prospective, double blind, randomized controlled trial, BMC Anesthesiology, 24 November 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03526-9)
10. The effect of remimazolam combined with low-dose propofol on diaphragmatic function in patients undergoing hysteroscopic surgery: a randomized clinical trial, BMC Anesthesiology, 22 November 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03524-x)
11. Impact of Mental Training on the stress of anaesthesiology residents before performing obstetrical epidural analgesia: a prospective randomised educational trial, Anaesthesia Critical Care & Pain Medicine, 15 November 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556825002073)
12. Intrathecal bupivacaine *versus* bupivacaine plus fentanyl for anaesthesia for Caesarean delivery: a randomised double-blind noninferiority trial, BJA, 12 November 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900737-8/fulltext)
13. Comparison of the potency-ratio of ciprofol and propofol on sedative effects in painless hysteroscopy: a randomized double-blind dose-response study, BMC Anesthesiology, 31 October 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03416-0)
14. Estimation of median effective doses and 95% effective doses of oliceridine combined with propofol for day-case hysteroscopy under total intravenous anesthesia with preserved spontaneous breathing: an up-and-down sequential allocation trial, BMC Anesthesiology, 28 October 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03411-5)
15. Optimal analgesia after laparoscopic total hysterectomy with pre-pneumoperitoneum phrenic nerve block using different ropivacaine concentrations: randomized controlled trial, BMC Anesthesiology, 27 October 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03391-6)
### 7- Pediatric:
1. Comparison of positive pressure ventilation strategies in young children undergoing laparoscopic inguinal hernia repair with laryngeal mask airway: a prospective randomized study, BMC Anesthesiology, 19 December 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03541-w)
2. A cost-effectiveness analysis of melatonin in comparison with midazolam for anxiety prior to general anaesthesia in children: the MAGIC randomised controlled trial (melatonin for anxiety prior to general anaesthesia in children), BMC Anesthesiology, 17 December 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03489-x)
3. Erector Spinae Plane Block Versus Retrolaminar Block for Perioperative Analgesia in Pediatric Cardiac Surgery: A Randomized, Double-blinded, Noninferiority Clinical Trial, Journal of Cardiothoracic and Vascular Anesthesia, December 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025006767)
4. Effect of High Positive End-Expiratory Pressure on Perioperative Atelectasis in Neonates and Small Infants (0–6 months) with Healthy Lungs: A Randomized Controlled Trial, Anaesthesia Critical Care & Pain Medicine, 19 November 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556825002115)
5. Preoperative sedation with intravenous S-ketamine versus midazolam in preschool children: a randomized controlled trial, BMC Anesthesiology, 21 November 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03454-8)
6. Comparison of the anesthetic efficacy and recovery quality of remimazolam besylate versus sevoflurane for pediatric circumcision: a single-center, prospective, assessor-blinded, randomized controlled study protocol, BMC Anesthesiology, 28 October 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03378-3)
7. Intravenous Lidocaine for Postoperative Pain in Children Undergoing Tonsillectomies: A Double-Blinded, Randomized, Placebo-Controlled Trial, A&A, 24 October 2025, [Link](https://journals.lww.com/anesthesia-analgesia/abstract/9900/intravenous%5Flidocaine%5Ffor%5Fpostoperative%5Fpain%5Fin.1506.aspx)
### 8- Orthopedic:
1. Effect of S-Ketamine on Postoperative Delirium in Elderly Patients Undergoing Arthroplasty: A Randomized Controlled Trial, Anesthesiology, January 2026, [Link](https://journals.lww.com/anesthesiology/fulltext/2026/01000/effect%5Fof%5Fs%5Fketamine%5Fon%5Fpostoperative%5Fdelirium%5Fin.17.aspx)
2. The effect of intraoperative dexmedetomidine versus ketamine on postoperative pain in patients receiving a femoral nerve block for total knee arthroplasty: a randomized trial, BMC Anesthesiology, 27 December 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03572-3)
3. Optimizing Postoperative Analgesia in Total Knee Arthroplasty: A Randomized Controlled Trial on the Efficacy of Perineural Dexamethasone with iPACK and Adductor Canal Block, *The Clinical Journal of Pain*, 19 December 2025, [Link](https://journals.lww.com/clinicalpain/abstract/9900/optimizing%5Fpostoperative%5Fanalgesia%5Fin%5Ftotal%5Fknee.303.aspx)
4. Comparison of anesthetic effects of spinal anesthesia at L5-S1 and L3-4 under real-time ultrasound guidance in total knee arthroplasty: a single center randomized controlled trial, BMC Anesthesiology, 1 December 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03483-3)
### 9- Regional Anesthesia & Pain Management
1. Thoracic epidural insertion using extended reality hologram assistance: a randomised trial of regional anaesthesia skill performance on the soft embalmed Thiel cadaver, BJA, 31 December 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900817-7/abstract)
2. Ultrasound-guided External Oblique Intercostal Plane Block with Ropivacaine for Analgesia after Open Hepatectomy: A Randomized Controlled Study, Anesthesiology, 29 December 2025, [Link](https://journals.lww.com/anesthesiology/fulltext/9900/ultrasound%5Fguided%5Fexternal%5Foblique%5Fintercostal.813.aspx)
3. Effect of nalbuphine and morphine as adjuvants to bupivacaine in ultrasound-guided supraclavicular block: a randomized controlled trial with machine learning-based predictive analysis, BMC Anesthesiology, 28 December 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03537-6)
4. The analgesic effect of fascia iliaca compartment block combined with superior cluneal nerve block after total hip arthroplasty: a prospective, triple-blind, randomized controlled trial, BMC Anesthesiology, 22 December 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03533-w)
5. Optimizing Postoperative Analgesia in Total Knee Arthroplasty: A Randomized Controlled Trial on the Efficacy of Perineural Dexamethasone with iPACK and Adductor Canal Block, *The Clinical Journal of Pain*, 19 December 2025, [Link](https://journals.lww.com/clinicalpain/abstract/9900/optimizing%5Fpostoperative%5Fanalgesia%5Fin%5Ftotal%5Fknee.303.aspx)
6. Ultrasound-Guided Regional Anesthesia by Emergency Physicians for Hip Fractures and Delirium: A Randomized Clinical Trial, JAMA Open, 15 December 2025, [Link](https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2842817)
7. Dexmedetomidine versus ketamine for preemptive caudal analgesia in single-level lumbar laminectomy: A randomized controlled trial, Medicine, 12 December 2025, [Link](https://journals.lww.com/md-journal/pages/articleviewer.aspx?year=2025&issue=12120&article=00013&type=Fulltext)
8. Combined Betamethasone and Ropivacaine for Scalp Nerve Block for Patients Undergoing Elective Craniotomy: A Prospective, Randomized, Controlled Clinical Study, *Journal of Neurosurgical Anesthesiology*, 10 December 2025, [Link](https://journals.lww.com/jnsa/fulltext/9900/combined%5Fbetamethasone%5Fand%5Fropivacaine%5Ffor%5Fscalp.194.aspx)
9. Oxycodone reduces postoperative pulmonary complications compared to sufentanil in high-risk patients with pulmonary dysfunction: a randomized clinical trial, BMC Anesthesiology, 9 December 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03540-x)
10. Liposomal bupivacaine as an adjunct to bupivacaine-based brachial plexus block in patients undergoing rotator cuff repair: a prospective double-blind randomized controlled clinical trial, BMC Anesthesiology, 7 December 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03550-9)
11. A comparative study on the efficacy of ultrasound-guided interscalene brachial plexus block combined with modified superficial cervical plexus block in proximal humerus fracture surgery, Medicine, 5 December 2025, [Link](https://journals.lww.com/md-journal/fulltext/2025/12050/a%5Fcomparative%5Fstudy%5Fon%5Fthe%5Fefficacy%5Fof.70.aspx/)
12. External oblique intercostal plane block as an alternative to subcostal TAP block for laparoscopic cholecystectomy: a prospective randomized study, BMC Anesthesiology, 5 December 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03548-3)
13. Pain as a Driver of Myocardial Injury in Hip Fracture Patients: A Hip Fracture Accelerated Surgical Treatment and Care Track (HIP ATTACK) Trial Secondary Analysis, Anesthesiology, 4 December 2025, [Link](https://journals.lww.com/anesthesiology/abstract/9900/pain%5Fas%5Fa%5Fdriver%5Fof%5Fmyocardial%5Finjury%5Fin%5Fhip.796.aspx)
14. The Analgesic Effects of Ultrasound-guided Recto-intercostal Fascial Plane Block in Laparoscopic Hiatus Hernia Repair: A Randomized Double-Blind Controlled Study, Anaesthesia Critical Care & Pain Medicine, 3 December 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556825002565)
15. Effect of postoperative analgesia with the combination of dexmedetomidine and butorphanol after spinal posterior surgery: a randomized controlled trial, BMC Anesthesiology, 3 December 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03466-4)
16. Duration of analgesia after supraclavicular brachial plexus block with intravenous dexamethasone with or without dexmedetomidine: a randomised, placebo-controlled, triple-blind trial, BJA, 1 December 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900792-5/fulltext)
17. Liposomal Bupivacaine, Plain Bupivacaine, and Saline for Transversus Abdominis Plane Blocks: The CLEVELAND Randomized Trial, Anesthesiology, 1 December 2025, [Link](https://journals.lww.com/anesthesiology/abstract/9900/liposomal%5Fbupivacaine,%5Fplain%5Fbupivacaine,%5Fand.828.aspx)
18. Impact of Intraoperative Clonidine on Postoperative Opioid Use in Patients With Endometriosis: A Randomized Controlled Trial, A&A practice, december 2025, [Link](https://journals.lww.com/aacr/fulltext/2025/12000/impact%5Fof%5Fintraoperative%5Fclonidine%5Fon.17.aspx)
19. Ultrasound-guided *versus* neurostimulation-guided bilateral transperineal pudendal nerve block for analgesia in outpatient haemorrhoid surgery: protocol for a multicentre, randomised, double-blind, non-inferiority trial, BJA Open, December 2025, [Link](https://www.sciencedirect.com/science/article/pii/S2772609625001364)
20. Perioperative cognitive behavioural therapy compared with pain education and mindfulness for chronic postsurgical pain in breast cancer patients with high pain catastrophising characteristics: a randomised, controlled, parallel group clinical trial, BJA Open, December 2025, [Link](https://www.sciencedirect.com/science/article/pii/S2772609625001236)
21. Erector Spinae Plane block with fascial plane catheter for the Early Analgesia of Rib fractures in trauma (ESPEAR): a multicentre feasibility randomised trial, BJA Open, December 2025, [Link](https://www.sciencedirect.com/science/article/pii/S2772609625001224)
22. Is there a difference in the postoperative quality of recovery and analgesia between erector spinae and serratus anterior plane blocks following modified radical mastectomy: a randomized controlled study, BMC Anesthesiology, 29 November 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03477-1)
23. Is the serratus posterior superior intercostal plane block a viable alternative to the erector spinae plane block for postoperative analgesia in breast surgery? A prospective, randomized trial, BMC Anesthesiology, 29 November 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03531-y)
24. Comparison of genicular nerve block and its combination with IPACK block for analgesia and recovery after total knee arthroplasty: a randomized trial, BMC Anesthesiology, 29 November 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03408-0)
25. Efficacy and safety of lidocaine versus sufentanil in patient-controlled intravenous analgesia after laparoscopic colorectal cancer surgery: a prospective, randomized, double-blind clinical trial, BMC Anesthesiology, 27 November 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03506-z)
26. Virtual reality for reducing intraoperative anxiety and improving patient satisfaction under regional anesthesia among palestinian patients: a randomized controlled trial, BMC Anesthesiology, 27 November 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03475-3)
27. Dexmedetomidine versus ketamine as adjuvants in external oblique intercostal plane block for post-thoracotomy pain: a randomised trial, BMC Anesthesiology, 26 November 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03476-2)
28. Effectiveness of pericapsular nerve group block for hip fracture pain management in the emergency department: results of the ED-PENG-B randomised controlled trial, BMC Emergency Medicine, 26 November 2025, [Link](https://link.springer.com/article/10.1186/s12873-025-01401-x)
29. Ultrasound-guided intermediate cervical plexus block versus local infiltration anesthesia for thermal ablation of benign thyroid nodules: a non-inferior, double-blinded, randomized controlled trial, BMC Anesthesiology, 25 November 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03457-5)
30. Quality of early recovery after ultrasound-guided serratus plane block for transapical transcatheter aortic valve implantation surgery under general anesthesia: a single-center randomized controlled trial, BMC Anesthesiology, 24 November 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03528-7)
31. Ultrasound-guided thoracic paravertebral block *versus* erector spinae plane block analgesia for cardiac surgery with median sternotomy: a noninferiority randomised controlled trial, BJA, 24 November 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900777-9/abstract)
32. Ultrasound-guided intermediate versus deep cervical plexus block for carotid endarterectomy: a randomized controlled study, BMC Anesthesiology, 21 November 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03460-w)
33. Impact of Ultrasound-guided Superficial Cervical Plexus Block on Early Postoperative Recovery in Patients Undergoing Microvascular Decompression: A Randomized Controlled Trial, *Journal of Neurosurgical Anesthesiology*, 21 November 2025, [Link](https://journals.lww.com/jnsa/abstract/9900/impact%5Fof%5Fultrasound%5Fguided%5Fsuperficial%5Fcervical.188.aspx)
34. Oxycodone/naloxone *versus* placebo for acute spinal pain in compliant participants: secondary analysis of a randomised clinical trial, BJA, 20 November 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900739-1/abstract)
35. Continuous posterior extrathoracic fascial plane block *versus* continuous paravertebral block for pain management in patients with multiple rib fractures: a randomised controlled noninferiority trial, BJA, 20 November 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900735-4/abstract)
36. The effect of continuous intravenous lidocaine infusion on postoperative analgesia in elderly patients undergoing laparoscopic colorectal surgery, BMC Anesthesiology, 20 November 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03422-2)
37. Addition of metamizole to paracetamol at home after painful ambulatory arthroscopic shoulder surgery: A double-blind randomised controlled superiority trial, EJA, 19 November 2025, [Link](https://journals.lww.com/ejanaesthesiology/citation/9900/addition%5Fof%5Fmetamizole%5Fto%5Fparacetamol%5Fat%5Fhome.373.aspx)
38. Comparison of subcostal transversus abdominis block with intraperitoneal instillation of bupivacaine and dexmedetomidine for pain relief after laparoscopic cholecystectomy, randomized double-blinded controlled study, BMC Anesthesiology, 14 November 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03412-4)
39. Efficacy of Erector Spinae Plane Block in Preventing Chronic Pain After Breast Cancer Surgery: A Randomized Controlled Trial, Anaesthesia Critical Care & Pain Medicine, 12 November 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556825002085)
40. Single-shot versus slow infusion interscalene block and its impact on diaphragmatic function in patients undergoing shoulder surgery, a double blind randomized controlled trial, Anaesthesia Critical Care & Pain Medicine, 7 November 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556825002000)
41. Optimizing the superior trunk block for arthroscopic shoulder surgery: a randomized, double-blind comparison of low- vs. conventional-dose ropivacaine on anesthesia, analgesia, and diaphragmatic function, BMC Anesthesiology, 31 October 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03409-z)
42. Ultrasound-guided trans-perineal pudendal nerve block for post-hemorrhoidectomy voiding complications: a prospective randomized double-blinded study, BMC Anesthesiology, 31 October 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03458-4)
43. Comfort-Focused Assessment and Patient-Reported Experience After Regional versus General Anaesthesia: Post Hoc Analysis of a Cluster-Randomised Trial, Anaesthesia Critical Care & Pain Medicine, 31 October 2025, [Link](https://www.sciencedirect.com/science/article/pii/S2352556825001924)
44. Lower thoracic paravertebral block via posterior pathway of medial arcuate ligament under direct visualization versus transmuscular quadratus lumborum block for postoperative analgesia following retroperitoneal laparoscopic nephrectomy: a randomized controlled trial, BMC Anesthesiology, 29 October 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03417-z)
45. Ultrasound-guided erector spinae plane block versus rhomboid intercostal sub-serratus plane block for postoperative analgesia in open radical nephrectomy: a randomized clinical study, BMC Anesthesiology, 22 October 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03377-4)
46. Effects of ultrasound-guided adductor canal block at different volumes on postoperative analgesia management in patients undergoing total knee arthroplasty: a prospective clinical study, BMC Anesthesiology, 20 October 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03383-6)
47. Effect of liposomal bupivacaine for the suprascapular nerve combined with axillary nerve block on postoperative analgesia in patients undergoing shoulder surgery: a randomized, observer-blinded trial, BMC Anesthesiology, 17 October 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03392-5)
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## ***Reviews:***
### 1- AI:
1. Artificial intelligence in cardiothoracic monitoring and echocardiography, *Current Opinion in Anesthesiology*, 3 December 2025, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/artificial%5Fintelligence%5Fin%5Fcardiothoracic.374.aspx)
2. Dependability of Large Language Models in Cardiovascular Medicine: A Scoping Review, Journal of Cardiothoracic and Vascular Anesthesia, December 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025006214)
3. The Potential Impacts of Artificial Intelligence on Preoperative Optimization and Predicting Risks of Morbidity and Mortality: A Narrative Focused Review, A&A Practice, October 2025, [Link](https://journals.lww.com/aacr/abstract/2025/10000/the%5Fpotential%5Fimpacts%5Fof%5Fartificial%5Fintelligence.2.aspx)
### 2- General:
1. Future directions in viscoelastic hemostatic assay usage in bleeding patients, *Current Opinion in Anesthesiology*, 9 December 2025, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/future%5Fdirections%5Fin%5Fviscoelastic%5Fhemostatic%5Fassay.377.aspx)
2. Protecting clinician autonomy and patient safety within the climate debate: the case for desflurane in modern anaesthesia, *Current Opinion in Anesthesiology*, 3 December 2025, [Link](https://journals.lww.com/co-anesthesiology/fulltext/9900/protecting%5Fclinician%5Fautonomy%5Fand%5Fpatient%5Fsafety.367.aspx)
3. Improving the safety of prehospital emergency anaesthesia, *Current Opinion in Critical Care*, December 2025, [Link](https://journals.lww.com/co-criticalcare/abstract/2025/12000/improving%5Fthe%5Fsafety%5Fof%5Fprehospital%5Femergency.11.aspx)
4. Characterisation and evaluation of early mobilisation interventions after emergency laparotomy surgery: a scoping review, BJA Open, December 2025, [Link](https://www.sciencedirect.com/science/article/pii/S277260962500125X)
5. Sex-based differences in anesthesia approaches and outcomes: a narrative review, Anaesthesia Critical Care & Pain Medicine, 3 December 2025, [Link](https://www.sciencedirect.com/science/article/pii/S2352556825002553)
6. The effect of patient resilience on perioperative outcomes: a scoping review, BJA, December 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900605-1/fulltext)
7. Leveraging the Multifaceted Platelet Storage Lesion to Advance Precision Platelet Transfusion Medicine, Anesthesiology, 21 November 2025, [Link](https://journals.lww.com/anesthesiology/abstract/9900/leveraging%5Fthe%5Fmultifaceted%5Fplatelet%5Fstorage.818.aspx)
8. Psychological safety in the operating theatre environment, BJA Edu, 21 November 2025, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900096-4/fulltext)
9. Perioperative care of patients who decline blood products, BJA Edu, 21 November 2025, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900095-2/abstract)
10. Perioperative Inflammation and Immune Response in Anesthesia: Implications for Recovery and Postoperative Outcomes, Journal of Cardiothoracic and Vascular Anesthesia, 13 November 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025011425)
11. Perioperative antimicrobial prophylaxis and surgical site infection prevention, what clinicians and researchers must know, Anaesthesia Critical Care & Pain Medicine, November 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556825001328)
12. Society for Perioperative Assessment and Quality Improvement: a narrative review of best practices for perioperative management of patients with bleeding disorders, BJA, November 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900557-4/fulltext)
13. Anaesthetic Considerations for Patient Blood Management in Cancer Surgery: A Narrative Review, Anaesthesia Critical Care & Pain Medicine, 29 October 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556825001833)
### 3- Airway & Mechanical Ventilation:
1. High-Frequency Jet Ventilation for Percutaneous Image-Guided Tumor Ablation, A&A Practice, January 2026, [Link](https://journals.lww.com/aacr/abstract/2026/01000/high%5Ffrequency%5Fjet%5Fventilation%5Ffor%5Fpercutaneous.4.aspx)
2. Management of Out–of–operating room Tracheostomy and Laryngectomy-related Emergencies, Anesthesiology, 29 December 2025, [Link](https://journals.lww.com/anesthesiology/citation/9900/management%5Fof%5Fout%5Fof%5Foperating%5Froom%5Ftracheostomy.858.aspx)
3. Anesthetic Care of Interventional Pulmonology Patients, Anesthesiology, December 2025, [Link](https://journals.lww.com/anesthesiology/fulltext/2025/12000/anesthetic%5Fcare%5Fof%5Finterventional%5Fpulmonology.23.aspx)
4. Pulmonary atelectasis in anaesthesia and critical care, BJA Edu, 17 November 2025, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900094-0/fulltext)
5. Education in airway management: a narrative review, BJA, 4 November 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900717-2/abstract)
6. Positive end-expiratory pressure optimisation during general anaesthesia in patients with obesity: a narrative review of respiratory and cardiovascular outcomes, BJA, 16 October 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900639-7/fulltext)
### 4- Cardiovascular & Hemodynamics:
1. Perioperative Considerations for Patients Undergoing Percutaneous Ablative Therapy for Atrial Fibrillation, Anesthesiology, January 2026, [Link](https://journals.lww.com/anesthesiology/fulltext/2026/01000/perioperative%5Fconsiderations%5Ffor%5Fpatients.29.aspx)
2. Patients with adult congenital heart disease presenting for noncardiac surgery, *Current Opinion in Anesthesiology*, 16 December 2025, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/patients%5Fwith%5Fadult%5Fcongenital%5Fheart%5Fdisease.379.aspx)
3. Combined Inhaled Pulmonary Vasodilators in Cardiac Surgery: A Scoping Review, Journal of Cardiothoracic and Vascular Anesthesia, 12 December 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025012200)
4. Perioperative Vasopressor Management in Noncardiac Surgical Patients, Anesthesiology, 12 December 2025, [Link](https://journals.lww.com/anesthesiology/citation/9900/perioperative%5Fvasopressor%5Fmanagement%5Fin%5Fnoncardiac.848.aspx)
5. Preoperative anemia in cardiac surgery patients: how to achieve clinical optimization – a narrative review, *Current Opinion in Anesthesiology*, 9 December 2025, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/preoperative%5Fanemia%5Fin%5Fcardiac%5Fsurgery%5Fpatients%5F.378.aspx)
6. Cardiac surgery-associated acute kidney injury, BJA Edu, 8 December 2025, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900098-8/fulltext)
7. Advances in cardiovascular pharmacotherapy. VI. Sacubitril/valsartan, an angiotensin receptor-neprilysin inhibitor, Journal of Cardiothoracic and Vascular Anesthesia, 5 December 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025012042)
8. Will prothrombin complex concentrate replace plasma in cardiac surgical bleeding in North America?, *Current Opinion in Anesthesiology*, 4 December 2025, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/will%5Fprothrombin%5Fcomplex%5Fconcentrate%5Freplace.375.aspx)
9. The use of methadone in cardiac surgery: resurgence of an old drug?, *Current Opinion in Anesthesiology*, 3 December 2025, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/the%5Fuse%5Fof%5Fmethadone%5Fin%5Fcardiac%5Fsurgery%5F.373.aspx)
10. Heart Failure in 2025: Update With Perioperative Considerations, Journal of Cardiothoracic and Vascular Anesthesia, December 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025006627)
11. Intraoperative Management for Valve-Sparing Aortic Root Replacement, Journal of Cardiothoracic and Vascular Anesthesia, 19 November 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025011589)
12. Acute Kidney Injury in Cardiac Surgery: A Comprehensive Review of Perioperative Strategies and Emerging Biomarkers, Journal of Cardiothoracic and Vascular Anesthesia, 13 November 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025011383)
13. Cardiovascular Risks of Nonsteroidal Anti-Inflammatory Drugs: A Narrative Review, *The Clinical Journal of Pain,* 13 November 2025, [Link](https://journals.lww.com/clinicalpain/abstract/9900/cardiovascular%5Frisks%5Fof%5Fnonsteroidal.299.aspx)
14. Anesthetic Perspective on Total Arch Replacement With Frozen Elephant Trunk Surgery, Journal of Cardiothoracic and Vascular Anesthesia, 7 November 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025011371)
15. Dissecting the “Triple Hit” of Perioperative Neurocognitive Disorders after CABG: A Narrative Review of Microemboli, Hypoperfusion, and Inflammation, Journal of Cardiothoracic and Vascular Anesthesia, 30 October 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025011115)
16. The Year in Cardiothoracic and Vascular Anesthesia: Selected Highlights From 2025, Journal of Cardiothoracic and Vascular Anesthesia, 29 October 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025010626)
17. Microcirculation in Anaesthesia: What Every Anaesthesiologist Should Know?, Anaesthesia Critical Care & Pain Medicine, 29 October 2025, [Link](https://www.sciencedirect.com/science/article/pii/S2352556825001869)
18. Cardiac Tamponade: Impact of Pathophysiology on Clinical Practice, Anesthesiology, 20 October 2025, [Link](https://journals.lww.com/anesthesiology/citation/9900/cardiac%5Ftamponade%5F%5Fimpact%5Fof%5Fpathophysiology%5Fon.781.aspx)
### 5- Thoracic:
1. Intraoperative mechanical ventilation during thoracic surgery: contemporary controversies and evolving strategies, *Current Opinion in Anesthesiology*, February 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/2026/02000/intraoperative%5Fmechanical%5Fventilation%5Fduring.16.aspx)
2. Airway management in thoracic anesthesia in the light of the guidelines of EACTAIC-thoracic group: what is next?, *Current Opinion in Anesthesiology*, February 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/2026/02000/airway%5Fmanagement%5Fin%5Fthoracic%5Fanesthesia%5Fin%5Fthe.11.aspx)
3. Robotic thoracic surgery: what is different in anesthesia?, *Current Opinion in Anesthesiology*, February 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/2026/02000/robotic%5Fthoracic%5Fsurgery%5F%5Fwhat%5Fis%5Fdifferent%5Fin.17.aspx)
4. Cognitive aids in thoracic emergencies, *Current Opinion in Anesthesiology*, February 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/2026/02000/cognitive%5Faids%5Fin%5Fthoracic%5Femergencies.12.aspx)
5. Pain management in thoracic surgery: bridging evidence and practice, *Current Opinion in Anesthesiology*, February 2026, [Link](https://journals.lww.com/co-anesthesiology/abstract/2026/02000/pain%5Fmanagement%5Fin%5Fthoracic%5Fsurgery%5F%5Fbridging.15.aspx)
6. Fraction of inspired oxygen in thoracic surgery: how much is too much?, *Current Opinion in Anesthesiology*, 1 December 2025, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/fraction%5Fof%5Finspired%5Foxygen%5Fin%5Fthoracic%5Fsurgery%5F.371.aspx)
7. Pharmacology of thoracic anesthesia, *Current Opinion in Anesthesiology*, 25 November 2025, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/pharmacology%5Fof%5Fthoracic%5Fanesthesia.368.aspx)
8. Perioperative Extracorporeal Membrane Oxygenation Use in Lung Transplantation: Analysis of Outcomes and Future Directions, Journal of Cardiothoracic and Vascular Anesthesia, 27 October 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025011048)
9. Anesthesia strategies to minimize lung atelectasis in peripheral bronchoscopy, Current Opinion in Pulmonary Medicine, 6 October 2025, [Link](https://journals.lww.com/co-pulmonarymedicine/abstract/9900/anesthesia%5Fstrategies%5Fto%5Fminimize%5Flung%5Fatelectasis.281.aspx)
### 6- Neuro:
1. Dexmedetomidine for prevention of postoperative delirium in elderly patients through hypoxia-inducible factor: A narrative review, Medicine, 19 December 2025, [Link](https://journals.lww.com/md-journal/fulltext/2025/12190/dexmedetomidine%5Ffor%5Fprevention%5Fof%5Fpostoperative.71.aspx/)
2. Anaesthesia for cervical spine surgery. Part 1: elective surgery, BJA Edu, 19 December 2025, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900105-2/abstract)
3. Optimising postoperative spine outcomes: an umbrella review of enhanced recovery after spinal surgery (ERASS) protocols, BJA, December 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900603-8/fulltext)
4. Effects of Adjunct Analgesics and Novel Anesthetic Agents on Intraoperative Neuromonitoring: A Scoping Review, AA, 25 November 2025, [Link](https://journals.lww.com/anesthesia-analgesia/abstract/9900/effects%5Fof%5Fadjunct%5Fanalgesics%5Fand%5Fnovel%5Fanesthetic.1577.aspx)
5. Targeting glycolysis and maintaining glucose homeostasis for treating perioperative neurocognitive disorder: a narrative review, BJA, 14 November 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900738-X/abstract)
6. Emerging Role of Electroencephalographic Aperiodic Activity in Anesthesia: A Narrative Review, Anesthesiology, 4 November 2025, [Link](https://journals.lww.com/anesthesiology/abstract/9900/emerging%5Frole%5Fof%5Felectroencephalographic%5Faperiodic.801.aspx)
### 7- Obstetrics & Gynecology:
1. Management of phaeochromocytoma in pregnancy, BJA Edu, 29 December 2025, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900108-8/abstract)
2. Respiratory disease in pregnancy, BJA Edu, December 2025, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900083-6/fulltext)
3. Management of uterine atony in obstetric anaesthesia, BJA Edu, 21 November 2025, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900097-6/abstract)
4. The pregnant and postpartum stomach, EJA, 19 November 2025, [Link](https://journals.lww.com/ejanaesthesiology/fulltext/9900/the%5Fpregnant%5Fand%5Fpostpartum%5Fstomach.374.aspx)
5. Postpartum Hemorrhage, JAMA, 22 October 2025, Mini review, [Link](https://jamanetwork.com/journals/jama/fullarticle/2840462)
6. Point-of-care visco-elastic testing for postpartum hemorrhage: A narrative review, EJA, 14 October 2025, [Link](https://journals.lww.com/ejanaesthesiology/abstract/9900/point%5Fof%5Fcare%5Fvisco%5Felastic%5Ftesting%5Ffor%5Fpostpartum.363.aspx)
### 8- Pediatric:
1. Postoperative respiratory adverse events in pediatric anesthesia: Risk factors, clinical implications, and management strategies, Medicine, 26 December 2025, [Link](https://journals.lww.com/md-journal/fulltext/2025/12260/postoperative%5Frespiratory%5Fadverse%5Fevents%5Fin.57.aspx/)
2. Peripheral regional anesthesia techniques in pediatric cardiac surgery: A scoping review, Journal of Cardiothoracic and Vascular Anesthesia, 18 December 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025012273)
3. Neuromuscular scoliosis surgery in children, BJA Edu, December 2025, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900085-X/abstract)
4. Analgesia for paediatric scoliosis surgery, BJA Edu, December 2025, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900086-1/abstract)
5. Anaesthesia for paediatric interventional radiology, BJA Edu, December 2025, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900084-8/abstract)
6. Environmental exposure to air pollution and pollen and the risk of perioperative respiratory adverse events in paediatric anaesthesia: A narrative review, Anaesthesia Critical Care & Pain Medicine, November 2025, [Link](https://www.sciencedirect.com/science/article/pii/S235255682500133X)
7. Foreign body removal, Current Opinion in Pulmonary Medicine, 13 October 2025, [Link](https://journals.lww.com/co-pulmonarymedicine/abstract/9900/foreign%5Fbody%5Fremoval.285.aspx)
### 9- Orthopedic:
1. Postoperative delirium in orthopedic patients – identifying contributing factors and therapeutic strategies: A review, Medicine, 5 December 2025, [Link](https://journals.lww.com/md-journal/fulltext/2025/12050/postoperative%5Fdelirium%5Fin%5Forthopedic%5Fpatients%5F%5F.26.aspx/)
### 10- Regional Anesthesia & Pain Management
1. Is It Time to Reassess Local Anesthetic and Adjuvant Mixtures? A Narrative Review of Practice, Evidence, and Risks, Anesthesiology, January 2026, [Link](https://journals.lww.com/anesthesiology/abstract/2026/01000/is%5Fit%5Ftime%5Fto%5Freassess%5Flocal%5Fanesthetic%5Fand.28.aspx)
2. Pain after lower limb amputation, BJA Edu, 30 December 2025, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900107-6/abstract)
3. Intraoperative pain management for patients undergoing medication-assisted rehabilitation: a scoping review, BMC Anesthesiology, 10 December 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03538-5)
4. Regional anesthesia in cardiothoracic surgery: techniques, evidence, and evolving practice, *Current Opinion in Anesthesiology*, 9 December 2025, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/regional%5Fanesthesia%5Fin%5Fcardiothoracic%5Fsurgery%5F.376.aspx)
5. Suzetrigine, a selective NaV1.8 inhibitor in acute and chronic pain: mechanistic insights, clinical outcomes, and future perspectives, *Current Opinion in Anesthesiology*, 1 December 2025, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/suzetrigine,%5Fa%5Fselective%5Fnav1%5F8%5Finhibitor%5Fin%5Facute.370.aspx)
6. The effects of platelet-rich plasma on zoster-associated pain: a scoping review, BMC Anesthesiology, 1 December 2025, [Link](https://link.springer.com/article/10.1186/s12871-025-03426-y)
7. Advances in spinal cord stimulation, BJA Edu, December 2025, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900087-3/abstract)
8. New persistent opioid use after surgery and traumatic injury: a narrative review of global rates, risk factors, and healthcare interventions, BJA Open, December 2025, [Link](https://www.sciencedirect.com/science/article/pii/S2772609625001339)
9. Perioperative analgesia in high-risk patients: what clinicians and researchers must know? A narrative review, Anesthesia Critical Care & Pain Medicine, 14 October 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556825001766)
---
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# **Critical Care:**
## ***Guidelines & Consensus:***
### 1- Cardiovascular & Hemodynamics:
1. 2025 ACC/AHA/HRS/ISACHD/SCAI Guideline for the Management of Adults With Congenital Heart Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines, JACC, 18 December 2025, [Link](https://www.jacc.org/doi/10.1016/j.jacc.2025.09.006)
2. ESICM guidelines on circulatory shock and hemodynamic monitoring 2025, Intensive Care Medicine, 14 November 2025, [Link](https://link.springer.com/article/10.1007/s00134-025-08137-z)
3. UK consensus statement on priorities to support the process of withdrawal of veno-venous extracorporeal membrane oxygenation, BJA, November 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900581-1/fulltext)
4. 2025 International Liaison Committee on Resuscitation Consensus on Science With Treatment Recommendations, Circulation, 22 October 2025, [Link](https://www.ahajournals.org/toc/circ/152/16%5Fsuppl%5F1) (Full issue)
5. 2025 American Heart Association and American Academy of Pediatrics Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care, Circulation, 22 October 2025, [Link](https://www.ahajournals.org/toc/circ/152/16%5Fsuppl%5F2) (Full issue)
6. European Resuscitation Council Guidelines 2025 Executive Summary, Resuscitation, October 2025, [Link](https://www.sciencedirect.com/science/article/pii/S0300957225002825)
7. European Resuscitation Council Guidelines 2025 Epidemiology in Resuscitation, Resuscitation, October 2025, [Link](https://www.sciencedirect.com/science/article/pii/S030095722500245X)
8. European Resuscitation Council Guidelines 2025 System Saving Lives, Resuscitation, October 2025, [Link](https://www.sciencedirect.com/science/article/pii/S0300957225003338)
9. European Resuscitation Council Guidelines 2025 Adult Basic Life Support, Resuscitation, October 2025, [Link](https://www.sciencedirect.com/science/article/pii/S0300957225002837)
10. European Resuscitation Council Guidelines 2025 Adult Advanced Life Support, Resuscitation, October 2025, [Link](https://www.sciencedirect.com/science/article/pii/S0300957225002813)
11. European Resuscitation Council Guidelines 2025 Special Circumstances in Resuscitation, Resuscitation, October 2025, [Link](https://www.sciencedirect.com/science/article/pii/S0300957225002655)
12. European Resuscitation Council and European Society of Intensive Care Medicine Guidelines 2025 Post-Resuscitation Care, Resuscitation, October 2025, [Link](https://www.sciencedirect.com/science/article/pii/S0300957225003211)
13. European Resuscitation Council Guidelines 2025 Education for Resuscitation, Resuscitation, October 2025, [Link](https://www.sciencedirect.com/science/article/pii/S0300957225002515)
14. European Resuscitation Council Guidelines 2025 Ethics in Resuscitation, Resuscitation, October 2025, [Link](https://www.sciencedirect.com/science/article/pii/S0300957225002461)
15. European Resuscitation Council Guidelines 2025 First Aid, Resuscitation, October 2025, [Link](https://www.sciencedirect.com/science/article/pii/S0300957225002643)
### 2- Thorax/Lungs/Airways/Mechanical ventilation:
1. Difficult Airway Society 2025 guidelines for management of unanticipated difficult tracheal intubation in adults, BJA, 6 November 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900693-2/fulltext)
### 3- Neuro-muscular:
1. Consensus statement on standards for neurocritical care units in low-income and middle-income countries (LMICs), Journal of Critical Care, February 2026, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0883944125002837)
2. Every Minute Counts: A Paradigm Shift in ICH: Perspectives and Recommendations From the Fourth Hemorrhagic Stroke Academia Industry (HEADS) Roundtable, Stroke, 24 November 2025, [Link](https://www.ahajournals.org/doi/10.1161/STROKEAHA.125.052984)
3. Technical Performance and Interpretation of Digital Subtraction Angiography to Determine Cerebral Circulatory Arrest in Patients Being Evaluated for Brain Death/Death by Neurological Criteria: A Brief Practice Update From the Society of Vascular and Interventional Neurology (SVIN), Stroke: Vascular and Interventional Neurology, 18 November 2025, [Link](https://www.ahajournals.org/doi/10.1161/SVIN.125.002091)
4. The intensive care medicine research agenda for the management of ICU acquired weakness: a multinational, interprofessional perspective, Intensive Care Medicine, 3 November 2025, [Link](https://link.springer.com/article/10.1007/s00134-025-08186-4)
### 4- Trauma:
1. Western Trauma Association critical decisions in trauma: Penetrating thoracic injury, *Journal of Trauma and Acute Care Surgery*, 17 December 2025, [Link](https://journals.lww.com/jtrauma/citation/9900/western%5Ftrauma%5Fassociation%5Fcritical%5Fdecisions%5Fin.1191.aspx)
### 5- Nutrition:
1. Towards optimised nutrition therapy after critical illness: a position statement and research framework by the global research initiative on post-intensive care nutrition (GRIP) consortium, Critical Care, 29 October 2025, [Link](https://link.springer.com/article/10.1186/s13054-025-05710-2)
### 6- Infectious Diseases:
1. Necrotizing soft-tissue infections survival guide in adult patients: A position statement by the Global Alliance for Infections in Surgery, *Journal of Trauma and Acute Care Surgery*, 17 December 2025, [Link](https://journals.lww.com/jtrauma/abstract/9900/necrotizing%5Fsoft%5Ftissue%5Finfections%5Fsurvival%5Fguide.1190.aspx)
2. Empirical and targeted antimicrobial therapy in patients with febrile neutropenia and haematological malignancy or after haematopoietic cell transplantation: recommendations from the 10th European Conference on Infections in Leukaemia, The Lancet Infectious Diseases, 25 November 2025, [Link](https://www.thelancet.com/journals/laninf/article/PIIS1473-3099%2825%2900619-X/abstract)
3. British Society for Medical Mycology best practice recommendations for the diagnosis of serious fungal diseases: 2025 update, The Lancet Infectious Diseases, 10 November 2025, [Link](https://www.thelancet.com/journals/laninf/article/PIIS1473-3099%2825%2900550-X/abstract)
### 7- Pediatric critical care:
1. Pediatric Intracerebral Hemorrhage Management—Consensus Statement of the International Pediatric Stroke Organization—Part 1: Acute Phase and Workup, Journal of the American Heart Association, 30 December 2025, [Link](https://www.ahajournals.org/doi/10.1161/JAHA.124.039594)
2. Pediatric Intracerebral Hemorrhage Management—Consensus Statement of the International Pediatric Stroke Organization—Part 2: Outcomes, Rehabilitation, and Transition to Adulthood, Journal of the American Heart Association, 30 December 2025, [Link](https://www.ahajournals.org/doi/10.1161/JAHA.124.039595)
3. Care of Infants and Children with Tracheostomies: An Official American Thoracic Society Clinical Practice Guideline, AJRCCM, 20 October 2025, [Link](https://www.atsjournals.org/doi/full/10.1164/rccm.202508-2055ST)
4. European Resuscitation Council Guidelines 2025 Paediatric Life Support, Resuscitation, October 2025, [Link](https://www.sciencedirect.com/science/article/pii/S0300957225002795)
5. European Resuscitation Council Guidelines 2025 Newborn Resuscitation and Support of Transition of Infants at Birth, Resuscitation, October 2025, [Link](https://www.sciencedirect.com/science/article/pii/S0300957225002783)
### 8- Other:
1. Challenges and Recommendations for Integrating Circadian Medicine in Critical Care: A Roadmap, CHEST, 20 December 2025, [Link](https://www.sciencedirect.com/science/article/pii/S0012369225059318)
2. Sustainability in Critical Care units: an opinion paper from the SFAR (French Society of Anaesthesia and Critical Care) Sustainability and Critical Care Committees, Anaesthesia Critical Care & Pain Medicine, November 2025, [Link](https://www.sciencedirect.com/science/article/pii/S2352556825001419)
3. Rationale and Methodological Approach Underlying the Development of the Sequential Organ Failure Assessment (SOFA)–2 Score: A Consensus Statement, JAMA Open, 29 October 2025, [Link](https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2840786)
1. Development and Validation of the Sequential Organ Failure Assessment (SOFA)-2 Score, JAMA, 29 October 2025, [Link](https://jamanetwork.com/journals/jama/fullarticle/2840822)
2. A Revision to Organ Failure Assessment in Critically Ill Patients, JAMA, 29 October 2025, [Link](https://jamanetwork.com/journals/jama/fullarticle/2840827)
_This post is for subscribers only._
### Anecrit's Newsletter #08-14
URL: https://www.anecrit.com/newsletter-08-14/
Last updated: 2026-06-21T12:07:43.000Z
### **Issue #\[08-14\] | Week of \[23/08/2025\] - \[09/10/2025\]**
## Welcome!
**Hey everyone — it’s been a minute!**
I haven’t sent out an issue since August 23rd — life’s been busy with my pediatric anesthesia and critical care rotation 🎉. But I’m back now and excited to share a fresh roundup of the latest guidelines, reviews, and studies worth your time.
This issue is all about catching up on what’s new and important in the world of anesthesia and critical care — so grab a coffee and let’s dive in.
This issue covers over 150 papers in anesthesiology and more than 130 in critical care.
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# **Anesthesiology:**
## ***Guidelines:***
1. Society for Perioperative Assessment and Quality Improvement: a narrative review of best practices for perioperative management of patients with bleeding disorders, BJA, 29 September 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900557-4/abstract)
2. The Definition and Aims of Anesthesia: a Delphi-based Consensus Statement, Anesthesia Critical Care & Pain Medicine, 27 September 2025, [Link](https://www.sciencedirect.com/science/article/pii/S2352556825001468)
3. Ethical decision making in airway management: a Difficult Airway Society position statement on good practice**,** BJA Open, September 2025, [Link](https://www.sciencedirect.com/science/article/pii/S2772609625000401)
4. Multidisciplinary, evidence-based, patient-centered perioperative patient safety recommendations: a European consensus study**,** BJA, September 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900299-5/fulltext)
5. Perioperative Quality Initiative consensus statement on goal-directed hemodynamic therapy**,** BJA, September 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900347-2/fulltext)
---
## ***Systematic reviews & meta-analyses:***
### 1- General:
1. Efficacy of fascial plane blocks in enhanced recovery after surgery protocols for abdominal surgery: A brief meta-analysis, EJAIC, October 2025, [Link](https://journals.lww.com/ejaintensivecare/pages/articleviewer.aspx?year=2025&issue=10000&article=00003&type=Fulltext)
2. Granisetron for prevention of postoperative shivering in surgical patients: a systematic review and meta-analysis, BMC Anesthesiology, 30 September 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03348-9)
3. Addition of sufentanil to fospropofol disodium during induction of general anesthesia shortens time to sedation onset in elderly patients: a randomized controlled trial, BMC Anesthesiology, 29 September 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03355-w)
4. Prevalence of perioperative functional disability using WHODAS 2.0 and associated adverse outcomes in surgical populations: A systematic review and meta-analysis, Anesthesia Critical Care & Pain Medicine, 26 September 2025, [Link](https://www.sciencedirect.com/science/article/pii/S2352556825001559)
5. The effect of sugammadex on postoperative urinary retention and recovery characteristics: a systematic review and meta-analysis, BMC Anesthesiology, 26 September 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03334-1)
6. Use of prothrombin complex concentrates in liver transplantation: a systematic review and meta-analysis, BJA, 12 September 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900536-7/abstract)
7. Hemodynamic and Postoperative Benefits of Remimazolam Over Sevoflurane: A Comparative Meta-Analysis, Journal of Cardiothoracic and Vascular Anesthesia, 4 September 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S105307702500744X)
8. A systematic review on predictors of postreperfusion hyperkalemia during liver transplantation**,** BMC Anesthesiology, 2 September 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03234-4)
9. The impact of perioperative hypothermia on surgical site infection risk: a meta-analysis, BMC Anesthesiology, 2 September 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03277-7)
10. Effect of perioperative autonomic nervous system imbalance on surgical outcomes: a systematic review, BJA, September 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900352-6/fulltext)
11. Impact of genetic variations on the pharmacokinetics, dose requirements, and clinical effects of propofol: a systematic review, BJA, September 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900350-2/fulltext)
12. Adherence to prehabilitation in adult surgical patients: a systematic review, meta-analysis, meta-regression, and qualitative synthesis, BJA, September 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900351-4/fulltext)
13. Effects of sevoflurane inhalation anesthesia versus propofol intravenous anesthesia on postoperative cognitive function in patients with malignant tumors: A meta-analysis, Medicine, 29 August 2025, [Link](https://journals.lww.com/md-journal/fulltext/2025/08290/effects%5Fof%5Fsevoflurane%5Finhalation%5Fanesthesia.92.aspx/)
14. Effect of intraoperative Electroencephalogram-guided anesthesia on postoperative cognitive function in elderly patients: a systematic review, meta-analysis, and trial sequential analysis of randomized controlled trials, BMC Anesthesiology, 26 August 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03297-3)
### 2- Cardiovascular & Hemodynamics:
1. Robustness of Randomized Controlled Trials Evaluating Acute Normovolemic Hemodilution as a Blood Conservation Strategy in Cardiac Surgery, Journal of Cardiothoracic and Vascular Anesthesia, October 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S105307702500549X)
2. Efficacy of Superficial versus Deep Parasternal Intercostal Plane Blocks in Cardiac Surgery: A Systematic Review and Meta-Analysis, Journal of Cardiothoracic and Vascular Anesthesia, October 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025004409)
3. The Protective Effect of Remote Ischemic Preconditioning on Acute Kidney Injury Following Pediatric Cardiac Surgery: A Systematic Review and Meta-Analysis, Journal of Cardiothoracic and Vascular Anesthesia, October 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025004033)
4. Ketamine in Cardiac Surgery: A Systematic Review and Meta-analysis of Effects on Inflammatory Markers and Clinical Outcomes, Journal of Cardiothoracic and Vascular Anesthesia, 1 October 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025010018)
5. Less Is More for Bleeding Management Algorithms in Cardiac Surgery: A Network Meta-Analysis and Meta-Regression of Randomized Studies, A&A, 17 September 2025, [Link](https://journals.lww.com/anesthesia-analgesia/abstract/9900/less%5Fis%5Fmore%5Ffor%5Fbleeding%5Fmanagement%5Falgorithms%5Fin.1484.aspx)
6. The prognostic value of postoperative cardiac troponin I and T for major adverse cardiac events after coronary artery bypass grafting: a systematic review, BJA Open, September 2025, [Link](https://www.sciencedirect.com/science/article/pii/S277260962500108X)
7. Nonsteroidal Anti-Inflammatory Drugs as Part of a Multimodal Postoperative Pain Management Strategy in Patients Undergoing Cardiac Surgery: A Meta-Analysis of 11 Randomized Clinical Trials, Journal of Cardiothoracic and Vascular Anesthesia, 23 September 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025008134)
8. Recombinant factor VIIa versus Prothrombin Complex Concentrate (PCC) in patients undergoing Cardiac Surgery: a systematic review and meta-analysis, Journal of Cardiothoracic and Vascular Anesthesia, 22 September 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025008110)
9. Impact of Intraoperative Hyperoxia vs. Normoxia on Mortality and Organ Injury in Cardiac Surgery: A Systematic Review and Meta-Analysis of Randomized Clinical Trials, Journal of Cardiothoracic and Vascular Anesthesia, 22 September 2025, [Link](https://www.sciencedirect.com/science/article/pii/S1053077025008109)
10. Does Autologous Platelet-Rich Plasma Improve Blood Conservation and Postoperative Outcomes in Acute Type A Aortic Dissection Surgery? A Systematic Review and Meta-Analysis, Journal of Cardiothoracic and Vascular Anesthesia, 18 September 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025007918)
11. The Impact of Prothrombin Complex Concentrate versus Fresh Frozen Plasma for Hemorrhage Management in Cardiac Surgery: A Systematic Review and Meta-Analysis of Randomized Clinical Trials, Journal of Cardiothoracic and Vascular Anesthesia, 6 September 2025, [Link](https://www.sciencedirect.com/science/article/pii/S1053077025007499)
12. Efficacy and Safety of Pulmonary Vasodilator and Inodilator Drugs in Congenital Heart Disease Surgery: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials, Journal of Cardiothoracic and Vascular Anesthesia, 27 August 2025, [Link](https://www.sciencedirect.com/science/article/pii/S1053077025007323)
### 3- Neuro:
1. Intraoperative electroencephalogram-derived measures and their association with postoperative delirium: a systematic review and meta-analysis, BJA, 25 September 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900604-X/abstract)
### 4- Obstetrics & Gynecology:
1. Neonatal outcomes with regional versus general anesthesia for cesarean delivery: A meta-analysis of randomized controlled trials, Anesthesiology, 6 October 2025, [Link](https://journals.lww.com/anesthesiology/abstract/9900/neonatal%5Foutcomes%5Fwith%5Fregional%5Fversus%5Fgeneral.771.aspx)
2. Intubation conditions and neonatal outcomes with rocuronium versus suxamethonium in cesarean sections: A systematic review and meta-analysis, BMC Anesthesiology, 2 October 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03321-6)
### 5- Pediatric:
1. The Protective Effect of Remote Ischemic Preconditioning on Acute Kidney Injury Following Pediatric Cardiac Surgery: A Systematic Review and Meta-Analysis, Journal of Cardiothoracic and Vascular Anesthesia, October 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025004033)
2. Bispectral Index-guided Anesthesia in Children: A Systematic Review and Meta-Analysis, Anesthesia Critical Care & Pain Medicine, 29 September 2025, [Link](https://www.sciencedirect.com/science/article/pii/S2352556825001390)
3. Effect of high-flow nasal oxygen therapy on perioperative hypoxemia in children: a systematic review and meta-analysis, BMC Anesthesiology, 27 August 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03214-8)
### 6- Orthopedic:
1. Comparison of interscalene block versus shoulder anterior capsule block for postoperative pain management in rotator cuff surgery: a randomized controlled trial, BMC Anesthesiology, 29 September 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03351-0)
2. Comparison between combined suprainguinal fascia iliaca compartment block with intra-articular bupivacaine and suprainguinal fascia iliaca compartment block in total hip arthroplasty: randomized double-blinded controlled trial, BMC Anesthesiology, 29 September 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03345-y)
3. Analgesic strategies prior to spinal anesthesia for patients with hip and femoral shaft fractures: A network meta-analysis of randomized controlled trials, Medicine, 26 September 2025, [Link](https://journals.lww.com/md-journal/fulltext/2025/09260/analgesic%5Fstrategies%5Fprior%5Fto%5Fspinal%5Fanesthesia.46.aspx/)
4. Effect of oral preemptive analgesia on pain management after total knee arthroplasty: A systematic review and meta-analysis of randomized control trials, Medicine, 12 September 2025, [Link](https://journals.lww.com/md-journal/fulltext/2025/09120/effect%5Fof%5Foral%5Fpreemptive%5Fanalgesia%5Fon%5Fpain.33.aspx/)
5. Genicular nerve block in people with total knee arthroplasty: A systematic review and meta-analysis, Medicine, 12 September 2025, [Link](https://journals.lww.com/md-journal/fulltext/2025/09120/genicular%5Fnerve%5Fblock%5Fin%5Fpeople%5Fwith%5Ftotal%5Fknee.1.aspx/)
6. Comparison between lumbar plexus block and fascia iliaca block in hip surgery: A systematic review and meta-analysis, Medicine, 5 September 2025, [Link](https://journals.lww.com/md-journal/pages/articleviewer.aspx?year=2025&issue=09050&article=00028&type=Fulltext)
7. Influence of spinal anesthesia versus general anesthesia on postoperative delirium in patients with hip fractures: A systematic review and meta-analysis, Medicine, 29 August 2025, [Link](https://journals.lww.com/md-journal/fulltext/2025/08290/influence%5Fof%5Fspinal%5Fanesthesia%5Fversus%5Fgeneral.4.aspx/)
### 7- Regional Anesthesia & Pain Management
1. Efficacy of Superficial versus Deep Parasternal Intercostal Plane Blocks in Cardiac Surgery: A Systematic Review and Meta-Analysis, Journal of Cardiothoracic and Vascular Anesthesia, October 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025004409)
2. Efficacy of fascial plane blocks in enhanced recovery after surgery protocols for abdominal surgery: A brief meta-analysis, EJAIC, October 2025, [Link](https://journals.lww.com/ejaintensivecare/pages/articleviewer.aspx?year=2025&issue=10000&article=00003&type=Fulltext)
3. Efficacy of paravertebral block on postoperative nausea and vomiting: a meta-analysis of randomized controlled trials, BMC Anesthesiology, 1 October 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03304-7)
4. Comparison of interscalene block versus shoulder anterior capsule block for postoperative pain management in rotator cuff surgery: a randomized controlled trial, BMC Anesthesiology, 29 September 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03351-0)
5. Comparison between combined suprainguinal fascia iliaca compartment block with intra-articular bupivacaine and suprainguinal fascia iliaca compartment block in total hip arthroplasty: randomized double-blinded controlled trial, BMC Anesthesiology, 29 September 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03345-y)
6. Analgesic strategies prior to spinal anesthesia for patients with hip and femoral shaft fractures: A network meta-analysis of randomized controlled trials, Medicine, 26 September 2025, [Link](https://journals.lww.com/md-journal/fulltext/2025/09260/analgesic%5Fstrategies%5Fprior%5Fto%5Fspinal%5Fanesthesia.46.aspx/)
7. Effect of oral preemptive analgesia on pain management after total knee arthroplasty: A systematic review and meta-analysis of randomized control trials, Medicine, 12 September 2025, [Link](https://journals.lww.com/md-journal/fulltext/2025/09120/effect%5Fof%5Foral%5Fpreemptive%5Fanalgesia%5Fon%5Fpain.33.aspx/)
8. Local anesthetic systemic toxicity induced by penile nerve block: A systematic review, Medicine, 12 September 2025, [Link](https://journals.lww.com/md-journal/fulltext/2025/09120/local%5Fanesthetic%5Fsystemic%5Ftoxicity%5Finduced%5Fby.19.aspx/)
9. Genicular nerve block in people with total knee arthroplasty: A systematic review and meta-analysis, Medicine, 12 September 2025, [Link](https://journals.lww.com/md-journal/fulltext/2025/09120/genicular%5Fnerve%5Fblock%5Fin%5Fpeople%5Fwith%5Ftotal%5Fknee.1.aspx/)
10. Are adults with chronic pain more likely to develop hypertension than adults without chronic pain? A systematic review and meta-analysis, BJA, September 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900358-7/fulltext)
11. Comparison between lumbar plexus block and fascia iliaca block in hip surgery: A systematic review and meta-analysis, Medicine, 5 September 2025, [Link](https://journals.lww.com/md-journal/pages/articleviewer.aspx?year=2025&issue=09050&article=00028&type=Fulltext)
12. Analgesic safety and efficacy of regional anesthetic blocks in anterior lumbar interbody fusion surgery: A systematic review with meta-analyses, Medicine, 29 August 2025, [Link](https://journals.lww.com/md-journal/fulltext/2025/08290/analgesic%5Fsafety%5Fand%5Fefficacy%5Fof%5Fregional.121.aspx/)
13. Influence of spinal anesthesia versus general anesthesia on postoperative delirium in patients with hip fractures: A systematic review and meta-analysis, Medicine, 29 August 2025, [Link](https://journals.lww.com/md-journal/fulltext/2025/08290/influence%5Fof%5Fspinal%5Fanesthesia%5Fversus%5Fgeneral.4.aspx/)
14. Efficacy of anterior quadratus lumborum block at the lateral supra-arcuate ligament for pain control in abdominal surgery: a systematic review and meta-analysis, BMC Anesthesiology, 25 August 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03284-8)
---
## ***Clinical Trials:***
### 1- General:
1. Remimazolam vs. dexmedetomidine for postoperative sedation in oral tumor patients undergoing free flap reconstruction: a randomized controlled pilot trial, BMC Anesthesiology, 6 October 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03346-x)
2. Efficacy and safety of preemptive magnesium sulfate infusion during pheochromocytoma and paraganglioma resection: a randomized, double-blind, placebo-controlled trial, Anesthesiology, 3 October 2025, [Link](https://journals.lww.com/anesthesiology/abstract/9900/efficacy%5Fand%5Fsafety%5Fof%5Fpreemptive%5Fmagnesium.765.aspx)
3. The effect of intravenous lignocaine infusion on intraoperative desflurane requirement: A randomized controlled trial, Medicine, 3 October 2025, [Link](https://journals.lww.com/md-journal/fulltext/2025/10030/the%5Feffect%5Fof%5Fintravenous%5Flignocaine%5Finfusion%5Fon.52.aspx/)
4. Safety, pharmacokinetics, and pharmacodynamics of Dexmedetomidine two-phase flow atomization in healthy subjects: a randomized, parallel study, BMC Anesthesiology, 1 October 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03358-7)
5. Efficacy and safety of remimazolam for induction and maintenance of general anesthesia in day surgery: a randomized controlled non-inferiority clinical trial, BMC Anesthesiology, 30 September 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03322-5)
6. Effect of perioperative dexmedetomidine on acute kidney injury after partial nephrectomy: a single-center, randomized, double-blind, placebo-controlled trial, BJA, 10 September 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900547-1/abstract)
7. A novel technique to minimize facial pressure ulcers during prone surgery: A randomized controlled trial, Medicine, 12 September 2025, [Link](https://journals.lww.com/md-journal/fulltext/2025/09120/a%5Fnovel%5Ftechnique%5Fto%5Fminimize%5Ffacial%5Fpressure.80.aspx/)
8. Sevoflurane or remimazolam anesthesia and emergence agitation after nasal surgery in adults: A randomized clinical trial, European Journal of Anaesthesiology, 8 September 2025, [Link](https://journals.lww.com/ejanaesthesiology/abstract/9900/sevoflurane%5For%5Fremimazolam%5Fanaesthesia%5Fand.349.aspx)
9. IMpact of PerioperAtive KeTamine on Enhanced Recovery After Abdominal Surgery (IMPAKT ERAS): a pragmatic randomized single-cluster trial, BJA, 3 September 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900508-2/fulltext)
10. Efficacy of intraoperative low-dose remimazolam as a third antiemetic agent for preventing early postoperative nausea in high-risk patients: A Randomized controlled trial, BMC Anesthesiology, 2 September 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03332-3)
11. Effect of epidural dexmedetomidine on post-operative nausea & vomiting in adult patients undergoing abdominopelvic surgery: a randomized controlled study, BMC Anesthesiology, 27 August 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03324-3)
12. Effect of propofol sedation via a narrow-bore tube on hypoxemia risk during gastroscopy: a single-center, prospective, randomized controlled trial, BMC Anesthesiology, 25 August 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03283-9)
13. Heat Loss in Humans Warmed with Various Full-Body Forced-air Heating Systems, Anesthesiology, 20 August 2025, [Link](https://journals.lww.com/anesthesiology/abstract/9900/heat%5Floss%5Fin%5Fhumans%5Fwarmed%5Fwith%5Fvarious%5Ffull%5Fbody.745.aspx)
### 2- Airway & Mechanical Ventilation:
1. Supraglottic airway devices in awake tracheal intubation: a viable alternative to fiberoptic and video laryngoscopy, BMC Anesthesiology, 7 October 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03331-4)
2. Clinical efficacy of COMBO endoscopy of oropharyngeal airways in elderly patients undergoing painless gastroenteroscopy under anesthesia: a randomized controlled trial protocol, BMC Anesthesiology, 26 September 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03311-8)
3. Comparison of the oropharyngeal leak pressure in head rotation between a first-generation laryngeal mask and the i-gel laryngeal mask during general anesthesia - a randomized controlled trial, BMC Anesthesiology, 17 September 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03368-5)
4. Open-lung ventilation and mechanical power in thoracic surgery: Post hoc analysis of a multicentre randomized trial, European Journal of Anaesthesiology, 4 September 2025, [Link](https://journals.lww.com/ejanaesthesiology/abstract/9900/open%5Flung%5Fventilation%5Fand%5Fmechanical%5Fpower%5Fin.345.aspx)
5. Randomized Trial of Safety, Effectiveness, and Acceptability of Two Different 2% Lidocaine Preparations for Airway Topicalization, A&A, 29 August 2025, [Link](https://journals.lww.com/anesthesia-analgesia/pages/articleviewer.aspx?year=9900&issue=00000&article=01446&type=Citation)
6. Effect of propofol sedation via a narrow-bore tube on hypoxemia risk during gastroscopy: a single-center, prospective, randomized controlled trial, BMC Anesthesiology, 25 August 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03283-9)
### 3- Cardiovascular & Hemodynamics:
1. Acute Normovolemic Hemodilution Versus Norepinephrine Infusion During Autologous Blood Donation in Coronary Artery Bypass Graft Surgery: A Prospective Randomized Study, Journal of Cardiothoracic and Vascular Anesthesia, October 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025005518)
2. A New Perspective in Cardiac Surgery: Single- and Two-level Deep Parasternal Intercostal Plane Blocks for Median Sternotomy Pain, Journal of Cardiothoracic and Vascular Anesthesia, October 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025005683)
3. Nefopam for Analgesia Following Cardiac Surgery: A Randomized Placebo-Controlled Double-Blind Clinical Trial, Journal of Cardiothoracic and Vascular Anesthesia, October 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025005312)
4. Comparison of Two Activated Clotting Time Targets During Cardiac Surgery With Cardiopulmonary Bypass: A Prospective Multicenter Randomized Controlled Trial, Journal of Cardiothoracic and Vascular Anesthesia, October 2025, [Link](https://www.sciencedirect.com/science/article/pii/S1053077025005580)
5. Total Intravenous Versus Volatile Anesthesia in Pediatric Cardiac Surgery: Inflammatory Response and Early Recovery Profiles, Journal of Cardiothoracic and Vascular Anesthesia, 9 October 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025010080)
6. Effect of dexmedetomidine on endothelial glycocalyx in patients undergoing cardiac surgery with cardiopulmonary bypass, Journal of Cardiothoracic and Vascular Anesthesia, 1 October 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025010055)
7. Limited effect of leg elevation in preventing intraoperative hypotension during total shoulder arthroplasty in the beach chair position: a randomized controlled trial, BMC Anesthesiology, 1 October 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03299-1)
8. Combined Pecto-intercostal Fascial Plane and Rectus Sheath Blocks Versus Local Infiltration for Pain Management Following Pediatric Cardiac Surgery: A Randomized Clinical Trial, Anesthesia & Analgesia, 1 October 2025, [Link](https://journals.lww.com/anesthesia-analgesia/abstract/9900/combined%5Fpecto%5Fintercostal%5Ffascial%5Fplane%5Fand.1496.aspx)
9. Restrictive *versus* liberal oxygenation in patients undergoing cardiopulmonary bypass-assisted heart surgery: a randomized controlled trial, BJA, 19 September 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900533-1/fulltext)
10. Intensive vs Conventional Intraoperative Blood Pressure Management on Cardiovascular Events After Major Abdominal Surgery: The BP-CARES Randomized Trial, JACC, 15 September 2025, [Link](https://www.jacc.org/doi/10.1016/j.jacc.2025.07.027)
11. Impact of superficial and deep parasternal blocks on recovery after cardiac surgery with sternotomy: a randomized controlled trial, BJA, September 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900362-9/abstract)
12. Continuous versus intermittent noninvasive blood pressure monitoring during beach chair position for shoulder surgery: A randomized controlled trial, European Journal of Anaesthesiology, 25 August 2025, [Link](https://journals.lww.com/ejanaesthesiology/abstract/9900/continuous%5Fversus%5Fintermittent%5Fnoninvasive%5Fblood.341.aspx)
13. Erector Spinae Plane Block Versus Retrolaminar Block for Perioperative Analgesia in Pediatric Cardiac Surgery: A Randomized, Double-blinded, Noninferiority Clinical Trial, Journal of Cardiothoracic and Vascular Anesthesia, 22 August 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025006767)
### 4- Thoracic:
1. Effect of liposomal bupivacaine for preoperative thoracic paravertebral blockade on postoperative pain following video-assisted thoracoscopic lung surgery: a prospective, double-blind, randomized controlled trial, Journal of Cardiothoracic and Vascular Anesthesia, 22 September 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025008122)
2. Open-lung ventilation and mechanical power in thoracic surgery: Post hoc analysis of a multicentre randomized trial, European Journal of Anaesthesiology, 4 September 2025, [Link](https://journals.lww.com/ejanaesthesiology/abstract/9900/open%5Flung%5Fventilation%5Fand%5Fmechanical%5Fpower%5Fin.345.aspx)
3. Ultrasound-guided modified versus conventional serratus anterior plane block as a preemptive analgesic for unilateral video-assisted thoracoscopic surgery, BMC Anesthesiology, 29 August 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03314-5)
### 5- Neuro:
1. Influence of remazolam and propofol on intraoperative neurophysiological monitoring during spinal surgery: A prospective randomized study, Medicine, 12 September 2025, [Link](https://journals.lww.com/md-journal/fulltext/2025/09120/influence%5Fof%5Fremazolam%5Fand%5Fpropofol%5Fon.127.aspx/)
2. Analgesic efficacy of different volumes in erector spinae plane block in patients undergoing single-level lumbar spine fixation: a non-inferiority randomized trial, BMC Anesthesiology, 1 September 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03247-z)
3. Comparing the efficacy of combining ketorolac and Paracetamol (Acetaminophen) with Paracetamol alone on postoperative pain after laminectomy. A double-blinded randomized clinical trial, BMC Anesthesiology, 29 August 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03335-0)
4. Opioid-sparing multimodal analgesia for post-craniotomy pain: a randomized, double-blind, placebo-controlled trial, BMC Anesthesiology, 29 August 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03306-5)
### 6- Obstetrics & Gynecology:
1. Prevention of spinal anesthesia-induced hypotension during cesarean section using noninvasive cardiac output monitoring: A randomized clinical trial, EJAIC, October 2025, [Link](https://journals.lww.com/ejaintensivecare/fulltext/2025/10000/prevention%5Fof%5Fspinal%5Fanaesthesia%5Finduced.2.aspx)
2. Comparison of outcomes between total intravenous (propofol and remifentanil) and inhalation (isoflurane) anesthesia in women undergoing abdominal myomectomy: a randomized controlled trial, BMC Anesthesiology, 1 October 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03337-y)
3. Effect of intraoperative remimazolam infusion on postoperative sleep disturbance in elderly patients after gynecological laparoscopy: A randomized clinical trial, Anesthesia Critical Care & Pain Medicine, 29 September 2025, [Link](https://www.sciencedirect.com/science/article/pii/S2352556825001572)
4. Comparison of erector spinae plane block and tramadol on postoperative systemic immune-inflammatory response in breast cancer surgery: A prospective randomized controlled trial, Medicine, 12 September 2025, [Link](https://journals.lww.com/md-journal/fulltext/2025/09120/comparison%5Fof%5Ferector%5Fspinae%5Fplane%5Fblock%5Fand.26.aspx/)
5. Erector spinae plane block *versus* paravertebral block for major oncological breast surgery: a multicentre randomized controlled trial, BJA, September 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900382-4/abstract)
6. Transcutaneous Auricular Vagus Nerve Stimulation for Postpartum Contraction Pain During Elective Cesarean Delivery: A Randomized Clinical Trial, JAMA Open, 29 August 2025, [Link](https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2838258)
7. Prophylactic phenylephrine and norepinephrine infusions during cesarean delivery for non-reassuring fetal heart rate: A randomized noninferiority trial to assess neonatal outcome, European Journal of Anaesthesiology, 25 August 2025, [Link](https://journals.lww.com/ejanaesthesiology/abstract/9900/prophylactic%5Fphenylephrine%5Fand%5Fnorepinephrine.342.aspx)
### 7- Pediatric:
1. Positive End-Expiratory Pressure and Atelectasis after Bronchial Blockade One-Lung Ventilation in Infants: A Randomized Controlled Study, Journal of Cardiothoracic and Vascular Anesthesia, October 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025004914)
2. Total Intravenous Versus Volatile Anesthesia in Pediatric Cardiac Surgery: Inflammatory Response and Early Recovery Profiles, Journal of Cardiothoracic and Vascular Anesthesia, 9 October 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025010080)
3. Propofol-esketamine versus propofol-fentanyl combinations for sedation in pediatric flexible fiberoptic bronchoscopy: a randomized controlled trial, BMC Anesthesiology, 6 October 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03323-4)
4. Combined Pecto-intercostal Fascial Plane and Rectus Sheath Blocks Versus Local Infiltration for Pain Management Following Pediatric Cardiac Surgery: A Randomized Clinical Trial, Anesthesia & Analgesia, 1 October 2025, [Link](https://journals.lww.com/anesthesia-analgesia/abstract/9900/combined%5Fpecto%5Fintercostal%5Ffascial%5Fplane%5Fand.1496.aspx)
5. The Effectiveness of Intranasal Ketamine on Intramuscular Ketamine Injection Pain Among Children in the Emergency Department, a Randomized, Controlled Trial, Pediatric Emergency Care*,* 23 September 2025, [Link](https://journals.lww.com/pec-online/abstract/9900/the%5Feffectiveness%5Fof%5Fintranasal%5Fketamine%5Fon.726.aspx)
6. Effects of sufentanil combined with remifentanil on hemodynamics during induction and postoperative recovery quality in preschool children undergoing tonsillectomy and adenoidectomy, BMC Anesthesiology, 29 August 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03315-4)
7. Hyomental distance measured ultrasonography versus weight-based criteria for laryngeal mask size selection in children: a randomized controlled trial, BMC Anesthesiology, 25 August 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03303-8)
### 8- Orthopedic:
1. Effect of ultrasound-guided fascia iliaca compartment block on pain management in hip fracture patients: A double-blind placebo-controlled randomized clinical trial, Medicine, 3 October 2025, [Link](https://journals.lww.com/md-journal/pages/articleviewer.aspx?year=2025&issue=10030&article=00130&type=Fulltext)
2. Limited effect of leg elevation in preventing intraoperative hypotension during total shoulder arthroplasty in the beach chair position: a randomized controlled trial, BMC Anesthesiology, 1 October 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03299-1)
3. Effect of virtual reality on perioperative anxiety, stress, and pain in total hip arthroplasty: a randomized controlled trial, BMC Anesthesiology, 9 September 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03316-3)
### 9- Regional Anesthesia & Pain Management:
1. Effect of ultrasound-guided fascia iliaca compartment block on pain management in hip fracture patients: A double-blind placebo-controlled randomized clinical trial, Medicine, 3 October 2025, [Link](https://journals.lww.com/md-journal/pages/articleviewer.aspx?year=2025&issue=10030&article=00130&type=Fulltext)
2. Splanchnic nerve block via transdiscal and paraspinal approach in the treatment of pain in advanced pancreatic cancer: A randomized controlled trial, Medicine, 19 September 2025, [Link](https://journals.lww.com/md-journal/fulltext/2025/09190/splanchnic%5Fnerve%5Fblock%5Fvia%5Ftransdiscal%5Fand.82.aspx)
3. The effect of adding lateral femoral cutaneous nerve block to pericapsular nerve group (PENG) block in hip surgery on postoperative morphine consumption: A randomized controlled trial, Medicine, 19 September 2025, [Link](https://journals.lww.com/md-journal/fulltext/2025/09190/the%5Feffect%5Fof%5Fadding%5Flateral%5Ffemoral%5Fcutaneous.13.aspx)
4. Impact of continuous nerve block at different iliac fascia compartment regions on postoperative analgesia following total hip arthroplasty: A randomized controlled trial, Medicine, 19 September 2025, [Link](https://journals.lww.com/md-journal/fulltext/2025/09190/impact%5Fof%5Fcontinuous%5Fnerve%5Fblock%5Fat%5Fdifferent.44.aspx)
5. Analgesic efficacy of different volumes in erector spinae plane block in patients undergoing single-level lumbar spine fixation: a non-inferiority randomized trial, BMC Anesthesiology, 1 September 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03247-z)
6. Effect of intraoperative paravertebral or intravenous lidocaine infusion on postoperative complications and inflammation after lung resection surgery: a randomized controlled trial, BJA, 1 September 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900452-0/abstract)
7. Patient preference for intraoperative opioid use and early recovery after noncardiac surgery: protocol for a randomized factorial design trial of opioid-free *versus* opioid-based anesthesia (the PERFECT trial), BJA Open, September 2025, [Link](https://www.sciencedirect.com/science/article/pii/S2772609625000449)
8. Efficacy of ultrasound-guided lateral quadratus lumborum block on postoperative pain and quality of recovery in patients undergoing open nephrectomy: A randomized controlled study, Medicine, 12 September 2025, [Link](https://journals.lww.com/md-journal/fulltext/2025/09120/efficacy%5Fof%5Fultrasound%5Fguided%5Flateral%5Fquadratus.46.aspx/)
9. Comparison of the effect of acupoint injection and tramadol for the treatment of catheter-related bladder discomfort: A randomized controlled trial, Medicine, 12 September 2025, [Link](https://journals.lww.com/md-journal/fulltext/2025/09120/comparison%5Fof%5Fthe%5Feffect%5Fof%5Facupoint%5Finjection%5Fand.13.aspx/)
10. Comparison of erector spinae plane block and tramadol on postoperative systemic immune-inflammatory response in breast cancer surgery: A prospective randomized controlled trial, Medicine, 12 September 2025, [Link](https://journals.lww.com/md-journal/fulltext/2025/09120/comparison%5Fof%5Ferector%5Fspinae%5Fplane%5Fblock%5Fand.26.aspx/)
11. Effect of virtual reality on perioperative anxiety, stress, and pain in total hip arthroplasty: a randomized controlled trial, BMC Anesthesiology, 9 September 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03316-3)
12. Erector spinae plane block *versus* paravertebral block for major oncological breast surgery: a multicentre randomized controlled trial, BJA, September 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900382-4/abstract)
13. Impact of superficial and deep parasternal blocks on recovery after cardiac surgery with sternotomy: a randomized controlled trial, BJA, September 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900362-9/abstract)
14. Comparing the efficacy of combining ketorolac and Paracetamol (Acetaminophen) with Paracetamol alone on postoperative pain after laminectomy. A double-blinded randomized clinical trial, BMC Anesthesiology, 29 August 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03335-0)
15. Transcutaneous Auricular Vagus Nerve Stimulation for Postpartum Contraction Pain During Elective Cesarean Delivery: A Randomized Clinical Trial, JAMA Open, 29 August 2025, [Link](https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2838258)
16. Ultrasound-guided modified versus conventional serratus anterior plane block as a preemptive analgesic for unilateral video-assisted thoracoscopic surgery, BMC Anesthesiology, 29 August 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03314-5)
17. Efficacy and safety of hydromorphone caudal block combined with intercostal nerve block during VATS: a single-center randomized controlled study, BMC Anesthesiology, 29 August 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03307-4)
18. Opioid-sparing multimodal analgesia for post-craniotomy pain: a randomized, double-blind, placebo-controlled trial, BMC Anesthesiology, 29 August 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03306-5)
19. The effect of combining lidocaine and ropivacaine on the duration and onset time of an ultrasound-guided infraclavicular brachial plexus nerve block: A randomized controlled trial, European Journal of Anaesthesiology, 27 August 2025, [Link](https://journals.lww.com/ejanaesthesiology/abstract/9900/the%5Feffect%5Fof%5Fcombining%5Flidocaine%5Fand%5Fropivacaine.344.aspx)
20. Comparison of different hydromorphone bolus doses in patient-controlled intravenous analgesia for post-laparoscopic surgery: a randomized controlled trial, BMC Anesthesiology, 25 August 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03287-5)
---
## ***Reviews:***
### 1- AI:
1. Artificial intelligence for electrocardiographic diagnosis of perioperative myocardial ischemia: a scoping review, BJA, September 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900353-8/fulltext)
### 2- General:
1. The role of the anesthetist in mitigating the environmental impacts of nitrous oxide: a narrative review, BJA, 8 October 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900613-0/abstract)
2. Opioid-free Anesthesia and Analgesia in Clinical Practice: Considerations, Techniques, and Limitations**,** Anesthesiology, 6 October 2025, [Link](https://journals.lww.com/anesthesiology/citation/9900/opioid%5Ffree%5Fanesthesia%5Fand%5Fanalgesia%5Fin%5Fclinical.770.aspx)
3. Interdisciplinary Medical-Engineering Research in Anesthesia: A Mini-Review of Promising Trends, Journal of Cardiothoracic and Vascular Anesthesia, October 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025005750)
4. Climate resilience as a strategic lever for long-term healthcare sustainability: a narrative review, BJA, 27 September 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900609-9/fulltext)
5. Perioperative antimicrobial prophylaxis and surgical site infection prevention, what clinicians and researchers must know, Anesthesia Critical Care & Pain Medicine, 27 September 2025, [Link](https://www.sciencedirect.com/science/article/pii/S2352556825001328)
6. Exploring Myths of Perioperative Autologous Red Blood Cell Salvage, Anesthesiology, 15 September 2025, [Link](https://journals.lww.com/anesthesiology/citation/9900/exploring%5Fmyths%5Fof%5Fperioperative%5Fautologous%5Fred.755.aspx)
### 3- Airway & Mechanical Ventilation:
1. Grading systems for tracheal intubation using videolaryngoscopy**,** BJA Edu, October 2025, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900064-2/abstract)
### 4- Cardiovascular & Hemodynamics:
1. Anesthesia for non-cardiac surgery in patients with adult congenital heart disease**,** BJA Edu, October 2025, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900066-6/fulltext)
2. The Year in Aortic Surgery: Selected Highlights from 2024, Journal of Cardiothoracic and Vascular Anesthesia, October 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025004963)
3. The Year in Electrophysiology: Selected Highlights from 2024, Journal of Cardiothoracic and Vascular Anesthesia, October 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025003404)
4. Highlights and Perioperative Implications from the 2024 European Society of Cardiology Guidelines for the Management of Peripheral Arterial and Aortic Diseases, Journal of Cardiothoracic and Vascular Anesthesia, October 2025, [Link](https://www.sciencedirect.com/science/article/pii/S1053077025002204)
5. Modified Measurement of Tricuspid Annular Plane Systolic Excursion for Assessing Right Ventricular Function During Cardiac Surgery, Journal of Cardiothoracic and Vascular Anesthesia, October 2025, [Link](https://www.sciencedirect.com/science/article/pii/S1053077025004586)
6. Right Ventricular Function and Echocardiographic Pressure-Volume Loops: Overview and Perioperative Clinical Implications, Journal of Cardiothoracic and Vascular Anesthesia, October 2025, [Link](https://www.sciencedirect.com/science/article/pii/S105307702500401X)
7. Pro: Use of Sterile Technique for Ultrasound-guided Noncentral Line Vascular Access Procedures, Journal of Cardiothoracic and Vascular Anesthesia, October 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025002186)
8. Con: Sterile Technique for Peripheral Vascular Access: Are We as Sterile as We Think?, Journal of Cardiothoracic and Vascular Anesthesia, October 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025003325)
9. Respiratory Reactivation of Herpes Simplex Virus-1 Following Cardiac Surgery in Immunocompetent Individuals, Journal of Cardiothoracic and Vascular Anesthesia, 16 September 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025007591)
10. Minimally Invasive, Maximally Effective: Anesthetic Management for Endoscopic Cardiac Surgery, Journal of Cardiothoracic and Vascular Anesthesia, 13 September 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025007840)
11. Analysis of the Updated EACTS/STS Aortic Guidelines, Journal of Cardiothoracic and Vascular Anesthesia, 13 September 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025007359)
12. Artificial intelligence for electrocardiographic diagnosis of perioperative myocardial ischemia: a scoping review, BJA, September 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900353-8/fulltext)
### 5- Thoracic:
1. Comparative analysis of guidelines and recommendations for sedation during flexible bronchoscopy: a narrative review, European Respiratory Review, 20 August 2025, [Link](https://publications.ersnet.org/content/errev/34/177/250045)
### 6- Neuro:
1. Optimizing postoperative spine outcomes: an umbrella review of enhanced recovery after spinal surgery (ERASS) protocols**,** BJA, 8 October 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900603-8/fulltext)
2. The role of perioperatively acquired muscle weakness in postoperative fatigue, European Journal of Anaesthesiology, 8 September 2025, [Link](https://journals.lww.com/ejanaesthesiology/abstract/9900/the%5Frole%5Fof%5Fperioperatively%5Facquired%5Fmuscle.351.aspx)
3. Effects of ketamine on postoperative cognition: a scoping review, BJA, September 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900349-6/fulltext),
4. Interpreting Intraoperative EEG: Beyond Indices to the Essential Role of Raw EEG and Density Spectral Array, Journal of Neurosurgical Anesthesiology, 27 August 2025, [Link](https://journals.lww.com/jnsa/abstract/9900/interpreting%5Fintraoperative%5Feeg%5F%5Fbeyond%5Findices%5Fto.175.aspx)
### 7- Obstetrics & Gynecology:
1. Neuraxial labor analgesia and maternal fever: A narrative review, EJA, 25 September 2025, [Link](https://journals.lww.com/ejanaesthesiology/abstract/9900/neuraxial%5Flabour%5Fanalgesia%5Fand%5Fmaternal%5Ffever%5F%5Fa.357.aspx)
2. Management of pregnant patients with substance use disorder, BJA Edu, 16 September 2025, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900076-9/abstract)
---
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### 8- Pediatric:
1. Environmental exposure to air pollution and pollen and the risk of perioperative respiratory adverse events in pediatric anesthesia: A narrative review, Anesthesia Critical Care & Pain Medicine, 27 September 2025, [Link](https://www.sciencedirect.com/science/article/pii/S235255682500133X)
2. Procedural Pain Assessments for Neonates at Risk of Neonatal Opioid Withdrawal Syndrome: A Scoping Review, The Clinical Journal of Pain, 19 September 2025, [Link](https://journals.lww.com/clinicalpain/abstract/9900/procedural%5Fpain%5Fassessments%5Ffor%5Fneonates%5Fat%5Frisk.284.aspx)
3. Perioperative ventilation practices in children, BJA Edu, 8 September 2025, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900073-3/abstract)
4. Development of the neuromuscular junction and neuromuscular blocking agents in neonates, infants, and children: A narrative review, European Journal of Anaesthesiology, 4 September 2025, [Link](https://journals.lww.com/ejanaesthesiology/fulltext/9900/development%5Fof%5Fthe%5Fneuromuscular%5Fjunction%5Fand.346.aspx)
### **9**\- Regional Anesthesia & Pain Management:
1. Neurobiological mechanisms of central sensitization underlying chronic pain states**,** BJA Edu, October 2025, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900063-0/abstract)
2. Stellate ganglion block in perioperative practice: a narrative review, BJA, 29 September 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900606-3/abstract)
3. Procedural Pain Assessments for Neonates at Risk of Neonatal Opioid Withdrawal Syndrome: A Scoping Review, The Clinical Journal of Pain, 19 September 2025, [Link](https://journals.lww.com/clinicalpain/abstract/9900/procedural%5Fpain%5Fassessments%5Ffor%5Fneonates%5Fat%5Frisk.284.aspx)
4. Topical Analgesics: Pharmacology and Clinical Applications, Anesthesiology, 18 September 2025, [Link](https://journals.lww.com/anesthesiology/pages/articleviewer.aspx?year=9900&issue=00000&article=00759&type=Fulltext)
5. Innovative technologies in regional anesthesia education: a scoping review, BJA Open, September 2025, [Link](https://www.sciencedirect.com/science/article/pii/S2772609625000978)
6. Transitional Pain Service for Preventing Chronic Postsurgical Pain: A Scoping Review of Published Literature and Considerations for Research and Practice, Anesthesiology, 25 August 2025, [Link](https://journals.lww.com/anesthesiology/abstract/9900/transitional%5Fpain%5Fservice%5Ffor%5Fpreventing%5Fchronic.746.aspx)
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# **Critical Care:**
## ***Guidelines:***
1. Vascular access for initial treatment of adult emergency patients in the resuscitation room: short summary of recommendations from the German national S1 guideline, International Journal of Emergency Medicine, 2 October 2025, [Link](https://intjem.biomedcentral.com/articles/10.1186/s12245-025-01015-x)
2. Expert consensus statement on the evaluation, treatment, and transfer of cardiogenic shock using a Delphi method approach: a report of the Japan Critical Care Cardiology Committee (J4 CS), Journal of Intensive Care, 30 September 2025, [Link](https://jintensivecare.biomedcentral.com/articles/10.1186/s40560-025-00791-1)
3. Early diagnosis and treatment of acute heart failure in prehospital and emergency settings. Part 1 of the International Expert Opinion Series on acute heart failure management, European Journal of Emergency Medicine, 29 September 2025, [Link](https://journals.lww.com/euro-emergencymed/abstract/9900/early%5Fdiagnosis%5Fand%5Ftreatment%5Fof%5Facute%5Fheart.198.aspx)
4. UK consensus statement on priorities to support the process of withdrawal of veno-venous extracorporeal membrane oxygenation, BJA, 25 September 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900581-1/fulltext)
5. Sustainability in critical care units: an opinion paper from the SFAR (French Society of Anesthesia and Critical Care) Sustainability and Critical Care Committees, Anesthesia Critical Care & Pain Medicine, 27 September 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556825001419)
6. Transfusion of Fresh Frozen Plasma and Platelets in Critically Ill Adults: An American College of Chest Physicians Clinical Practice Guideline**,** CHEST, September 2025, [Link](https://www.sciencedirect.com/science/article/pii/S001236922500279X)
7. Consensus Statement on Middle Meningeal Artery Embolization in Chronic Subdural Hematoma Treatment: A Guideline From the Society of Vascular and Interventional Neurology Guidelines and Practice Standards Committee, Stroke: Vascular and Interventional Neurology, 15 September 2025, [Link](https://www.ahajournals.org/doi/10.1161/SVIN.125.001814)
---
_This post is for subscribers only._
### Anecrit's Newsletter #07
URL: https://www.anecrit.com/newsletter07/
Last updated: 2025-10-12T19:02:33.000Z
### **Issue #\[07\] | Week of \[08/08/2025\] - \[22/08/2025\]**
### **Welcome!**
I hope this week finds you well! You’ll notice a couple of changes in this issue: I’ve focused exclusively on **guidelines, systematic reviews & meta-analyses, clinical trials, and reviews**. I’ve also refreshed the **layout**—now, articles are **sorted by type of paper**, with topics neatly grouped under each category.
I’m not sure yet if this format is better, but the only way to know is to try! Your thoughts mean a lot to me, so I’d love to hear what you think of these changes. After all, this newsletter (and the website) grows and improves **with you**. :)
You can comment below!
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---
# **Anesthesiology**
## 1-Systematic reviews & Meta-analyses:
### Airways & Ventilation:
1. The Effect of Sleep Disorder Interventions in Patients With Obstructive Sleep Apnea Undergoing Solid-Organ Transplants: A Systematic Review, Anesthesia & Analgesia, 8 August 2025, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/the%5Feffect%5Fof%5Fsleep%5Fdisorder%5Finterventions%5Fin.1423.aspx)
### Cardiothoracic & Vascular:
1. The Impact of Perioperative Hemodynamic and Blood Pressure Variability in Outcomes and Mortality: A Comprehensive Systematic Review, Journal of Cardiothoracic and Vascular Anesthesia, 18 August 2025, [Link](https://www.sciencedirect.com/science/article/pii/S1053077025006731)
2. Dexmedetomidine for the prevention of postoperative delirium in patients undergoing cardiac surgery: a systematic review and meta-analysis with trial sequential analysis, BMC Anesthesiology, 20 August 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03264-y)
3. Pulmonary protective and antiinflammatory effects of dexmedetomidine in cardiac surgery with cardiopulmonary bypass: a systematic review and metaanalysis, BMC anesthesiology, 20 August 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03286-6)
4. Volatile Sedation Versus Propofol on Time to Extubation in the Intensive Care Unit after Cardiac Surgery: A Systematic Review and Meta-Analysis. Journal of Cardiothoracic and Vascular Anesthesia, 14 August 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025006718)
### Regional Anesthesia & Pain Management:
1. Liposomal bupivacaine versus conventional anesthetics in adductor canal block for total knee arthroplasty: a meta-analysis of randomized controlled trials, BMC Anesthesiology, 9 August 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03289-3)
2. Efficacy and safety of midazolam compared to fentanyl as adjuvants to hyperbaric bupivacaine in spinal anesthesia: a systematic review and meta-analysis of randomized controlled trials, BMC Anesthesiology, 7 August 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03261-1)
### Other:
1. The role of non-physician providers of anaesthesia: a systematic review, British Journal of Anaesthesia, 11 August 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900471-4/fulltext)
---
## 2-Clinical trials:
### Cardiothoracic & Vascular:
1. TIVA vs Volatile Anesthesia in CABG Surgery: Effects on Inflammatory and Cognitive Outcomes, Journal of Cardiothoracic and Vascular Anesthesia, 21 August 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025006846)
2. Effect of controlled hypotension on postoperative awakening quality in shoulder arthroscopy with lateral decubitus rotator cuff repair, BMC Anesthesiology, 13 August 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03302-9)
3. Transfusion of Amustaline/Glutathione Pathogen-Reduced Red Blood Cells in Cardiac Surgery - A Randomized Phase III Clinical Trial, Anesthesiology, 12 August 2025, [**L**ink](https://journals.lww.com/anesthesiology/abstract/9900/transfusion%5Fof%5Famustaline%5Fglutathione.741.aspx)
4. Effect of urine-guided intraoperative hydration on incidence of acute kidney injury after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for pseudomyxoma peritonei: a randomized trial, Anesthesiology, 13 August 2025, [Link](https://journals.lww.com/anesthesiology/fulltext/9900/effect%5Fof%5Furine%5Fguided%5Fintraoperative%5Fhydration%5Fon.743.aspx)
### General:
1. A randomized trial evaluating hemodynamics during minor hepatectomy under general anesthesia combined with thoracic epidural anesthesia: remimazolam versus propofol, BMC Anesthesiology, 20 August 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03290-w)
2. Effects of Methylprednisolone on Postoperative Quality of Recovery in Patients Undergoing Minimally Invasive Esophagectomy: A Multicenter Randomized Clinical Trial, Anesthesiology, 15 August 2025, research letter, [Link](https://journals.lww.com/anesthesiology/citation/9900/effects%5Fof%5Fmethylprednisolone%5Fon%5Fpostoperative.744.aspx)
3. A Randomized Noninferiority Split Face Trial of Transpore Versus Tegaderm for Eyelid Protection During Anesthesia, Anesthesia & Analgesia, 8 August 2025, research letter, [Link](https://journals.lww.com/anesthesia-analgesia/citation/9900/a%5Frandomized%5Fnoninferiority%5Fsplit%5Fface%5Ftrial%5Fof.1421.aspx)
### Pediatric:
1. Evaluation of Intraoperative Bivalirudin Anticoagulation in Neonates and Infants Undergoing Arterial Switch Operation on Integrated ECMO-CPB Circuit: A Prospective Study, Journal of Cardiothoracic and Vascular Anesthesia, September 2025, Pilot study, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025004525)
2. Driving pressure-guided dynamic PEEP titration reduces atelectasis and improves oxygenation in pediatric laparoscopy: a randomized trial on personalized ventilation strategies, BMC Anesthesiology, 20 August 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03274-w)
3. Using capnography in children to prevent oxygen desaturation during procedural sedation: A randomised trial, European Journal of Anaesthesiology, August 2025, [Link](https://journals.lww.com/ejanaesthesiology/fulltext/9900/using%5Fcapnography%5Fin%5Fchildren%5Fto%5Fprevent%5Foxygen.337.aspx)
4. Effect of Intravenous, Inhalational, or Combined Anesthesia Maintenance on Postoperative Respiratory Adverse Events in Children Undergoing Adenotonsillectomy (AmPRAEC): A Multicenter Randomized Clinical Trial, Anesthesiology, 6 August 2025, [Link](https://journals.lww.com/anesthesiology/abstract/9900/effect%5Fof%5Fintravenous,%5Finhalational,%5For%5Fcombined.739.aspx)
### Regional Anesthesia & Pain Management:
_This post is for subscribers only._
### Anecrit's Newsletter #06
URL: https://www.anecrit.com/newsletter06/
Last updated: 2025-08-24T14:56:48.000Z
### **Issue #\[06\] | Week of \[25/07/2025\] - \[07/08/2025\]**
## Welcome!
**Hey there!**
This week’s issue is packed with fascinating new research. I’m running a little behind—this was supposed to land in your inbox yesterday—so thanks for your patience!
We’ve got **141 papers in anesthesiology** and **180 papers in critical care** for you to explore. As always, I’ve sorted everything by subject and paper type so you can breeze through and jump straight to what matters most to you.
If you find this newsletter useful, please share it with colleagues, friends, or anyone who might benefit—it really helps the community grow.
---
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---
# **Anesthesiology**
## AI:
#### Observational studies:
1. A patient-focused comparative analysis of large language models for epidural analgesia education, A&A Practice, 5 August 2025, [Link](https://journals.lww.com/aacr/fulltext/2025/08000/a%5Fpatient%5Ffocused%5Fcomparative%5Fanalysis%5Fof%5Flarge.5.aspx)
2. Dynamic and Interpretable Deep Learning Model for Predicting Respiratory Failure Following Cardiac Surgery, BMC Anesthesiology, 5 August 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03239-z)
3. Establishment of predictive models for postoperative delirium in elderly patients after knee/hip surgery based on total bilirubin concentration: machine learning algorithms, BMC Anesthesiology, 30 July 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03259-9)
4. Evaluation of the impact of artificial intelligence-assisted image interpretation on the diagnostic performance of clinicians in identifying endotracheal tube position on plain chest X-ray: a multi-case multi-reader study, Critical Care, 28 July 2025, [Link](https://ccforum.biomedcentral.com/articles/10.1186/s13054-025-05566-6)
#### Editorial/ Correspondence/ commentary/ Letter to the editor:
1. Machine learning in clinical trials – developing a framework for transparency and interpretation, Journal of Cardiothoracic and Vascular Anesthesia, 06 August 2025, Editorial, [Link](https://www.sciencedirect.com/science?%5Fob=GatewayURL&%5Fmethod=citationSearch&%5Fversion=1&%5Fpiikey=S1053077025006469&%5Forigin=RV%5FSD%5FAIP%5FEMAIL&dgcid=raven%5Fsd%5Faip%5Femail)
---
## Airways & Ventilation:
#### Systematic reviews & Meta-analyses:
1. Difficult airway management: An analysis of systematic review evidence underpinning clinical practice guidelines, Anaesthesia Critical Care & Pain Medicine, August 2025, [Link](https://www.sciencedirect.com/science/article/pii/S2352556825000669)
#### Clinical trials:
1. A Comparison of Deep Versus Awake Tracheal Extubation in Adults: A Randomized Controlled Trial, BMC Anesthesiology, 31 July 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03224-6)
2. Comparison of SEEKflex/videolaryngoscopy and fibreoptic bronchoscope for awake tracheal intubation: a randomized clinical trial, BMC Anesthesiology, 29 July 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03229-1)
#### Reviews:
1. The Narrow Airway: From High-Frequency Jet Ventilation to Flow-Controlled Ventilation, Current Opinion in Anesthesiology, 5 August 2025, [Link](https://journals.lww.com/co-anesthesiology/fulltext/9900/the%5Fnarrow%5Fairway%5F%5Ffrom%5Fhigh%5Ffrequency%5Fjet.337.aspx)
2. Augmented Reality in Airway Management: A Scoping Review, Anesthesia & Analgesia, 5 August 2025, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/augmented%5Freality%5Fin%5Fairway%5Fmanagement%5F%5Fa%5Fscoping.1412.aspx)
#### Observational studies:
1. Evaluation of a Novel, Image-Guided Robotic Intubation Platform for Difficult Airways: A Prospective Observational Study, Anesthesia & Analgesia, 1 August 2025, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/evaluation%5Fof%5Fa%5Fnovel,%5Fimage%5Fguided%5Frobotic.1399.aspx)
2. Predictive validity of chronic obstructive pulmonary disease phenotypes in inpatient elective surgery: a population-based study, British Journal of Anaesthesia, 31 July 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900453-2/fulltext)
#### Case reports:
1. Airway management in CHARGE syndrome, devising a well-tolerated approach: Principio del formulario, European Journal of Anaesthesiology & Intensive Care, August 2025, [Link](https://journals.lww.com/ejaintensivecare/fulltext/2025/08000/airway%5Fmanagement%5Fin%5Fcharge%5Fsyndrome,%5Fdevising%5Fa.2.aspx)
2. Lung isolation on a patient with a tracheal bronchus: Advanced airway management, European Journal of Anaesthesiology & Intensive Care, August 2025, [Link](https://journals.lww.com/ejaintensivecare/fulltext/2025/08000/lung%5Fisolation%5Fon%5Fa%5Fpatient%5Fwith%5Fa%5Ftracheal.5.aspx)
---
## Cardiothoracic & Vascular:
#### Guidelines:
1. Guidelines for anaesthesia of adults with congenital heart disease in non-cardiac surgery, Anaesthesia Critical Care & Pain Medicine, August 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556825000724)
#### Systematic reviews & Meta-analyses:
1. Intraoperative Hypotension Prediction in Cardiac and Noncardiac Procedures: Is HPI Truly Worthwhile? A Systematic Review and Meta-Analysis, BMC Anesthesiology, 31 July 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03250-4)
2. Perioperative Management of Renin–Angiotensin System Inhibitors in Patients Undergoing Elective Major Noncardiac Surgery: A Mixed Model Investigation Using Systematic Review, Meta-analysis, Multicentre Service Evaluation, and National Survey, British Journal of Anaesthesia, 31 July 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900409-X/fulltext)
#### Clinical trials:
1. Robotic Process Automation to Identify Patients at High Risk for Perioperative Myocardial Infarction or Injury: A Prospective, Blinded, Paired Reader-Controlled Single-Centre Study, British Journal of Anaesthesia, 31 July 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900451-9/abstract)
2. Hemodynamic Impact of Mechanical Ventilation in Anesthetized Patients With Cavopulmonary Connection: A Physiologic Crossover Study, Journal of Cardiothoracic and Vascular Anesthesia, 31 July 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025006330)
3. Early Use of Norepinephrine in High-Risk Patients Undergoing Major Abdominal Surgery: A Randomized Controlled Trial, Anesthesiology, 4 August 2025, [Link](https://journals.lww.com/anesthesiology/abstract/9900/early%5Fuse%5Fof%5Fnorepinephrine%5Fin%5Fhigh%5Frisk%5Fpatients.737.aspx)
4. Preoperative oral caffeine as prophylaxis against post-spinal hypotension in patients undergoing orthopedic lower limb surgery: A randomized, placebo-controlled, double-blinded study, Anaesthesia Critical Care & Pain Medicine, August 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556825000694)
#### Reviews:
1. Advances in Cardiovascular Pharmacotherapy. V. Molecular Targets in Transthyretin Amyloid Cardiomyopathy, Journal of Cardiothoracic and Vascular Anesthesia, 06 August 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025006524)
2. Remimazolam for anesthesia in cardiac and noncardiac surgery. A narrative literature review and synthesis, Anaesthesia Critical Care & Pain Medicine, August 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556825000876)
3. Pro: Supplemental Cardioplegia During Heart Transplant Implantation, Journal of Cardiothoracic and Vascular Anesthesia, 29 July 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025006354)
4. Decoding Bleeding Risks and Survival in Patients Undergoing Percutaneous Coronary Intervention on Antiplatelet Therapy, JACC Asia, 29 July 2025, [Link](https://www.jacc.org/doi/10.1016/j.jacasi.2025.05.017)
#### Observational studies:
1. Camera-based photoplethysmography for measuring heartbeat intervals during general anesthesia, Anesthesia & Analgesia, 5 August 2025, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/camera%5Fbased%5Fphotoplethysmography%5Ffor%5Fmeasuring.1411.aspx)
2. Optimal Catheter-to-Vein Ratios to Prevent Peripheral Venous Catheter Failure: A Single-centre Prospective Cohort Study, British Journal of Anaesthesia, 5 August 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900465-9/fulltext)
3. Preoperative rectus femoris muscle characteristics as predictors of postoperative walking ability in elderly cardiac surgery patients: A prospective observational study, Journal of Cardiothoracic and Vascular Anesthesia, 5 August 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025006366)
4. Predictive value of early postoperative copeptin after cardiac surgery: A two-centre prospective cohort study, European Journal of Anaesthesiology, 4 August 2025, [Link](https://journals.lww.com/ejanaesthesiology/fulltext/9900/predictive%5Fvalue%5Fof%5Fearly%5Fpostoperative%5Fcopeptin.332.aspx)
5. Association between sleep disorder and delirium in adult patients undergoing cardiac surgery: a retrospective cohort study, BMC Anesthesiology, 30 July 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03243-3)
6. The effect of propofol on the grading of diastolic function: a prospective observational study, BMC Anesthesiology, 30 July 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03260-2)
7. A retrospective analysis of hemodynamic stability in TAVR and TTVR under general anesthesia: implications for sedation in TTVR, BMC Anesthesiology, 30 July 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03258-w)
8. Association Between COVID-19 Infection and Post-Operative Outcomes Following Coronary Artery Bypass Grafting: A Retrospective Cohort Study, Journal of Cardiothoracic and Vascular Anesthesia, 27 July 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025006123)
#### Case reports:
1. Anesthetic management of a patient with suspected insulinoma undergoing cardiopulmonary bypass for left atrial myxoma: a case report, A&A Practice, 5 August 2025, [Link](https://journals.lww.com/aacr/fulltext/2025/08000/anesthetic%5Fmanagement%5Fof%5Fa%5Fpatient%5Fwith%5Fsuspected.7.aspx)
2. Chordae tendineae rupture: a rare cause of tricuspid regurgitation following coronary artery bypass grafting, BMC Anesthesiology, 29 July 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03270-0)
#### Editorial/ Correspondence/Commentary/ Letter to the Editor:
1. Re-evaluating the impact of mechanical ventilation strategies during cardiac surgery with cardiopulmonary bypass: work in progress, Intensive Care Medicine, 4 August 2025, Editorial, [Link](https://link.springer.com/article/10.1007/s00134-025-08057-y)
2. Reevaluating Hemodynamic Targets for AKI Prevention During CABG: Methodological and Interpretative Concerns, Anesthesia & Analgesia, 31 July 2025, Letter to the Editor, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/reevaluating%5Fhemodynamic%5Ftargets%5Ffor%5Faki.1396.aspx)
3. Reconsidering iron substitution for anemia after cardiac surgery, Anesthesia & Analgesia, 1 August 2025, Letter to the Editor, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/reconsidering%5Firon%5Fsubstitution%5Ffor%5Fanemia%5Fafter.1401.aspx)
4. Acute normovolemic hemodilution in cardiac surgery: evidence-based exit or a chance for refinement?, Journal of Cardiothoracic and Vascular Anesthesia, 5 August 2025, Editorial, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025006378)
5. Advancing training in cardiac anesthesiology: telemedicine for real-time echocardiography education and monitoring, Journal of Cardiothoracic and Vascular Anesthesia, 5 August 2025, Correspondence, [Link](https://www.sciencedirect.com/science/article/abs/pii/S105307702500638X)
6. The hunt for antithrombin-independent heparin resistance: can you find it with partial thromboplastin time?, Journal of Cardiothoracic and Vascular Anesthesia, 5 August 2025, Correspondence, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025006408)
7. In response, Anesthesia & Analgesia, 31 July 2025, Correspondence, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/in%5Fresponse.1398.aspx)
8. Questions About Strategies and Dosing Levels of PCC for Coagulopathic Bleeding in Cardiac Surgery, JAMA, 28 July 2025, Commentary, [Link](https://jamanetwork.com/journals/jama/article-abstract/2836865)
9. Questions About Strategies and Dosing Levels of PCC for Coagulopathic Bleeding in Cardiac Surgery, JAMA, 28 July 2025, Commentary, [Link](https://jamanetwork.com/journals/jama/article-abstract/2836864)
10. Questions About Strategies and Dosing Levels of PCC for Coagulapathic Bleeding in Cardiac Surgery, JAMA, 28 July 2025, Commentary, [Link](https://jamanetwork.com/journals/jama/article-abstract/2836863)
11. Questions About Strategies and Dosing Levels of PCC for Coagulopathic Bleeding in Cardiac Surgery—Reply, JAMA, 28 July 2025, Commentary, [Link](https://jamanetwork.com/journals/jama/article-abstract/2836862)
12. Timing Is Everything—Or Is It? When to Perform Non-Cardiac Surgery after Cardiac Surgery, Journal of Cardiothoracic and Vascular Anesthesia, 27 July 2025, Editorial, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025006287)
13. Elevating anesthesia standards for adult congenital heart disease patients: Comprehensive guidelines for non-cardiac surgery, Anaesthesia Critical Care & Pain Medicine, August 2025, Editorial, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556825000736)
14. “Noninvasive Ventilation in Cardiac Surgery Patients to Reduce Pulmonary Complications: Teaching an Old Dog New Tricks”, Journal of Cardiothoracic and Vascular Anesthesia, 25 July 2025, Editorial, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025006184)
---
## General:
#### Systematic reviews & Meta-analyses:
1. Effectiveness and Safety of Enhanced Postoperative Care Units for Noncardiac, Non-Neurological Surgery: A Systematic Review, A&A Practice, 5 August 2025, [Link](https://journals.lww.com/aacr/fulltext/2025/08000/effectiveness%5Fand%5Fsafety%5Fof%5Fenhanced%5Fpostoperative.4.aspx)
2. Impact of Genetic Variations on the Pharmacokinetics, Dose Requirements, and Clinical Effects of Propofol: A Systematic Review, British Journal of Anaesthesia, 5 August 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900350-2/fulltext)
3. Effect of Anesthetics on the Occurrence of Posttraumatic Stress Disorder in Patients Undergoing Emergency Trauma Surgery Under General Anesthesia: A Systematic Review, Anesthesia & Analgesia, 1 August 2025, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/effect%5Fof%5Fanesthetics%5Fon%5Fthe%5Foccurrence%5Fof.1400.aspx)
#### Clinical trials:
1. Use of Personalized Body-Worn Alcohol Dispenser, Without Practitioner Feedback, on Bacterial Transmission, Hourly Hand Decontamination Events, and Practitioner Hand Contamination: A Multicenter Randomized Controlled Study, Anesthesia & Analgesia, 4 August 2025, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/use%5Fof%5Fpersonalized%5Fbody%5Fworn%5Falcohol%5Fdispenser,.1410.aspx)
2. A prospective randomized clinical trial on the differential effect of left versus right stellate ganglion block on perioperative stress response, BMC Anesthesiology, 30 July 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03272-y)
3. Effect of nasal mask oxygenation on incidence of hypoxemia during gastroscopy with propofol sedation in patients at risk of hypoxemia: a prospective randomized controlled study, BMC Anesthesiology, 30 July 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03245-1)
4. Low-dose esketamine combined with propofol versus fentanyl-propofol for preventing hypoxemia during gastroscopy sedation in high-altitude residents: a randomized controlled trial, BMC Anesthesiology, 30 July 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03280-y)
5. Esketamine for Preventing Catheter-Related Bladder Discomfort After Ureteroscopic Lithotripsy: A Randomized Controlled Trial, BMC Anesthesiology, 29 July 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03236-2)
6. Continuous **versus* bolus norepinephrine administration and arterial blood pressure stability during induction of general anaesthesia in high-risk noncardiac surgery patients: a randomised trial, BJA, 30 July 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900408-8/fulltext)
7. Pharmacodynamics study of remimazolam besylate in anxious patients undergoing gastroscopy: a biased-coin design up-and-down sequential allocation trial, BMC Anesthesiology, 29 July 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03235-3)
#### Reviews:
1. Using Safety-I, II, and III to Level Up Patient Safety, Current Opinion in Anesthesiology, 5 August 2025, [Link](https://journals.lww.com/co-anesthesiology/fulltext/9900/using%5Fsafety%5Fi,%5Fii,%5Fand%5Fiii%5Fto%5Flevel%5Fup%5Fpatient.339.aspx)
2. Outcomes in Ambulatory Surgery, Current Opinion in Anesthesiology, 28 July 2025, [Link](https://journals.lww.com/co-anesthesiology/fulltext/9900/outcomes%5Fin%5Fambulatory%5Fsurgery.336.aspx)
3. The Future of Anesthesia Education: Incorporating Technology for Safer Practices, Current Opinion in Anesthesiology, 5 August 2025, [Link](https://journals.lww.com/co-anesthesiology/fulltext/9900/the%5Ffuture%5Fof%5Fanesthesia%5Feducation%5F%5Fincorporating.338.aspx)
4. Perioperative Care of the Geriatric Patient, European Journal of Anaesthesiology, 4 August 2025, [Link](https://journals.lww.com/ejanaesthesiology/fulltext/9900/perioperative%5Fcare%5Fof%5Fthe%5Fgeriatric%5Fpatient.334.aspx)
5. Remimazolam for anesthesia in cardiac and noncardiac surgery. A narrative literature review and synthesis, Anaesthesia Critical Care & Pain Medicine, August 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556825000876)
#### Observational studies:
1. Association of Risk of Suspected Ocular Injury With Forced-Air Upper Body Heating During General Anesthesia, Anesthesia & Analgesia, 31 July 2025, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/association%5Fof%5Frisk%5Fof%5Fsuspected%5Focular%5Finjury.1395.aspx)
2. Comparison of Phonomyography Prototype With Train-of-Four Watch SX for Neuromuscular Monitoring: A Prospective Observational Study, Anesthesia & Analgesia, 31 July 2025, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/comparison%5Fof%5Fphonomyography%5Fprototype%5Fwith.1392.aspx)
3. Association Between Preoperative Platelet Count and Postoperative Acute Kidney Injury of Patients Undergoing Abdominal Surgery: A Retrospective Cohort Analysis of the INSPIRE Database, BMC Anesthesiology, 2 August 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03269-7)
4. Reliability and validity of a new postoperative track assessment tool (PoTra-tool) as a decision-making aid: A prospective observational study, European Journal of Anaesthesiology & Intensive Care, August 2025, [Link](https://journals.lww.com/ejaintensivecare/fulltext/2025/08000/reliability%5Fand%5Fvalidity%5Fof%5Fa%5Fnew%5Fpostoperative.1.aspx)
5. An observational laboratory study to evaluate an anesthetic gas adsorber without anesthetic gas scavenging system, BMC Anesthesiology, 30 July 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03223-7)
6. Accuracy of continuous glucose monitoring during noncardiac surgery: a prospective, blinded observational multicentre cohort study, British Journal of Anaesthesia, 24 July 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900410-6/fulltext)
#### Case reports:
1. Postoperative Visual Loss After Nonocular Surgery: A Case Report, A&A Practice, August 2025, [Link](https://journals.lww.com/aacr/fulltext/2025/08000/postoperative%5Fvisual%5Floss%5Fafter%5Fnonocular%5Fsurgery%5F.1.aspx)
2. Inadvertent Intra-Arterial Methohexital Injection During Procedural Sedation: A Case Report and Contemporary Perspective, A&A Practice, August 2025, [Link](https://journals.lww.com/aacr/fulltext/2025/08000/inadvertent%5Fintra%5Farterial%5Fmethohexital%5Finjection.3.aspx)
#### Editorial/ Correspondence/ Commentary/ Letter to the editor:
1. Sugammadex and gastric emptying: individualized patient effects, Anesthesia & Analgesia, 31 July 2025, Letter to the Editor, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/sugammadex%5Fand%5Fgastric%5Femptying%5F%5Findividualized.1393.aspx)
2. Pharmacodynamic modeling in sedation optimization: promises and pitfalls, Anesthesia & Analgesia, 4 August 2025, Letter to the Editor, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/pharmacodynamic%5Fmodeling%5Fin%5Fsedation%5Foptimization%5F.1406.aspx)
3. Desflurane’s effect on the environment: climate and much more …, Anesthesia & Analgesia, 4 August 2025, Letter to the Editor, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/desflurane%5Fs%5Feffect%5Fon%5Fthe%5Fenvironment%5F%5Fclimate.1403.aspx)
4. Education and training in perioperative medicine: current versus ideal future state, Anesthesia & Analgesia, 5 August 2025, Editorial, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/education%5Fand%5Ftraining%5Fin%5Fperioperative%5Fmedicine%5F.1414.aspx)
5. Safety and recovery profile of patients after inhalational anaesthesia versus target-controlled or manual total intravenous anaesthesia, British Journal of Anaesthesia, 1 August 2025, Commentary, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900458-1/fulltext)
6. Cutting corners: is mixing remifentanil and propofol a bad idea?, Anesthesia & Analgesia, 21 July 2025, Commentary, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/cutting%5Fcorners%5F%5Fis%5Fmixing%5Fremifentanil%5Fand.1382.aspx)
7. Looks Can Be Deceiving: Prevalence of Burst Suppression During Liver Transplantation Surgery****,** Journal of Neururgical Anesthesiology, 30 July 2025, Correspondence, [Link](https://journals.lww.com/jnsa/citation/9900/looks%5Fcan%5Fbe%5Fdeceiving%5F%5Fprevalence%5Fof%5Fburst.168.aspx)
8. Timing Is Everything—Or Is It? When to Perform Non-Cardiac Surgery after Cardiac Surgery, Journal of Cardiothoracic and Vascular Anesthesia, 27 July 2025, Editorial, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025006287)
9. Suzetrigine-Induced Metabolism of Factor Xa Inhibitors May Increase Risk of Thrombosis in Perioperative and Pain Patients, Anesthesia & Analgesia, 29 July 2025, Letter to the editor, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/suzetrigine%5Finduced%5Fmetabolism%5Fof%5Ffactor%5Fxa.1390.aspx)
---
_This post is for subscribers only._
### Anecrit's Newsletter #05
URL: https://www.anecrit.com/newsletter-05/
Last updated: 2025-08-24T14:57:13.000Z
### **Issue #\[05\] | Week of \[18/07/2025\] - \[24/07/2025\]**
## Welcome!
Hey there!
This week's issue is full of Obsevational studies, but there's some interesting papers including some RCTs and systematic reviews & meta-analyses.
Do you think it's better to include all papers in the newsletter, or should I limit it to **guidelines, systematic reviews & meta-analyses, RCTs, and reviews**?
### Some numbers:
#### 1-Anesthesiology:
- Guidelines: 01
- Systematic reviews & meta analyses: 06
- RCTs: 15
- Obsevational studies: 04
- Reviews: 07
- Other: 32
#### 2-Critical Care:
- Guidelines: 00
- Systematic reviews & meta analyses: 03
- RCTs: 05
- Obsevational studies: 36
- Reviews: 06
- Other: 41
Follow me on Facebook and LinkedIn:
- [Facebook](https://www.facebook.com/profile.php?id=61576540237541)
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---
# **Anesthesiology:**
### **1-General:**
1. Efficacy and safety of ciprofol versus propofol for anesthesia in patients undergoing gastrointestinal endoscope: a systematic review and meta-analysis of randomized controlled trials (RCT), BMC Anesthesiology, 19 July 2025, Systematic Review and Meta-analysis, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03079-x)
2. Continuation versus Discontinuation of Renin-Angiotensin System Inhibitors Before Noncardiac Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Journal of Cardiothoracic and Vascular Anesthesia, August 2025, Systematic Review and Meta-Analysis, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025003155)
3. Efficacy and safety of adamgammadex for reversing rocuronium-induced deep neuromuscular block: a multicentre, randomized, double-blind, positive-controlled phase III trial, BJA, August 2025, RCT, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900275-2/fulltext)
4. Deep versus Moderate Neuromuscular Blockade During Total Hip Replacement Surgery on Postoperative Recovery and Immune Function: A Randomized Controlled Trial, Anesthesia & Analgesia, 17 July 2025, RCT, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/deep%5Fversus%5Fmoderate%5Fneuromuscular%5Fblockade%5Fduring.1376.aspx)
5. Development of insulin and its pharmacology and perioperative use: a narrative review, BJA, August 2025, Review, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900296-X/fulltext)
6. Evidence-Based Frailty Assessment for the Older Surgical Patient: a Narrative Review of Instruments, Barriers and Solutions, Current Anesthesiology Reports, 21 July 2025, Review, [Link](https://link.springer.com/article/10.1007/s40140-025-00702-y)
7. Anesthetic Management of a Bronchopleural Fistula for Non-Thoracic Surgery, Journal of Cardiothoracic and Vascular Anesthesia, August 2025, Case Reports, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077024005184)
8. Frailty and perioperative outcomes: SNAP-3 as a call to action, BJA, August 2025, Editorial, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900341-1/fulltext)
9. Frailty in the perioperative setting: lessons from SNAP-3, BJA, August 2025, Editorial, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900336-8/fulltext)
10. Non-anaemic iron deficiency in surgical patients: more than just a laboratory finding?, BJA, August 2025, Editorial, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900303-4/fulltext)
11. Intra-arterial lidocaine improves long-term survival in patients with hepatocellular carcinoma undergoing transcatheter arterial chemoembolisation. Response to Br J Anaesth 2025, BJA, 23 July 2025, Correspondence, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900416-7/fulltext)
12. A black swan spotted during emergence from general anaesthesia: alpha and delta oscillations present in a conversing patient, British Journal of Anaesthesia, 23 July 2025, Correspondence, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900417-9/fulltext)
13. Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in the perioperative period: withdraw or continue? A multicentre randomised controlled trial, BJA, 22 July 2025, Correspondence, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900404-0/fulltext)
14. Drug challenge testing in the investigation of neuromuscular blocking agent hypersensitivity. Comment on Br J Anaesth 2025, BJA, August 2025, Correspondence, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900289-2/fulltext)
15. Mitigating the systemic loss of nitrous oxide. Comment on Br J Anaesth 2024, BJA, August 2025, Correspondence, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900286-7/fulltext)
16. Intra-arterial lidocaine improves long-term survival in patients with hepatocellular carcinoma undergoing transcatheter arterial chemoembolisation. Comment on Br J Anaesth 2025, BJA, August 2025, Correspondence, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900285-5/fulltext)
---
### 2-Airway & Mechanical Ventilation:
1. High-Flow Nasal Oxygen versus Mechanical Ventilation Through a Laryngeal Mask During General Anesthesia Without Muscle Paralysis: A Randomized Clinical Trial, Anesthesia & Analgesia, 21 July 2025, RCT, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/high%5Fflow%5Fnasal%5Foxygen%5Fversus%5Fmechanical.1383.aspx)
2. Incidence of transient sinus pause in cardiac rhythm increases with the use of hyperangulated videolaryngoscope blade compared to standard angle blade during tracheal intubation: A prospective randomized controlled trial, European Journal of Anaesthesiology, 24 July 2025, RCT, [Link](https://journals.lww.com/ejanaesthesiology/fulltext/9900/incidence%5Fof%5Ftransient%5Fsinus%5Fpause%5Fin%5Fcardiac.331.aspx)
3. Clinical Decision-Making and Process Complications During Difficult Airway Management, Anesthesia & Analgesia, 17 July 2025, Letter to the Editor, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/clinical%5Fdecision%5Fmaking%5Fand%5Fprocess%5Fcomplications.1374.aspx)
---
### **3-Cardiovascular & Hemodynamics:**
1. 2024 EACTS/EACTAIC Guidelines on Patient Blood Management in Adult Cardiac Surgery in Collaboration With EBCP, Journal of Cardiothoracic and Vascular Anesthesia, August 2025, Guidelines, [Link](https://www.sciencedirect.com/science/article/pii/S1053077024007894)
2. A Systematic Review and Meta-Analysis of Local-Regional versus General Anesthesia for Elective Endovascular Abdominal Aortic Aneurysm Repair, Journal of Cardiothoracic and Vascular Anesthesia, August 2025, Systematic Review and Meta-Analysis, [Link](https://www.sciencedirect.com/science/article/abs/pii/S105307702500271X)
3. Local Versus General Anesthesia for Endovascular Repair of Abdominal Aortic Aneurysm: A Systematic Review and Meta-analysis, Journal of Cardiothoracic and Vascular Anesthesia, August 2025, Systematic Review and Meta-analysis, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025002617)
4. A single, blind, randomised controlled trial comparing postoperative analgesic effects of superficial and deep parasternal intercostal blocks in patients undergoing coronary artery bypass grafting surgery, Journal of Cardiothoracic and Vascular Anesthesia, 23 July 2025, RCT, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025006196)
5. Effects of liquid resuscitation guided by internal jugular vein variability during deep inhalation on preventing propofol-induced hypotension in elderly patients, BMC Anesthesiology, 17 July 2025, RCT, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03227-3)
6. Effect of Esketamine on Postoperative Delirium and Inflammatory Response in Patients Undergoing Off-Pump Coronary Artery Bypass Grafting: A Randomized Controlled Study, Journal of Cardiothoracic and Vascular Anesthesia, August 2025, RCT, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025003131)
7. Effect of Bicuspid or Tricuspid Aortic Valve on Preoperative Coagulation in Patients Scheduled for Thoracic Aortic Surgery, Journal of Cardiothoracic and Vascular Anesthesia, August 2025, observational study, [Link](https://www.sciencedirect.com/science/article/pii/S1053077025003386)
8. How We Would Use Enhanced Recovery After Cardiac Surgery: What We Would Do for Ourselves During the Perioperative Period, Journal of Cardiothoracic and Vascular Anesthesia, August 2025, Review, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025001843)
9. Dependability of Large Language Models in Cardiovascular Medicine: A Scoping Review, Journal of Cardiothoracic and Vascular Anesthesia, 22 July 2025, Review, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025006214)
10. Examining the Safety of Continuing Preoperative Renin-angiotensin System Inhibitors in Noncardiac Surgery, Journal of Cardiothoracic and Vascular Anesthesia, August 2025, Review, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025002654)
11. Hyperoxia in Cardiac Surgery: Where Do We Stand?, Journal of Cardiothoracic and Vascular Anesthesia, 21 July 2025, Review, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025005749)
12. Advances in Cardiovascular Pharmacotherapy. III. Sodium-Glucose Cotransporter Type 2 Inhibitors, Part 1: Efficacy in Heart Failure and Myocardial Infarction, Journal of Cardiothoracic and Vascular Anesthesia, August 2025, Review, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025003684)
13. A 2024 Update From the American Society of Echocardiography: Multimodality Imaging for Patients With Left Ventricular Assist Devices and Temporary Mechanical Circulatory Support, Journal of Cardiothoracic and Vascular Anesthesia, August 2025, Editorial, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025003714)
14. Commentary: refining patient stratification for haemoadsorption in cardiac surgery: comparative reflections on RECCAS, REMOVE, and SIRAKI02, Critical Care, 23 July 2025, Commentary, [Link](https://ccforum.biomedcentral.com/articles/10.1186/s13054-025-05525-1)
15. Beyond the 3Ds of the Aortic Valve: Rethinking Durability, Dysfunction, and Decision-Making in TAVR and SAVR, Journal of Cardiothoracic and Vascular Anesthesia, 18 July 2025, Commentary, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025005592)
16. Three-Dimensional Intracardiac Echo: Have Structural Heart Interventions Moved Beyond Transesophageal Echocardiography?, Journal of Cardiothoracic and Vascular Anesthesia, August 2025, Editorial, [Link](https://www.sciencedirect.com/science/article/abs/pii/S105307702500326X)
17. Artificial Intelligence to Evaluate Aortic Insufficiency: An Exercise in Machine Learning, Journal of Cardiothoracic and Vascular Anesthesia, August 2025, Editorial, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025003301)
18. Noninvasion and Its Relevance in Modern Imaging for Aortic Regurgitation, Journal of Cardiothoracic and Vascular Anesthesia, August 2025, Editorial, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025002198)
19. Moderate Aortic Stenosis: Can We Predict Who Will Benefit from Intervention?, Journal of Cardiothoracic and Vascular Anesthesia, August 2025, Editorial, [Link](https://www.sciencedirect.com/science/article/abs/pii/S105307702500374X)
20. Aortic Stenosis: A Lifetime of Decision Making, Journal of Cardiothoracic and Vascular Anesthesia, August 2025, Editorial, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025003246)
21. Does Benzodiazepine-Free Cardiac Anesthesia Reduce Postoperative Delirium?, Journal of Cardiothoracic and Vascular Anesthesia, August 2025, Editorial, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025002496)
22. The Cardiothoracic Anesthesiology Workforce in 2025: The Good, the Bad, and the Admittedly Ugly, Journal of Cardiothoracic and Vascular Anesthesia, August 2025, Editorial, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025002605)
23. The Evolving Landscape of Cardiac Anesthesia: Strength in Numbers, Journal of Cardiothoracic and Vascular Anesthesia, August 2025, Editorial, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025003118)
24. Advances in Acute Type A Aortic Dissection – expanding the roles of goal-directed echocardiographic imaging throughout the perioperative period, Journal of Cardiothoracic and Vascular Anesthesia, 23 July 2025, Editorial, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025006251)
25. Optimizing Sedation Strategies for Catheter Ablation Procedures: Balancing Safety, Efficacy, and Practice Variations, Circulation, 21 July 2025, Editorial, [Link](https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.125.075339)
---
### **4-Thoracic:**
1. Comparison of the Effects of Combined Rhomboid Intercostal and Sub-Serratus Plane Block versus Rhomboid Intercostal Block on Postoperative Analgesia in Patients Undergoing Video-Assisted Thoracoscopic Surgery for Wedge Resection, Journal of Cardiothoracic and Vascular Anesthesia, August 2025, RCT, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025003611)
2. Anesthetic Management of a Bronchopleural Fistula for Non-Thoracic Surgery, Journal of Cardiothoracic and Vascular Anesthesia, August 2025, Case Reports, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077024005184)
---
### **5-Neuro:**
1. Solving the enigma of burst suppression. Response to Br J Anaesth 2025, BJA, 2025, Commentary, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900381-2/fulltext)
---
### **6-Obstetrics & Gynecology:**
1. The median Effective Dose (ED50) and the 95% Effective Dose (ED95) of alfentanil in inhibiting responses to cervical dilation when combined with ciprofol during hysteroscopic procedure: a prospective, double-blind, dose-finding clinical study, BMC Anesthesiology, 19 July 2025, RCT! dose finding study, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03217-5)
2. Prevalence of Point-of-Care Ultrasound Abnormalities and Raised Serum NT-proBNP in Early-Onset Preeclampsia, Anesthesia & Analgesia, 21 July 2025, observational study, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/prevalence%5Fof%5Fpoint%5Fof%5Fcare%5Fultrasound.1384.aspx)
---
### **7-Pediatric:**
1. Intraoperative Assessment of Cerebral Autoregulation With Cerebral Oximetry Index in Neonates Undergoing Cardiac Surgery: A Pilot Study, Journal of Cardiothoracic and Vascular Anesthesia, August 2025, observational study, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025003271)
2. Combining A ‘Z’ Suture With A Stopcock Assembly For Pediatric Femoral Venous Access Closure, Journal of Cardiothoracic and Vascular Anesthesia, 21 July 2025, Letter to the Editor, [Link](https://www.sciencedirect.com/science/article/abs/pii/S105307702500624X)
---
### **8-Regional Anesthesia & Pain Management:**
_This post is for subscribers only._
### Anecrit's Newsletter #04
URL: https://www.anecrit.com/newsletter-04/
Last updated: 2025-08-24T14:57:36.000Z
### **Issue #\[04\] | Week of \[27/06/2025\] - \[17/07/2025\]**
## Welcome!
Hey there!
Sorry for the delay—this issue should have been published two weeks ago, I know. I recently started my pediatric anesthesiology and critical care rotation, so it's been a little difficult to balance work, study, night shifts, and creating content for the newsletter and the website. But things are going to change, and let's hope I can publish articles consistently. When it comes to the newsletter, I'll do my best to publish it every week at a fixed day and time; it will be out every Friday!
This issue of the newsletter is full of very interesting and important papers, including guidelines and multiple RCTs—more than you can read in a week! I hope you enjoy it, and don't forget to share it with those who might be interested.
Follow me on Facebook and LinkedIn:
- [Facebook](https://www.facebook.com/profile.php?id=61576540237541)
- [Linkedin](https://www.linkedin.com/in/othmane-benhalima-023ba379)
---
# **Anesthesiology:**
### 1-AI:
1. Artificial Intelligence in Airway Management: A Systematic Review and Meta-Analysis, Anaesthesia Critical Care & Pain Medicine, 9 July 2025, Systematic Review and Meta-analysis, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556825001213)
2. Leveraging Artificial Intelligence in Anesthesiology Research and Article Writing: Opportunities, Challenges, and Best Practices, A&A Practice, July 14, 2025, Point-of-View, [Link](https://journals.lww.com/aacr/fulltext/2025/07000/leveraging%5Fartificial%5Fintelligence%5Fin.11.aspx)
3. Generation of preoperative anaesthetic plans by ChatGPT-4.0, British Journal of Anaesthesia, 2025, Commentary, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900387-3/fulltext)
4. Differential reasoning and chain-of-thought processes in Deepseek-R1 and Open AI o3-mini-high for determining American Society of Anesthesiologists physical status, British Journal of Anaesthesia, 7 July 2025, Correspondence, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900364-2/abstract)
5. Utility of AI-based nerve recognition (cNerve) in difficult-to-image patients, British Journal of Anaesthesia, 1 July 2025, Correspondence, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900356-3/fulltext)
---
### **2-General:**
1. Post-discharge digital health technology interventions in ambulatory surgery: A systematic review and meta-analysis, European Journal of Anaesthesiology | EJA, July 14, 2025, Systematic Review and Meta-analysis, [Link](https://journals.lww.com/ejanaesthesiology/fulltext/9900/post%5Fdischarge%5Fdigital%5Fhealth%5Ftechnology.326.aspx)
2. Continuous Vital Sign Monitoring at the Surgical Ward for Improved Outcomes After Major Noncardiac Surgery: A Randomized Clinical Trial, Anesthesia & Analgesia, June 30, 2025, RCT, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/continuous%5Fvital%5Fsign%5Fmonitoring%5Fat%5Fthe%5Fsurgical.1350.aspx)
3. Remimazolam Tosylate or Propofol and Delirium in Frail Elderly Patients After Hip Surgery: A Randomised Controlled Clinical Trial, European Journal of Anaesthesiology, 27 June 2025, RCT, [Link](https://journals.lww.com/ejanaesthesiology/fulltext/9900/remimazolam%5Ftosylate%5For%5Fpropofol%5Fand%5Fdelirium%5Fin.318.aspx)
4. Comparison of oropharyngeal leak pressure between the SaCoVLM™ video laryngeal mask and LMA supreme in adult elective surgery patients: a prospective randomized controlled trial, BMC Anesthesiology, 3 July 2025, RCT, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03218-4)
5. The electromyographic single twitch stimulation for monitoring the effect of rocuronium on vocal cord opening – a randomised controlled trial, BMC Anesthesiology, 3 July 2025, RCT, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03201-z)
6. Remimazolam tosylate or propofol and delirium in frail elderly patients after hip surgery: A randomised controlled clinical trial, European Journal of Anaesthesiology, 27 June 2025, RCT, [Link](https://journals.lww.com/ejanaesthesiology/fulltext/9900/remimazolam%5Ftosylate%5For%5Fpropofol%5Fand%5Fdelirium%5Fin.318.aspx)
7. Neurally adjusted ventilatory assisted ventilation compared to pressure support during post-operative weaning of hepatic patients undergoing major abdominal surgeries: a randomized control trial, BMC Anesthesiology, 26 June 2025, RCT, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03159-y)
8. Anesthetic Amnesia: The Forgotten Importance of Forgetting?, Anesthesiology, 8 July 2025, Review, [Link](https://journals.lww.com/anesthesiology/abstract/9900/anesthetic%5Famnesia%5F%5Fthe%5Fforgotten%5Fimportance%5Fof.713.aspx)
9. Review of cannabis use and propofol anesthesia: recent insights and clinical implications, Current Opinion in Anesthesiology, 1 July 2025, Review, [Link](https://journals.lww.com/co-anesthesiology/fulltext/9900/review%5Fof%5Fcannabis%5Fuse%5Fand%5Fpropofol%5Fanesthesia%5F.329.aspx)
10. The Myth of the Phase I Block After Succinylcholine in Clinical Practice, Anesthesia & Analgesia, July 11, 2025, Review, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/the%5Fmyth%5Fof%5Fthe%5Fphase%5Fi%5Fblock%5Fafter.1363.aspx)
11. Meralgia paraesthetica, BJA Education, August 2025, Review, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900039-3/fulltext)
12. Non-insulin diabetes medicines: a narrative review for anaesthetists and intensivists, BJA, 11 July 2025, Review, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900376-9/fulltext)
13. Patient-centred outcomes, BJA Education, August 2025, Review, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900037-X/abstract)
14. Core concepts in statistics and research methods. Part 3: essentials of Bayesian inference, *BJA Education*, August 2025, Review, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900027-7/fulltext)
15. Effects of ketamine on postoperative cognition: a scoping review, British Journal of Anaesthesia, 7 July 2025, Review, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900349-6/abstract)
16. Bone cement implantation syndrome: a scoping review, British Journal of Anaesthesia, 9 July 2025, Review, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900360-5/fulltext)
17. Perioperative Medicine, Perioperative Surgical Home, and Enhanced Recovery After Surgery: Distinct Constructs or Different Names for the Same Journey, Anesthesia & Analgesia, July 2, 2025, Review, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/perioperative%5Fmedicine,%5Fperioperative%5Fsurgical.1353.aspx)
18. Anaesthesia in 2050: How Emerging Technologies Will Transform Our Practice: The Sir Robert Macintosh Lecture 2025, European Journal of Anaesthesiology, 27 June 2025, Review, [Link](https://journals.lww.com/ejanaesthesiology/fulltext/9900/anaesthesia%5Fin%5F2050%5F%5Fhow%5Femerging%5Ftechnologies.319.aspx)
19. Automated Robotic Airway Insertion Using Flexible Optical Bronchoscope in a Manikin: A Feasibility Pilot Study, Anesthesia & Analgesia, 02 July 2025, Letter to the Editor, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/automated%5Frobotic%5Fairway%5Finsertion%5Fusing%5Fflexible.1354.aspx)
20. SGLT2 Inhibitors: Increasing Benefits, Continued Concerns, Journal of Cardiothoracic and Vascular Anesthesia, 28 June 2025, Editorial, [Link](https://www.sciencedirect.com/science/article/abs/pii/S105307702500552X)
21. Hypotension after general anaesthesia induction with remimazolam or propofol in geriatric patients undergoing sevoflurane anaesthesia with remifentanil. Response to comments on Br J Anaesth, British Journal of Anaesthesia, 1 July 2025, Correspondence, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900355-1/fulltext)
22. Effect of intraoperative dexmedetomidine on prognosis in patients with cancer undergoing surgical procedures. Comment on Br J Anaesth 2025; 135: 89–98, BJA, 2025, Commentary, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900374-5/abstract)
23. Perioperative Dexamethasone to Regulate Inflammation: Not For Everyone?, Anesthesia & Analgesia, July 11, 2025, Editorial, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/perioperative%5Fdexamethasone%5Fto%5Fregulate.1362.aspx)
---
### 3-Airway & Mechanical ventilation:
1. Videolaryngoscopy versus direct laryngoscopy for teaching direct laryngoscopy skills: a systematic review and meta-analysis, British Journal of Anaesthesia, 8 July 2025, Systematic Review and Meta-analysis, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900348-4/fulltext)
2. Comparison of Oropharyngeal Leak Pressure Between the Sacovlm™ Video Laryngeal Mask and LMA Supreme in Adult Elective Surgery Patients: A Prospective Randomized Controlled Trial, BMC Anesthesiology, 3 July 2025, RCT, [Link](http://click.springernature.com/f/a/oGoU3yqhauaugC4ybA1oPw~~/AAEGiRA~/bzHJnSJuaYeCyykZysgf6EHAKgiouf9H1ucq5yvUkjJYP7Y1YB%5FWeMiioMemywSv4WMGGiAOJNN5jUK8V917Qc1lbiRpg4RmBFVAM9hdQTEaYiXSkpagBEbo9BrDK1bZN4wo-D05LpClZDhjp42KX3kJylL1Oo8lrmWkA-HM9mxAobun1kZOIYYMw1bMOMto7NVH1Gn8Qn%5FHeYx%5FqVR2opN5kO0vnx24a4%5FScYs%5FIQtPYGyhETJ%5FkAai6HAxZtHOwFuUC6g1ZX%5FOYn-TM7-boPcKby2UYC8hoC7Cphs1b34~)
3. The Electromyographic Single Twitch Stimulation for Monitoring the Effect of Rocuronium on Vocal Cord Opening – A Randomised Controlled Trial, BMC Anesthesiology, 3 July 2025, RCT, [Link](http://click.springernature.com/f/a/U5ETy6kXTHXSiqyUF-DiZA~~/AAEGiRA~/bzHJnSJuaYeCyykZysgf6EHAKgiouf9H1ucq5yvUkjJYP7Y1YB%5FWeMiioMemywSv4WMGGiAOJNN5jUK8V917Qc1lbiRpg4RmBFVAM9hdQTFpqbywDXzsTYwLHZDzcGj6cILIv00cf2OSIGEgJ%5F6LpBZ6vIp3%5FACFpyDuqj0C7-DPsl8or-TeJnMtS3luarR%5FBr8DgAeNMn3mTlsNwTAZZ1tquQVYKtq8rBsxdAFI5anevlMbojLwu6f2%5FuVLmNIYdBqiMQqfxSsWZZp9SCqWqsfyIHYWVnX3ZYfRecBG8qM~)
4. Continuous Positive Airway Pressure to Prevent Reintubation in Patients Recovering from Cardiac Surgery: A Multicentre Randomised Clinical Trial, European Journal of Anaesthesiology, 27 June 2025, RCT, [Link](https://journals.lww.com/ejanaesthesiology/fulltext/9900/continuous%5Fpositive%5Fairway%5Fpressure%5Fto%5Fprevent.320.aspx)
5. Neurally Adjusted Ventilatory Assisted Ventilation Compared to Pressure Support During Post-Operative Weaning of Hepatic Patients Undergoing Major Abdominal Surgeries: A Randomized Control Trial, BMC Anesthesiology, 26 June 2025, RCT, [Link](http://click.springernature.com/f/a/rIMZm-wv23RAGiHXSVnWWQ~~/AAEGiRA~/lNvhKVpdFt1mvOQNfQsOhtSdcTGjB3PohyUjCemt0n0hm-wcsIodG5he9sVnWTSfw2FZMv3-yw5YMFUQChIKoGXLtxa5OBvuv5%5FdckRpQSgvD9hVr087eAzx1koTMtplr6Phu5jT6GrMH6IPkStm4YSnAp5pdL59UToXGiHUZxFg1Acqo7B8HIZa1FDndfy45XXoZlEd2DKwzVNhirolWKzJ0GwpLRyvDNyuXZ5rIoNOBVe8LAd5OSN7LQi7c9zArnKRrwcLkozvn1woZLyEyi9wwMjkO5GUXddZ0fQVJzo~)
6. Comparison of sacovlm™ video laryngeal mask-guided intubation and fastrach combined with flexible bronchoscopy-guided intubation: a prospective study, BMC Anesthesiology, 01 July 2025, RCT!, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03172-1)
7. A Variation of Submental Endotracheal Intubation: A Case Report, A&A Practice, 9 July 2025, Case report, [Link](https://journals.lww.com/aacr/fulltext/2025/07000/a%5Fvariation%5Fof%5Fsubmental%5Fendotracheal%5Fintubation%5F.7.aspx)
8. ‘The trachea heals but the hypoxia does not’ an emergency front-of-neck access in a 4-year-old with foreign body airway obstruction, EJA, 07 July 2025, Case report, [Link](https://journals.lww.com/ejanaesthesiology/abstract/9900/%5Fthe%5Ftrachea%5Fheals%5Fbut%5Fthe%5Fhypoxia%5Fdoes%5Fnot%5F%5Fan.323.aspx)
9. Stabbed in the Back: Airway Management for Penetrating Thoracic Trauma in the Prone Position, Journal of Cardiothoracic and Vascular Anesthesia, 27 June 2025, Letter to the Editor, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025005397)
---
### **4-Cardiovascular & Hemodynamics:**
1. Perioperative Quality Initiative consensus statement on goal-directed haemodynamic therapy, British Journal of Anaesthesia, 2025, Guidelines, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900347-2/fulltext)
2. Opioid Sparing Anesthesia in Cardiac Surgery: A Meta-Analysis, Journal of Cardiothoracic and Vascular Anesthesia, 27 June 2025, Systematic Review and Meta-analysis, [Link](https://click.notification.elsevier.com/CL0/https:%2F%2Fwww.sciencedirect.com%2Fscience%3F%5Fob=GatewayURL%26%5Fmethod=citationSearch%26%5Fversion=1%26%5Fpiikey=S1053077025005361%26%5Forigin=RV%5FSD%5FAIP%5FEMAIL%26dgcid=raven%5Fsd%5Faip%5Femail/1/01000197b3ba1a7d-2ba22fa1-b35b-4aad-86d9-55c15166edf7-000000/GlYWkfvrEiPfWrk7Bn03xcdrLkm2DdzbQEB9WqfEy5U=411)
3. Is Prior Cardiac Surgery a Risk Factor for Patients in Aortic Surgery: A Systematic Review and Meta-Analysis, Journal of Cardiothoracic and Vascular Anesthesia, 02 July 2025, Systematic Review and Meta-analysis, [Link](https://click.notification.elsevier.com/CL0/https:%2F%2Fwww.sciencedirect.com%2Fscience%3F%5Fob=GatewayURL%26%5Fmethod=citationSearch%26%5Fversion=1%26%5Fpiikey=S1053077025005567%26%5Forigin=RV%5FSD%5FAIP%5FEMAIL%26dgcid=raven%5Fsd%5Faip%5Femail/1/01000197cef8b756-ace85060-beb4-4244-b0fc-4057960fdb6e-000000/vWi7jabYcMkTwRcfpwOLfF7dItdGUrRSOknn-OGyS1g=412)
4. Is Prior Cardiac Surgery a Risk Factor for patients in aortic surgery: a systematic review and meta-analysis, Journal of Cardiothoracic and Vascular Anesthesia, 02 July 2025, Systematic Review and Meta-analysis, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025005567)
5. Opioid sparing anesthesia in cardiac surgery: a meta-analysis, Journal of Cardiothoracic and Vascular Anesthesia, 2 July 2025, 27 June 2025, Systematic Review and Meta-analysis, [Link](https://www.sciencedirect.com/science/article/pii/S1053077025005361)
6. The organ-protective effects of nitric oxide in adult patients undergoing cardiac surgery with cardiopulmonary bypass: a systematic review and meta-analysis, BMC Anesthesiology, 3 July 2025, Systematic Review and Meta-analysis, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03207-7)
7. Robustness of Randomized Controlled Trials Evaluating Acute Normovolemic Haemodilution as a Blood Conservation Strategy in Cardiac Surgery, Journal of Cardiothoracic and Vascular Anesthesia, 1 July 2025, systematic review, [Link](https://www.sciencedirect.com/science/article/abs/pii/S105307702500549X)
8. Acute Normovolemic Hemodilution versus Norepinephrine Infusion During Autologous Blood Donation in Coronary Artery Bypass Graft Surgery: A Prospective Randomized Study, Journal of Cardiothoracic and Vascular Anesthesia, 28 June 2025, RCT, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025005518)
9. Continuous positive airway pressure to prevent reintubation in patients recovering from cardiac surgery: A multicentre randomised clinical trial, European Journal of Anaesthesiology, 27 June 2025, RCT, [Link](https://journals.lww.com/ejanaesthesiology/fulltext/9900/continuous%5Fpositive%5Fairway%5Fpressure%5Fto%5Fprevent.320.aspx)
10. A New Perspective in Cardiac Surgery: Single and Two-Level Deep Parasternal Intercostal Plane (DPIP) Blocks for Median Sternotomy Pain, Journal of Cardiothoracic and Vascular Anesthesia, 11 July 2025, RCT, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025005683)
11. Effects of increased cardiopulmonary bypass pump flow on renal filtration, perfusion, oxygenation and tubular injury in cardiac surgical patients - a randomized controlled trial, Anesthesiology, 7 July 2025, RCT, [Link](https://journals.lww.com/anesthesiology/abstract/9900/effects%5Fof%5Fincreased%5Fcardiopulmonary%5Fbypass%5Fpump.715.aspx)
12. Comparison of Two Activated Clotting Time Targets During Cardiac Surgery with Cardiopulmonary Bypass: A Prospective Multicenter Randomized Controlled Trial, Journal of Cardiothoracic and Vascular Anesthesia, 8 July 2025, RCT, [Link](https://www.sciencedirect.com/science/article/pii/S1053077025005580)
13. Multimodal prehabilitation as a strategy to reduce postoperative complications in cardiac surgery: A randomised controlled trial, European Journal of Anaesthesiology, 17 July 2025, RCT, [Link](https://journals.lww.com/ejanaesthesiology/fulltext/9900/multimodal%5Fprehabilitation%5Fas%5Fa%5Fstrategy%5Fto%5Freduce.328.aspx)
14. Impact of superficial and deep parasternal blocks on recovery after cardiac surgery with sternotomy: a randomised controlled trial, British Journal of Anaesthesia, 9 July 2025, RCT, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900362-9/fulltext)
15. Robustness of Randomized Controlled Trials Evaluating Acute Normovolemic Haemodilution as a Blood Conservation Strategy in Cardiac Surgery, Journal of Cardiothoracic and Vascular Anesthesia, 1 July 2025, RCT, [Link](https://click.notification.elsevier.com/CL0/https:%2F%2Fwww.sciencedirect.com%2Fscience%3F%5Fob=GatewayURL%26%5Fmethod=citationSearch%26%5Fversion=1%26%5Fpiikey=S105307702500549X%26%5Forigin=RV%5FSD%5FAIP%5FEMAIL%26dgcid=raven%5Fsd%5Faip%5Femail/1/01000197c9cb3e16-fbda8b84-4507-45d0-8f3f-61157cab9a8b-000000/6nnmWMhg%5F2T-hTvXnglQLdEME56kCtsfh9hiHCHBd%5Fs=412)
16. Acute Normovolemic Hemodilution Versus Norepinephrine Infusion During Autologous Blood Donation in Coronary Artery Bypass Graft Surgery: A Prospective Randomized Study, Journal of Cardiothoracic and Vascular Anesthesia, 28 June 2025, RCT, [Link](https://click.notification.elsevier.com/CL0/https:%2F%2Fwww.sciencedirect.com%2Fscience%3F%5Fob=GatewayURL%26%5Fmethod=citationSearch%26%5Fversion=1%26%5Fpiikey=S1053077025005518%26%5Forigin=RV%5FSD%5FAIP%5FEMAIL%26dgcid=raven%5Fsd%5Faip%5Femail/1/01000197b8e8bde7-ef8e1f76-6a8f-42a7-bfa3-3671fdba5e29-000000/qeYifR9BiTrULsuYPWFgccKP2IAvpocma98VEyYD9AA=411)
17. Effects of two different partial pressure of end-tidal carbon dioxide levels on cardiac function in patients undergoing carotid endarterectomy: a randomized controlled trial, BMC Anesthesiology, 1 July 2025, RCT, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03186-9)
18. Perioperative cardiac output monitoring for the many, Intensive Crae Medicine, 15 July 2025, Review, [Link](https://link.springer.com/article/10.1007/s00134-025-08031-8)
19. Con: Supplemental Cardioplegia During Heart Transplant Implantation, Journal of Cardiothoracic and Vascular Anesthesia, 02 July 2025, Commentary, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025005579)
20. Neuromonitoring for Carotid Endarterectomy: Does it Provide Value-Based Care?, Journal of Neurosurgical Anesthesiology, 30 June 2025, Commentary, [Link](https://journals.lww.com/jnsa/fulltext/9900/neuromonitoring%5Ffor%5Fcarotid%5Fendarterectomy%5F%5Fdoes.163.aspx)
21. Renal Vein Stasis Index in Cardiac Surgery: Imaging the Left Renal Vein, Anesthesia & Analgesia, 10 July 2025, Letter to the Editor, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/renal%5Fvein%5Fstasis%5Findex%5Fin%5Fcardiac%5Fsurgery%5F.1366.aspx)
22. That’s not supposed to be in the left ventricle!, Journal of Cardiothoracic and Vascular Anesthesia, 16 July 2025, Case report, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025005786)
23. CON: Supplemental Cardioplegia During Heart Transplant Implantation, Journal of Cardiothoracic and Vascular Anesthesia, 2 July 2025, Commentary, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025005579)
24. Neuromonitoring for Carotid Endarterectomy: Does it Provide Value-Based Care?, Journal of Neurosurgical Anesthesiology, 30 June 2025, Commentary, [Link](https://journals.lww.com/jnsa/fulltext/9900/neuromonitoring%5Ffor%5Fcarotid%5Fendarterectomy%5F%5Fdoes.163.aspx)
25. Advancing Cardiac Anesthesia: Innovative Strategies for Pulsed Field Ablation in Paroxysmal Atrial Fibrillation – Exploring the Next Frontier, Journal of Cardiothoracic and Vascular Anesthesia, 27 June 2025, Editorial, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025005348)
26. Sausage Interventricular Septal Hematoma Due to Ruptured Type V Right Sinus of Valsalva Aneurysm, Journal of Cardiothoracic and Vascular Anesthesia, 30 June 2025, Letter to the Editor, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025005385)
27. SGLT2 Inhibitors: Increasing Benefits, Continued Concerns, Journal of Cardiothoracic and Vascular Anesthesia, 28 June 2025, Editorial, [Link](https://www.sciencedirect.com/science/article/abs/pii/S105307702500552X)
---
### **5-Thoracic:**
1. Effect of Inhaled Volatile and IV Anesthetics on Biological Markers of Inflammation in Adult ICU and Thoracic Surgical Patients: A Systematic Review and Meta-Analysis, Critical Care Explorations, 15 July 2025, Systematic Review and Meta-analysis, [Link](https://journals.lww.com/ccejournal/fulltext/2025/07000/effect%5Fof%5Finhaled%5Fvolatile%5Fand%5Fiv%5Fanesthetics%5Fon.5.aspx)
2. Effects of individualized positive end-expiratory pressure on patients undergoing one-lung ventilation during thoracic surgery: a systematic review and meta-analysis, Journal of Cardiothoracic and Vascular Anesthesia, 11 July 2025, Systematic Review and Meta-analysis, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025004835)
3. Effect of dynamic lung compliance-guided positive end-expiratory pressure on postoperative pulmonary complications following thoracoscopic lobectomy: a randomized controlled trial, BMC Anesthesiology, 1 July 2025, RCT, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03183-y)
4. Stabbed in the Back: Airway Management for Penetrating Thoracic Trauma in the Prone Position, Journal of Cardiothoracic and Vascular Anesthesia, 27 June 2025, Letter to the Editor, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025005397)
---
### **6-Neuro:**
1. Comparison of the effects of remimazolam and propofol on postoperative delirium in elderly surgical patients: a meta-analysis, BMC Anesthesiology, 1 July 2025, Systematic Review and Meta-analysis, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03197-6)
2. The effects of remimazolam and propofol on delirium following anesthesia and sedation in elderly patients: a systematic review and meta-analysis, 1 July 2025, Systematic Review and Meta-analysis, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03167-y)
3. Effects of Volatile Versus Intravenous Anesthesia on Cerebral Vasospasm in Open Surgical and Endovascular Procedures for Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis, Journal of Neurosurgical Anesthesiology, 2 July 2025, Systematic Review and Meta-analysis, [Link](https://journals.lww.com/jnsa/fulltext/9900/effects%5Fof%5Fvolatile%5Fversus%5Fintravenous%5Fanesthesia.164.aspx)
4. Effects of Volatile Versus Intravenous Anesthesia on Cerebral Vasospasm in Open Surgical and Endovascular Procedures for Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis, Journal of Neurosurgical Anesthesiology, 2 July 2025, Systematic Review and Meta-analysis, [Link](https://journals.lww.com/jnsa/fulltext/9900/effects%5Fof%5Fvolatile%5Fversus%5Fintravenous%5Fanesthesia.164.aspx)
5. Perioperative Management of Anticoagulant and Antiplatelet Therapy in Elective Neurosurgery Patients: A Narrative Review, *Journal of Neurosurgical Anesthesiology*, 4 July 2025, Review Article, [Link](https://journals.lww.com/jnsa/abstract/9900/perioperative%5Fmanagement%5Fof%5Fanticoagulant%5Fand.165.aspx)
6. Temporary Intraoperative Cerebral Blood Flow Reduction to Facilitate Neurovascular Procedures, *Journal of Neurosurgical Anesthesiology*, 4 July 2025, Review Article, [Link](https://journals.lww.com/jnsa/abstract/9900/temporary%5Fintraoperative%5Fcerebral%5Fblood%5Fflow.166.aspx)
7. Transfusion strategies in neuroanaesthesia and neurocritical care, Current Opinion in Anesthesiology, 4 July 2025, Review Article, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/transfusion%5Fstrategies%5Fin%5Fneuroanaesthesia%5Fand.330.aspx)
8. Anaesthesia for clipping of intracranial aneurysms, BJA Education, August 2025, Review Article, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900038-1/fulltext)
---
### **7-Obstetric:**
1. Esketamine prevents carboprost-induced adverse reactions during cesarean section under combined spinal-epidural anesthesia: a double-blind, randomized trial, BMC Anesthesiology, 12 July 2025, RCT, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03173-0)
2. Comparison of Intravenous Nalbuphine and Sufentanil on the Median Effective Effect-Site Concentration of Propofol to Attenuate the Response to Cervical Dilation During Hysteroscopy: A Double-Blind, Dose–Response Study, BMC Anesthesiology, 7 July 2025, RCT!, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03208-6)
3. Ultrasound-assisted technique versus the conventional landmark location method in spinal anesthesia for cesarean delivery in parturients with class 3 obesity: a randomized controlled trial, BMC Anesthesiology, 1 July 2025, RCT, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03176-x)
---
### **8-Pediatric:**
1. Ultrasonographic assessment of sugammadex-enhanced early recovery of diaphragmatic function in children: A randomised double-blind controlled trial, European Journal of Anaesthesiology, 8 July 2025, RCT, [Link](https://journals.lww.com/ejanaesthesiology/fulltext/9900/ultrasonographic%5Fassessment%5Fof%5Fsugammadex%5Fenhanced.324.aspx)
2. Comparison of Analgesic Efficacy and Safety of Caudal Dexmedetomidine Versus Intranasal Dexmedetomidine in Paediatric Infraumbilical Surgeries: A Randomised Controlled Trial, European Journal of Anaesthesiology, 27 June 2025, RCT, [Link](https://journals.lww.com/ejanaesthesiology/fulltext/9900/comparison%5Fof%5Fanalgesic%5Fefficacy%5Fand%5Fsafety%5Fof.317.aspx)
3. Comparison of analgesic efficacy and safety of caudal dexmedetomidine versus intranasal dexmedetomidine in paediatric infraumbilical surgeries: A randomised controlled trial, European Journal of Anaesthesiology, 27 June 2025, RCT, [Link](https://journals.lww.com/ejanaesthesiology/fulltext/9900/comparison%5Fof%5Fanalgesic%5Fefficacy%5Fand%5Fsafety%5Fof.317.aspx)
4. The effect of methylprednisolone on the reversal time of rocuronium by sugammadex in the paediatric patient group: A randomised controlled trial, European Journal of Anaesthesiology, 17 July 2025, RCT, [Link](https://journals.lww.com/ejanaesthesiology/fulltext/9900/the%5Feffect%5Fof%5Fmethylprednisolone%5Fon%5Fthe%5Freversal.329.aspx)
5. Anaesthesia for infants and young children with achondroplasia, BJA Education, August 2025, Review Article, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900041-1/fulltext)
6. The Single Child With a Single Ventricle, Anesthesia & Analgesia, 2 July 2025, Commentary, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/the%5Fsingle%5Fchild%5Fwith%5Fa%5Fsingle%5Fventricle.1351.aspx)
7. Cognitive errors in paediatric difficult airway management: a step into the unknown, British Journal of Anaesthesia, 27 June 2025, Editorial, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900340-X/fulltext)
8. Radiologic evaluation of three smaller-sized supraglottic airway device prototypes for low-birth-weight neonates, British Journal of Anaesthesia, 2 July 2025,Correspondence, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900354-X/abstract)
9. The Single Child With a Single Ventricle, Anesthesia & Analgesia, 2 July 2025, Commentary, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/the%5Fsingle%5Fchild%5Fwith%5Fa%5Fsingle%5Fventricle.1351.aspx)
10. Cognitive errors in paediatric difficult airway management: a step into the unknown, British Journal of Anaesthesia, 27 June 2025, Commentary, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900340-X/fulltext)
11. Radiologic evaluation of three smaller-sized supraglottic airway device prototypes for low-birth-weight neonates, British Journal of Anaesthesia, 2 July 2025, Correspondence, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900354-X/abstract)
---
### **9-Regional Anesthesia & Pain Management**
1. The GENIFEM Pilot Randomized Trial: Genicular Nerve Block vs Femoral Triangle Block vs Local Infiltration Analgesia for Total Knee Arthroplasty, A&A, 3 July 2025, RCT, [Link](https://journals.lww.com/anesthesia-analgesia/citation/9900/the%5Fgenifem%5Fpilot%5Frandomized%5Ftrial%5F%5Fgenicular.1358.aspx)
2. Parascapular sub-iliocostalis plane block for postoperative analgesia in patients with multiple rib fractures: a randomized controlled trial, BMC Anesthesiology, 1 July 2025, RCT, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03181-0)
3. Ultrasound-assisted technique versus the conventional landmark location method in spinal anesthesia for cesarean delivery in parturients with class 3 obesity: a randomized controlled trial, BMC Anesthesiology, 1 July 2025, RCT, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03176-x)
4. Ultrasound-guided Mandibular Nerve Block Combined with Superficial Cervical Plexus Nerve Block in Patients Undergoing Radical Surgery for Tongue Cancer: A Randomized Controlled Trial, BMC Anesthesiology, 7 July 2025, RCT, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03219-3)
5. Impact of superficial and deep parasternal blocks on recovery after cardiac surgery with sternotomy: a randomised controlled trial, British Journal of Anaesthesia, 9 July 2025, RCT, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900362-9/fulltext)
6. Pharmacokinetic modelling and simulation for prolonged infusion of levobupivacaine with or without epinephrine in transversus abdominis plane and erector spinae plane blocks: a randomised controlled trial and analysis of pooled data, British Journal of Anaesthesia, 9 July 2025, RCT, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900368-X/fulltext)
7. Erector Spinae Plane Block in Multimodal Analgesia After Lumbar Spinal Fusion Surgery: A Blinded Randomized Placebo-Controlled Trial, Anesthesia & Analgesia, 2 July 2025, RCT, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/erector%5Fspinae%5Fplane%5Fblock%5Fin%5Fmultimodal%5Fanalgesia.1352.aspx)
8. Erector Spinae Plane Block in Multimodal Analgesia After Lumbar Spinal Fusion Surgery: A Blinded Randomized Placebo-Controlled Trial, Anesthesia & Analgesia, 2 July 2025, RCT, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/erector%5Fspinae%5Fplane%5Fblock%5Fin%5Fmultimodal%5Fanalgesia.1352.aspx)
9. Anterior quadratus lumborum block is superior to erector spinae plane block for analgesia after renal transplantation: a randomized controlled trial, BMC Anesthesiology, 10 July 2025, RCT, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03209-5)
10. Efficacy of Peripheral Cutaneous Nerve (PCN) on postoperative pain and functional outcome after total knee arthroplasty: a single-blind, randomized controlled clinical trial, BMC Anesthesiology, 1 July 2025, RCT, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03182-z)
11. The History of Ultrasound-guided Regional Anesthesia, Anesthesiology, 1 July 2025, Review, [Link](https://journals.lww.com/anesthesiology/fulltext/9900/the%5Fhistory%5Fof%5Fultrasound%5Fguided%5Fregional.709.aspx)
12. PECS blocks: where are we now?, Current Opinion in Anesthesiology, July 8, 2025, Review, [Link](https://journals.lww.com/co-anesthesiology/fulltext/9900/pecs%5Fblocks%5F%5Fwhere%5Fare%5Fwe%5Fnow%5F.331.aspx)
13. Regional Anesthetic Techniques in Chronic Obstructive Pulmonary Disease Patients, A&A Practice, July 2025, Review, [Link](https://journals.lww.com/aacr/fulltext/2025/07000/regional%5Fanesthetic%5Ftechniques%5Fin%5Fchronic.10.aspx)
14. The History of Ultrasound-guided Regional Anesthesia, Anesthesiology, 1 July 2025, Review, [Link](https://journals.lww.com/anesthesiology/fulltext/9900/the%5Fhistory%5Fof%5Fultrasound%5Fguided%5Fregional.709.aspx)
15. Ilioinguinal, Iliohypogastric, and Quadratus Lumborum Blocks for the Treatment of Chronic Pelvic Pain from Endometriosis: A Case Report, A&A Practice, July 2025, Case Report, [Link](https://journals.lww.com/aacr/fulltext/2025/07000/ilioinguinal,%5Filiohypogastric,%5Fand%5Fquadratus.8.aspx)
16. Perineural Blocks: Ropivacaine 0.2% Can Provide Surgical Anesthesia: A Case Report, A&A Practice, July 2025, Case Report, [Link](https://journals.lww.com/aacr/fulltext/2025/07000/perineural%5Fblocks%5F%5Fropivacaine%5F0%5F2%5F%5Fcan%5Fprovide.12.aspx)
17. Regional Anesthesia in Brugada Syndrome—Worth the Risk? A Dual-Case Report, A&A Practice, July 2025, Case Report, [Link](https://journals.lww.com/aacr/fulltext/2025/07000/regional%5Fanesthesia%5Fin%5Fbrugada%5Fsyndrome%5Fworth%5Fthe.9.aspx)
18. Utility of AI-based nerve recognition (cNerve) in difficult-to-image patients, British Journal of Anaesthesia, 1 July 2025, Correspondence, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900356-3/fulltext)
19. Letter to the Editor: Hyperbaric Oxygen, The Clinical Journal of Pain, 3 July 2025, Letter to Editor, [Link](https://journals.lww.com/clinicalpain/fulltext/9900/letter%5Fto%5Fthe%5Feditor%5Fhyperbaric%5Foxygen.268.aspx)
20. Reply to Letter to the Editor Regarding Hyperbaric Oxygen Therapy (HBOT) for Management of Complex Regional Pain Syndrome, The Clinical Journal of Pain, 3 July 2025, Letter to Editor, [Link](https://journals.lww.com/clinicalpain/fulltext/9900/reply%5Fto%5Fletter%5Fto%5Fthe%5Feditor%5Fregarding%5Fhyperbaric.266.aspx)
21. Utility of AI-based nerve recognition (cNerve) in difficult-to-image patients, British Journal of Anaesthesia, 1 July 2025, Correspondence, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900356-3/fulltext)
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# **Critical Care:**
### 1-AI:
1. Implementing Artificial Intelligence in Critical Care Medicine: a consensus of 22, Critical Care, 8 July 2025, Guidelines, [Link](https://ccforum.biomedcentral.com/articles/10.1186/s13054-025-05532-2)
2. Application progress of machine learning in patient-ventilator asynchrony during mechanical ventilation: a systematic review, *Critical Care*, 10 July 2025, Systematic Review and Meta-analysis, [Link](https://ccforum.biomedcentral.com/articles/10.1186/s13054-025-05523-3)
3. Role of artificial intelligence in ICU therapeutic decision-making for severe infections, Current Opinion in Critical Care, 7 July 2025, Review, [Link](https://journals.lww.com/co-criticalcare/fulltext/9900/role%5Fof%5Fartificial%5Fintelligence%5Fin%5Ficu%5Ftherapeutic.284.aspx)
4. AI ethics for the everyday intensivist, Critical Care and Resuscitation, June 2025, Point of view, [Link](https://www.sciencedirect.com/science/article/pii/S1441277225000195)
---
### **2-Cardiovascular & Hemodynamics:**
1. Invasive Versus Conservative Management Among Older Adult Patients With Non–ST‐Segment–Elevation Myocardial Infarction: A Meta‐Analysis of Randomized Controlled Trials, AHA, 14 July 2025, Systematic Review and Meta-analysis, [Link](https://www.ahajournals.org/doi/10.1161/JAHA.124.039601)
2. Long-term functional outcomes and health-related quality of life following in-hospital cardiac arrest (IHCA): A systematic review, *Resuscitation*, September 2025, Systematic Review and Meta-analysis, [Link](https://www.sciencedirect.com/science/article/pii/S0300957225001856)
3. Selective Serotonin Reuptake Inhibitors Increase Gastrointestinal but Not Other Site Bleeding Risk in Left Ventricular Assist Device Patients: A Systematic Review and Meta-Analysis, Journal of Cardiothoracic and Vascular Anesthesia, 16 July 2025, Systematic Review and Meta-Analysis, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025005828)
4. A randomised, controlled, feasibility trial comparing vasopressors infused via peripheral cannula versus central venous access for critically ill adults: The VIPCA trial, Critical Care and Resuscitation, June 2025, RCT, [Link](https://www.sciencedirect.com/science/article/pii/S1441277225000109)
5. Comparison of the Incidence of Arterial Pressure Line Insufficiency Between Polyethylene and Polyurethane Catheters in the ICU: A Randomized Study, *Critical Care Medicine*, 16 July 2025, RCT, [Link](https://journals.lww.com/ccmjournal/fulltext/9900/comparison%5Fof%5Fthe%5Fincidence%5Fof%5Farterial%5Fpressure.563.aspx)
6. Cardiac index, SvO2 or pCO2 gap may determine benefit from ECMO in cardiogenic shock: post-hoc analysis of the multicenter, randomized ECMO-CS trial, *Critical Care*, 14 July 2025, RCT, [Link](https://ccforum.biomedcentral.com/articles/10.1186/s13054-025-05513-5)
7. Endotoxin removal by the OXIRIS filter for cardiogenic shock requiring veno-arterial extra-corporeal life support: the ECMORIX randomized controlled trial, Annals of Intensive Care, 8 July 2025, RCT, [Link](https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-025-01499-z)
8. Cardiac Rhythm Conversions and the Outcome in Refractory Out-of-Hospital Cardiac Arrest: Extracorporeal Versus Conventional Resuscitation, *Critical Care Medicine*, 16 July 2025, RCT!, [Link](https://journals.lww.com/ccmjournal/fulltext/9900/cardiac%5Frhythm%5Fconversions%5Fand%5Fthe%5Foutcome%5Fin.564.aspx)
9. Cardiogenic shock syndrome unraveled: understanding the different layers of heterogeneity, Intensive Care Medicine, 14 July 2025, Review, [Link](https://link.springer.com/article/10.1007/s00134-025-08021-w)
10. When blood purification meets cardiogenic shock: exploring new perspectives on inflammatory clearance from CLEAN ECMO's null results, *Critical Care*, 14 July 2025, Correspondence, [Link](https://ccforum.biomedcentral.com/articles/10.1186/s13054-025-05549-7)
11. Cardiac arrest from neurological causes: for whom the brain tolls, *Resuscitation*, September 2025, Editorial, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0300957225001819)
12. Toward data-driven prognostication after cardiac arrest, *Resuscitation*, September 2025, Editorial, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0300957225001820)
13. The apnea interval in OHCA – A potential modifiable factor in resuscitation outcomes, *Resuscitation*, September 2025, Editorial, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0300957225001224)
14. Time for consensus: establishing core outcomes meaningful to survivors of out-of-hospital cardiac arrest, *Resuscitation*, September 2025, Editorial, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0300957225001972)
15. Malperfusion in Acute Type A Dissection – understanding and managing the full implications of the Penn Classification beyond mortality, *Journal of Cardiothoracic and Vascular Anesthesia*, 9 July 2025, Editorial, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025005646)
16. Beyond survival: the societal value of extracorporeal cardiopulmonary resuscitation, *Critical Care*, 10 July 2025, Matters Arising, [Link](https://ccforum.biomedcentral.com/articles/10.1186/s13054-025-05561-x)
17. Mesenteric ischemia after cardiac arrest: this sneaky and invisible enemy, *Resuscitation*, September 2025, Editorial, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0300957225001807)
18. Prehospital thrombolytic treatment of high-risk acute pulmonary embolism, Critical Care, 7 July 2025, Correspondence, [Link](https://ccforum.biomedcentral.com/articles/10.1186/s13054-025-05465-w)
19. Co-existence of congestion and preload-dependence identified by pulse pressure respiratory variations: right ventricular afterload might be the key, Critical Care, 1 July 2025, Editorial, [Link](https://ccforum.biomedcentral.com/articles/10.1186/s13054-025-05440-5)
20. Reply to: Co-existence of congestion and preload-dependence identified by pulse pressure respiratory variations: right ventricular afterload might be the key, Critical Care, 4 July 2025, Editorial, [Link](https://ccforum.biomedcentral.com/articles/10.1186/s13054-025-05497-2)
21. Combined RV Dysfunction and PVR Elevation: An Underappreciated Red Flag in Emergency Sepsis Care, Journal of Cardiothoracic and Vascular Anesthesia, 30 June 2025, Letter to the Editor, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025005476)
22. Context-Dependent Nature of the Obesity Paradox in Cardiac Events, Resuscitation, 01 July 2025, Correspondence, [Link](https://www.sciencedirect.com/science/article/abs/pii/S030095722500214X)
---
### **3-**Thorax**/**Lungs/Airways/Mechanical ventilation:
1. Application progress of machine learning in patient-ventilator asynchrony during mechanical ventilation: a systematic review, *Critical Care*, 10 July 2025, Systematic Review and Meta-analysis, [Link](https://ccforum.biomedcentral.com/articles/10.1186/s13054-025-05523-3)
2. Effects of different respiratory training methods on respiratory function in patients with spinal cord injury: a network meta-analysis of randomized controlled trials, Critical Care, 7 July 2025, Systematic Review and Meta-analysis, [Link](https://ccforum.biomedcentral.com/articles/10.1186/s13054-025-05535-z)
3. Effect of pretreatment opioids on hemodynamics during emergency intubations: a systematic review, European Journal of Emergency Medicine, 7 July 2025, Systematic Review and Meta-analysis, [Link](https://journals.lww.com/euro-emergencymed/fulltext/9900/effect%5Fof%5Fpretreatment%5Fopioids%5Fon%5Fhemodynamics.185.aspx)
4. Modified Cuff Leak Test for Predicting the Risk of Reintubation in Patients With Invasive Mechanical Ventilation: A Multicenter, Single-Anonymized, Randomized Controlled Trial, chest, July 2025, RCT, [Link](https://journal.chestnet.org/article/S0012-3692%2825%2900146-1/abstract)
5. Comparison of the effects of esketamine/midazolam and remifentanil/midazolam on respiratory mechanics in mechanically ventilated patients with acute respiratory distress syndrome, BMC Anesthesiology, 5 July 2025, RCT, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03211-x)
6. Comparison of Tolerance of 4 Interfaces for Preventive Non Invasive Ventilation After Abdominal Surgery in Intensive Care Units Assessed by Patients and Caregivers: A Prospective Randomized Cross-Over Study, Anaesthesia Critical Care & Pain Medicine, 1 July 2025, RCT, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556825001195)
7. Prehospital Management of the Airway in Trauma, BJA Education, 30 June, Review, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900052-6/fulltext)
8. Airway Management in Critically Ill Patients, BJA Education, 30 June 2025, Review, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900053-8/fulltext)
9. Acute respiratory distress syndrome: new pathophysiological insights, Current Opinion in Critical Care, 8 July 2025, Review, [Link](https://journals.lww.com/co-criticalcare/fulltext/9900/acute%5Frespiratory%5Fdistress%5Fsyndrome%5F%5Fnew.285.aspx)
10. Imaging and pulmonary function techniques in ARDS diagnosis and management: current insights and challenges, Critical Care, 6 July, Review, [Link](https://ccforum.biomedcentral.com/articles/10.1186/s13054-025-05520-6)
11. Ventilator-associated pneumonia: how long is long enough?, Current Opinion in Critical Care, 8 July 2025, Review, [Link](https://journals.lww.com/co-criticalcare/fulltext/9900/ventilator%5Fassociated%5Fpneumonia%5F%5Fhow%5Flong%5Fis%5Flong.283.aspx)
12. Crosstalk between lung and extrapulmonary organs in sepsis-related acute lung injury/acute respiratory distress syndrome, *Annals of Intensive Care*, 14 July 2025, Review, [Link](https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-025-01513-4)
13. Rheological theory of ergotrauma: a good explanation for VILI, chest critical care, 05 July 2025, Editorial, [Link](https://www.sciencedirect.com/science/article/pii/S2949788425000632)
14. How should spontaneous breathing trials be performed in the light of recent literature?, *Annals of Intensive Care*, 16 July 2025, Editorial, [Link](https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-025-01507-2)
15. Is high flow nasal therapy still warranted for patients with AECOPD and acute hypercapnic respiratory failure?, Annals of Intensive Care, 7 July 2025, Letter to the editor, [Link](https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-025-01511-6)
16. What should be done with PEEP during weaning from mechanical ventilation?, Critical Care, 7 July 2025, Editorial, [Link](https://ccforum.biomedcentral.com/articles/10.1186/s13054-025-05542-0)
17. Endotracheal Tube Obstruction: New insights into an old problem, CHEST Critical Care, 07 July 2025, Editorial, [Link](https://www.chestcc.org/article/S2949-7884%2825%2900064-4/fulltext)
18. High-Flow Nasal Therapy Versus Non-Invasive Ventilation for AECOPD: Navigating Beyond a Simple Choice– Are We Asking the Right Questions??, Annals of Intensive Care, 2 July 2025, Letter to editor, [Link](https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-025-01510-7)
19. Watch Out For Postoperative Pulmonary Complications After Emergency Abdominal Surgery!, Anaesthesia Critical Care & Pain Medicine, 01 July 2025, Editorial, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556825001158)
20. Limitations of SpO2-based Oxygenation Indices in ARDS and PARDS Severity Classification, Critical Care, 3 July 2025, Correspondence, [Link](https://ccforum.biomedcentral.com/articles/10.1186/s13054-025-05406-7)
21. Predicted bodyweight—a misleading metric for tidal volume titration?, The Lancet Respiratory Medicine, 15 July 2025, commentary, [Link](https://www.thelancet.com/journals/lanres/article/PIIS2213-2600%2825%2900134-1/abstract)
22. Consensus on quantitative lung ultrasound: are experts moving ahead of evidence?, 14 July 2025, correspondence, [Link](https://link.springer.com/article/10.1007/s00134-025-08017-6)
23. Consensus on quantitative lung ultrasound: Are experts moving ahead of evidence? Author’s reply, 14 July 2025, correspondence, [Link](https://link.springer.com/article/10.1007/s00134-025-08032-7)
---
### **4-Neuro-muscular:**
1. Effect of blood pressure threshold on adverse outcomes in patients with acute spinal cord injury: a systematic review and meta-analysis, Critical Care, 16 July 2025, Systematic Review and Meta-analysis, [Link](https://ccforum.biomedcentral.com/articles/10.1186/s13054-025-05531-3)
2. Neuroimaging for prognosis of central nervous system infections: a systematic review and meta-analysis, *Annals of Intensive Care*, 16 July 2025, Systematic Review and Meta-analysis, [Link](https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-025-01516-1)
3. The Efficacy and Safety of Glibenclamide in Improving Cerebral Edema and Neurological Outcomes in Stroke: a GRADE-Evaluated Systematic Review and Meta-analysis with Subgroup Analysis, Neurocritical Care, 8 July 2025, Systematic Review and Meta-analysis, [Link](https://link.springer.com/article/10.1007/s12028-025-02311-3)
4. Noninvasive Neuromodulation for Disorders of Consciousness: An Updated Systematic Review and Meta-Analysis, Critical Care, 3 July 2025, Systematic Review and Meta-analysis, [Link](https://ccforum.biomedcentral.com/articles/10.1186/s13054-025-05429-0)
5. Biomarkers for Intensive Care Unit-Acquired Weakness: A Systematic Review for Prediction, Diagnosis and Prognosis, Annals of Intensive Care, 2 July 2025, Systematic Review and Meta-analysis, [Link](https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-025-01500-9)
6. Remote Ischemic Preconditioning to Prevent Delayed Cerebral Ischemia Due to Vasospasm in the Treatment of Patients with Aneurysmal Subarachnoid Hemorrhage, Neurocritical Care, 15 July 2025, RCT, [Link](https://link.springer.com/article/10.1007/s12028-025-02324-y)
7. Fludrocortisone to treat patients with aneurysmal subarachnoid haemorrhage: Protocol for an international, phase 3, randomised, placebo-controlled, multicentre trial, Critical Care and Resuscitation, June 2025, RCT, [Link](https://www.sciencedirect.com/science/article/pii/S1441277225000134)
8. Guillain–Barré syndrome, *BJA Education*, August 2025, Review, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900046-0/fulltext)
9. Clinical heterogeneity and phenotyping of post cardiac arrest brain injury: one size may not fit all, Intensive Crae Medicine, 16 July 2025, Review, [Link](https://link.springer.com/article/10.1007/s00134-025-08012-x)
10. Reconsidering the symmetric assumption in CPP–PRx modeling for traumatic brain injury, *Critical Care*, 14 July 2025, Correspondence, [Link](https://ccforum.biomedcentral.com/articles/10.1186/s13054-025-05551-z)
11. Cerebral Autoregulation in Traumatic Brain Injury: Looking Upwards, Critical Care, 1 July 2025, Editorial, [Link](https://ccforum.biomedcentral.com/articles/10.1186/s13054-025-05489-2)
12. Too Severe to Save? Association Between the Timing of Decompressive Craniectomy and Mortality in Pediatric Traumatic Brain Injury Using the German Hospital Database, Critical Care, 1 July 2025, Correspondence, [Link](https://ccforum.biomedcentral.com/articles/10.1186/s13054-025-05488-3)
13. Additional Considerations on “Individualized ICP and CPP Targets in Severe CVT”: Comment to the Editor, Journal of Neurosurgical Anesthesiology, 27 June 2025, Correspondence, [Link](https://journals.lww.com/jnsa/fulltext/9900/additional%5Fconsiderations%5Fon%5F%5Findividualized%5Ficp.162.aspx)
14. Response to Letter to the Editor for: “The Pupillary Light-Off Reflex in Acute Disorders of Consciousness”, Neurocritical Care, 8 July 2025, Letter To The Editor, [Link](https://link.springer.com/article/10.1007/s12028-025-02318-w)
15. Comment on “The Pupillary Light-Off Reflex in Acute Disorders of Consciousness”, Neurocritical Care, 8 July 2025, Commentary, [Link](https://link.springer.com/article/10.1007/s12028-025-02317-x)
---
### **5-Renal:**
1. Liberation from continuous renal replacement therapy due to renal recovery in adults and children: a literature review and Delphi consensus on clinical practice, Critical Care, 8 July 2025, Guidelines, [Link](https://ccforum.biomedcentral.com/articles/10.1186/s13054-025-05517-1)
1. Renal replacement therapy in an intensive care unit: guidelines from the SRLF-GFRUP consensus conference, *Annals of Intensive Care*, 16 July 2025, Guidelines, [Link](https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-025-01517-0)
2. Effects of dapagliflozin on urinary output, fluid balance, and biochemistry in critically ill patients: a post-hoc secondary analysis of the DEFENDER trial, *Critical Care*, 11 July 2025, RCT, [Link](https://ccforum.biomedcentral.com/articles/10.1186/s13054-025-05534-0)
3. Study protocol and statistical plan for the ICRAKI trial: Intermittent haemodialysis versus continuous renal replacement therapy for severe acute kidney injury in critically ill patients, Critical Care and Resuscitation, June 2025, RCT, [Link](https://www.sciencedirect.com/science/article/pii/S1441277225000110)
4. Preventing acute kidney injury and its longer-term impact in the critically ill, Intensive Care Medicine, 15 July 2025, Review, [Link](https://link.springer.com/article/10.1007/s00134-025-08015-8)
5. Renal tubular epithelial cells: A revived kidney biomarker?, Intensive Care Medicine, 30 June 2025, Editorial, [Link](https://link.springer.com/article/10.1007/s00134-025-07988-w)
6. Kidney replacement therapy in critically ill obese patients: an urgent call for precision and evidence-based practice!, Intensive Care Medicine, 14 July 2025, Editorial, [Link](https://link.springer.com/article/10.1007/s00134-025-08028-3)
---
### **6-Trauma:**
1. Parascapular sub-iliocostalis plane block for postoperative analgesia in patients with multiple rib fractures: a randomized controlled trial, BMC Anesthesiology, 1 July 2025, RCT, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03181-0)
2. Reconsidering the symmetric assumption in CPP–PRx modeling for traumatic brain injury, *Critical Care*, 14 July 2025, Correspondence, [Link](https://ccforum.biomedcentral.com/articles/10.1186/s13054-025-05551-z)
3. Postdischarge venous thromboembolism after trauma: Extending care beyond hospital walls, *Journal of Trauma and Acute Care Surgery*, 17 July 2025, Letter to the editor, [Link](https://journals.lww.com/jtrauma/fulltext/9900/postdischarge%5Fvenous%5Fthromboembolism%5Fafter%5Ftrauma%5F.1078.aspx)
---
### **7-Liver:**
1. Acute-on-chronic liver failure, *BJA Education*, 15 July 2025, Review, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900054-X/fulltext)
---
### **8-Digestive:**
1. Selective Serotonin Reuptake Inhibitors Increase Gastrointestinal but Not Other Site Bleeding Risk in Left Ventricular Assist Device Patients: A Systematic Review and Meta-Analysis, Journal of Cardiothoracic and Vascular Anesthesia, 16 July 2025, Systematic Review and Meta-Analysis, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025005828)
2. Early versus delayed catheter drainage for patients with necrotizing pancreatitis and early persistent organ failure (TIMING): a multicenter randomized controlled trial, Intensive Care Medicine, 14 July 2025, RCT, [Link](https://link.springer.com/article/10.1007/s00134-025-08020-x)
3. Gastrointestinal function and nutritional interventions in septic shock, *Current Opinion in Critical Care*, 9 July 2025, Review, [Link](https://journals.lww.com/co-criticalcare/fulltext/9900/gastrointestinal%5Ffunction%5Fand%5Fnutritional.287.aspx)
4. Mesenteric ischemia after cardiac arrest: this sneaky and invisible enemy, *Resuscitation*, September 2025, Editorial, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0300957225001807)
---
### **9-Endocrine and Metabolic:**
1. Hyperglycemia and insulin use in patients with COVID-19 and severe hypoxemia allocated to 12 mg vs. 6 mg of dexamethasone: a secondary analysis of the COVID STEROID 2 randomized trial, *Annals of Intensive Care*, 15 July 2025, RCT!, [Link](https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-025-01512-5)
2. Protocol summary and statistical analysis plan for the sodium bicarbonate for metabolic acidosis in the intensive care unit (SODa-BIC) trial, Critical Care and Resuscitation, June 2025, RCT!, [Link](https://www.sciencedirect.com/science/article/pii/S1441277225000122)
---
### **10-Blood & hemostasis:**
1. Thrombotic thrombocytopenic purpura: early diagnosis and effective treatment in 2025, Intensive Care Medicine, 30 June 2025, Review, [Link](https://link.springer.com/article/10.1007/s00134-025-07981-3)
2. Venous thromboprophylaxis in the ICU: navigating evidence, risk, and practice gaps, Intensive Care Medicine, 16 July 2025, Editorial, [Link](https://link.springer.com/article/10.1007/s00134-025-08009-6)
---
### **11-Nutrition:**
1. Expert consensus‑based clinical practice guidelines for nutritional support in the intensive care unit: the French Intensive Care Society (SRLF) and the French-Speaking Group of Pediatric Emergency Physicians and Intensivists (GFRUP), *Annals of Intensive Care*, 15 July 2025, Guidelines, [Link](https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-025-01509-0)
2. Enteral protein supplementation in critically ill trauma and surgical patients: A single-center randomized clinical trial, *Journal of Trauma and Acute Care Surgery*, 17 July 2025, RCT, [Link](https://journals.lww.com/jtrauma/fulltext/9900/enteral%5Fprotein%5Fsupplementation%5Fin%5Fcritically%5Fill.1080.aspx)
3. Hypocaloric feeding in critically ill trauma patients: A scoping review of the literature, *Journal of Trauma and Acute Care Surgery*, 17 July 2025, Review, [Link](https://journals.lww.com/jtrauma/fulltext/9900/hypocaloric%5Ffeeding%5Fin%5Fcritically%5Fill%5Ftrauma.1084.aspx)
---
### **12-Infectious Diseases:**
1. Cardiac output monitors in septic shock: do they deliver what matters? A systematic review and meta-analysis, Critical care, 12 July 2025, systematic review and meta-analysis, [Link](https://ccforum.biomedcentral.com/articles/10.1186/s13054-025-05547-9)
2. The Effect of Early Fluid Resuscitation on Mortality in Sepsis: A Systematic Review and Meta-Analysis, *Critical Care Medicine*, 10 July 2025, Systematic Review and Meta-analysis, [Link](https://journals.lww.com/ccmjournal/fulltext/9900/the%5Feffect%5Fof%5Fearly%5Ffluid%5Fresuscitation%5Fon.556.aspx)
3. The clinical significance of thrombocytopenia in sepsis and septic shock: a systematic review and meta-analysis, BMC Anesthesiology, 1 July 2025, Systematic Review and Meta-analysis, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03188-7)
4. A gene expression-based approach for the precision use of hydrocortisone in septic shock patients; a secondary analysis of the ADRENAL trial, Critical Care and Resuscitation, June 2025, RCT, [Link](https://www.sciencedirect.com/science/article/pii/S1441277225000134)
5. Combined use of a multiplex PCR and serum procalcitonin to reduce antibiotic exposure in critically ill patients with community-acquired pneumonia: the MULTI-CAP randomized controlled trial, Intensive Care Medicine, 15 July 2025, RCT, [Link](https://link.springer.com/article/10.1007/s00134-025-08014-9)
6. Penicillin allergy assessment and testing: worth the risk in critically ill patients, Intensive Care Medicine, 16 July 2025, Review, [Link](https://link.springer.com/article/10.1007/s00134-025-08034-5)
7. Source control in bloodstream infections in patients with sepsis, septic shock, or requiring ICU admission: a scoping review with recommendations for standardizing research, Intensive Care Medicine, 14 July 2025, Review, [Link](https://link.springer.com/article/10.1007/s00134-025-08026-5)
8. Harnessing adiponectin for sepsis: current knowledge, clinical insights and future therapies, Critical care, 12 July 2025, review, [Link](https://ccforum.biomedcentral.com/articles/10.1186/s13054-025-05516-2)
9. The Sepsis Chain of Survival: A Comprehensive Framework for Improving Sepsis Outcomes, *Critical Care Medicine*, 16 July 2025, Review, [Link](https://journals.lww.com/ccmjournal/fulltext/9900/the%5Fsepsis%5Fchain%5Fof%5Fsurvival%5F%5Fa%5Fcomprehensive.566.aspx)
10. Gastrointestinal function and nutritional interventions in septic shock, *Current Opinion in Critical Care*, 9 July 2025, Review, [Link](https://journals.lww.com/co-criticalcare/fulltext/9900/gastrointestinal%5Ffunction%5Fand%5Fnutritional.287.aspx)
11. Role of artificial intelligence in ICU therapeutic decision-making for severe infections, Current Opinion in Critical Care, 7 July 2025, Review, [Link](https://journals.lww.com/co-criticalcare/fulltext/9900/role%5Fof%5Fartificial%5Fintelligence%5Fin%5Ficu%5Ftherapeutic.284.aspx)
12. Ventilator-associated pneumonia: how long is long enough?, Current Opinion in Critical Care, July 8, 2025, Review, [Link](https://journals.lww.com/co-criticalcare/fulltext/9900/ventilator%5Fassociated%5Fpneumonia%5F%5Fhow%5Flong%5Fis%5Flong.283.aspx)
13. Current Corticosteroid Therapeutic Strategy for Community-Acquired Pneumonia in Adults: Indications, Dosage, and Timing, Journal of Intensive Care, 1 July 2025, Review, [Link](https://jintensivecare.biomedcentral.com/articles/10.1186/s40560-025-00809-8)
14. Corticosteroids in Septic Shock: A Double-Edged Sword, Current Opinion in Critical Care, 27 June 2025, Review, [Link](https://journals.lww.com/co-criticalcare/fulltext/9900/corticosteroids%5Fin%5Fseptic%5Fshock%5F%5Fa%5Fdouble%5Fedged.281.aspx)
15. Optimal Vasopressin Initiation in Septic Shock, *JAMA*, 17 July 2025, Commentary, [Link](https://jamanetwork.com/journals/jama/fullarticle/2836674)
16. Optimal Vasopressin Initiation in Septic Shock—Reply, *JAMA*, 17 July 2025, Commentary, [Link](https://jamanetwork.com/journals/jama/fullarticle/2836673)
17. Assessment of Tissue Perfusion Pressure in Patients With Septic Shock: Beyond Mean Arterial Pressure, *Critical Care Medicine*, 16 July 2025, Review, [Link](https://journals.lww.com/ccmjournal/fulltext/9900/assessment%5Fof%5Ftissue%5Fperfusion%5Fpressure%5Fin.567.aspx)
18. Vascular hyporesponsiveness to norepinephrine is a major but not exclusive determinant of mortality in septic shock, *Annals of Intensive Care*, 14 July 2025, Letter to Editor, [Link](https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-025-01520-5)
19. Combined RV Dysfunction and PVR Elevation: An Underappreciated Red Flag in Emergency Sepsis Care, Journal of Cardiothoracic and Vascular Anesthesia, 30 June 2025, Letter to the Editor, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025005476)
20. Corticosteroids for non-viral community-acquired pneumonia: strengthened evidence amid persistent clinical uncertainties, Intensive Care Medicine, 30 June 2025, correspondence, [Link](https://link.springer.com/article/10.1007/s00134-025-07963-5)
21. OPTPRESS or OPTPRESSIN? Authors' reply, Intensive Care Medicine, 30 June 2025, correspondence, [Link](https://link.springer.com/article/10.1007/s00134-025-08011-y)
22. Hemodynamic targets in the initial resuscitation of older patients with sepsis: time for a reappraisal?, Intensive Care Medicine, 3 July 2025, Editorial, [Link](https://link.springer.com/article/10.1007/s00134-025-08010-z)
---
### **13-Sedation & analgesia:**
1. Melatonin Use in the ICU: A Systematic Review and Meta-Analysis, *Critical Care Medicine*, 15 July 2025, Systematic Review and Meta-analysis, [Link](https://journals.lww.com/ccmjournal/fulltext/9900/melatonin%5Fuse%5Fin%5Fthe%5Ficu%5F%5Fa%5Fsystematic%5Freview%5Fand.561.aspx)
2. The effects of remimazolam and propofol on delirium following anesthesia and sedation in elderly patients: a systematic review and meta-analysis, 1 July 2025, Systematic Review and Meta-analysis, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03167-y)
3. Melatonin for prevention of delirium in patients receiving mechanical ventilation in the intensive care unit: a multiarm multistage adaptive randomized controlled clinical trial (DEMEL), Intensive Care Medicine, 3 July 2025, RCT, [Link](https://link.springer.com/article/10.1007/s00134-025-08002-z)
4. Optimal Sedation and Analgesia in Patients with Polytrauma, Excluding Brain Injury, Critical Care Clinics, 14 July 2025, Review, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070425000466)
5. Monitoring Sedation Depth in Critical Illness, State-of-the-Art Practice, *Critical Care Clinics*, 14 July 2025, Review, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070425000454)
6. Future Directions in Sedation and Analgesia, Critical Care Clinics, 10 July 2025, Review, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070425000429)
7. Pharmacology of Alpha-2 Agonists Applied to Sedation, Sleep, and Analgesia, Critical Care Clinics, 3 July 2025, Review, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070425000417)
---
### 14-Pediatric critical care:
1. Inhaled isoflurane for sedation of mechanically ventilated children in intensive care (IsoCOMFORT): a multicentre, randomised, active-control, assessor-masked, non-inferiority phase 3 trial, The Lancet Respiratory Medicine, 15 July 2025, RCT, [Link](https://www.thelancet.com/journals/lanres/article/PIIS2213-2600%2825%2900203-6/fulltext)
2. The Inconceivable Complexity of Lung Mechanics in Critical Bronchiolitis, *Pediatric Critical Care Medicine*, 16 July 2025, Editorial, [Link](https://journals.lww.com/pccmjournal/fulltext/9900/the%5Finconceivable%5Fcomplexity%5Fof%5Flung%5Fmechanics%5Fin.520.aspx)
3. Response to the correspondence, “Hemodynamic augmentation through abdominal counterpulsation in pediatric resuscitation” by Peng An et al., Resuscitation, 08 July 2025, Correspondence, [Link](https://www.resuscitationjournal.com/article/S0300-9572%2825%2900224-2/fulltext)
4. How Low Should We Go?—Blood Pressure Targets in Pediatric Sepsis, Critical Care Medicine, 2 July 2025, Editorial, [Link](https://journals.lww.com/ccmjournal/fulltext/9900/how%5Flow%5Fshould%5Fwe%5Fgo%5F%5Fblood%5Fpressure%5Ftargets%5Fin.554.aspx)
5. Isoflurane instead of midazolam: is it really first-line?, The Lancet Respiratory Medicine, 15 July 2025, Commentary, [Link](https://www.thelancet.com/journals/lanres/article/PIIS2213-2600%2825%2900245-0/abstract)
---
### **15-Other:**
1. Factors Influencing Quality of Life After Intensive Care: A Systematic Review and Meta-Analysis, *Critical Care Medicine*, 15 July 2025, Systematic Review and Meta-analysis, [Link](https://journals.lww.com/ccmjournal/fulltext/9900/factors%5Finfluencing%5Fquality%5Fof%5Flife%5Fafter.560.aspx)
2. ICU scoring systems: current perspectives and future directions, Current Opinion in Critical Care, 8 July 2025, Review, [Link](https://journals.lww.com/co-criticalcare/fulltext/9900/icu%5Fscoring%5Fsystems%5F%5Fcurrent%5Fperspectives%5Fand.286.aspx)
3. From Risk to Recovery: Predicting Quality of Life After Critical Illness, *Critical Care Medicine*, 16 July 2025, Editorial, [Link](https://journals.lww.com/ccmjournal/fulltext/9900/from%5Frisk%5Fto%5Frecovery%5F%5Fpredicting%5Fquality%5Fof%5Flife.562.aspx)
4. Comment on the CIBCD model for chronic critical illness, Critical Care, 8 July 2025, Commentary, [Link](https://ccforum.biomedcentral.com/articles/10.1186/s13054-025-05471-y)
5. The misunderstood P-value: why statistical significance is not enough in clinical practice. Comment on Br J Anaesth 2025, British Journal of Anaesthesia, 7 July 2025, Commentary, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900367-8/abstract)
6. Missing the target in target trial emulation, Critical Care, 11 July 2025, Commentary, [Link](https://ccforum.biomedcentral.com/articles/10.1186/s13054-025-05515-3)
7. Missing the target in target trial emulation: the authors' reply, Critical Care, 18 July 2025, Commentary, [Link](https://ccforum.biomedcentral.com/articles/10.1186/s13054-025-05567-5)
---
### **Feedback & Suggestions**
Don't hesitate to share your thoughts and suggestions in the comments below; they'll be a great help in improving future issues of the newsletter.
**Disclaimer**
💡
****Disclaimer:**
The is for educational and informational purposes only and is not intended to replace professional medical advice, diagnosis, or treatment.
See you next Friday :)
**Benhalima Othmane.**
**Anecrit.com**
### Anecrit's Newsletter #03
URL: https://www.anecrit.com/newsletter-0327062025/
Last updated: 2025-08-24T14:58:00.000Z
### **Issue #\[03\] | Week of \[20/06/2025\] - \[26/06/2025\]**
**Welcome**
Hey there!
This week, there weren’t many important papers published in our field. Honestly, that’s a good thing, considering there’s already a long list of papers waiting to be read from previous weeks: RCTs, guidelines, and more. So, I hope you take this opportunity to clear your backlog and catch up on your reading.
---
# **Anesthesiology:**
### **Guidelines & Consensus Statements:**
1. Anticoagulant management in emergency settings: 2024 guidelines from the French Society of Emergency Medicine (SFMU), the French Society of Anaesthesia and Intensive Care Medicine (SFAR), the French Society of Thrombosis and Haemostasis (SFTH) and the French Working Group on Perioperative Haemostasis (GIHP)\*, Anaesthesia Critical Care & Pain Medicine, 26 June 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S235255682500116X)
### **Systematic Reviews & Meta-Analyses:**
1. The association between preoperative depression and length of stay after major surgery: a systematic review and meta-analysis, Anesthesiology, 20 June 2025, [Link](https://journals.lww.com/anesthesiology/abstract/9900/the%5Fassociation%5Fbetween%5Fpreoperative%5Fdepression.703.aspx)
2. Impact of Electroencephalography-Guided Anesthesia in Cardiothoracic Surgery: A Systematic Review and Updated Meta-Analysis of Randomized Controlled Trials, Journal of Cardiothoracic and Vascular Anesthesia, 25 June 2025, [Link](https://www.sciencedirect.com/science?%5Fob=GatewayURL&%5Fmethod=citationSearch&%5Fversion=1&%5Fpiikey=S105307702500535X&%5Forigin=RV%5FSD%5FAIP%5FEMAIL)
3. Dexmedetomidine for delirium prevention after cardiac surgery: an updated systematic review and meta-analysis with trial sequential analysis, Anaesthesia Critical Care & Pain Medicine, 24 June 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556825001109)
### **Randomized Controlled Trials (RCTs):**
1. Nefopam for analgesia following cardiac surgery: A randomized placebo-controlled double-blind clinical trial, Journal of Cardiothoracic and Vascular Anesthesia, 23 June 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025005312)
2. Association of plasma biomarkers of lung injury with positive end expiratory pressure and postoperative pulmonary complications in obese surgical patients: A substudy of the PROBESE randomised controlled trial, European Journal of Anaesthesiology, 23 June 2025, [Link](https://journals.lww.com/ejanaesthesiology/fulltext/9900/association%5Fof%5Fplasma%5Fbiomarkers%5Fof%5Flung%5Finjury.314.aspx)
3. Comparison of different bolus delivery speeds of a programmed intermittent epidural bolus combined with dural puncture epidural block during labour analgesia: A randomised controlled study, European Journal of Anaesthesiology, 23 June 2025, [Link](https://journals.lww.com/ejanaesthesiology/fulltext/9900/comparison%5Fof%5Fdifferent%5Fbolus%5Fdelivery%5Fspeeds%5Fof%5Fa.313.aspx)
4. Erector spinae plane block versus intercostal nerve blocks in uniportal videoscopic assisted thoracic surgery: a multicenter, double-blind, prospective randomized placebo controlled trial, Anesthesiology, 20 June 2025, [Link](https://journals.lww.com/anesthesiology/abstract/9900/erector%5Fspinae%5Fplane%5Fblock%5Fversus%5Fintercostal.704.aspx)
### **Reviews**
1. Shared decision-making for older adults in the peri-operative setting: A narrative review, European Journal of Anaesthesiology, 24 June 2025, [Link](https://journals.lww.com/ejanaesthesiology/fulltext/9900/shared%5Fdecision%5Fmaking%5Ffor%5Folder%5Fadults%5Fin%5Fthe.316.aspx)
2. Identification, Evaluation And Management Of Perioperative Right Ventricular Dysfunction In Noncardiac Surgery: A Multimodal Approach, Journal of Cardiothoracic and Vascular Anesthesia, 22 June 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025005300)
3. The Year in Aortic Surgery: Selected Highlights from 2024, Journal of Cardiothoracic and Vascular Anesthesia, 20 June 2025, [Link](https://www.sciencedirect.com/science?%5Fob=GatewayURL&%5Fmethod=citationSearch&%5Fversion=1&%5Fpiikey=S1053077025004963&%5Forigin=RV%5FSD%5FAIP%5FEMAIL&dgcid=raven%5Fsd%5Faip%5Femail)
4. Brain ultrasonography in neurosurgical patients, Current Opinion in Anesthesiology, 24 June 2025, [Link](https://journals.lww.com/co-anesthesiology/fulltext/9900/brain%5Fultrasonography%5Fin%5Fneurosurgical%5Fpatients.328.aspx)
5. Update on scalp nerve block for craniotomy, Current Opinion in Anesthesiology, 24 June 2025, [Link](https://journals.lww.com/co-anesthesiology/fulltext/9900/update%5Fon%5Fscalp%5Fnerve%5Fblock%5Ffor%5Fcraniotomy.327.aspx)
6. Fasting and nutrition in neuroanesthesia and neurocritical care patients, Current Opinion in Anesthesiology, 24 June 2025, [Link](https://journals.lww.com/co-anesthesiology/fulltext/9900/fasting%5Fand%5Fnutrition%5Fin%5Fneuroanesthesia%5Fand.326.aspx)
### **Editorials/Commentaries:**
1. Frailty in the perioperative setting: lessons from SNAP-3, British Journal of Anaesthesia, 2025, Editorial, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900336-8/fulltext)
2. Frailty and perioperative outcomes: SNAP-3 as a call to action, British Journal of Anaesthesia, In Press, Editorial, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900341-1/fulltext)
3. Morphine and Cardioprotection in a Failing Heart: Are Opioids A Friend, Foe, or Both?, Anesthesia & Analgesia, June 25, 2025, Letter to editor, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/morphine%5Fand%5Fcardioprotection%5Fin%5Fa%5Ffailing%5Fheart%5F.1345.aspx)
4. Differential nerve block: axons are not all the same, nor are local anaesthetics, British Journal of Anaesthesia, In Press, Correspondence, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900337-X/fulltext)
5. Gaps in Personalizing Anesthetic Drug Delivery During Cardiopulmonary Bypass, Anesthesia & Analgesia, June 25, 2025, Editorial, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/gaps%5Fin%5Fpersonalizing%5Fanesthetic%5Fdrug%5Fdelivery.1348.aspx)
6. From Anecdote to Evidence, the FARES II Trial, Journal of Cardiothoracic and Vascular Anesthesia, 21 June 2025, Editorial, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025004987)
7. Malignant Hyperthermia and Genetic Variability: A Complex Interaction, Anaesthesia Critical Care & Pain Medicine, 24 June 2025, Letter to the editor, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556825001092)
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# **Critical Care:**
### **Systematic Reviews & Meta-Analyses:**
1. Effects of intravenous paracetamol on mean arterial pressure in critically ill patients: A systematic review and meta-analysis with trial sequential analysis, Anaesthesia Critical Care & Pain Medicine, 25 June 2025, [Link](https://www.sciencedirect.com/science/article/pii/S2352556825001110)
2. Does cardiopulmonary resuscitation before donor death affect solid organ transplant function? A systematic review and *meta*\-analysis, Resuscitation, August 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0300957225001662)
3. Surgical ICU Admission Criteria: A Scoping Review, Critical Care Explorations, July 2025, [Link](https://journals.lww.com/ccejournal/fulltext/2025/07000/surgical%5Ficu%5Fadmission%5Fcriteria%5F%5Fa%5Fscoping%5Freview.1.aspx)
### **Randomized Controlled Trials (RCTs):**
1. Impact of awake prone positioning duration on intubation or mortality in COVID-19 patients with acute respiratory failure: secondary analysis of a randomized clinical trial, Annals of Intensive Care, 23 June 2025, [Link](https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-025-01501-8)
2. The effects of extracorporeal blood purification (oXiris®) in patients with cardiogenic shock who require VA-ECMO (CLEAN ECMO): a prospective, open-label, randomized controlled pilot study, Critical Care, 20 June 2025, [Link](https://ccforum.biomedcentral.com/articles/10.1186/s13054-025-05495-4)
### **Reviews**
1. Renal replacement therapy, Intensive care medicine, 25 June 2025, [Link](https://link.springer.com/article/10.1007/s00134-025-07987-x)
2. Central venous pressure: current uses and prospects for an old parameter, Intensive care medicine, 25 June 2025, [Link](https://link.springer.com/article/10.1007/s00134-025-07975-1)
3. Optimal Sedation and Analgesia for Critical Care Patients with Acute Brain Injury Including Post-Cardiac Arrest, Critical Care Clinics, 23 June 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070425000399)
4. Translational Insights Into Pericyte-Mediated Regulation of Cerebral Blood Flow: Implications for Ischemic Stroke, Stroke, 25 June 2025, [Link](https://doi.org/10.1161/STROKEAHA.125.052018)
5. Analgesia First in Critically Ill Adults: Current Practices and Future Directions, Critical Care Clinics, 23 June 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0749070425000363)
6. Diagnosis and management of cardiogenic shock, Current Opinion in Critical Care, 24 June 2025, [Link](https://journals.lww.com/co-criticalcare/fulltext/9900/diagnosis%5Fand%5Fmanagement%5Fof%5Fcardiogenic%5Fshock.280.aspx)
### **Editorials/Commentaries:**
1. Beyond delegation: on the reflective transformation of clinical practice in the age of artificial intelligence, Intensive Care Medicine, 25 June 2025, Correspondence, [Link](https://link.springer.com/article/10.1007/s00134-025-08006-9)
2. High versus low positive end-expiratory pressure during noninvasive ventilation for hypoxemic respiratory failure: balancing efficacy and lung protection—author’s reply, Intensive Care Medicine, 26 June 2025, Correspondence, [Link](https://link.springer.com/article/10.1007/s00134-025-07982-2)
3. High mean arterial pressure (MAP) targets in septic shock: one size does not fit all. Authors’ reply, Intensive Care Medicine, 26 June 2025, Correspondence, [Link](https://link.springer.com/article/10.1007/s00134-025-07997-9)
4. Preoxygenation strategies for endotracheal intubation in resource-limited settings: reframing the basics, Critical Care, 23 June 2025, Editorial, [Link](https://ccforum.biomedcentral.com/articles/10.1186/s13054-025-05508-2)
5. Tocilizumab in improving the hemodynamics of septic children with vasoplegia shock, Critical Care, 20 June 2025, Correspondence, [Link](https://pmc.ncbi.nlm.nih.gov/articles/PMC12181828/)
6. Young ERC Masterclass Journal Club Article: The TOMAHAWK trial, Resuscitation Plus, 25 June 2025, Commentary, [Link](https://www.sciencedirect.com/science/article/pii/S2666520425001523)
### **Feedback & Suggestions**
Don't hesitate to share your thoughts and suggestions in the comments below; they'll be a great help in improving future issues of the newsletter.
**Disclaimer**
💡
****Disclaimer:**
The is for educational and informational purposes only and is not intended to replace professional medical advice, diagnosis, or treatment.
See you next week :)
**Benhalima Othmane.**
**Anecrit.com**
### Anecrit's Newsletter #02
URL: https://www.anecrit.com/anecrit-newsletter-02/
Last updated: 2025-08-24T14:58:30.000Z
**Anecrit's Newsletter**
**Weekly Digest of New Publications: Anesthesiology & Critical Care**
**Issue #\[02\] | Week of \[05/06/2025\] - \[19/06/2025\]**
**Welcome**
Hey there!
It's been a little while, I know! I didn't get last week's newsletter out because, well, us clinicians are often swamped, especially when a night shift lands right before publication day. But, good news – the past two weeks have been fantastic for new literature, with some really important and highly anticipated papers, including multiple RCTs in big journals like NEJM and JAMA.
I hope you enjoy this issue! I'd love to hear any suggestions or thoughts you have. And please, feel free to share the newsletter with anyone you think could find it valuable!
#### **Featured Articles**
1. **Effect of Remote Ischemic Preconditioning on Myocardial Injury in Noncardiac Surgery: The PRINCE Randomized Clinical Trial, *Circulation*, 14 Jun 2025, RCT,** [**Link**](https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.125.075254)
2. **A Randomized Trial of Acute Normovolemic Hemodilution in Cardiac Surgery, NEJM, 12 June 2025,** [**Link**](https://www.nejm.org/doi/full/10.1056/NEJMoa2504948)
3. **Augmented enteral protein during critical illness: the TARGET protein randomized clinical trial, JAMA, 11 JUNE 2025,** [**Link**](https://jamanetwork.com/journals/jama/article-abstract/2835302)
4. **Conservative Oxygen Therapy in Mechanically Ventilated Critically Ill Adult Patients: The UK-ROX Randomized Clinical Trial, JAMA, 12 June 2025,** [**Link**](https://jamanetwork.com/journals/jama/article-abstract/2835384)
5. **Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation, NEJM, 13 June 2025,** [**Link**](https://www.nejm.org/doi/full/10.1056/NEJMoa2505708)
6. **Temporary transvenous diaphragm neurostimulation for weaning from mechanical ventilation (RESCUE-3), AJRCCM,** [**Link**](https://www.atsjournals.org/doi/abs/10.1164/rccm.202505-1056OC)
7. **A Crossover Trial of Hospital-Wide Lactated Ringer’s Solution versus Normal Saline, NEJM, 12 June 2025,** [**Link**](https://www.nejm.org/doi/full/10.1056/NEJMoa2416761)
8. **Intravenous Rehydration for Severe Acute Malnutrition with Gastroenteritis, NEJM, 13 June 2025,** [**Link**](https://www.nejm.org/doi/full/10.1056/NEJMoa2505752)
---
# **Anesthesiology Highlights**
### 1-AI:
1. Artificial Intelligence in Anesthesia Enters the Evidence-Based Era With Retrieval-Augmented Generation, *A&A*, June 10, 2025, Letter to Editor, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/artificial%5Fintelligence%5Fin%5Fanesthesia%5Fenters%5Fthe.1329.aspx)
2. Beyond the Score: Evaluating Large Language Models for Clinical Use in Anesthesia, *Journal of Cardiothoracic and Vascular Anesthesia*, Available Online 06 June 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S105307702500463X)
### **2-General:**
1. **Multidisciplinary, Evidence-Based, Patient-Centred Perioperative Patient Safety Recommendations: A European Consensus Study, *British Journal of Anaesthesia*, In Press (2025), Guidelines,** [**Link**](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900299-5/fulltext)
2. **Guidelines on strategies for the universal implementation of videolaryngoscopy, European Journal of Anaesthesiology, 19 June 2025,** [**Link**](https://journals.lww.com/ejanaesthesiology/fulltext/9900/guidelines%5Fon%5Fstrategies%5Ffor%5Fthe%5Funiversal.312.aspx)
3. **Perioperative Oxygen Therapy: An Overview of Systematic Reviews and Meta-Analyses, *Br J Anaesth*, In Press, Systematic Review and Meta-analysis,** [**Link**](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900257-0/fulltext)
4. **Prediction Models for Postoperative Pulmonary Complications: A Systematic Review and Meta-Analysis, *British Journal of Anaesthesia*, June 5, 2025, Systematic Review and Meta-analysis,** [**Link**](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900265-X/fulltext)
5. **Intraoperative Hypotension During Robotic-Assisted Radical Prostatectomy: A Randomised Controlled Trial Comparing Standard Goal-Directed Fluid Therapy with Hypotension Prediction Index-Guided Goal-Directed Fluid Therapy, *European Journal of Anaesthesiology*, June 10, 2025, RCT,** [**Link**](https://journals.lww.com/ejanaesthesiology/fulltext/9900/intraoperative%5Fhypotension%5Fduring%5Frobotic%5Fassisted.310.aspx)
6. **Post-Induction Hypotension During Rapid Sequence Intubation in the Operating Room: A Post Hoc Analysis of the Randomized Controlled REMICRUSH Trial, *Anaesthesia Critical Care & Pain Medicine*, May 2025, RCT,** [**Link**](https://www.sciencedirect.com/science/article/pii/S2352556825000347)
7. **Oxygen Reserve Index as a Peri-Operative Guide for Alveolar Recruitment Manoeuvre During Whipple's Surgical Procedure: A Randomised Controlled Trial, *European Journal of Anaesthesiology*, June 6, 2025, RCT,** [**Link**](https://journals.lww.com/ejanaesthesiology/fulltext/9900/oxygen%5Freserve%5Findex%5Fas%5Fa%5Fperi%5Foperative%5Fguide%5Ffor.307.aspx)
8. **Hypnotic and Antinociceptive Contribution of Magnesium Sulphate During Balanced Total Intravenous Anaesthesia in Total Thyroidectomy: A Randomised Double-Blind Clinical Trial, *European Journal of Anaesthesiology*, June 6, 2025, RCT,** [**Link**](https://journals.lww.com/ejanaesthesiology/fulltext/9900/hypnotic%5Fand%5Fantinociceptive%5Fcontribution%5Fof.308.aspx)
9. **Association of Intraoperative Hypotension with Postoperative Nausea and Vomiting in Laparoscopic Gastrointestinal Surgery: A Secondary Analysis of a Randomized Trial, *Anesthesiology*, June 2, 2025,** [**Link**](https://journals.lww.com/anesthesiology/abstract/9900/association%5Fof%5Fintraoperative%5Fhypotension%5Fwith.693.aspx)
10. Perioperative Implications of Antiretroviral Therapy: A Focus on Drug Interactions and Systemic Effects, *Anesthesia & Analgesia*, 2025-06-05, Review Article, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/perioperative%5Fimplications%5Fof%5Fantiretroviral.1326.aspx)
11. Pharmacological Approach to Rapid Sequence Induction/Intubation: A Contemporary Perspective, *Current Opinion in Anesthesiology*, June 10, 2025, Review Article,[ Link](https://journals.lww.com/co-anesthesiology/fulltext/9900/pharmacological%5Fapproach%5Fto%5Frapid%5Fsequence.311.aspx)
12. 2025 ISOBS OBA Emergency Manual: New Drugs, Devices, Diversions, and Dysfunction, *Current Opinion in Anesthesiology*, June 10, 2025, Review Article, [Link](https://journals.lww.com/co-anesthesiology/fulltext/9900/2025%5Fisobs%5Foba%5Femergency%5Fmanual%5F%5Fnew%5Fdrugs,.298.aspx)
13. Portable Wireless Monitoring of Vital Signs in Hospital Wards, *BJA Education*, July 2025, Review Article, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900036-8/fulltext)
14. Operations Research in Perioperative Clinical Decision-Making, *BJA Education*, July 2025, Review Article, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900033-2/abstract)
15. Perioperative Use of Activated Prothrombin Complex Concentrates, *Anesthesiology*, June 10, 2025, Review Article, [Link](https://journals.lww.com/anesthesiology/citation/9900/perioperative%5Fuse%5Fof%5Factivated%5Fprothrombin%5Fcomplex.696.aspx)
16. Diagnostics and Management of Direct Oral Anticoagulants–Induced Bleeding, *Current Opinion in Anesthesiology*, June 10, 2025, Review Article, [Link](https://journals.lww.com/co-anesthesiology/fulltext/9900/diagnostics%5Fand%5Fmanagement%5Fof%5Fdirect%5Foral.308.aspx)
17. Neurological Monitoring in Liver Transplantation: Innovative Approaches and Perioperative Strategies for Managing Brain Complications, *Current Opinion in Anesthesiology*, June 10, 2025, Review Article, [Link](https://journals.lww.com/co-anesthesiology/fulltext/9900/neurological%5Fmonitoring%5Fin%5Fliver%5Ftransplantation%5F.299.aspx)
18. ‘Fulminant Hepatic Failure’ Anesthesiologic Considerations, *Current Opinion in Anesthesiology*, May 26, 2025, Review Article, [Link](https://journals.lww.com/co-anesthesiology/fulltext/9900/%5Ffulminant%5Fhepatic%5Ffailure%5F%5Fanesthesiologic.305.aspx)
19. Anesthesia-Specific Protocol for Percutaneous Hepatic Perfusion Procedures, *Journal of Cardiothoracic and Vascular Anesthesia*, July 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025002228)
20. The Role of Veno-Venous Bypass in Liver Transplant, *Current Opinion in Anesthesiology*, June 10, 2025, Review Article, [Link](https://journals.lww.com/co-anesthesiology/fulltext/9900/the%5Frole%5Fof%5Fveno%5Fvenous%5Fbypass%5Fin%5Fliver%5Ftransplant.300.aspx)
21. Anesthetic Considerations for Outpatient Interventional Radiology Procedures for Cancer Patients, *Current Opinion in Anesthesiology*, June 10, 2025, Review Article, [Link](https://journals.lww.com/co-anesthesiology/fulltext/9900/anesthetic%5Fconsiderations%5Ffor%5Foutpatient.301.aspx)
22. Frailty in Liver Transplantation: Implications for Perioperative Management and Postoperative Outcomes, *Current Opinion in Anesthesiology*, June 10, 2025, Review Article, [Link](https://journals.lww.com/co-anesthesiology/fulltext/9900/ifrailty%5Fin%5Fliver%5Ftransplantation%5F%5Fimplications.294.aspx)
23. Closed Claims Analysis in Nonoperating Room Anesthesia, *Current Opinion in Anesthesiology*, June 10, 2025, Review Article, [Link](https://journals.lww.com/co-anesthesiology/fulltext/9900/closed%5Fclaims%5Fanalysis%5Fin%5Fnonoperating%5Froom.316.aspx)
24. Interdisciplinary In Situ Simulation in Nonoperating Room Anesthesia, *Current Opinion in Anesthesiology*, June 10, 2025, Review Article, [Link](https://journals.lww.com/co-anesthesiology/fulltext/9900/interdisciplinary%5Fin%5Fsitu%5Fsimulation%5Fin.296.aspx)
25. Enhanced Recovery After Surgery in Liver Transplantation: The Anesthesia Perspective, *Current Opinion in Anesthesiology*, June 10, 2025, Review Article, [Link](https://journals.lww.com/co-anesthesiology/fulltext/9900/enhanced%5Frecovery%5Fafter%5Fsurgery%5Fin%5Fliver.295.aspx)
26. Anaesthesia for Pancreatic Resection Surgery: Part 2, *BJA Education*, July 2025, Review Article, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900035-6/abstract)
27. Perioperative cardiovascular assessment and management of liver transplant patients, *Current Opinion in Anesthesiology*, 16 June 2025, [Link](https://journals.lww.com/co-anesthesiology/abstract/9900/perioperative%5Fcardiovascular%5Fassessment%5Fand.323.aspx)
28. Non-Anaemic Iron Deficiency in Surgical Patients: More Than Just a Laboratory Finding?, *British Journal of Anaesthesia*, In Press (2025), Editorial, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900303-4/fulltext)
### **3-Cardiovascular:**
1. **Considerations of Intraoperative Transesophageal Echocardiography During Adult Cardiac Surgery: A Scientific Statement From the American Heart Association, *Circulation*, 12 June 2025, Guidelines,** [**Link**](https://doi.org/10.1161/CIR.0000000000001342)
2. **Effect of Remote Ischemic Preconditioning on Myocardial Injury in Noncardiac Surgery: The PRINCE Randomized Clinical Trial, *Circulation*, 14 Jun 2025, RCT,** [**Link**](https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.125.075254)
3. **A Randomized Trial of Acute Normovolemic Hemodilution in Cardiac Surgery, NEJM, 12 June 2025,** [**Link**](https://www.nejm.org/doi/full/10.1056/NEJMoa2504948)
4. **Cerebral Oximetry Index–Guided Blood Pressure Management During Cardiopulmonary Bypass Reduces Postoperative Delirium in Patients with Acute Type A Aortic Dissection, *Journal of Cardiothoracic and Vascular Anesthesia*, July 2025, RCT,** [**Link**](https://www.sciencedirect.com/science/article/abs/pii/S1053077025000291)
5. **Effect of Combination of Subcutaneous Lidocaine with Two Different Doses of Nitroglycerin Versus Subcutaneous Lidocaine Alone for Ultrasound Guided Radial Artery Cannulation: A Randomized Controlled Trial, *Journal of Cardiothoracic and Vascular Anesthesia*, Available Online 06 June 2025, RCT,** [**Link**](https://www.sciencedirect.com/science/article/abs/pii/S1053077025004422)
6. **Perioperative Bleeding is Not an Independent Risk Factor for Acute Kidney Injury in On-Pump Cardiac Surgery—A Post-Hoc Analysis of a Randomized Clinical Trial, *Journal of Cardiothoracic and Vascular Anesthesia*, July 2025, RCT,** [**Link**](https://www.sciencedirect.com/science/article/pii/S1053077025002058)
7. **Ultrasound-Guided Stellate Ganglion Block Regulates Inflammatory Cytokines and Improves Short-Term Outcome After Cardiac Surgery with Cardiopulmonary Bypass: A Randomized Clinical Trial, *Journal of Cardiothoracic and Vascular Anesthesia*, 15 June 2025, RCT,** [**Link**](https://www.sciencedirect.com/science/article/abs/pii/S1053077025004902)
8. A Scoping Review of Validated Echocardiographic Methods for Grading Right Ventricular Dysfunction: Proposal for an Evidence-Based Multi-Parametric Framework, *Journal of Cardiothoracic and Vascular Anesthesia*, Available Online 06 June 2025, Review Article, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025004689)
9. Modified Measurement of Tricuspid Annular Plane Systolic Excursion for Assessing Right Ventricular Function During Cardiac Surgery, *Journal of Cardiothoracic and Vascular Anesthesia*, 04 June 2025, Review Article, [Link](https://www.sciencedirect.com/science/article/pii/S1053077025004586)
10. Advances in Cardiovascular Pharmacotherapy. IV. Sodium-Glucose Cotransporter Type 2 Inhibitors, Part 2: Mechanisms for Myocardial Protection, Adverse Effects, and Perioperative Implications, *Journal of Cardiothoracic and Vascular Anesthesia*, 08 June 2025, Review Article, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025004732)
11. The Year in Perioperative Echocardiography: Selected Highlights from 2024, *Journal of Cardiothoracic and Vascular Anesthesia*, July 2025, Review Article, [Link](https://www.sciencedirect.com/science/article/pii/S1053077025002708)
12. 2024 Update on Vascular Anesthesia, *Journal of Cardiothoracic and Vascular Anesthesia*, July 2025, Review Article, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025002095)
13. Chronic Thromboembolic Pulmonary Hypertension – An Update for the Anesthesiologist, *Journal of Cardiothoracic and Vascular Anesthesia*, 15 June 2025, Editorial, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025004884)
14. A Shocking Pause: Interplay Between Pacemaker Safety Mode-Switching and Generator Manipulation Leading to Asystole During Pacemaker Generator Change—A Case Report, *A&A*, June 6, 2025, Case Report,[ Link](https://journals.lww.com/aacr/fulltext/2025/06000/a%5Fshocking%5Fpause%5F%5Finterplay%5Fbetween%5Fpacemaker.5.aspx)
_This post is for subscribers only._
### Anecrit's Newsletter #01
URL: https://www.anecrit.com/papers-29-04-06-2025/
Last updated: 2025-08-24T14:55:32.000Z
**Issue #\[01\] | Week of \[29/05/2025\] - \[04/06/2025\]**
**Welcome**
Hey there!
Thanks for opening this week's update! I know your inbox is busy, so I've done the heavy lifting for you. This issue brings you a focused selection of the past week's essential published papers, distilled for quick review. Pick and choose what you want to read, enjoy!
# **Anesthesiology:**
### **1.Systematic Reviews & Meta-Analyses:**
1. Global prevalence of postoperative hypoxemia among adult and pediatric surgical patients: a systematic review and meta-analysis, BMC Anesthesiology, 3 June 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03146-3)
2. Efficiency and safety of double-lumen bronchial tube and bronchial blocker for one-lung ventilation in patients with thoracic surgery: a meta-analysis, BMC Anesthesiology, 31 May 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03144-5)
3. Comparison of non-intubated and intubated video-assisted thoracoscopic surgery for perioperative complications—a systematic review and meta-analysis, BMC Anesthesiology, 29 May 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03154-3)
4. Efficacy of Superficial vs. Deep Parasternal Intercostal Plane Blocks in Cardiac Surgery: A systematic Review and Meta-analysis, Journal of Cardiothoracic and Vascular Anesthesia, 29 May 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025004409)
### **2\. Randomized Controlled Trials (RCTs):**
_This post is for subscribers only._
### Anecrit's Newsletter #00
URL: https://www.anecrit.com/newsletter-0029052025/
Last updated: 2025-08-24T14:55:55.000Z
**Issue #\[00\] | \[13 - 28/05/2025\]**
### **Welcome!**
Hey there! Welcome to the very first issue of **Anecrit's newsletter**.
Can you guess how many papers were published across relevant journals in anesthesiology and critical care medicine recently? Try, over **400 papers**! That's an insane amount of literature for any clinician trying to stay updated, right? I think this newsletter solves a problem we all share: too little time.
This inaugural issue isn't perfect, and it might not cover every relevant paper you'd hoped for. But please remember, this is **our newsletter**. It will change and evolve over time to become a resource for all of us. So, please don't hesitate to share your **feedback and suggestions**. We're building this together!
### **Featured Articles :**
Have you read the OPTPRESS trial?
Efficacy of targeting high mean arterial pressure for older patients with septic shock (OPTPRESS): a multicentre, pragmatic, open-label, randomised controlled trial, Intensive care medicine, 13 May 2025, [Link](https://link.springer.com/article/10.1007/s00134-025-07910-4)
I'll be publishing a summary and an analysis of this trial tomorrow, stay tuned for it.
# **Anesthesiology Highlights**
### **I. Guidelines & Consensus Statements :**
1. Perioperative management of patients taking glucagon-like peptide 1 receptor agonists: Society for Perioperative Assessment and Quality Improvement (SPAQI) multidisciplinary consensus statement, British Journal of Anaesthesia, In Press 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900214-4/abstract).
### **II. Systematic Reviews & Meta-Analyses :**
1. Efficacy of Epidural Analgesia Compared to Intravenous Lidocaine for Postoperative Pain in Major Abdominal Surgery: A Systematic Review and Meta-Analysis, Current Anesthesiology Reports, 13 May 2025, [Link](https://link.springer.com/article/10.1007/s40140-025-00699-4).
2. Temporal Trends and Severity of Postoperative Delirium in Cardiac Surgery: Insights from A Systematic Review and Meta-Analysis, Journal of Cardiothoracic and Vascular Anesthesia, 17 May 2025, [Link](https://www.jcvaonline.com/article/S1053-0770%2825%2900402-1/abstract).
3. The Protective Effect of Remote Ischemic Preconditioning on Acute Kidney Injury Following Pediatric Cardiac Surgery: A Systematic Review and Meta-Analysis, Journal of Cardiothoracic and Vascular Anesthesia, 17 may 2025, [Link](https://www.jcvaonline.com/article/S1053-0770%2825%2900403-3/abstract)
4. Effect of dexmedetomidine on the incidence of postoperative delirium following major cardiac surgery: An updated meta-analysis, Journal of Cardiothoracic and Vascular Anesthesia, 27 May 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025004355).
### **III .Randomized Controlled Trials (RCTs) :**
1. Intravenous dexmedetomidine as addition to dexamethasone adjunct for interscalene brachial plexus block for postoperative analgesia after arthroscopic shoulder surgery: A randomised, double-blinded, single centre trial, European Journal of Anaesthesiology, May 14 2025, [Link](https://journals.lww.com/ejanaesthesiology/fulltext/9900/intravenous%5Fdexmedetomidine%5Fas%5Faddition%5Fto.296.aspx).
2. Impact of Erythromycin and Metoclopramide on Gastric Emptying of Solids in Term Pregnant Women Scheduled for Elective Cesarean Delivery: A Randomized Controlled Trial, Anaesthesia Critical Care & Pain Medicine, 14 May 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556825000761?via%3Dihub).
3. Repeat-dose dexamethasone to prevent pain relapse after total knee arthroplasty in high-pain-response patients: A randomised, double-blind, placebo-controlled superiority trial, European Journal of Anaesthesiology, May 14 2025, [Link](https://journals.lww.com/ejanaesthesiology/fulltext/9900/repeat%5Fdose%5Fdexamethasone%5Fto%5Fprevent%5Fpain%5Frelapse.297.aspx).
4. Multimodal prehabilitation before lung resection surgery: a multicentre randomised controlled trial, British Journal of Anaesthesia, 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900196-5/fulltext).
5. Effect of Dinalbuphine sebacate on postoperative multimodal analgesic strategy in video-assisted thoracoscopic surgery: a double-blind randomized controlled trial, BMC Anesthesiology, 17 May 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03118-7).
6. Interleukin-1 receptor antagonist polymorphisms in women receiving epidural analgesia who develop maternal intrapartum fever: a prospective, multicentre Mendelian randomised study, British Journal of Anaesthesia, 14 May 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900226-0/fulltext).
7. Low-dose Esketamine combined with Propofol in microscopic pediatric strabismus surgery: a randomized controlled study, BMC Anesthesiology, 14 May 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03095-x).
8. Effects of an opioid-free care pathway vs. opioid-based standard care on postoperative pain and postoperative quality of recovery after laparoscopic bariatric surgery: A multicentre randomised controlled trial, European Journal of Anaesthesiology, May 15 2025, [Link](https://journals.lww.com/ejanaesthesiology/fulltext/9900/effects%5Fof%5Fan%5Fopioid%5Ffree%5Fcare%5Fpathway%5Fvs%5F.298.aspx).
9. Safety of remimazolam in deep sedation during flexible fiberoptic bronchoscopy: a prospective, randomized controlled trial, BMC Anesthesiology, 15 May 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03117-8).
10. Effects of a national team training intervention for operating theatre teams on patient and staff outcomes: a stepped-wedge cluster-randomised trial and mixed-methods study, British Journal of Anaesthesia, In Press 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900230-2/fulltext?dgcid=raven%5Fjbs%5Faip%5Femail).
11. Ultrasound-guided supraclavicular brachial plexus block as an additive to sevoflurane anesthesia in pediatrics undergoing brachiobasilic arteriovenous fistula operation: randomized controlled clinical trial, BMC Anesthesiology, 16 May 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03091-1).
12. Sugammadex or neostigmine for reversal of neuromuscular block on the quality of postoperative recovery in elderly adults undergoing video-assisted thoracoscopic lobectomy: a randomised controlled trial, BMC Anesthesiology, 16 May 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03128-5).
13. Effects of different doses of remifentanil combined with sevoflurane anesthesia on postoperative analgesia and hemodynamics in pediatric patients undergoing laparoscopic inguinal hernia repair, BMC Anesthesiology, 15 May 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03104-z).
14. A novel approach to ultrasound-guided L3-4 thoracolumbar fascia injection for chronic pain after spine surgery: a prospective pilot study, BMC Anesthesiology, 15 May 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03046-6).
15. Methylprednisolone for Infant Heart Surgery: Subpopulation Analyses of a Randomized Controlled Trial, Critical Care Medicine, May 21 2025, [Link](https://journals.lww.com/ccmjournal/fulltext/9900/methylprednisolone%5Ffor%5Finfant%5Fheart%5Fsurgery%5F.527.aspx).
16. Ultrasound Gel versus Saline for Acoustic Coupling in Ultrasound-Guided Regional Anesthesia: A Randomized, Cross-Over, Simulation Study, Anesthesia & Analgesia, May 26, 2025, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/ultrasound%5Fgel%5Fversus%5Fsaline%5Ffor%5Facoustic%5Fcoupling.1312.aspx).
17. A Randomized Clinical Trial of Dexmedetomidine on Delirium, Cognitive Dysfunction, and Sleep After Non-Ambulatory Orthopedic Surgery With Regional Anesthesia, Anesthesia & Analgesia, May 22, 2025, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/a%5Frandomized%5Fclinical%5Ftrial%5Fof%5Fdexmedetomidine%5Fon.1303.aspx).
18. Thoracic paravertebral block versus local infiltration anesthesia for percutaneous kyphoplasty to treat osteoporotic vertebral compression fractures combined with intercostal neuralgia: a randomized controlled trial, BMC Anesthesiology, 19 May 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03114-x).
19. Chewing gum on postoperative oral Malodor in patients undergoing general anesthesia: a randomized non-inferiority trial, BMC Anesthesiology, 21 May 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03134-7#).
20. Comparison between upper body and full underbody forced-air warming blanket in pediatric patients undergoing cardiovascular interventions under general anesthesia: a randomized controlled trial, BMC Anesthesiology, 21 May 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03100-3#).
21. No effect of tetracosactide for treatment of postdural puncture headaches in parturient women: a double-blind randomised controlled clinical trial, British Journal of Anaesthesia, 20 May 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900233-8/fulltext).
22. PeRiOperative Glucose PRAgMatic (PROGRAM): a randomized trial of standardized insulin management in surgical patients, Anesthesiology, 23 May 2025, [Link](https://journals.lww.com/anesthesiology/abstract/9900/perioperative%5Fglucose%5Fpragmatic%5F%5Fprogram%5F%5F%5Fa.689.aspx).
23. Self-directed learning versus traditional instructor-led learning for education on a new anaesthesia workstation: a noninferiority, randomised, controlled trial, British Journal of Anaesthesia, 23 May 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900276-4/fulltext).
24. Double dural puncture epidural improves quality of labour analgesia without increasing adverse effects in primipara: A randomised controlled trial, European Journal of Anaesthesiology, 22 May 2025, [Link](https://journals.lww.com/ejanaesthesiology/fulltext/9900/double%5Fdural%5Fpuncture%5Fepidural%5Fimproves%5Fquality%5Fof.303.aspx).
25. QUAdratus lumborum block in caesarean section (QUALICS) study: A randomised clinical trial comparing intrathecal morphine, quadratus lumborum block and the combination of both for postoperative analgesia in caesarean sections, European Journal of Anaesthesiology, 22 May 2025, [Link](https://journals.lww.com/ejanaesthesiology/fulltext/9900/quadratus%5Flumborum%5Fblock%5Fin%5Fcaesarean%5Fsection.304.aspx).
26. Recovery from deep neuromuscular blockade using different sugammadex doses in elderly patients undergoing laparoscopic robot-assisted prostatectomy: A prospective, randomised, double-blind, phase III trial, European Journal of Anaesthesiology, 22 May 2025, [Link](https://journals.lww.com/ejanaesthesiology/fulltext/9900/recovery%5Ffrom%5Fdeep%5Fneuromuscular%5Fblockade%5Fusing.301.aspx).
27. Postoperative Analgesia Effect Evaluation of Perineural Dexamethasone Plus Various Doses of Ropivacaine in Interscalene Brachial Plexus Block: A Randomized Controlled Trial, The Clinical Journal of Pain, 22 May 2025, [Link](https://journals.lww.com/clinicalpain/fulltext/9900/postoperative%5Fanalgesia%5Feffect%5Fevaluation%5Fof.261.aspx).
28. Comparison between transtracheal and intravenous 2% lignocaine in attenuating hemodynamic stress response following direct laryngoscopy and endotracheal intubation: a randomized controlled trial, BMC Anesthesiology, 24 May 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03102-1).
29. Comparison of analgesic efficacy of erector spinae plane block at different levels in laparoscopic cholecystectomies: a randomized controlled trial, BMC Anesthesiology, 26 May 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03138-3) .
### **IV. Reviews:**
1. Pharmacokinetics and Pharmacodynamics of Analgesic and Anesthetic Drugs in Patients During Cardiac Surgery With Cardiopulmonary Bypass: A Narrative Review, Anesthesia & Analgesia, 16 May 2025, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/pharmacokinetics%5Fand%5Fpharmacodynamics%5Fof%5Fanalgesic.1299.aspx).
2. Anaesthesia for resection of vestibular schwannoma, BJA Education, May 14, 2025, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900026-5/fulltext?dgcid=raven%5Fjbs%5Faip%5Femail).
3. Hyperangulated videolaryngoscopy, BJA Education, June 2025, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900023-X/fulltext).
4. Adjuncts for neuraxial anaesthesia in obstetrics, BJA Education, June 2025, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900022-8/fulltext).
5. Perioperative management of tracheo-oesophageal fistula and oesophageal atresia, BJA Education, June 2025, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900025-3/fulltext).
6. Pathophysiology and risk factors for postoperative nausea and vomiting in adults and children, BJA Education, June 2025, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900024-1/fulltext).
7. Sublingual ketamine for acute postoperative pain: an emerging addition to multimodal analgesia, British Journal of Anaesthesia, In Press 2025, [Link](https://click.notification.elsevier.com/CL0/https:%2F%2Fwww.bjanaesthesia.org%2Farticle%2FS0007-0912%2825%2900232-6%2Ffulltext%3Fdgcid=raven%5Fjbs%5Faip%5Femail/1/01000196ddc6b16d-1a8131c5-3691-4f7f-9b71-cf2e1e379ddd-000000/ae3zvrS23gVhaUQ4gjiPLd6mzpjss9G3Od-nHlaRZHw=405).
8. Right Ventricular Function and Echocardiographic Pressure-Volume Loops; Overview and Perioperative Clinical Implications, Journal of Cardiothoracic and Vascular Anesthesia, 17 May 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S105307702500401X).
9. Perioperative ventilation support, what clinicians and searchers must know, Anaesthesia Critical Care & Pain Medicine, 22 May 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556825000864).
10. Sugammadex Anaphylaxis: Mechanisms, Diagnosis, and Incidence, Anesthesiology, 20 May 2025, [Link](https://journals.lww.com/anesthesiology/citation/9900/sugammadex%5Fanaphylaxis%5F%5Fmechanisms,%5Fdiagnosis,%5Fand.686.aspx).
11. Anaesthesia for clipping of intracranial aneurysms, BJA Education, 24 May 2025, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900038-1/abstract).
12. Regional anesthesia in bariatric surgery, Current Opinion in Anesthesiology, 29 April 2025, [Link](https://journals.lww.com/co-anesthesiology/fulltext/9900/regional%5Fanesthesia%5Fin%5Fbariatric%5Fsurgery.303.aspx).
13. The future of target-controlled infusion and new pharmacokinetic models, Current Opinion in Anesthesiology, 26 May 2025, [Link](https://journals.lww.com/co-anesthesiology/fulltext/9900/the%5Ffuture%5Fof%5Ftarget%5Fcontrolled%5Finfusion%5Fand%5Fnew.306.aspx).
14. Advancing electroencephalography education in anesthesiology, Current Opinion in Anesthesiology, 26 May 2025, [Link](https://journals.lww.com/co-anesthesiology/fulltext/9900/advancing%5Felectroencephalography%5Feducation%5Fin.304.aspx).
15. Remimazolam for anesthesia in cardiac and noncardiac surgery. A narrative literature review and synthesis, Anaesthesia Critical Care & Pain Medicine, 27 May 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556825000876).
## By topic:
#### By topic:
1. ****General:**
****Guidelines & Consensus Statements:**
- Perioperative management of patients taking glucagon-like peptide 1 receptor agonists: Society for Perioperative Assessment and Quality Improvement (SPAQI) multidisciplinary consensus statement, **British Journal of Anaesthesia*, In Press 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900214-4/abstract).
****Randomized Controlled Trials (RCTs):**
- Multimodal prehabilitation before lung resection surgery: a multicentre randomised controlled trial, **British Journal of Anaesthesia*, 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900196-5/fulltext).
- Chewing gum on postoperative oral Malodor in patients undergoing general anesthesia: a randomized non-inferiority trial, **BMC Anesthesiology*, 21 May 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03134-7#).
- Effects of a national team training intervention for operating theatre teams on patient and staff outcomes: a stepped-wedge cluster-randomised trial and mixed-methods study, British Journal of Anaesthesia, In Press 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900230-2/fulltext?dgcid=raven%5Fjbs%5Faip%5Femail).
- PeRiOperative Glucose PRAgmatic (PROGRAM): a randomized trial of standardized insulin management in surgical patients, **Anesthesiology*, 23 May 2025, [Link](https://journals.lww.com/anesthesiology/abstract/9900/perioperative%5Fglucose%5Fpragmatic%5F%5Fprogram%5F%5F%5Fa.689.aspx).
- Self-directed learning versus traditional instructor-led learning for education on a new anaesthesia workstation: a noninferiority, randomised, controlled trial, **British Journal of Anaesthesia*, 23 May 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900276-4/fulltext).
- Comparison between transtracheal and intravenous 2% lignocaine in attenuating hemodynamic stress response following direct laryngoscopy and endotracheal intubation: a randomized controlled trial, **BMC Anesthesiology*, 24 May 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03102-1).
****Reviews:**
- Hyperangulated videolaryngoscopy, **BJA Education*, June 2025, Review Article, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900023-X/fulltext).
- Pathophysiology and risk factors for postoperative nausea and vomiting in adults and children, **BJA Education*, June 2025, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900024-1/fulltext).
- Perioperative ventilation support, what clinicians and searchers must know, Anaesthesia Critical Care & Pain Medicine, 22 May 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556825000864).
- Sugammadex Anaphylaxis: Mechanisms, Diagnosis, and Incidence, **Anesthesiology*, 20 May 2025, [Link](https://journals.lww.com/anesthesiology/citation/9900/sugammadex%5Fanaphylaxis%5F%5Fmechanisms,%5Fdiagnosis,%5Fand.686.aspx).
- The future of target-controlled infusion and new pharmacokinetic models, **Current Opinion in Anesthesiology*, 26 May 2025, [Link](https://journals.lww.com/co-anesthesiology/fulltext/9900/the%5Ffuture%5Fof%5Ftarget%5Fcontrolled%5Finfusion%5Fand%5Fnew.306.aspx).
- Advancing electroencephalography education in anesthesiology, **Current Opinion in Anesthesiology*, 26 May 2025, [Link](https://journals.lww.com/co-anesthesiology/fulltext/9900/advancing%5Felectroencephalography%5Feducation%5Fin.304.aspx).
- Remimazolam for anesthesia in cardiac and noncardiac surgery. A narrative literature review and synthesis, **Anaesthesia Critical Care & Pain Medicine*, 27 May 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556825000876).
1. ****Regional Anesthesia & Pain Medicine:**
****Systematic Reviews & Meta-Analyses:**
- Efficacy of Epidural Analgesia Compared to Intravenous Lidocaine for Postoperative Pain in Major Abdominal Surgery: A Systematic Review and Meta-Analysis, **Current Anesthesiology Reports*, 13 May 2025, [Link](https://link.springer.com/article/10.1007/s40140-025-00699-4).
****Randomized Controlled Trials (RCTs):**
- Intravenous dexmedetomidine as addition to dexamethasone adjunct for interscalene brachial plexus block for postoperative analgesia after arthroscopic shoulder surgery: A randomised, double-blinded, single centre trial, **European Journal of Anaesthesiology*, 14 May 2025, [Link](https://journals.lww.com/ejanaesthesiology/fulltext/9900/intravenous%5Fdexmedetomidine%5Fas%5Faddition%5Fto.296.aspx).
- Repeat-dose dexamethasone to prevent pain relapse after total knee arthroplasty in high-pain-response patients: A randomised, double-blind, placebo-controlled superiority trial, **European Journal of Anaesthesiology*, 14 May 2025, [Link](https://journals.lww.com/ejanaesthesiology/fulltext/9900/repeat%5Fdose%5Fdexamethasone%5Fto%5Fprevent%5Fpain%5Frelapse.297.aspx).
- Ultrasound-guided supraclavicular brachial plexus block as an additive to sevoflurane anesthesia in pediatrics undergoing brachiobasilic arteriovenous fistula operation: randomized controlled clinical trial, **BMC Anesthesiology*, 16 May 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03091-1).
- A novel approach to ultrasound-guided L3-4 thoracolumbar fascia injection for chronic pain after spine surgery: a prospective pilot study, **BMC Anesthesiology*, 15 May 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03046-6).
- Ultrasound Gel versus Saline for Acoustic Coupling in Ultrasound-Guided Regional Anesthesia: A Randomized, Cross-Over, Simulation Study, **Anesthesia & Analgesia*, 26 May 2025, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/ultrasound%5Fgel%5Fversus%5Fsaline%5Ffor%5Facoustic%5Fcoupling.1312.aspx).
- A Randomized Clinical Trial of Dexmedetomidine on Delirium, Cognitive Dysfunction, and Sleep After Non-Ambulatory Orthopedic Surgery With Regional Anesthesia, **Anesthesia & Analgesia*, 22 May 2025, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/a%5Frandomized%5Fclinical%5Ftrial%5Fof%5Fdexmedetomidine%5Fon.1303.aspx).
- Thoracic paravertebral block versus local infiltration anesthesia for percutaneous kyphoplasty to treat osteoporotic vertebral compression fractures combined with intercostal neuralgia: a randomized controlled trial, **BMC Anesthesiology*, 19 May 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03114-x).
- Double dural puncture epidural improves quality of labour analgesia without increasing adverse effects in primipara: A randomised controlled trial, **European Journal of Anaesthesiology*, 22 May 2025, [Link](https://journals.lww.com/ejanaesthesiology/fulltext/9900/double%5Fdural%5Fpuncture%5Fepidural%5Fimproves%5Fquality%5Fof.303.aspx).
- Postoperative Analgesia Effect Evaluation of Perineural Dexamethasone Plus Various Doses of Ropivacaine in Interscalene Brachial Plexus Block: A Randomized Controlled Trial, **The Clinical Journal of Pain*, 22 May 2025, [Link](https://journals.lww.com/clinicalpain/fulltext/9900/postoperative%5Fanalgesia%5Feffect%5Fevaluation%5Fof.261.aspx).
- Comparison of analgesic efficacy of erector spinae plane block at different levels in laparoscopic cholecystectomies: a randomized controlled trial, **BMC Anesthesiology*, 26 May 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03138-3).
****Reviews:**
- Sublingual ketamine for acute postoperative pain: an emerging addition to multimodal analgesia, **British Journal of Anaesthesia*, In Press 2025, [Link](https://click.notification.elsevier.com/CL0/https:%2F%2Fwww.bjanaesthesia.org%2Farticle%2FS0007-0912%2825%2900232-6%2Ffulltext%3Fdgcid=raven%5Fjbs%5Faip%5Femail/1/01000196ddc6b16d-1a8131c5-3691-4f7f-9b71-cf2e1e379ddd-000000/ae3zvrS23gVhaUQ4gjiPLd6mzpjss9G3Od-nHlaRZHw=405).
- Regional anesthesia in bariatric surgery, **Current Opinion in Anesthesiology*, 29 April 2025, [Link](https://journals.lww.com/co-anesthesiology/fulltext/9900/regional%5Fanesthesia%5Fin%5Fbariatric%5Fsurgery.303.aspx) .
1. ****Cardiothoracic Anesthesia:**
****Systematic Reviews & Meta-Analyses:**
- Temporal Trends and Severity of Postoperative Delirium in Cardiac Surgery: Insights from A Systematic Review and Meta-Analysis, **Journal of Cardiothoracic and Vascular Anesthesia*, 17 May 2025, [Link](https://www.jcvaonline.com/article/S1053-0770%2825%2900402-1/abstract).
- The Protective Effect of Remote Ischemic Preconditioning on Acute Kidney Injury Following Pediatric Cardiac Surgery: A Systematic Review and Meta-Analysis, **Journal of Cardiothoracic and Vascular Anesthesia*, 17 may 2025, [Link](https://www.jcvaonline.com/article/S1053-0770%2825%2900403-3/abstract).
- Effect of dexmedetomidine on the incidence of postoperative delirium following major cardiac surgery: An updated meta-analysis, **Journal of Cardiothoracic and Vascular Anesthesia*, 27 May 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025004355).
****Randomized Controlled Trials (RCTs):**
- Effect of Dinalbuphine sebacate on postoperative multimodal analgesic strategy in video-assisted thoracoscopic surgery: a double-blind randomized controlled trial, **BMC Anesthesiology*, 17 May 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03118-7).
- Methylprednisolone for Infant Heart Surgery: Subpopulation Analyses of a Randomized Controlled Trial, **Critical Care Medicine*, May 21 2025, [Link](https://journals.lww.com/ccmjournal/fulltext/9900/methylprednisolone%5Ffor%5Finfant%5Fheart%5Fsurgery%5F.527.aspx).
- Comparison between upper body and full underbody forced-air warming blanket in pediatric patients undergoing cardiovascular interventions under general anesthesia: a randomized controlled trial, **BMC Anesthesiology*, 21 May 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03100-3#).
- Sugammadex or neostigmine for reversal of neuromuscular block on the quality of postoperative recovery in elderly adults undergoing video-assisted thoracoscopic lobectomy: a randomised controlled trial, **BMC Anesthesiology*, 16 May 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03128-5).
****Reviews:**
- Pharmacokinetics and Pharmacodynamics of Analgesic and Anesthetic Drugs in Patients During Cardiac Surgery With Cardiopulmonary Bypass: A Narrative Review, **Anesthesia & Analgesia*, May 16, 2025, narrative Review, [Link](https://journals.lww.com/anesthesia-analgesia/fulltext/9900/pharmacokinetics%5Fand%5Fpharmacodynamics%5Fof%5Fanalgesic.1299.aspx).
- Right Ventricular Function and Echocardiographic Pressure-Volume Loops; Overview and Perioperative Clinical Implications, Journal of Cardiothoracic and Vascular Anesthesia, 17 May 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S105307702500401X).
1. ****Neuroanesthesia:**
****Reviews:**
- Anaesthesia for resection of vestibular schwannoma, **BJA Education*, May 14, 2025, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900026-5/fulltext?dgcid=raven%5Fjbs%5Faip%5Femail).
- Anaesthesia for clipping of intracranial aneurysms, **BJA Education*, 24 May 2025, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900038-1/abstract).
1. ****Pediatric Anesthesia:**
****Randomized Controlled Trials (RCTs):**
- Low-dose Esketamine combined with Propofol in microscopic pediatric strabismus surgery: a randomized controlled study, **BMC Anesthesiology*, 14 May 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03095-x).
- Effects of different doses of remifentanil combined with sevoflurane anesthesia on postoperative analgesia and hemodynamics in pediatric patients undergoing laparoscopic inguinal hernia repair, **BMC Anesthesiology*, 15 May 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03104-z).
****Reviews:**
- Perioperative management of tracheo-oesophageal fistula and oesophageal atresia, **BJA Education*, June 2025, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900025-3/fulltext).
1. ****Obstetric Anesthesia:**
****Randomized Controlled Trials (RCTs):**
- Impact of Erythromycin and Metoclopramide on Gastric Emptying of Solids in Term Pregnant Women Scheduled for Elective Cesarean Delivery: A Randomized Controlled Trial, **Anaesthesia Critical Care & Pain Medicine*, 14 May 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556825000761?via%3Dihub).
- Interleukin-1 receptor antagonist polymorphisms in women receiving epidural analgesia who develop maternal intrapartum fever: a prospective, multicentre Mendelian randomised study, **British Journal of Anaesthesia*, 14 May 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900226-0/fulltext).
- No effect of tetracosactide for treatment of postdural puncture headaches in parturient women: a double-blind randomised controlled clinical trial, **British Journal of Anaesthesia*, 20 May 2025, [Link](https://www.bjanaesthesia.org/article/S0007-0912%2825%2900233-8/fulltext).
- QUAdratus lumborum block in caesarean section (QUALICS) study: A randomised clinical trial comparing intrathecal morphine, quadratus lumborum block and the combination of both for postoperative analgesia in caesarean sections, **European Journal of Anaesthesiology*, 22 May 2025, [Link](https://journals.lww.com/ejanaesthesiology/fulltext/9900/quadratus%5Flumborum%5Fblock%5Fin%5Fcaesarean%5Fsection.304.aspx).
****Reviews:**
- Adjuncts for neuraxial anaesthesia in obstetrics, **BJA Education*, June 2025, [Link](https://www.bjaed.org/article/S2058-5349%2825%2900022-8/fulltext).
1. ****Other:**
****Randomized Controlled Trials (RCTs):**
- Effects of an opioid-free care pathway vs. opioid-based standard care on postoperative pain and postoperative quality of recovery after laparoscopic bariatric surgery: A multicentre randomised controlled trial, **European Journal of Anaesthesiology*, 15 May 2025, [Link](https://journals.lww.com/ejanaesthesiology/fulltext/9900/effects%5Fof%5Fan%5Fopioid%5Ffree%5Fcare%5Fpathway%5Fvs%5F.298.aspx).
- Safety of remimazolam in deep sedation during flexible fiberoptic bronchoscopy: a prospective, randomized controlled trial, **BMC Anesthesiology*, 15 May 2025, [Link](https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-025-03117-8).
- Recovery from deep neuromuscular blockade using different sugammadex doses in elderly patients undergoing laparoscopic robot-assisted prostatectomy: A prospective, randomised, double-blind, phase III trial, **European Journal of Anaesthesiology*, 22 May 2025, [Link](https://journals.lww.com/ejanaesthesiology/fulltext/9900/recovery%5Ffrom%5Fdeep%5Fneuromuscular%5Fblockade%5Fusing.301.aspx).
###
---
###
# **Critical Care Highlights**
###
### **I. Systematic Reviews & Meta-Analyses:**
1. The influence of electronic AKI alert on prognosis of adult hospitalized patients: a systematic review and meta-analysis, Critical Care, 12 May 2025, [Link](https://ccforum.biomedcentral.com/articles/10.1186/s13054-025-05402-x).
2. Oxygen and carbon dioxide targets after cardiac arrest: an updated systematic review, Resuscitation, June 2025, [Link](https://www.sciencedirect.com/science/article/pii/S0300957225001327).
3. High flow nasal therapy versus noninvasive ventilation for AECOPD with acute hypercapnic respiratory failure: a meta-analysis of randomized controlled trials, Annals of Intensive Care, 14 May 2025, [Link](https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-025-01480-w).
4. Critical Care Ultrasonography for Volume Management: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis of Randomized Trials, Critical Care Explorations, 14 May 2025, [Link](https://journals.lww.com/ccejournal/fulltext/2025/05000/critical%5Fcare%5Fultrasonography%5Ffor%5Fvolume.11.aspx).
5. The diagnostic accuracy of serum procalcitonin for sepsis in adult emergency department patients. A systematic review and meta-analysis, CHEST Critical Care, 22 May 2025, [Link](https://www.chestcc.org/article/S2949-7884%2825%2900052-8/fulltext).
6. Treatment of agitation in dementia - a systematic review, International Journal of Emergency Medicine, 26 May 2025, [Link](https://intjem.biomedcentral.com/articles/10.1186/s12245-025-00902-7).
7. Comparison of the diagnostic accuracies of various biomarkers and scoring systems for sepsis: A systematic review and Bayesian diagnostic test accuracy network meta-analysis, Journal of critical care, August 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0883944125000747).
8. Does cardiopulmonary resuscitation before donor death affect solid organ transplant function? A systematic review and *meta*\-analysis, Resuscitation, 21 May 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0300957225001662#).
9. Use of CPR feedback devices in resuscitation training: A systematic review and meta-analysis of randomized controlled trials, Resuscitation Plus, May 2025, [Link](https://www.sciencedirect.com/science/article/pii/S2666520425000761).
10. Manikin physical realism for resuscitation education: A systematic review, Resuscitation Plus, May 2025, [Link](https://www.sciencedirect.com/science/article/pii/S2666520425000773).
11. Advanced airway interventions for paediatric cardiac arrest: updated systematic review and *meta*\-analysis, Resuscitation Plus, May 2025, [Link](https://www.sciencedirect.com/science/article/pii/S2666520425001006).
12. Pulse check accuracy in pediatrics during resuscitation: a systematic review, Resuscitation Plus, May 2025, [Link](https://www.sciencedirect.com/science/article/pii/S2666520425000967).
13. Video vs. traditional laryngoscopy for tracheal intubation at birth or in the neonatal unit: A systematic review and meta-analysis, Resuscitation Plus, May 2025, [Link](https://www.sciencedirect.com/science/article/pii/S266652042500102X).
14. Energy doses for paediatric defibrillation in cardiac arrest: systematic review and meta-analysis, Resuscitation Plus, 26 May 2025, [Link](https://www.sciencedirect.com/science/article/pii/S2666520425001286).
15. Novel biomarkers for predicting successful liberation of renal replacement therapy for acute kidney injury: a systematic review, Critical Care, 26 May 2025, [Link](https://ccforum.biomedcentral.com/articles/10.1186/s13054-025-05451-2).
### **II. Randomized Controlled Trials (RCTs):**
1. Efficacy of targeting high mean arterial pressure for older patients with septic shock (OPTPRESS): a multicentre, pragmatic, open-label, randomised controlled trial, Intensive care medicine, 13 May 2025, [Link](https://link.springer.com/article/10.1007/s00134-025-07910-4).
2. The Significance of Possible Non-Occlusive Mesenteric Ischemia in Relation to Neurological Outcomes in Patients with Refractory Cardiac Arrest - Secondary Analysis of the Prague OHCA Study, Resuscitation, 15 May 2025, [Link](https://www.resuscitationjournal.com/article/S0300-9572%2825%2900154-6/abstract).
3. Immediate or delayed initiation of renal replacement therapy in patients with leptospirosis and acute kidney injury: a target trial emulation, Annals of Intensive Care, 14 May 2025, [Link](https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-025-01477-5).
4. Dexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill PatientsThe A2B Randomized Clinical Trial, JAMA, 19 may 2025, [Link](https://jamanetwork.com/journals/jama/fullarticle/2834276).
5. Ascorbate for Organ Dysfunction in Critically Ill Patients with Sepsis – The Phase 2b ASTER Trial, Chest critical care, 19 may 2025, [Link](https://www.chestcc.org/article/S2949-7884%2825%2900041-3/fulltext).
6. Protocol and Statistical Analysis Plan for a Multicenter Randomized Trial of Ketamine vs Etomidate for Emergency Tracheal Intubation, CHEST Critical Care, 21 May 2025, [Link](https://www.sciencedirect.com/science/article/pii/S2949788425000504).
7. Cost-Effectiveness of α2 Agonists for Intravenous Sedation in Patients With Critical Illness, JAMA Network Open, 19 May 2025, [Link](https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2834255).
8. ROBotic-assisted Early Mobilization in Ventilated Surgical Critically ill Patients (ROBEM-I) – a randomized, controlled, outcome-assessor-blinded pilot study, Anaesthesia Critical Care & Pain Medicine, 23 May 2025, [Link](https://www.sciencedirect.com/science/article/pii/S2352556825000815).
9. Protocol and Statistical Analysis Plan for the Vasopressin for Septic Shock Pragmatic (VASSPR) Cluster-Crossover Randomized Trial, CHEST Critical Care, 21 May 2025, [Link](https://www.chestcc.org/article/S2949-7884%2825%2900051-6/fulltext).
10. Improving Recovery and Outcomes Every Day After the ICU (IMPROVE): A Randomized Controlled Trial, Critical Care Medicine, 22 May 2025, [Link](https://journals.lww.com/ccmjournal/abstract/9900/improving%5Frecovery%5Fand%5Foutcomes%5Fevery%5Fday%5Fafter.530.aspx).
11. Postresuscitation pleth variability index-guided hemodynamic management of out-of-hospital cardiac arrest survivors: A randomised controlled trial, Resuscitation Plus, May 2025, [Link](https://www.sciencedirect.com/science/article/pii/S2666520425000700).
12. Hydrocortisone and arginine vasopressin in post-resuscitation shock: the HYVAPRESS trial, Resuscitation Plus, 19 May 2025, [Link](https://www.sciencedirect.com/science/article/pii/S2666520425001195).
13. Temporal stability of inflammatory subphenotypes of acute respiratory distress syndrome: 28-day insights from the ICAR trial, Anaesthesia Critical Care & Pain Medicine, 26 May 2025, [Link](https://www.sciencedirect.com/science/article/pii/S2352556825000918).
14. Preoxygenation With and Without Positive End-Expiratory Pressure in Lung-Healthy VolunteersA Randomized Clinical Trial, JAMA Network Open, 20 May 2025, [Link](https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2834258).
###
### **III. Reviews**
1. Extracorporeal Membrane Oxygenation In The Awake Or Extubated Patien, Journal of Cardiothoracic and Vascular Anesthesia, 16 May 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025004057).
2. Individualized mean arterial pressure targets in critically ill patients guided by non-invasive cerebral-autoregulation: a scoping review, Critical Care, 16 May 2025, [Link](https://ccforum.biomedcentral.com/articles/10.1186/s13054-025-05432-5).
3. Acute traumatic coagulopathy: what you should know, what is debated and what should come next, Anaesthesia Critical Care & Pain Medicine, 16 May 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S235255682500075X).
4. Acute kidney injury: when and how to start renal replacement therapy, Intensive care medicine, 19 May 2025, [Link](https://link.springer.com/article/10.1007/s00134-025-07933-x).
5. Nutrition and metabolic control for ICU patients, Intensive care medicine, 19 May 2025, [Link](https://link.springer.com/article/10.1007/s00134-025-07937-7).
6. Understanding and mitigating medication errors associated with patient harm in adult intensive care units: a scoping review, Intensive care medicine, 20 May 2025, [Link](https://link.springer.com/article/10.1007/s00134-025-07938-6).
7. How to approach a patient hospitalized for pneumonia who is not responding to treatment?, Intensive care medicine, 24 May 2025, [Link](https://link.springer.com/article/10.1007/s00134-025-07903-3).
8. Immune Thrombotic Thrombocytopenic Purpura, JAMA, 19 may 2025, [Link](https://jamanetwork.com/journals/jama/article-abstract/2834159).
9. Diagnosing pulmonary embolism during pregnancy: A narrative review, CHEST, 20 May 2025, [Link](https://www.sciencedirect.com/science/article/pii/S001236922500649X).
10. Anticoagulation Monitoring during Extracorporeal Membrane Oxygenation: a Narrative Review, Journal of Cardiothoracic and Vascular Anesthesia, 24 May 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025004343).
11. Critical insights for intensivists on Guillain-Barré syndrome, Annals of Intensive Care, 21 May 2025, [Link](https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-025-01464-w).
12. Sepsis in patients who are immunocompromised: diagnostic challenges and future therapies, The Lancet Respiratory Medicine, 20 May 2025, [Link](https://www.thelancet.com/journals/lanres/article/PIIS2213-2600%2825%2900124-9/abstract).
13. Implementing Large Language Models in Critical Care: What is Behind the Delay?, CHEST Critical Care, 24 May 2025, [Link](https://www.chestcc.org/article/S2949-7884%2825%2900053-X/fulltext).
14. Contemporary Rationale for Delivering Enteral Nutrition in Critically Ill Adults, Critical Care Medicine, 21 May 2025, [Link](https://journals.lww.com/ccmjournal/abstract/9900/contemporary%5Frationale%5Ffor%5Fdelivering%5Fenteral.528.aspx).
15. Pulmonary Embolism: Unanswered Questions and Ongoing Evidence Gaps, Journal of Cardiothoracic and Vascular Anesthesia, 20 May 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025004070)
16. What every intensivist should know about type D hyperlactatemia, *Journal of critical care*, August 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S088394412500036X).
17. ICU-acquired weakness: Critical illness myopathy and polyneuropathy, *Journal of critical care*, August 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0883944125000619).
18. Optimization of antimicrobial therapy in critically ill patients, What Clinicians and Searchers Must Know, Anaesthesia Critical Care & Pain Medicine, 27 May 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556825000931).
19. Optimization of antimicrobial therapy in critically ill patients, What Clinicians and Searchers Must Know, Anaesthesia Critical Care & Pain Medicine, 27 May 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556825000931).
### **IV. Case Reports/Series:**
1. Diagnostic challenges in pulmonary lymphomatous spread mimicking ARDS in an AIDS patient: a case report, International Journal of Emergency Medicine, 16 May 2025, [Link](https://intjem.biomedcentral.com/articles/10.1186/s12245-025-00889-1).
###
---
#### By topic:
1. ****Sepsis & Infectious Diseases:**
****Systematic Reviews & Meta-Analyses:**
- The diagnostic accuracy of serum procalcitonin for sepsis in adult emergency department patients. A systematic review and meta-analysis, **CHEST Critical Care*, 22 May 2025, [Link](https://www.chestcc.org/article/S2949-7884%2825%2900052-8/fulltext).
- Comparison of the diagnostic accuracies of various biomarkers and scoring systems for sepsis: A systematic review and Bayesian diagnostic test accuracy network meta-analysis, **Journal of critical care*, August 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0883944125000747).
****Randomized Controlled Trials (RCTs):**
- Efficacy of targeting high mean arterial pressure for older patients with septic shock (OPTPRESS): a multicentre, pragmatic, open-label, randomised controlled trial, **Intensive care medicine*, 13 May 2025, [Link](https://link.springer.com/article/10.1007/s00134-025-07910-4).
- Ascorbate for Organ Dysfunction in Critically Ill Patients with Sepsis – The Phase 2b ASTER Trial, **Chest critical care*, 19 May 2025, [Link](https://www.chestcc.org/article/S2949-7884%2825%2900041-3/fulltext).
- Protocol and Statistical Analysis Plan for the Vasopressin for Septic Shock Pragmatic (VASSPR) Cluster-Crossover Randomized Trial, **CHEST Critical Care*, 21 May 2025, [Link](https://www.chestcc.org/article/S2949-7884%2825%2900051-6/fulltext).
****Reviews:**
- How to approach a patient hospitalized for pneumonia who is not responding to treatment?, **Intensive care medicine*, 24 May 2025, [Link](https://link.springer.com/article/10.1007/s00134-025-07903-3).
- Sepsis in patients who are immunocompromised: diagnostic challenges and future therapies, **The Lancet Respiratory Medicine*, May 20, 2025, [Link](https://www.thelancet.com/journals/lanres/article/PIIS2213-2600%2825%2900124-9/abstract).
- Optimization of antimicrobial therapy in critically ill patients, What Clinicians and Searchers Must Know, **Anaesthesia Critical Care & Pain Medicine*, 27 May 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S2352556825000931).
1. ****Mechanical Ventilation & pulmonary:**
****Systematic Reviews & Meta-Analyses:**
- High flow nasal therapy versus noninvasive ventilation for AECOPD with acute hypercapnic respiratory failure: a meta-analysis of randomized controlled trials, **Annals of Intensive Care*, 14 May 2025, [Link](https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-025-01480-w).
****Randomized Controlled Trials (RCTs):**
- Temporal stability of inflammatory subphenotypes of acute respiratory distress syndrome: 28-day insights from the ICAR trial, **Anaesthesia Critical Care & Pain Medicine*, 26 May 2025, [Link](https://www.sciencedirect.com/science/article/pii/S2352556825000918).
- Preoxygenation With and Without Positive End-Expiratory Pressure in Lung-Healthy VolunteersA Randomized Clinical Trial, **JAMA Network Open*, 20 May 2025, [Link](https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2834258).
- Protocol and Statistical Analysis Plan for a Multicenter Randomized Trial of Ketamine vs Etomidate for Emergency Tracheal Intubation, **CHEST Critical Care*, 21 May 2025, [Link](https://www.sciencedirect.com/science/article/pii/S2949788425000504).
****Reviews:**
- Extracorporeal Membrane Oxygenation In The Awake Or Extubated Patien, Journal of Cardiothoracic and Vascular Anesthesia, 16 May 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025004057).
****Case Reports/Series:**
- Diagnostic challenges in pulmonary lymphomatous spread mimicking ARDS in an AIDS patient: a case report, **International Journal of Emergency Medicine*, 16 May 2025, [Link](https://intjem.biomedcentral.com/articles/10.1186/s12245-025-00889-1).
1. ****Hemodynamics & Resuscitation:**
****Systematic Reviews & Meta-Analyses:**
- Oxygen and carbon dioxide targets after cardiac arrest: an updated systematic review, **Resuscitation*, June 2025, [Link](https://www.sciencedirect.com/science/article/pii/S0300957225001327).
- Critical Care Ultrasonography for Volume Management: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis of Randomized Trials, **Critical Care Explorations*, May 14, 2025, [Link](https://journals.lww.com/ccejournal/fulltext/2025/05000/critical%5Fcare%5Fultrasonography%5Ffor%5Fvolume.11.aspx).
- Does cardiopulmonary resuscitation before donor death affect solid organ transplant function? A systematic review and meta-analysis, Resuscitation, 21 May 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0300957225001662#).
- Advanced airway interventions for paediatric cardiac arrest: updated systematic review and meta-analysis, Resuscitation *Plus*, May 2025, [Link](https://www.sciencedirect.com/science/article/pii/S2666520425001006).
- Pulse check accuracy in pediatrics during resuscitation: a systematic review, Resuscitation *Plus*, May 2025, [Link](https://www.sciencedirect.com/science/article/pii/S2666520425000967).
- Video vs. traditional laryngoscopy for tracheal intubation at birth or in the neonatal unit: A systematic review and meta-analysis, Resuscitation *Plus*, May 2025, [Link](https://www.sciencedirect.com/science/article/pii/S266652042500102X).
- Energy doses for paediatric defibrillation in cardiac arrest: systematic review and meta-analysis, Resuscitation *Plus*, 26 May 2025, [Link](https://www.sciencedirect.com/science/article/pii/S2666520425001286).
****Randomized Controlled Trials (RCTs):**
- The Significance of Possible Non-Occlusive Mesenteric Ischemia in Relation to Neurological Outcomes in Patients with Refractory Cardiac Arrest - Secondary Analysis of the Prague OHCA Study, **Resuscitation*, 15 May 2025, [Link](https://www.resuscitationjournal.com/article/S0300-9572%2825%2900154-6/abstract).
- Postresuscitation pleth variability index-guided hemodynamic management of out-of-hospital cardiac arrest survivors: A randomised controlled trial, Resuscitation *Plus*, May 2025, [Link](https://www.sciencedirect.com/science/article/pii/S2666520425000700).
- Hydrocortisone and arginine vasopressin in post-resuscitation shock: the HYVAPRESS trial, Resuscitation *Plus*, 19 May 2025, [Link](https://www.sciencedirect.com/science/article/pii/S2666520425001195).
****Reviews:**
- Individualized mean arterial pressure targets in critically ill patients guided by non-invasive cerebral-autoregulation: a scoping review, **Critical Care*, 16 May 2025, [Link](https://ccforum.biomedcentral.com/articles/10.1186/s13054-025-05432-5).
- Acute traumatic coagulopathy: what you should know, what is debated and what should come next, Anaesthesia Critical Care & Pain Medicine, 16 May 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S235255682500075X).
- Anticoagulation Monitoring during Extracorporeal Membrane Oxygenation: a Narrative Review, Journal of Cardiothoracic and Vascular Anesthesia, 24 May 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025004343).
- Pulmonary Embolism: Unanswered Questions and Ongoing Evidence Gaps, Journal of Cardiothoracic and Vascular Anesthesia, 20 May 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S1053077025004070).
- What every intensivist should know about type D hyperlactatemia, **Journal of critical care*, August 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S088394412500036X).
1. ****Neurocritical Care:**
****Reviews:**
- Critical insights for intensivists on Guillain-Barré syndrome, **Annals of Intensive Care*, 21 May 2025, [Link](https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-025-01464-w).
1. ****Renal & Electrolyte Management:**
****Systematic Reviews & Meta-Analyses:**
- The influence of electronic AKI alert on prognosis of adult hospitalized patients: a systematic review and meta-analysis, **Critical Care*, 12 May 2025, [Link](https://ccforum.biomedcentral.com/articles/10.1186/s13054-025-05402-x).
- Novel biomarkers for predicting successful liberation of renal replacement therapy for acute kidney injury: a systematic review, **Critical Care*, 26 May 2025, [Link](https://ccforum.biomedcentral.com/articles/10.1186/s13054-025-05451-2).
****Randomized Controlled Trials (RCTs):**
- Immediate or delayed initiation of renal replacement therapy in patients with leptospirosis and acute kidney injury: a target trial emulation, **Annals of Intensive Care*, 14 May 2025, [Link](https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-025-01477-5).
****Reviews:**
- Acute kidney injury: when and how to start renal replacement therapy, **Intensive care medicine*, 19 May 2025, [Link](https://link.springer.com/article/10.1007/s00134-025-07933-x).
1. ****Nutrition & Metabolism in ICU:**
****Reviews:**
- Nutrition and metabolic control for ICU patients, **Intensive care medicine*, 19 May 2025, [Link](https://link.springer.com/article/10.1007/s00134-025-07937-7).
- Contemporary Rationale for Delivering Enteral Nutrition in Critically Ill Adults, **Critical Care Medicine*, May 21, 2025, [Link](https://journals.lww.com/ccmjournal/abstract/9900/contemporary%5Frationale%5Ffor%5Fdelivering%5Fenteral.528.aspx).
1. ****Sedation and Analgesia:**
****Randomized Controlled Trials (RCTs):**
- Dexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill PatientsThe A2B Randomized Clinical Trial, **JAMA*, 19 May 2025, [Link](https://jamanetwork.com/journals/jama/fullarticle/2834276).
- Cost-Effectiveness of α2 Agonists for Intravenous Sedation in Patients With Critical Illness, **JAMA Network Open*, 2025, 19 May 2025, [Link](https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2834255).
1. ****Other:**
****Randomized Controlled Trials (RCTs):**
- ROBotic-assisted Early Mobilization in Ventilated Surgical Critically ill Patients (ROBEM-I) – a randomized, controlled, outcome-assessor-blinded pilot study, **Anaesthesia Critical Care & Pain Medicine*, 23 May 2025, [Link](https://www.sciencedirect.com/science/article/pii/S2352556825000815).
- Improving Recovery and Outcomes Every Day After the ICU (IMPROVE): A Randomized Controlled Trial, **Critical Care Medicine*, May 22, 2025, [Link](https://journals.lww.com/ccmjournal/abstract/9900/improving%5Frecovery%5Fand%5Foutcomes%5Fevery%5Fday%5Fafter.530.aspx).
****Reviews:**
- Understanding and mitigating medication errors associated with patient harm in adult intensive care units: a scoping review, **Intensive care medicine*, 20 May 2025, [Link](https://link.springer.com/article/10.1007/s00134-025-07938-6).
- Immune Thrombotic Thrombocytopenic Purpura, **JAMA*, 19 May 2025, [Link](https://jamanetwork.com/journals/jama/article-abstract/2834159).
- Diagnosing pulmonary embolism during pregnancy: A narrative review, **CHEST*, 20 May 2025, [Link](https://www.sciencedirect.com/science/article/pii/S001236922500649X).
- Implementing Large Language Models in Critical Care: What is Behind the Delay?, **CHEST Critical Care*, 24 May 2025, [Link](https://www.chestcc.org/article/S2949-7884%2825%2900053-X/fulltext).
- ICU-acquired weakness: Critical illness myopathy and polyneuropathy, **Journal of critical care*, August 2025, [Link](https://www.sciencedirect.com/science/article/abs/pii/S0883944125000619).
###
---
### **Feedback & Suggestions**
Don't hesitate to share your thoughts and suggestions in the comments below; they'll be a great help in improving future issues of the newsletter.
**Disclaimer**
💡
****Disclaimer:**
The is for educational and informational purposes only and is not intended to replace professional medical advice, diagnosis, or treatment.
See you next week, Thursday 5th of June 2025 :)
**Benhalima Othmane.**
**Anecrit.com**
---
### Optimizing MAP Targets in Septic Shock: Insights from the OPTPRESS Trial
URL: https://www.anecrit.com/optimizing-map-targets-in-septic-shock-insights-from-the-optpress-trial/
Last updated: 2026-01-31T12:32:00.000Z
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## 1- Introduction:
When managing septic shock, particularly in older patients with chronic hypertension, a critical decision arises: what Mean Arterial Pressure (MAP) target should guide vasopressor therapy? While the Surviving Sepsis Campaign (SSC) typically recommends a 65 mmHg MAP, the optimal target for this complex patient population remains debated. The OPTPRESS trial (Efficacy of targeting high mean arterial pressure for older patients with septic shock) was specifically designed to investigate whether a higher MAP target could benefit elderly patients with hypertension in septic shock.
## 2- Research Methodology:
### **2.1- Study Design:**
The OPTPRESS trial was conducted as a multicenter, pragmatic, open-label, randomized controlled trial across 29 hospitals in Japan. While treating physicians were aware of group assignments, statisticians remained blinded to allocation until all analyses were complete, ensuring analytical objectivity.
### 2.2- Participant Eligibility: Defining the Study Population
### 2.3- Intervention Protocol:
Patients were randomized 1:1 to one of two distinct hemodynamic management strategies:
- **Group Assignment:**
- **High-Target Group:** Aimed for a Mean Arterial Pressure (MAP) of 80–85 mmHg.
- **Control Group:** Targeted a MAP of 65–70 mmHg, aligning with the 2021 Surviving Sepsis Campaign (SSC) guidelines.
- **MAP Target Duration:**
- Target MAPs were maintained for up to 72 hours post-randomization or until vasopressor support was no longer clinically required.
- Beyond 72 hours, the specific MAP target was determined at the treating physician's discretion!!
- **Blood Pressure Monitoring:**
- Primarily relied on non-invasive measurements.
- Invasive arterial pressure monitoring was utilized when non-invasive methods were impractical.
- **High-Target Group Safety Measures:**
- If vasopressor-related adverse events occurred (such as significant bleeding, myocardial infarction, severe arrhythmias, intestinal ischemia, or limb ischemia), the MAP target in the high-target group was reduced to 65 mmHg.
- **Fluid and Vasopressor Management:**
- **Fluid Therapy:** Volume and rate of fluid administration were determined by the physician.
- **First-Line Vasopressor:** Norepinephrine was the initial choice.
- **Vasopressin Integration:** To minimize catecholamine side effects, vasopressin (up to 0.04 U/min) was initiated if norepinephrine doses exceeded 0.1 μg/kg/min to maintain target MAP.
- **Escalation Options:** If targets remained unmet, physicians could introduce other vasopressors, increase norepinephrine dosage, or add dobutamine or hydrocortisone.
- **Clinical Guidance:** Treating physicians were generally expected to adhere to current guidelines for sepsis management.
- **Vasopressor Weaning:** Decisions to reduce or discontinue vasopressors were at the physician's discretion.
- **Ancillary Clinical Management:**
- Antibiotic selection, mechanical ventilation, renal replacement therapy, and other medical interventions were managed at the physician's discretion.
- Sedation and pain management aimed for a Richmond Agitation-Sedation Scale (RASS) score between -3 and 0.
---
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---
### 2.4- Outcome Measures: Assessing Efficacy and Safety
The trial utilized both primary and secondary endpoints to comprehensively evaluate the impact of the different MAP strategies.
- **Primary Outcome:**
- All-cause mortality at 90 days following randomization. This was confirmed by the treating physician via medical records, direct patient/relative contact, or communication with transfer facilities.
- **Secondary Outcomes:**
- **Mortality Rates:**
- All-cause mortality at 28 days.
- Sepsis-related mortality at 28 days.
- Sepsis-related mortality at 90 days.
- **Lactate clearance at 24 hours.**
- **Safety outcomes:**
- Incidence of arrhythmias (ventricular tachycardia or hemodynamically significant supraventricular arrhythmia) within 72 h.
- Incidence of thromboembolic events (e.g., myocardial infarction, cerebral infarction, intestinal necrosis, irreversible peripheral limb ischemia) within 72 h.
- Incidence of hemorrhagic events within 72 h.
- **Organ Support-Free Days at 28 Days:** (For these measures, patients who died within 28 days or remained on support after 28 days were assigned a score of zero.)
- Ventilator-free days.
- Renal replacement therapy (RRT)-free days.
- Catecholamine-free days.
- **Measurement Protocols:**
- Adverse events like arrhythmias or thromboembolism were clinically assessed by the physician using laboratory data, imaging, and other relevant findings.
- "Free days" were defined as consecutive 24-hour periods from day 1 to day 28 post-randomization where the patient was alive and did not require the specified support.
## 3- Results: Unveiling the Impact of MAP Targets
The trial's findings provided critical insights into the safety and efficacy of high-target MAP strategies in this patient population.
- **Participant Flow:** A total of 518 patients were enrolled and analyzed, with 258 assigned to the high-target group and 260 to the control group.
- **Baseline Comparability:** Patient baseline characteristics were well-balanced between both the high-target and control groups.
- **Primary Outcome Findings:** The trial was prematurely concluded following an interim analysis, which indicated potential harm associated with the high-target MAP strategy. At 90 days post-randomization, all-cause mortality was significantly higher in the high-target group (39.3%, 101 patients) compared to the control group (28.6%, 74 patients). This resulted in a risk difference of 10.7 (95% confidence interval, 2.6–18.9), demonstrating a statistically significant increase in mortality with the higher MAP target.
- **Secondary Outcomes Findings:**
- All mortality rates from the secondary outcomes were higher in the high target group.
- All organ support-free days outcomes were lower in the high target group.
---
- **Adverse Events/Side Effects:** While the published results did not find a statistically significant difference in safety outcomes, the early termination of the study could be the cause for that. (It's worth mentioning that the target MAP was reduced to 65- 70 mmHg in two patients in the high target group due to adverse events)
## 4- Strengths of the Study Design and Execution
- **Multicenter, Pragmatic, Randomized Controlled Trial:** The study design is robust for evaluating clinical effectiveness in a real-world setting. Conducting it across 29 hospitals in Japan enhances its practical relevance.
- **Targeted Underrepresented Population:** The study specifically focused on older patients (aged ≥ 65 years) with septic shock in Japan, a population and region previously underrepresented in similar trials, thereby adding global relevance to existing evidence.
- **Clear Primary Outcome:** The primary outcome of 90-day all-cause mortality is clinically relevant and objective.
- **Randomization and Stratification:** Patients were randomized 1:1 using a centralized, computer-generated allocation sequence, stratified by history of chronic hypertension and age (<80 years or older) to ensure balanced groups at baseline. Baseline characteristics were indeed similar between the groups.
- **Early Termination Based on Harm:** The trial's early termination due to an interim analysis suggesting harm in the high-target strategy demonstrates ethical conduct and responsiveness to patient safety.
- **Protocol for Vasopressin Use:** The protocol included early concomitant use of vasopressin to minimize potential adverse effects of catecholamines.
- **Intention-to-Treat Analysis:** The primary analysis was conducted on an intention-to-treat population, which maintains the benefits of randomization and provides a more pragmatic estimate of the intervention's effect.
- **Masked Statisticians:** The statisticians were masked to group allocation until all analyses were completed, reducing analytical bias.
## 5- Potential Limitations/Weaknesses:
- **Open-Label Design:** The trial was open-label, meaning treating physicians were aware of the assigned groups. This could influence clinical management and introduce performance bias.
- **Non-Invasive Blood Pressure Monitoring:** Blood pressure was measured non-invasively on the upper arm in principle for generalizability, but invasive intra-arterial blood pressure monitoring, which is more accurate, is typically feasible in ICU settings and might have provided more precise MAP control.
- **Physician Discretion for Certain Treatments:** Several aspects of patient management, including fluid administration volume and speed, vasopressor reduction/discontinuation, initial empiric antibacterial agents, mechanical ventilation/RRT introduction, and use of other adjunctive medications, were left to the treating physician's discretion. While this contributes to the pragmatic nature, it could introduce variability in care.
- **Lack of Strict Vasopressor Titration Protocol:** The absence of a strict titration or tapering protocol for vasopressors might have led to differences in the time to reach target MAP and the accuracy of MAP control.
- **Cardiac Function Monitoring Not Protocolized:** Cardiac function monitoring and management were not protocolized, despite the acknowledgement that the effectiveness of fluid resuscitation and vasoactive agents depends on pre-existing cardiovascular conditions and cardiac depression due to sepsis. This could be a significant uncontrolled variable.
- **Difference Between Target and Observed MAP in Control Group:** The discussion acknowledges that the actual MAP in the control group often exceeded the target range (65-70 mmHg), though it attributes this primarily to improved patient condition rather than protocol non-compliance. However, this could still potentially blur the distinction between the two intervention arms, especially if the "excess" MAP in the control group approached the lower end of the high-target group's range.
- **Generalizability of the Findings:**
- **Single-Country and Ethnic Homogeneity:** The study was conducted in 29 hospitals across Japan, and all participants were Japanese. This limits the generalizability of the findings to other ethnic groups and healthcare systems outside of Japan.
- **Specific Patient Population (Older Patients with Septic Shock):** The findings are specific to older patients (aged ≥ 65 years) with septic shock. While this was a strength in addressing an underrepresented population, it means the results may not be directly applicable to younger septic shock patients.
## 6- Question arises:
The OPTPRESS trial truly reinforces the current Surviving Sepsis Campaign guidelines regarding MAP targets. But this outcome naturally leads us to wonder: why these specific results?
From a pathophysiological standpoint, a higher MAP target might intuitively seem more appropriate for hypertensive patients with septic shock, yet this trial showed increased mortality in that group. This raises a compelling question about the underlying reasons. Could it be linked to adverse effects from catecholamine use? While the trial didn't find a statistically significant difference in adverse events, the study's early termination could be a factor here. Perhaps a completed trial would have revealed a clearer statistical significance regarding these adverse events.
I'll aim to delve deeper into this question in an upcoming article. If you're interested in not missing it, be sure to subscribe to get notified upon publication!
⏭️
Upcoming articles: - Summary of the recently published guidelines on management of emergencies and critical illness in pediatric and adult patients with sickle cell disease. - Summary of the SESAR trial. - Summary of the A2B trial. - Acute pancreatitis: a guidelines-based management. - And much more!
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### **Feedback & Suggestions**
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---
## References:
1. [Endo, A., Yamakawa, K., Tagami, T. *et al.* Efficacy of targeting high mean arterial pressure for older patients with septic shock (OPTPRESS): a multicentre, pragmatic, open-label, randomised controlled trial. *Intensive Care Med* **51**, 883–892 (2025).](https://link.springer.com/article/10.1007/s00134-025-07910-4)
2. [Evans, L., Rhodes, A., Alhazzani, W. *et al.* Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021\. *Intensive Care Med* **47**, 1181–1247 (2021).](https://link.springer.com/article/10.1007/s00134-021-06506-y)
💡
Disclaimer: This article summarizes the findings of the OPTPRESS trial, published in Intensive Care Medicine (ICM). For the complete study details, including methodology and results, please refer to the original publication: [Endo, A., Yamakawa, K., Tagami, T. **et al.* Efficacy of targeting high mean arterial pressure for older patients with septic shock (OPTPRESS): a multicentre, pragmatic, open-label, randomised controlled trial. **Intensive Care Med* ****51**, 883–892 (2025).](https://link.springer.com/article/10.1007/s00134-025-07910-4)
❗
The information provided on this page is for educational purposes related to anesthesiology and critical care medicine. It is not intended to serve as a substitute for professional medical advice, diagnosis, or treatment.
#### Keywords:
septic shock, MAP targets, Mean Arterial Pressure, older patients, vasopressors, OPTPRESS trial, randomized controlled trial, sepsis guidelines, mortality in sepsis, hemodynamic management, vasopressor therapy, sepsis treatment, clinical trial results, intensive care unit, sepsis mortality, Surviving Sepsis Campaign, norepinephrine, vasopressin, sepsis research, medical research, critical care medicine
### New insights into optimizing labor analgesia!
URL: https://www.anecrit.com/double-dural-puncture-epidural-randomized-controlled-trial/
Last updated: 2025-05-26T18:53:57.000Z
For labor analgesia, anesthesiologists have multiple options. One technique often discussed is the **Dural Puncture Epidural (DPE)**. This involves intentionally puncturing the dura mater with a spinal needle to facilitate the diffusion of the epidurally administered medication mixture into the subarachnoid compartment. Crucially, this puncture is not associated with any intrathecal injection of medication.
Recently, a single-center, prospective, single-blind, randomized controlled trial comparing the **Double Dural Puncture Epidural (DDPE)** technique with conventional epidural for labor analgesia in primiparous women has been published in the European Journal of Anaesthesiology (EJA). Here's a summary of the findings:
### 🔬Why this study matters:
Neuraxial anesthesia is a cornerstone of labor pain management. This trial aimed to rigorously compare the analgesic efficacy and safety profile of DDPE against the standard epidural technique. The motivation was to explore whether DDPE could offer a superior quality of analgesia, particularly regarding onset and extent of sensory block, without increasing adverse effects.
### Understanding Double Dural Puncture Epidural (DDPE):
DDPE is a technique where a 25-gauge Whitacre needle is used to perform *two* dural/arachnoid punctures (one cephalad and one caudad) via the epidural needle before catheter insertion. This aims to further improve drug distribution into the subarachnoid space compared to other techniques.
### ⁉️But why investigate this technique when we already have the "single" dural puncture epidural?
That's a great question, and the authors delve into it. They suggest that the "elastic properties of the dura mater, with closure or partial closure of the hole from a single dural puncture," might explain why classical DPE techniques sometimes show "less obvious advantages compared to epidural." This implies that a single dural puncture might not consistently or optimally facilitate the desired diffusion of epidural medication into the subarachnoid space. DDPE was designed to address this potential limitation.
### 📰Key Findings of the trial:
The results demonstrate significant advantages for DDPE:
- **Superior Analgesic Onset:** DDPE showed a significantly higher proportion of patients achieving adequate analgesia (VAS ≤ 30 mm) 10 minutes post-block (75.0% vs. 40.0%, p<0.001) and at 30 minutes (98.3% vs. 85.0%, p=0.017).
- **Enhanced Sacral Coverage:** DDPE achieved faster sacral coverage, which is crucial for perineal pain relief during the second stage of labor.
- **Reduced Medication Use:** The DDPE group required less total local anesthetic consumption (70 ml \[50 to 90\] vs. 80 ml \[60 to 110\], p=0.005) and had fewer unmet analgesia demands.
- **Comparable Safety Profile:** Importantly, the study found no statistically significant difference (P>0.05) in the incidence of adverse effects between the two groups, including nausea, vomiting, pruritus, hypotension, and fetal heart rate abnormalities. No cases of postdural puncture headache (PDPH) were observed in either group.
### Where do we go from here?
While promising, the authors highlighted areas for future investigation:
- **Larger Multicenter Trials:** The study, while having a calculated sample size, was single-center and relatively small. This suggests the need for larger, multicenter studies to further validate efficacy, definitively assess the safety profile (especially rare adverse events like PDPH), and improve generalizability.
- **Optimal Drug Mixtures:** Further research is needed to determine the optimal local anesthetic and opioid concentrations for use with the DDPE technique.
- **Mechanism of Action:** Investigating the precise relationship between drug distribution in the subarachnoid space and the double dural puncture mechanism could provide deeper insights.
- **DDPE vs. Single DPE:** Dedicated studies directly comparing Double Dural Puncture Epidural (DDPE) with single Dural Puncture Epidural (DPE) techniques are needed to assess whether DDPE truly offers a superior advantage over established DPE methods.
This study provides compelling evidence for DDPE as a valuable refinement in neuraxial labor analgesia, offering improved pain relief dynamics without increasing maternal complications.
## References:
- Double dural puncture epidural improves quality of labour analgesia without increasing adverse effects in primipara: A randomised controlled trial. European Journal of Anaesthesiology, May 21, 2025\. [Link](https://journals.lww.com/ejanaesthesiology/abstract/9900/double%5Fdural%5Fpuncture%5Fepidural%5Fimproves%5Fquality%5Fof.303.aspx)
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### I tried "deep search" in GROK 3 for medical research. Is it any good?
URL: https://www.anecrit.com/testing-deep-search-grok3-medical-research/
Last updated: 2025-08-24T16:02:37.000Z
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## 1\. Introduction:
Grok 3 was recently released, and I was particularly interested in testing its "deep search" capability. As a medical resident, I wanted to evaluate its potential as a research assistant, especially since they've made it temporarily accessible to free users.
## 2\. Testing Methodology
A fundamental challenge with AI models is their tendency to hallucinate—generating false or non-existent information. This is particularly concerning in medicine and other fields where accuracy is crucial.
There are typically two ways to identify AI hallucinations, in my opinion:
1. Having deep expertise in the subject matter (which is somewhat counterintuitive since we often use AI to learn about unfamiliar topics)
2. Verifying the provided sources, which is particularly relevant for Grok's "deep search" feature
For my evaluation, I chose to focus on a specific medical topic: the use of corticosteroids in Acute Respiratory Distress Syndrome (ARDS). Specifically, I wanted to examine published Randomized Controlled Trials (RCTs) regarding their efficacy and safety.
❔
My test prompt was: "I want an exhaustive list of all published RCTs about the safety and efficacy of corticosteroids in ARDS. Include only RCTs; no other study types should be included."
## 3.Results
The model conducted its search across 35 webpages over 2 minutes and 16 seconds before providing the following results:
Yes it crashed!
So I tried again and it took 1min 54s for the results, they are listed below:
#### Overview of grok-3's response:
Key Points
- There are 14 published Randomized Controlled Trials (RCTs) on the safety and efficacy of corticosteroids in Acute Respiratory Distress Syndrome (ARDS).
- These studies include both adult and pediatric patients, with some focusing on COVID-19-related ARDS.
- Some studies also cover related conditions like septic shock, which may include ARDS patients.
Overview
This response provides a comprehensive list of all published RCTs examining the safety and efficacy of corticosteroids in ARDS, ensuring only RCTs are included as requested. The studies span various patient groups, including adults and children, and some address ARDS in the context of COVID-19\. Notably, some trials also include patients with related conditions like septic shock, which may overlap with ARDS cases.
Below is the list of 14 RCTs, each with full citations for easy reference:
- Meduri GU, et al. Methylprednisolone infusion in early severe ARDS: results of a randomized controlled trial. **Chest*. 2007;131(4):954-963\. [PMID: 17426195](https://pubmed.ncbi.nlm.nih.gov/17426195/)
- Tongyoo S, et al. Hydrocortisone treatment in early sepsis-associated acute respiratory distress syndrome: results of a randomized controlled trial. **Critical Care*. 2016;20(1):329\. [PMID: 27784335](https://pubmed.ncbi.nlm.nih.gov/27784335/)
- Villar J, et al. Dexamethasone treatment for the acute respiratory distress syndrome: a multicentre, randomised controlled trial. **The Lancet Respiratory Medicine*. 2020;8(3):267-276\. [PMID: 31928907](https://pubmed.ncbi.nlm.nih.gov/31928907/)
- Annane D, et al. Effect of low doses of corticosteroids in septic shock patients with or without early acute respiratory distress syndrome. **Critical Care Medicine*. 2006;34(1):22-30\. [PMID: 16374157](https://pubmed.ncbi.nlm.nih.gov/16374157/)
- Steinberg KP, et al. Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome. **The New England Journal of Medicine*. 2006;354(16):1671-1684\. [PMID: 16625008](https://pubmed.ncbi.nlm.nih.gov/16625008/)
- Jamaati H, et al. No clinical benefit of high dose corticosteroid administration in patients with COVID-19: a preliminary report of a randomized clinical trial. **European Journal of Pharmacology*. 2021;897:173947\. [PMID: 33647378](https://pubmed.ncbi.nlm.nih.gov/33647378/)
- Tomazini BM, et al. Effect of dexamethasone on days alive and ventilator-free in patients with moderate or severe acute respiratory distress syndrome and COVID-19: The CoDEX Randomized Clinical Trial. **JAMA*. 2020;324(13):1307-1316\. [PMID: 32876697](https://pubmed.ncbi.nlm.nih.gov/32876697/)
- Drago BB, et al. Double-blind, placebo-controlled pilot randomized trial of methylprednisolone infusion in pediatric acute respiratory distress syndrome. **Pediatric Critical Care Medicine*. 2015;16(3):e74-81\. [PMID: 25647114](https://pubmed.ncbi.nlm.nih.gov/25647114/)
- Bernard GR, et al. High-dose corticosteroids in patients with the adult respiratory distress syndrome. **The New England Journal of Medicine*. 1987;317(25):1565-1570\. [PMID: 3317054](https://pubmed.ncbi.nlm.nih.gov/3317054/)
- Rezk NA, Ibrahim AM. Effects of methyl prednisolone in early ARDS. **Egyptian Journal of Chest Diseases and Tuberculosis*. 2013;62(3):519-524\. [DOI: 10.1016/j.ejcdt.2013.05.005](https://www.sciencedirect.com/science/article/pii/S001393571300079X)
- Liu L, et al. The effect of stress dose glucocorticoid on patients with acute respiratory distress syndrome combined with critical illness-related corticosteroid insufficiency. **Chinese Journal of Internal Medicine*. 2012;51(8):599-603\. [PMID: 23158856](https://pubmed.ncbi.nlm.nih.gov/23158856/)
- Confalonieri M, et al. Hydrocortisone infusion for severe community-acquired pneumonia: a preliminary randomized study. **American Journal of Respiratory and Critical Care Medicine*. 2005;171(3):242-248\. [PMID: 15516528](https://pubmed.ncbi.nlm.nih.gov/15516528/)
- Meduri GU, et al. Effect of prolonged methylprednisolone therapy in unresolving acute respiratory distress syndrome: a randomized controlled trial. **JAMA*. 1998;280(2):159-165\. [PMID: 9669789](https://pubmed.ncbi.nlm.nih.gov/9669789/)
- Seam N, et al. Effects of methylprednisolone infusion on markers of inflammation, coagulation, and fibrinolysis in patients with severe sepsis or acute respiratory distress syndrome. **Annals of Intensive Care*. 2012;2(1):49\. [PMID: 23210475](https://pubmed.ncbi.nlm.nih.gov/23210475/)
I wanted to test it more but unfortunately, I reached my limit as a free user and I have to pay 30$/month to use the "deep search" feature in what they call supergrok. In my opinion it's quite expensive but it's less expensive than the 200$/month for the pro version of openai's chatGPT.
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## 4.Evaluating Grok's Search Accuracy:
## Search Performance
The model completed its search in 1 minute and 54 seconds, yielding good but mixed results. Let's break down this performance into its strengths and limitations:
#### Strengths
The model demonstrated impressive accuracy in identifying core bibliographic elements:
- Successfully captured 13 out of 14 study titles with perfect accuracy
- Nailed all 14 first-author names (100% accuracy)
- Correctly identified publication details (journal and date) for 13 out of 14 studies
#### Limitations
However, some notable inconsistencies emerged:
- The final study entry showed partial inaccuracies:
- Title was partially misrepresented
- Journal of publication was incorrectly cited
- Though interestingly, both first author name and publication date remained accurate
- PMIDs showed significant discrepancies:
- Only 4 papers had correct PMIDs
- The remaining identifiers were inaccurate
This mixed performance highlights both the promising potential and current limitations of AI-powered research tools. While the high accuracy in capturing basic bibliographic information is encouraging, the inconsistencies in unique identifiers like PMIDs suggest there's still room for improvement in data verification and cross-referencing capabilities.
## 5.Comparing AI Performance with Human Systematic Reviews:
### Benchmarking Against Published Research
I've found something truly remarkable in comparing Grok 3's performance with traditional human-conducted systematic reviews. Let me break it down:
##### Key Reference Points
The comparison was made against two recent meta-analyses:
- Chang et al. (2022)\[1\]: A comprehensive systematic review and meta-analysis
- Li et al. (2024)\[2\]: A more recent meta-analysis
##### Remarkable Alignment
What's particularly fascinating is the perfect alignment between Grok 3's results and the Chang et al. study. All 14 studies identified by the human researchers were also captured by the AI model. This isn't just coincidence - it reflects the model's ability to access and process open-access content effectively.
Here you can see the paper in question being included in the research:
and it was explicitly stated in the final result:
The alignment with the Li et al. (2024)\[2\] meta-analysis further reinforces our findings - all 9 RCTs from their study were accurately captured in Grok's results. Again, the open-access nature of this paper likely contributed to this performance.
##### Understanding the Context
This alignment makes perfect sense when we consider that Chang's and Li's papers are openly accessible. It's a brilliant example of how AI can leverage existing high-quality systematic reviews to rapidly synthesize information. The model's ability to identify and extract this information demonstrates both its potential and its current limitations - it's excellent at finding and processing accessible, well-structured academic content.
Note that Grok-3 didn't stop there, it searched for RCTs published after the Chang et al. paper. as illustrated below:
I wanted to highlight the rapid evolution of AI models and their capacity to understand, reason, and search for specific information. Believe me, I tried the same task with other models, and they were unable to give such a detailed response—they would tell me that they could not provide an exhaustive list and that I had to use PubMed for a manual search.
## 6.Implications for Research
This comparison opens up exciting possibilities for how AI could transform systematic review processes and research in general:
- Rapid initial screening of literature
- Validation of reference lists
- Cross-checking of study inclusion criteria
- Time-saving in the preliminary stages of review work
The technology isn't replacing the need for human expertise but rather amplifying our ability to conduct thorough, comprehensive reviews more efficiently.
## 7.Looking to the Future: Beyond Traditional Research Methods
Here's where things get really exciting! While some might ask, "Why use AI when we can directly consult systematic reviews?", this perspective misses the revolutionary potential unfolding before us. Let me explain why this test reveals something truly remarkable about the evolution of AI in medical research:
### Current Breakthroughs
What sets this performance apart is the model's ability to:
- Understand complex medical queries with remarkable precision
- Execute targeted searches across multiple studies
- Synthesize information from various sources
- Provide detailed, specific responses where other models simply defer to manual searches
### Imagining the Future of Medical Research
The possibilities are absolutely thrilling! Consider these potential developments:
- A PubMed integration with advanced AI search capabilities
- Specialized models fine-tuned for medical research analysis
- AI-powered statistical analysis tools for instant meta-analysis
- Real-time research assistants that can process thousands of papers simultaneously
For medical professionals and researchers, this isn't just about saving time - it's about transforming how we interact with medical literature. Imagine having a research assistant that could instantly synthesize decades of clinical trials, while maintaining the crucial element of human oversight and expertise.
## 8.The Bigger Picture
While we must remain vigilant about AI hallucinations and maintain rigorous verification processes, these results hint at an approaching revolution in medical research methodology. We're witnessing the early stages of tools that could dramatically accelerate the pace of medical discovery while making research more accessible and efficient than ever before.
What excites me most is not just what these tools can do today, but how they're laying the groundwork for even more sophisticated research assistance tomorrow. We're not looking to replace traditional research methods - we're enhancing them in ways that could fundamentally transform how we advance medical knowledge.
If you want me to create more content about this topic like comparing this model with other models, more detailed analysis, and other use cases in our field, let me know in the comments below and don't forget to subscribe so you won't miss any upcoming content.
## References:
1. [Safety and efficacy of corticosteroids in ARDS patients: a systematic review and meta-analysis of RCT data.](https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-022-02186-4)
2. [Efficacy of corticosteroids in patients with acute respiratory distress syndrome: a meta-analysis.](https://www.tandfonline.com/doi/full/10.1080/07853890.2024.2381086?rfr%5Fdat=cr%5Fpub++0pubmed&url%5Fver=Z39.88-2003&rfr%5Fid=ori%3Arid%3Acrossref.org)
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### Keywords:
Grok 3, Deep search capability, Medical research, AI in healthcare, AI research assistant, Corticosteroids in ARDS, Acute Respiratory Distress Syndrome, ARDS randomized controlled trials, RCT evaluation, Systematic review automation, AI hallucinations, Bibliographic search automation, Evidence-based medicine, Clinical trial analysis, PubMed.
💡
****Disclaimer:**
The information provided in this article is for educational and informational purposes only and is not intended to replace professional medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider before making any decisions related to your health, particularly if you are experiencing any symptoms or have concerns about seizure management. The author and publisher assume no responsibility or liability for any errors or omissions in the content or for any outcomes resulting from the use of this information.
### Seizure Prophylaxis in Acute Non-Traumatic Intracerebral Hemorrhage: summary of the new guidelines from NCS.
URL: https://www.anecrit.com/ich-seizure-prophylaxis-ncs-guidelines-summary/
Last updated: 2026-01-31T12:32:26.000Z
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## 1.Introduction
Intracerebral hemorrhage (ICH) remains one of the most challenging emergencies in intensive care, where managing potential complications such as seizures is critical. The Neurocritical Care Society (NCS) published new guidelines about seizure prophylaxis in non-traumatic ICH, in this article I tried to summarize those guidelines.
*Keywords: intracerebral hemorrhage, seizure prophylaxis, antiseizure medications, intensive care, levetiracetam, phenytoin, ICH guidelines.*
## 2.Scope of the Guidelines
The recommendations tried to answer frequent questions that every clinician asks when taking care of patients with non-traumatic ICH :
- Prophylaxis versus no prophylaxis,
- Levetiracetam versus phenytoin/fosphenytoin,
- Long versus short duration of prophylaxis when indicated.
## 3.The Actual Guidelines
### 3.1\. PICO 1:
❓
****"Question:** Should ASM Versus No ASM be Used in Patients Hospitalized for Acute Nontraumatic ICH with No History of Clinical or Electrographic Seizures? To Prevent Early Seizure (≤ 14 Days from ICH Onset or During Hospitalization)"
✅
****"Recommendation:** In adult patients hospitalized with acute nontraumatic ICH and no history of clinical or electrographic seizure, we suggest against the use of prophylactic ASMs (weak recommendation, very low quality of evidence)."
**Evidence Highlights:**
Several questions were addressed in the body of the evidence for the guidelines:
- **Is ASM effective for preventing late seizures defined as seizures occurring after 14 days from ICH onset or post-hospitalization?**
- Two randomized controlled trials (RCTs) showed no significant difference in late clinical seizures at 12 months (RR 1.40, 95% CI 0.48–4.13, P=0.54, I²=0%).
- **Is ASM associated with more adverse event rates compared to no ASM?**
- Analysis of two RCTs and three non-RCTs indicated a significantly higher risk of any adverse event with ASM use (RR 1.95, 95% CI 1.03–3.68, P=0.04 I2 = 35%, P = 0.19 for heterogeneity). However, some studies reported no differences in behavioral side effects or delirium when comparing LEV to no ASM.
- **Functional outcomes in ASM vs no ASM groups:**
- Meta-analysis slightly favored the non-ASM group (RR 1.17, 95% CI 1.02–1.35, P=0.03) despite significant heterogeneity (I²=65%, P=0.01 for heterogeneity).
- A pooled analysis of five studies showed no significant impact of ASM on 90-day adjusted modified Rankin Scale (mRS) scores (RR 1.34, 95% CI 0.79–2.27, P=0.28, I²=79%, P<0.001 for heterogeneity).
- **Is there a difference in mortality between ASM and no ASM groups of patients?**
- overall, there was no difference in mortality (nor in the adjusted risk of death, in a pooled analysis) between the ASM vs no ASM groups based on a meta-analysis of six studies (two RCTs and four non-RCTs studies).
- **cognitive outcomes in ASM vs no ASM groups:**
- A retrospective study noted worse neuroQOL (Quality Of Life) cognitive function scores at 1 month in patients receiving LEV vs patients that did not receive ASM; however, these differences were not observed at 3 and 12 months.
### 3.2\. PICO 2:
❓
****"Question:** If an ASM is Used, Should LEV or PHT/fPHT be Preferentially Used for Patients with Acute Nontraumatic ICH with No History of Clinical or Electrographic Seizures? To Prevent Early Seizure (≤ 14 Days from ICH Onset or During Hospitalization)"
✅
****"Recommendation:** If a prophylactic ASM is used after acute nontraumatic ICH, we suggest LEV should be used over PHT/fPHT for seizure prophylaxis (weak recommendation, very low quality of evidence)."
**Evidence Highlights:**
Several questions were addressed in the body of the evidence for the guidelines:
- **Between LEV and PHT/fPHT, which one prevents better late seizures (>14 days from ICH onset or post-hospitalization)?**
- No eligible studies were available to compare late seizure prevention between LEV and PHT/fPHT.
- **Adverse events rate with LEV vs PHT/fPHT:**
- Based on a meta-analysis of three non-RCT studies, no significant difference in adverse event rates was found between the two medications (pooled RR 2.62, 95% CI 0.74–9.26, P=0.14, I²=0%).
- **Functional outcomes with LEV vs PHT/fPHT:**
- One observational study (compared prophylaxis with PHT post ICH vs LEV prophylaxis/no ASM) reported that PHT was significantly associated with worse outcomes (mRS scores 4–6) at 90 days (adjusted OR 9.0, 95% CI 1.2–68.5, P=0.03). *Note that some patients with underlying epilepsy were included in the PHT group*.
### 3.3\. PICO 3:
❓
****"Question:** If an ASM is Used, Should a Long (> 7 days) Versus Short (≤ 7 Days) Duration of Prophylaxis be Used for Patients with Acute Nontraumatic ICH with No History of Clinical or Electrographic Seizures?"
✅
****"Recommendation:** If a prophylactic ASM is used after acute nontraumatic ICH, we suggest a short duration of use (≤ 7 days) versus a longer duration of use (weak recommendation, very low quality of evidence)."
**Evidence Highlights:**
Several questions were addressed in the body of the evidence for the guidelines:
- **Does long-duration prophylaxis prevent late seizures (defined as seizures occurring after 14 days from ICH onset or post-hospitalization)?**
- two small RCTs found no difference in rates of late seizures at 12 months between ASM and placebo groups. One RCT evaluated LEV for 6 weeks vs placebo and the other VPA for one month vs placebo
- **Is long-duration prophylaxis associated with more adverse event rates compared to short-duration prophylaxis?**
- As stated in PICO 1, ASM is probably associated with more adverse event rates compared to no ASM, the authors concluded that an increased duration of exposure would increase the risk of adverse events.
- **Functional Outcomes in Short‐Duration Versus Long‐Duration ASM**
- The authors used the same meta-analysis stated in the response to the question of functional outcomes in ASM vs no ASM groups in PICO 1 (pooled RR 1.17, 95% CI 1.02–1.35, P = 0.03).
## 4.Limitations in the Evidence
Overall, the certainty of the evidence ranged from very low to low. This limitation underscores the pressing need for more robust, high-quality studies to better inform clinical decisions regarding seizure prophylaxis in ICH patients.
Figure 1: Summary of guideline statements in a Q&A format\[1\] .
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## 5.Authors' opinion:
### 5.1.PICO 1:
The decision to initiate ASM prophylaxis should be guided by a careful risk/benefit analysis. Tools such as the 2HELPS2B\[2\] or the CAVE\[3\] scores can assist in risk stratification:
- **Medium - high Seizure Risk:** Prophylactic ASM may be considered for medium seizure risk (12% risk, 2HELPS2B score = 1) or high seizure risk (>25% risk, 2HELPS2B score ≥2).
- **Low Seizure Risk:** ASM prophylaxis may be avoided in patients with a low seizure risk (<5% risk, 2HELPS2B score = 0).
In high-risk patients requiring continuous EEG—when not available—shorter duration routine EEG or limited montage rapid response EEG can be used, albeit with reduced sensitivity and specificity. When EEG is not available at all, the CAVE score (which is based solely on clinical features) may be employed.
The committee generally does not favor routine prophylactic ASM use in ICH patients. However, EEG findings may help identify a subset of patients who could benefit from targeted prophylactic therapy.
*N.B: Most panel members reported use of continuous EEG monitoring for both deep and lobar ICH locations.*
### 5.2.PICO 2:
LEV is increasingly preferred over PHT for ASM prophylaxis. The suggested dosing for LEV is as follows:
- **For Creatinine Clearance >30 mL/min:** 750–1,000 mg twice daily.
- **For Augmented Renal Clearance ≥130 mL/min:** Consider higher or more frequent dosing.
- **For Creatinine Clearance ≤30 mL/min:** Lower doses (e.g., 500 mg once or twice daily) are typically used.
N.B: Other molecules were also discussed.
### 5.3.PICO 3:
For patients without clinical seizures or high-risk EEG features, and if an ASM was used, the panel members reported that they would minimize the duration of ASM prophylaxis to ≤7 days.
However, the duration of secondary prophylaxis or primary prophylaxis when EEG demonstrates high-risk features, many panel members would opt to continue ASM post discharge taking into account the benefits/risks balance and reevaluate the patient in follow-up.
## 6.Conclusion
In summary, current evidence does not support routine prophylactic use of antiseizure medications in patients with acute non-traumatic ICH (in the absence of clinical or electrographic seizures). If seizure prophylaxis is prescribed, levetiracetam is preferred over phenytoin/fosphenytoin, and a short treatment duration (≤7 days) is suggested to reduce potential adverse events. These guidelines emphasize individualized patient assessment using risk stratification tools like the 2HELPS2B and CAVE scores. This balanced approach aims to optimize outcomes and ensure that interventions are both effective and safe for patients with ICH. Given the low quality of available evidence, further research is essential to refine these recommendations and improve seizure management in the intensive care setting.
💡
****Disclaimer:**
The information provided in this article is for educational and informational purposes only and is not intended to replace professional medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider before making any decisions related to your health, particularly if you are experiencing any symptoms or have concerns about seizure management. The author and publisher assume no responsibility or liability for any errors or omissions in the content or for any outcomes resulting from the use of this information.
## 7.References:
1. [Guidelines for Seizure Prophylaxis in Patients Hospitalized with Nontraumatic Intracerebral Hemorrhage: A Clinical Practice Guideline for Health Care Professionals from the Neurocritical Care Society.](https://link.springer.com/article/10.1007/s12028-024-02183-z)
2. [The **2HELPS2B Score** calculator (Medscape).](https://reference.medscape.com/calculator/700/2helps2b-score)
3. [The **CAVE Score** for Predicting Late Seizures After Intracerebral Hemorrhage.](https://www.ahajournals.org/doi/10.1161/strokeaha.114.004686)
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### Perioperative management of patients taking GLP-1 RAs and SGLT2i: What Do the Guidelines Say?
URL: https://www.anecrit.com/glp1ra-gip-sglt2i-management-perioperative/
Last updated: 2026-01-31T12:31:51.000Z
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# 1\. Introduction
Recently, a new consensus statement has been published by a group of UK scientific societies regarding the perioperative management of adult patients taking GLP‑1 receptor agonists (GLP‑1 RAs), GIP agonists, and SGLT2 inhibitors. I thought it would be timely to write an article about this topic—especially since, as anesthesiologists, we are increasingly encountering patients on these medications who are undergoing surgery.
# 2\. GLP‑1 RAs and GIP Agonists
## 2.1 Mechanism of Action
GLP‑1 and GIP are incretins secreted by specialized cells in the intestinal tract. Specifically, GLP‑1 is secreted by L cells and GIP by K cells in response to the presence of glucose in the gut lumen. Their key actions include:
- **Insulin Secretion:** Both GLP‑1 and GIP enhance insulin secretion from pancreatic beta cells.
- **Glucagon Modulation:** GLP‑1 reduces glucagon secretion, whereas GIP tends to increase it.
- **Gastric Emptying:** Both delay gastric emptying, which results in a slower rise in postprandial blood glucose.
- **Satiety and Nausea:** Both activate satiety centers in the hypothalamus, which may contribute to the nausea commonly seen during drug initiation or dose escalation.
- **Insulin Sensitivity:** Both agents improve insulin sensitivity.
Figure 1 \[6\] , no changes were made.
## 2.2 Indications
The currently approved indications for these agents include:
- Type 2 diabetes mellitus
- Overweight and obesity
**Beyond diabetes and obesity, further indications under investigation for GLP‑1 RAs include:**
- Osteoarthritis
- Obstructive sleep apnea
- Metabolic dysfunction-associated steatotic liver disease
- Metabolic dysfunction-associated steatohepatitis
## 2.3 Benefits and Harms of Continuation/Discontinuation in the Perioperative Period:
### 2.3.1 Benefits:
According to the guidelines, the acute use of these drugs may offer benefits based on published data:
- Improved perioperative glycemic control
- Lower postoperative insulin requirements
- Reduced risk of hypoglycemia
- These benefits may lead to reduced complications associated with hyperglycemia (such as a shorter hospital stay, fewer surgical site infections, less acute kidney injury, fewer acute coronary syndromes, reduced critical care admissions, and shorter durations on a ventilator)
- Improved cardiovascular outcomes
### 2.3.2 Harms
- There is an increased risk of pulmonary aspiration. In one study, the odds ratio (95% CI) was 10.23 (2.94–35.82) in the elective surgical setting, and the hazard ratio (95% CI) was 1.33 (1.02–1.74) in the endoscopy setting. This risk may be explained by the delay in gastric emptying caused by incretins and the associated increase in nausea; however, the effect of tachyphylaxis on gastric emptying (especially with chronic use) remains unclear.
- GLP‑1 RAs commonly induce side effects such as nausea, vomiting, abdominal pain, and constipation. These symptoms may complicate the diagnosis and management of perioperative conditions that share similar clinical presentations. The incidence of these side effects during chronic use is not yet clearly defined.
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## 2.4 What Do the Guidelines Say?
> **"Box 1\. Recommendations for the peri-operative management of patients taking glucagon-like peptide-1 receptor agonists and glucose-dependent insulinotropic peptide** \[1\] :
> • The risk of pulmonary aspiration and mitigation strategies should be discussed with the patient using a shared decision-making approach."
> • "Patients should continue to take glucagon-like peptide-1 receptor agonists throughout the perioperative period."
> • "Patients and clinicians should adhere to recommended fasting guidelines."
> • "Upper gastrointestinal symptoms alone should not be used to determine gastric content."
> • "Regional anaesthesia should be considered as the primary anaesthetic technique, if appropriate."
> • "Point-of-care gastric ultrasound should be considered before induction of anaesthesia to facilitate risk stratification, if appropriate."
> • "Individualised pulmonary aspiration risk assessment should be completed, accounting for drug, patient and procedural factors."
> • "Anaesthesia and airway management should aim to reduce the risk of pulmonary aspiration on induction of anaesthesia, during maintenance and after emergence of anaesthesia. This could include: administering prokinetics; using a tracheal tube; modified rapid sequence intubation (with or without cricoid force, depending on local practice); head-up position for induction of anaesthesia; potential use of gastric tubes to empty the stomach before induction of anaesthesia and tracheal extubation; and awake tracheal extubation."
## 2.5 Comparison with Other Guidelines:
### 2.5.1 ASA Guidelines:
A multisociety consensus for the perioperative management of patients taking GLP‑1 RAs was developed by representatives from:
- The American Society of Anesthesiologists
- The American Gastroenterological Association
- The American Society for Metabolic and Bariatric Surgery
- The International Society of Perioperative Care of Patients with Obesity
- The Society of American Gastrointestinal and Endoscopic Surgeons
**Recommendation 1\[2\] :**
> **Consider variables that increase the risk of delayed gastric emptying and aspiration with the periprocedural use of GLP-1RA:**\- The escalation phase of the medication- Higher doses- Weekly dosing- The presence of gastrointestinal symptoms (nausea, vomiting, abdominal pain, dyspepsia, and constipation) suggestive of delayed gastric emptying- Other medical conditions that may delay gastric emptying.
>
> **GLP‑1 RA therapy may be continued preoperatively in patients without an elevated risk of delayed gastric emptying and aspiration.** If the decision is made to hold GLP‑1 RAs, follow ASA guidance: hold daily formulations on the day of surgery and weekly formulations one week prior. Assess all patients for symptoms of delayed gastric emptying on the day of the procedure\[2\] \[8\].
**Recommendation 2\[2\]:**
> \- Minimize the aspiration risk by modifying the preoperative diet and/or altering the anesthesia plan.- Consider a preoperative diet modification (e.g., a liquid diet for at least 24 hours) for patients with concerns about delayed gastric emptying.- Use point-of-care gastric ultrasound to assess aspiration risk if there is clinical concern for retained gastric contents.- If there is a clinical concern for retained gastric contents, weigh the benefits and risks of rapid sequence induction of general anesthesia versus procedure cancellation.
N.B: the formulation of these two recommendations has been changed!
### 2.5.2 ESAIC Guidelines:
The ESAIC has published new guidelines on the preoperative assessment of adults undergoing elective noncardiac surgery, dedicating a full section to the perioperative management of GLP‑1 RAs and SGLT2 inhibitors\[3\]:
> **"R12.1:** When a GLP-1 agonist is prescribed as a weekly injection and considering the long half-life of GLP-1 agonists, we recommend pausing GLP-1 agonists at least 1 week before a scheduled procedure requiring sedation/anaesthesia. If these drugs are given for obesity, then 2 weeks (three half-lives) are recommended. (CPS)"
> **"R12.2:** If the medication is prescribed as daily oral or subcutaneous administration, we recommend pausing GLP-1 agonists on the day of the procedure. (CPS)"
> **"R12.3:** There is no evidence to show that stopping these medications even 1 week before the procedure will eliminate the risk of delayed gastric emptying, despite following the usual fasting timing for surgery. (CPS)"
> **"R12.4:** A clear fluid diet should be encouraged 24 h before any procedure in patients taking GLP-1 agonists. (CPS)"
> **"R12.5:** All patients taking GLP-1 agonists should be considered as at risk of having a full stomach despite a lack of gastrointestinal symptoms. (CPS)"
> **"R12.6:** Whenever possible, a gastric ultrasound should be performed. If gastric contents are found by ultrasound and these are considered as a high risk for aspiration, patients should be counselled about this risk before deciding to proceed with sedation/general anaesthesia. (CPS)"
> **"R12.7:** If the procedure is of such urgency that postponement is not desirable, endotracheal intubation by rapid sequence induction/intubation is advised.(CPS)"
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---
# 3\. SGLT2 Inhibitors (SGLT2i):
## 3.1 Mechanism of Action:
SGLT2 inhibitors (commonly known as “-flozin” drugs) work by blocking the SGLT2 protein in the proximal tubule of the kidneys. This protein is responsible for reabsorbing filtered sodium and glucose; blocking it leads to reduced blood glucose levels and increased sodium excretion.
Figure 2: ****Schematic diagram showing conventional mechanisms of action of SGLT2 inhibitors. SGLT, sodium-glucose co-transporter** \[7\], no changes were made.
## 3.2 Indications:
The approved indications for SGLT2 inhibitors include:
- Diabetes mellitus
- Heart failure
- Chronic kidney disease
## 3.3 Benefits and Harms of Continuation/Discontinuation in the Perioperative Period:
### 3.3.1 Benefits:
- **Improved Glycemic Control:** Continued use may help maintain stable blood glucose levels.
- **Heart Failure Patients:** Data suggest that discontinuing SGLT2 inhibitors in patients treated for heart failure may be associated with worsening heart failure, so maintaining treatment may be beneficial.
### 3.3.2 Harms:
- **Risk of Ketoacidosis:** The major concern is the development of diabetic ketoacidosis (DKA), including euglycemic DKA. The inhibition of glucose reabsorption increases ketone production, and the stress of the perioperative period may further predispose patients to hyperketonemia. One study reported a higher risk of perioperative DKA in patients taking SGLT2 inhibitors (1.02 vs. 0.69 per 1000 patients, OR 1.48; 95% CI 1.02–2.15; p=0.037)\[1\].
- **Hyperglycemia:** Ceasing SGLT2 inhibitors may lead to hyperglycemia and its associated complications.
- **Heart Failure:** In patients with heart failure, stopping SGLT2 inhibitors may be associated with worsening of the condition.
## 3.4 What Do the Guidelines Say?
> **"Box 2\. Recommendations for the peri-operative management of patients taking sodium-glucose cotransporter-2 inhibitors \[1\]:**
> • The risk of peri-operative ketoacidosis and mitigation strategies should be discussed with the patient using a shared decision-making approach."
> •"Sodium-glucose cotransporter-2 inhibitors should be omitted the day before and the day of a procedure. "
> •"Patients and clinicians should adhere to recommended fasting guidelines and avoid prolonged starvation times."
> •"For patients discharged from hospital on the day of surgery, sodium-glucose cotransporter-2 inhibitors should be restarted once eating and drinking normally (usually 24–48 h after surgery)."
> •"For patients staying in hospital after surgery, consider restarting sodium-glucose cotransporter-2 inhibitors once eating and drinking normally and capillary ketones are < 0.6 mmol.l-1\. "
> •"For patients diagnosed with diabetes mellitus on a very low energy/liver reduction diet for the purposes of surgery, sodium-glucose cotransporter-2 inhibitors should be stopped at commencement of the diet, and adjust diabetes mellitus treatment as necessary."
> •"Written sick-day rules should be provided to patients at pre-operative assessment and at discharge."
## 3.5 Comparison with Other Guidelines:
### 3.5.1 American Heart Association (AHA) Guidelines\[4\] :
> "In patients scheduled for NCS, SGLT2i should be discontinued 3 to 4 days\* days before surgery to reduce the risk of perioperative metabolic acidosis (COR I/LOE C-LD) \*Canagliflozin, dapagliflozin, and empagliflozin should be stopped ≥3 days and ertugliflozin ≥4 days before scheduled surgery."
### 3.5.2 European Society of Cardiology (ESC) Guidelines\[5\] :
> "It should be considered to interrupt SGLT-2 inhibitor therapy for at least 3 days before intermediate- and high-risk NCS." (Class IIa/Level C)
### 3.5.3 ESAIC Guidelines\[3\] :
> "R12.8: SGLT2 inhibitors (SGLT2i) drugs should be withheld for 3 to 4 days before elective procedures to reduce the risk of euglycemic diabetic ketoacidosis. (CPS)"
> "R12.9: Patients taking SGLT2i medications should consume clear fluids approximately 2 h before the procedure to keep regular hydration. (CPS)"
> "R12.10: Euglycemic diabetic ketoacidosis should be suspected in this category of patients, and blood b-hydroxybutyrate (BOHB) is a functional confirmatory test. (CPS)"
> "R12.11: If a patient taking SGLT2i drugs did not discontinue the medication in time, dehydration caused by bowel preparation for endoscopy can increase the ketone levels, and the patient should be adequately hydrated before leaving the hospital. (CPS)"
In summary, all three guidelines agree that SGLT2 inhibitors should be discontinued for at least 3 days preoperatively, with the main concern being the prevention of DKA/euglycemic DKA and metabolic acidosis due to increased ketone production. Additionally, maintaining adequate hydration, avoiding prolonged starvation, and ensuring appropriate glucose and ketone monitoring are crucial.
# 4\. Conclusion:
The perioperative management of patients taking incretin‐based therapies (GLP‑1 and GIP receptor agonists) and SGLT2 inhibitors is evolving as these drugs gain widespread use for diabetes, obesity, and cardio‐renal protection. Current consensus guidelines (in patients without elevated risk of delayed gastric emptying and aspiration) advocate for the continuation of GLP‑1 receptor agonists and GIP agonists in the perioperative period—coupled with careful risk assessment, adherence to fasting protocols, and possible dietary modifications—to mitigate the risks of delayed gastric emptying and pulmonary aspiration. In contrast, SGLT2 inhibitors should be withheld (typically at least one day preoperatively) to minimize the risk of euglycemic diabetic ketoacidosis. The current evidence base is limited by a predominance of retrospective studies and case reports. Therefore, further large-scale, prospective research is essential to refine these guidelines, ensure individualized patient safety, and improve overall perioperative outcomes. A multidisciplinary approach and shared decision-making remain key to balancing the benefits of these therapies with their potential risks during the perioperative period.
# 5\. References:
1. [Elective peri‐operative management of adults taking glucagon‐like peptide‐1 receptor agonists, glucose‐dependent insulinotropic peptide agonists and sodium‐glucose cotransporter‐2 inhibitors: A multidisciplinary consensus statement: A consensus statement from the Association of Anaesthetists, Association of British Clinical Diabetologists, British Obesity and Metabolic Surgery Society, Centre for Perioperative Care, Joint British Diabetes Societies for Inpatient Care, Royal College of Anaesthetists, Society for Obesity and Bariatric Anaesthesia and UK Clinical Pharmacy Association. *Anaesthesia*, anae.16541.](https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/10.1111/anae.16541)
2. [Multisociety clinical practice guidance for the safe use of glucagon-like peptide-1 receptor agonists in the perioperative period. *Surgery for Obesity and Related Diseases*, *20*(12), 1183–1186\. ](https://www.sciencedirect.com/science/article/pii/S1550728924007949)
3. [Preoperative assessment of adults undergoing elective noncardiac surgery: Updated guidelines from the European Society of Anaesthesiology and Intensive Care. *European Journal of Anaesthesiology*, *42*(1), 1–35.](https://journals.lww.com/ejanaesthesiology/fulltext/2025/01000/preoperative%5Fassessment%5Fof%5Fadults%5Fundergoing.1.aspx)
4. [2024 AHA/ACC/ACS/ASNC/HRS/SCA/SCCT/SCMR/SVM Guideline for Perioperative Cardiovascular Management for Noncardiac Surgery: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. *Circulation*, *150*(19).](https://www.ahajournals.org/doi/10.1161/CIR.0000000000001285)
5. [2022 ESC Guidelines on cardiovascular assessment and management of patients undergoing non-cardiac surgery: Developed by the task force for cardiovascular assessment and management of patients undergoing non-cardiac surgery of the European Society of Cardiology (ESC) Endorsed by the European Society of Anaesthesiology and Intensive Care (ESAIC), *European Heart Journal*, Volume 43, Issue 39, 14 October 2022, Pages 3826–3924.](https://academic.oup.com/eurheartj/article/43/39/3826/6675076)
6. [Role of a Dual Glucose-Dependent Insulinotropic Peptide (GIP)/Glucagon-like Peptide-1 Receptor Agonist (Twincretin) in Glycemic Control: From Pathophysiology to Treatment. *Life*, *12*(1), 29.](https://www.mdpi.com/2075-1729/12/1/29)
7. [Sodium-glucose co-transporter 2 inhibitor therapy: mechanisms of action in heart failure*Heart* 2021;**107:**1032-1038.](https://heart.bmj.com/content/107/13/1032)
8. [American Society of Anesthesiologists Consensus-Based Guidance on Preoperative Management of Patients (Adults and Children) on Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists.](https://www.asahq.org/about-asa/newsroom/news-releases/2023/06/american-society-of-anesthesiologists-consensus-based-guidance-on-preoperative)
❗
The information provided on this page is for general informational purposes related to anesthesiology and critical care medicine. It is not intended to serve as a substitute for professional medical advice, diagnosis, or treatment. We encourage you to consult the original, peer‐reviewed literature for further details and verification.
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### Keywords:
Perioperative management, GLP‑1 receptor agonists, GIP agonists, SGLT2 inhibitors, Diabetic ketoacidosis, Aspiration risk, Glycemic control, Preoperative fasting, Obesity management, Anesthesia safety, Cardiorenal protection, Consensus guidelines, Shared decision-making, Perioperative complications.
### The ADAPT-sepsis trial: Biomarker-Guided Antibiotic Duration in Sepsis
URL: https://www.anecrit.com/the-adapt-sepsis-trial-biomarker-guided-antibiotic-duration-in-sepsis/
Last updated: 2025-08-24T16:03:10.000Z
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Disclaimer: This article summarizes the findings of the ADAPT trial, published in the **Journale of american medical association (JAMA)*. For the complete study details, including methodology and results, please refer to the original publication: [Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected Sepsis: The ADAPT-Sepsis Randomized Clinical Trial.](https://jamanetwork.com/journals/jama/article-abstract/2828036) JAMA. 2024 Dec 9\. doi: 10.1001/jama.2024.26458.
## 1-Introduction:
Sepsis, a life-threatening condition arising from the body's dysregulated response to infection, requires prompt and effective treatment with antibiotics. However, determining the optimal duration of antibiotic therapy remains a challenge. Prolonged treatment can drive antibiotic resistance, increase adverse effects, and inflate healthcare costs, while prematurely discontinuing antibiotics risks treatment failure and worse outcomes.
A recent study, the Biomarker-Guided Duration of Antibiotic Treatment in Hospitalised Patients With Suspected Sepsis (ADAPT-Sepsis) trial, published in *JAMA*, sought to address this dilemma by evaluating the safety and effectiveness of using biomarkers to guide antibiotic discontinuation in critically ill patients with suspected sepsis.
---
## **2-Study Design: Rigorous and Patient-Centered**
The ADAPT-Sepsis trial was a multicenter, randomized clinical trial conducted in 41 intensive care units across the UK, involving 2,760 adult patients. The study aimed to determine if using procalcitonin (PCT) or C-reactive protein (CRP) to guide the duration of antibiotic therapy would safely reduce the total duration of antibiotic treatment.
### **Inclusion Criteria:**
- Adult patients (≥18 years) admitted to a critical care or intensive care unit (ICU).
- Initiation of intravenous antibiotics for suspected sepsis within 24 hours of admission, with expected continuation for at least 72 hours.
- Suspected sepsis defined as "acute organ dysfunction associated with suspected infection," assessed via the Sequential Organ Failure Assessment (SOFA) score.
### **Exclusion Criteria:**
- Expected prolonged antibiotic therapy (>21 days).
- Severe immunocompromise unrelated to sepsis (e.g., neutropenia <500/µL).
- Anticipation of IL-6 receptor inhibitors (e.g., tocilizumab).
- Futile sepsis treatment expected to end within 24 hours.
- Declined consent or prior trial enrollment.
### **Intervention:**
Patients were randomized into three groups (1:1:1):
1. **Daily PCT-guided protocol.**
2. **Daily CRP-guided protocol.**
3. **Standard care.**
- In the biomarker-guided groups, clinicians received standardized, web-based recommendations to continue or stop antibiotics based on daily serum levels of PCT or CRP.
- The standard care group had daily blood samples but no biomarker guidance.
- The concealed design ensured clinicians were unaware of group assignments, minimizing bias.
---
### **Outcomes: Safety and Effectiveness Evaluated**
#### **Primary Outcomes:**
1. **Total antibiotic duration** (days, from randomization to day 28).
2. **All-cause 28-day mortality** to assess safety, with a noninferiority margin of 5.4%.
#### **Secondary Outcomes:**
- Antibiotic duration and dose for the initial sepsis period.
- Unscheduled care escalation or readmission.
- Infection relapse, superinfection, and adverse reactions.
- Time to readiness for hospital discharge.
- ICU and hospital length of stay.
- 90-day all-cause mortality.
Fig 1: General overview of the study design.
---
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## **3-Results: PCT Shines, CRP Falls Short**
### **Primary Outcomes:**
- **PCT-guided protocol:** Significantly reduced total antibiotic duration (mean difference: 0.88 days(0.19 to 1.58) **p= 0.01**) and demonstrated noninferiority for 28-day mortality vs. standard care (AD: 1.57 (-2.18 to **5.32**) **p=0.02)**.
- **CRP-guided protocol:** No significant difference in total antibiotic duration (MD: 0.09(-0.60 to 0.79) **p=0.79**) and did not definitively meet the noninferiority margin for 28-day mortality (AD: 1.69 (-2.07 to **5.45**) **p=0.03**).
💡
“P values of the test if the RD is less than or equal to the prespecified margin 5.4%(significance level = 0.025)” as mentioned in the paper.
Fig 2: Primary outcome (effictiveness).
Fig 3: Primary outcome (safety).
### **Secondary Outcomes:**
- Both biomarker-guided protocols reduced antibiotic use during the initial sepsis period, though CRP's effect was not sustained through the trial.
- No significant differences in other secondary outcomes.
---
## **4-Discussion: Clinical and Practical Implications**
### **PCT: A Promising Tool with Limitations**
The ADAPT-Sepsis trial provides compelling evidence that daily PCT guidance can (**safely!?**) reduce antibiotic duration in critically ill adults with suspected sepsis. While a reduction of 0.88 days may seem modest, its impact on a population level could significantly curb antibiotic overuse, mitigate resistance, and minimize adverse effects. However, the cost-effectiveness of daily PCT monitoring warrants further exploration, especially in resource-limited settings where access to procalcitonin testing remains restricted.
The statement regarding the safety of the PCT-guided protocol in the ADAPT-Sepsis trial requires further nuance. While the trial met the pre-specified non-inferiority margin for 28-day all-cause mortality, this margin (5.4%) may not be sufficiently stringent to definitively rule out a small but potentially clinically significant increase in mortality associated with shorter antibiotic courses. Further investigation and longer-term follow-up are necessary to fully assess the long-term safety implications of antibiotic duration reduction guided by PCT.
### **CRP**
The lack of effectiveness of the CRP-guided protocol underscores the importance of biomarker selection. While both PCT and CRP are inflammatory markers, PCT's more specific kinetics and reliability in bacterial infections make it superior for guiding antibiotic discontinuation.
### **Economic Considerations**
Procalcitonin testing is costly and not universally accessible, particularly in low- and middle-income countries (LMICs). The latest guidelines from the Surviving Sepsis Campaign acknowledge these limitations. Furthermore, while some studies suggest cost savings associated with PCT-guided strategies, these benefits need validation across diverse economic contexts.
📖
"Limited data on the cost-effectiveness are available, although a single centre study reported decreased hospital costs associated with PCT-guided antibiotic in medical ICU patient with undifferentiated sepsis \[323\]. Procalcitonin testing may not be available in all countries and healthcare settings, including LMICs." The 2021 Surviving Sepsis Campaign guidelines p24/67 (1204).
---
### **Strengths and Limitations of the Study**
#### **Strengths:**
- **Multicenter design** enhances generalizability.
- **Concealed intervention** minimizes bias.
- **Comprehensive outcomes** robustly assess protocol effects.
- **Large sample size** ensures statistical power.
- Alignment with Sepsis-3 criteria strengthens clinical relevance.
#### **Limitations:**
- Potential for **contamination bias** due to shared care environments.
- Open CRP monitoring outside the trial protocol may have influenced decisions.
- Unadjusted multiple comparisons for primary outcomes.
- Limited applicability to resource-constrained settings.
- And as the authors mentionned the concealement strategy could have impact on the difference in the total antibiotic duration for the standard care group.
📑
"it is possible that the concealment strategy could have led clinicians to stop antibiotics later in the standard care group while awaiting the return of stop advice." The ADAPT-sepsis trial paper p10/12.
---
### **Current Guidelines and Future Directions**
The 2021 Surviving Sepsis Campaign guidelines suggest using procalcitonin alongside clinical evaluation to guide antibiotic discontinuation, though this remains a weak recommendation based on low-quality evidence.
📖
"****Biomarkers to discontinue antibiotics**
****Recommendation**
31\. For adults with an initial diagnosis of sepsis or septic shock and
adequate source control where optimal duration of therapy is unclear,
we suggest using procalcitonin AND clinical evaluation to decide
when to discontinue antimicrobials over clinical evaluation alone.
Weak recommendation, low quality of evidence." The 2021 Surviving Sepsis Campaign guidelines p22/67 (1202).
The ADAPT-Sepsis trial bolsters support for PCT-guided strategies but highlights the need for further research to refine biomarker-driven approaches.
---
## **5-Conclusion**
The ADAPT-Sepsis trial represents a potential advancement in optimizing antibiotic therapy for sepsis. However, the safety profile of the daily PCT-guided protocol warrants careful consideration. While the study met its non-inferiority margin for mortality, the pre-specified margin itself may not be sufficiently conservative to definitively exclude the possibility of a small increase in harm associated with reduced antibiotic exposure. Furthermore, challenges related to cost-effectiveness and implementation, particularly in resource-limited settings (though outside the primary scope of this trial), remain significant barriers to widespread adoption. Future research should prioritize validating these findings across diverse healthcare settings and exploring the long-term impact on patient outcomes.
---
## 6-References
1. [Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected Sepsis: The ADAPT-Sepsis Randomized Clinical Trial.](https://jamanetwork.com/journals/jama/article-abstract/2828036) JAMA. 2024 Dec 9\. doi: 10.1001/jama.2024.26458.
2. [Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021\. Intensive Care Med. ](https://link.springer.com/article/10.1007/s00134-021-06506-y)2021 Nov;47(11):1181-1247\. doi: 10.1007/s00134-021-06506-y.
❗
The information provided on this page is for general informational purposes related to anesthesiology and critical care medicine. It is not intended to serve as a substitute for professional medical advice, diagnosis, or treatment.
**Keywords:** Sepsis, Antibiotics, Procalcitonin (PCT), C-Reactive Protein (CRP), Biomarkers, Antibiotic Stewardship, Antibiotic Duration, ADAPT-Sepsis Trial, Critical Care, Intensive Care Unit (ICU).
### Red Blood Cell Transfusion Strategies in Aneurysmal Subarachnoid Hemorrhage: A Deep Dive into the SAHARA Trial
URL: https://www.anecrit.com/sahara-trial-transfusion-strategies/
Last updated: 2025-08-24T16:02:18.000Z
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Disclaimer: This article summarizes the findings of the SAHARA trial, published in the **New England Journal of Medicine*. For the complete study details, including methodology and results, please refer to the original publication: [Liberal or Restrictive Transfusion Strategy in Aneurysmal Subarachnoid Hemorrhage.](https://www.nejm.org/doi/full/10.1056/NEJMoa2410962) N Engl J Med. 2024 Dec 9\. doi: 10.1056/NEJMoa2410962.
## **1- Introduction:**
Anemia is a common complication following aneurysmal subarachnoid hemorrhage (aSAH), impacting over 50% of patients and correlating with poorer outcomes. This secondary insult can exacerbate neurological damage by further compromising cerebral oxygen delivery, potentially contributing to delayed cerebral ischemia (DCI) and other complications. While red blood cell (RBC) transfusions can augment oxygen supply to the brain, the optimal transfusion strategy in this vulnerable population has remained a subject of debate. This article provides a summary of the Subarachnoid Hemorrhage Red Cell Transfusion Strategies and Outcome (SAHARA) trial, recently published in the *New England Journal of Medicine*, offering insights relevant to specialists in neurocritical care and related fields.
## **2- The SAHARA Trial: Design and Methodology:**
The SAHARA trial was a pragmatic, open-label, randomized controlled trial (RCT) conducted across 23 centers in Canada, Australia, and the United States, enrolling 742 patients. The study aimed to determine the impact of liberal versus restrictive RBC transfusion strategies on 12-month neurological outcomes in anemic aSAH patients.
- **Inclusion Criteria:** Adults (≥18 years) with a first-time aSAH and hemoglobin ≤10.0 g/dL within 10 days of admission.
- **Exclusion Criteria:** Non-aneurysmal SAH, active bleeding causing hemodynamic instability, or contraindications to blood transfusion.
- **Interventions:**
- **Liberal Strategy:** Mandatory transfusion to maintain hemoglobin >10 g/dL. This threshold was informed by physician preference, evidence of brain tissue hypoxia below this level, and data suggesting improved oxygen delivery and extraction.
- **Restrictive Strategy:** Transfusion only when hemoglobin ≤8 g/dL, a threshold based on specialist surveys and observational studies.
- **Outcomes:**
- **Primary Outcome:** Unfavorable neurological outcome at 12 months, defined as a modified Rankin Scale (mRS) score ≥4 (ranging from 0 \[full recovery\] to 6 \[death\]).
- **Secondary Outcomes (12 months):** Functional Independence Measure (FIM), EQ-5D-5L utility index and visual analogue scale (VAS), radiographic vasospasm, delayed cerebral ischemia (DCI) within 21 days, and new cerebral infarction.
- **Tertiary Outcomes:** Lowest daily hemoglobin (within 21 days), proportion of patients transfused, mechanical ventilation duration, ICU and hospital length of stay, and transfusion-related adverse events (within 28 days).
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## **3- Key Findings of the SAHARA Trial:**
- **Primary Outcome:** No statistically significant difference in unfavorable neurological outcome at 12 months between the liberal (33.5%) and restrictive (37.7%) strategies.
Figure 01: primary outcomes.
- **Secondary Outcomes:** No significant differences in FIM scores, EQ-5D-5L scores, VAS scores, or 12-month mortality between the groups. While radiographic vasospasm was observed more frequently in the restrictive group (40.7% vs. 31.5%), this did not translate to differences in clinical outcomes like DCI or new cerebral infarction.
Figure 02: Secondary outcomes.
- **Tertiary Outcomes:** As expected, the liberal strategy resulted in significantly more transfusions (99.7% vs. 34.9%). Duration of mechanical ventilation, ICU, and hospital length of stay, and transfusion-related adverse events were similar between groups.
## **5- Comparison with Previous Trials:**
The SAHARA trial provides crucial context when compared to other recent studies on transfusion strategies in neurocritical care, these other trials are the HEMOTION and TRAIN trials published in NEJM and JAMA respectively:
- **Neurological Function Assessment:** The SAHARA trial used the mRS at 12 months, whereas the HEMOTION trial and the TRAIN trial used the Glasgow Outcome Scale-Extended (GOSE) at 6 months. This difference in assessment tools and time points makes direct comparison challenging.
- **Transfusion Thresholds:** The HEMOTION trial in TBI patients used thresholds of ≤10 g/dL (liberal) and ≤7 g/dL (restrictive). The TRAIN trial used <9 g/dL (liberal) and <7 g/dL (restrictive). The SAHARA trial used ≤10 g/dL (liberal) and ≤8 g/dL (restrictive). These variations in thresholds highlight the ongoing debate regarding optimal hemoglobin targets.
- **Patient Population:** The HEMOTION trial focused on traumatic brain injury (TBI), while the TRAIN trial included a heterogeneous neurocritical care population (only 23% with SAH). SAHARA specifically targeted aSAH patients, providing more targeted data for this population.
- **Results:** While the HEMOTION trial, like SAHARA, found no difference between strategies, the TRAIN trial suggested a benefit of a liberal strategy in acute brain injury. This discrepancy may be due to differences in patient populations, transfusion thresholds, and outcome measures.
## **6- Clinical Implications:**
The SAHARA trial provides robust evidence supporting the use of a restrictive transfusion strategy in anemic aSAH patients. The findings demonstrate that a restrictive approach is non-inferior to a liberal strategy in achieving favorable 12-month neurological outcomes. This has significant implications for resource utilization and minimizing unnecessary transfusion-related risks.
## **7- Conclusion:**
The SAHARA trial represents a significant contribution to the management of aSAH. Its rigorous methodology and focused patient population offer valuable guidance for clinicians. The findings suggest that a restrictive transfusion strategy (transfusing at ≤8 g/dL) is a safe and effective approach in anemic aSAH patients, challenging previous assumptions and potentially refining clinical practice. Further research is needed to explore the optimal transfusion strategies in specific subgroups of aSAH patients and to investigate the long-term impact of these strategies on cognitive and functional outcomes.
## References:
1. [Liberal or Restrictive Transfusion Strategy in Aneurysmal Subarachnoid Hemorrhage.](https://www.nejm.org/doi/full/10.1056/NEJMoa2410962) N Engl J Med. 2024 Dec 9\. doi: 10.1056/NEJMoa2410962\. (SAHARA trial).
2. [Liberal or Restrictive Transfusion Strategy in Patients with Traumatic Brain Injury.](https://www.nejm.org/doi/full/10.1056/NEJMoa2404360) N Engl J Med. 2024 Aug 22;391(8):722-735\. doi: 10.1056/NEJMoa2404360\. (HEMOTION trial).
3. [Restrictive vs Liberal Transfusion Strategy in Patients With Acute Brain Injury: The TRAIN Randomized Clinical Trial.](https://jamanetwork.com/journals/jama/article-abstract/2824930) JAMA. 2024 Nov 19;332(19):1623-1633\. doi: 10.1001/jama.2024.20424\. (TRAIN trial).
❗
The information provided on this page is for general informational purposes related to anesthesiology and critical care medicine. It is not intended to serve as a substitute for professional medical advice, diagnosis, or treatment.
**Keywords:** aSAH, red blood cell transfusion, SAHARA trial, neurocritical care, anemia.